Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers

Anticancer Research

Volumn 19, Issue 4 B, 1999, Pages 3249-3252

  Kawakami, Kazuyuki ^a,b   Omura, Kenji ^a   Kanehira, Eiji ^a   Watanabe, Yoh ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Gastrointestinal cancer; Polymorphism; Thymidylate synthase

Indexed keywords

DEOXYURIDINE PHOSPHATE; DNA; THYMIDYLATE SYNTHASE; TRITIUM; UFT;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA POLYMORPHISM; GASTROINTESTINAL CARCINOMA; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOASSAY; TANDEM REPEAT;

5' UNTRANSLATED REGIONS; BASE SEQUENCE; BINDING SITES; DNA, NEOPLASM; FLUORODEOXYURIDYLATE; GASTROINTESTINAL NEOPLASMS; GENOTYPE; HUMANS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TANDEM REPEAT SEQUENCES; THYMIDYLATE SYNTHASE;

EID: 0033427561     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Danenberg PV: Thymidylate synthetase - a target enzyme in cancer chemotherapy. Biochim Biophys Acta 473: 73-92, 1977.
2. Schipper DL and Wagener DJ: Chemotherapy of gastric cancer. Anticancer Drugs 7: 137-149, 1996.
3. Bruckner HW and Motwani BT: Chemotherapy of advanced cancer of the colon and rectum. Semin Oncol 18: 443-461, 1991.
4. Pinedo HM and Peters GF: Fluorouracil: biochemistry and pharmacology. J Clin Oncol 6: 1653-1664, 1988.
5. Chu E, Drake JC, Koeller DM, Zinn S, Jamis-Dow CA, Yen GC and Allegra CJ: Induction of thymidylale synthase associated with multidrug resistance in human breast and colon cancer cell lines. Mol Pharmacol 39: 136-143, 1991.
6. Spears CP, Shahinian AH, Moran RG, Heidelberger C and Corbett TH: In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil- sensitive and -resistant murine colon adenocarcinomas. Cancer Res 42: 450-456, 1982.
7. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV and Leichman L: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55: 1407-1412, 1995.
8. Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T and Ayusawa D: Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem 265: 20277-20284, 1990.
9. Horie N, Aiba H, Oguro K, Hojo H and Takeishi K: Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 20: 191-197, 1995.
10. Marchuk D, Drumm M, Saulino A and Collins FS: Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res 19: 1154, 1991.
11. Omura K, Kawakami K, Kanehira E, Nagasato A, Kawashima S, Tawaraya K, Watanabe S, Hirano K, Shirasaka T and Watanabe Y: The number of 5-fluoro-2'-deoxyuridine-5'-monophosphate binding sites and reduced folate pool in human colorectal carcinoma tissues: changes after tegafur and uracil treatment. Cancer Res 55: 3897-3901, 1995.
12. Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, Groshen S, Boswell W, Metzger R, Tan M and Danenberg PV: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 15: 3223-3229, 1997.
13. Boku N, Chin K, Hosokawa K, Ohtsu A, Tajiri H, Yoshida S, Yamao T, Kondo H, Shirao K, Shimada Y, Saito D, Hasebe T, Mukai K, Seki S, Saito H and Johnston PG: Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum. Clinical Cancer Research 4: 1469-1474, 1998.
14. Yeh KH, Shun CT, Chen CL, Lin JT, Lee WJ, Lee PH, Chen YC and Cheng AL: High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy. Cancer 82: 1626-1631, 1998.
15. Van der Wilt CL, Pinedo HM, Smid K and Peters GJ: Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res 52: 4922-4928, 1992.
16. Chu E and Allegra CJ: Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. Adv Exp Med Biol 339: 143-151, 1993.
17. Parr AL, Drake JC, Gress RE, Schwartz G, Steinberg SM and Allegra CJ: 5-fluorouracil-mediated thymidylate synthase induction in malignant and nonmalignant human cells. Biochemical Pharmacology 56: 231-235, 1998.
18. Jenh CH, Geyer PK and Johnson LF: Control of thymidylate synthase mRNA content and gene transcription in an overproducing mouse cell line. Mol Cell Biol 5: 2527-2532, 1985.
19. Ayusawa D, Shimizu K, Koyama H, Kaneda S, Takeishi K and Seno T: Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate. J Mol Biol 190: 559-567, 1986.
20. Takeishi K, Kaneda S, Ayusawa D, Shimizu K, Gotoh O and Seno T: Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucleic Acids Res 13: 2035-2043, 1985.