A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: Critical role of arginine-482 in methotrexate transport

Biochemical Journal

Volumn 373, Issue 3, 2003, Pages 767-774

  Mitomo, Hideyuki ^a   Kato, Ryo ^a   Ito, Akiko ^b   Kasamatsu, Shiho ^a   Ikegami, Yoji ^b   Kii, Isao ^a   Kudos, Akira ^a   Kobatake, Eiry ^a   Sumino, Yasuhiro ^c,d   Ishikawa, Toshihisa ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^d Pharma SNP Consortium   (Japan)

Author keywords

ABCG2; Acquired mutation; ATP binding cassette transporter (ABC transporter); Methotrexate; Multidrug resistance; Single nucleotide plymorphism

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; BIOLOGICAL MEMBRANES; DRUG PRODUCTS; MUTAGENESIS;

POLYMORPHISM;

BIOCHEMISTRY;

ABC TRANSPORTER; ARGININE; DOXORUBICIN; MERCAPTOETHANOL; METHOTREXATE; MITOXANTRONE; RHODAMINE 123;

ARTICLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISULFIDE BOND; DRUG TRANSPORT; EMBRYO; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IC 50; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATE; ARGININE; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL LINE; DNA PRIMERS; HUMANS; METHOTREXATE; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0042068263     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030150     Document Type: Article

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