Pharmacogenomics of drug metabolizing enzymes and transporters: Implications for cancer therapy

Pharmacogenomics and Personalized Medicine

Volumn 4, Issue 1, 2011, Pages 11-33

  Li, Jing ^a   Bluth, Martin H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drug; Enzymes; Oncology; Personalized medicine; Polymorphisms; Transporters

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; ABC TRANSPORTER; ACYLTRANSFERASE; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; CISPLATIN; CYTOCHROME P450; CYTOCHROME P450 2D6; DIGOXIN; DIHYDROPYRIMIDINE DEHYDROGENASE; DRUG METABOLITE; DRUG METABOLIZING ENZYME; FLUOROURACIL; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; IRINOTECAN; METFORMIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; OROTATE PHOSPHORIBOSYLTRANSFERASE; PRODRUG; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SULFOTRANSFERASE; TAMOXIFEN; THIOPURINE METHYLTRANSFERASE; UNINDEXED DRUG;

AREA UNDER THE CURVE; BLOOD TOXICITY; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER THERAPY; COLORECTAL CANCER; DIARRHEA; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG SAFETY; DRUG TRANSPORT; GASTROINTESTINAL TOXICITY; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYDROLYSIS; KIDNEY CLEARANCE; LUNG NON SMALL CELL CANCER; METASTASIS POTENTIAL; NEUTROPENIA; OXIDATION; PHARMACOGENOMICS; REDUCTION; REVIEW;

EID: 79957860946     PISSN: None     EISSN: 11787066     Source Type: Journal    
DOI: 10.2147/PGPM.S18861     Document Type: Review

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