Natural inhibitors of pancreatic lipase as new players in obesity treatment

Planta Medica

Volumn 77, Issue 8, 2011, Pages 773-785

  De La Garza, Ana Laura ^a   Milagro, Fermín I ^a   Boque, Noemí ^a   Campión, Javier ^a   Martínez, J Alfredo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

fat digestion; high fat diet; obesity; Orlistat; polyphenols; saponins

Indexed keywords

ALCOHOL; ANTIOBESITY AGENT; BENZENEBORONIC ACID; CARNOSIC ACID; CATECHOL DERIVATIVE; CETILISTAT; CHUNGHYULDAN; DAIDZEIN; DIOSCIN; EBELACTONE A; EBELACTONE B; ELLAGIC ACID; FLAVONOID; GREEN TEA EXTRACT; LICOCHALCONE A; LUTEOLIN; NATURAL PRODUCT; PHYTIC ACID; POLYPHENOL DERIVATIVE; PROANTHOCYANIDIN DERIVATIVE; PROBIOTIC AGENT; PROCYANIDIN; QUERCETIN; SAPONIN; SAPONIN DERIVATIVE; TANNIN DERIVATIVE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APPLE; BLOATING; DANDELION; DEFECATION URGENCY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FECES INCONTINENCE; GINSENG; GRAPEVINE; HUMAN; ILEX PARAGUARIENSIS; LIPID DIET; LIPID METABOLISM; LIVER DISEASE; MEDICINAL PLANT; NONHUMAN; OBESITY; OILY SPOTTING; PEANUT; PROPHYLAXIS; REVIEW; SOYBEAN; SPOTTING; STEATORRHEA; TEA; UNSPECIFIED SIDE EFFECT; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; BIOLOGICAL PRODUCTS; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; LIPASE; OBESITY; PHENOLS; SAPONINS;

ALGAE; ARACHIS HYPOGAEA; CROTON OVALIFOLIUS; FUNGI; GLYCINE MAX; MALUS X DOMESTICA; PANAX GINSENG; VITIS;

EID: 79957507525     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1270924     Document Type: Review

References (163)

1. Drew B, Dixon A, Dixon J. Obesity management: update on orlistat. Vasc Health Risk Manag 2007 3 817-821
2. Brug J, Crawford D. The obesity pandemic. Is it bad or worse? Eur J Public Health 2009 19 570-571
3. Schrauwen P, Westerterp K R. The role of high-fat diets and physical activity in the regulation of body weight. Br J Nutr 2000 84 417-427
4. Voshol P, Rensen P C. N., van Dijk K, Romijn J, Havekes L. Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models. Biochim Biophys Acta 2009 1791 479-485
5. Abete I, Astrup A, Martnez J A., Thorsdottir I, Zulet M. Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance. Nutr Rev 2010 68 214-231
6. Little T, Horowitz M, Feinle-Bisset C. Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity. Am J Clin Nutr 2007 86 531-541 (Pubitemid 47435817)
7. Rubio M, Gargallo M, Millán A, Moreno B. Drugs in the treatment of obesity: sibutramine, orlistat and rimonabant. Public Health Nutr 2007 10 1200-1205 (Pubitemid 350085210)
8. Moreno D, Ilic N, Poulev A, Brasaemle D, Fried S, Raskin I. Inhibitory effects of grape seed extract on lipases. Nutrition 2003 19 876-879 (Pubitemid 37244144)
9. Birari R, Bhutani K. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov Today 2007 12 879-889 (Pubitemid 47539967)
10. Sumantran V. Experimental approaches for studying uptake and action of herbal medicines. Phytother Res 2007 21 210-214 (Pubitemid 46479668)
11. Yamagishi S, Matsui T, Ueda S, Fukami K, Okuda S. Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders. Curr Drug Metab 2009 10 159-163
12. Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res 2005 21 3-14
13. Hosoyama H, Sugimoto A, Suzuki Y, Sakane I, Kakuda T. [Isolation and quantitative analysis of the alpha-amylase inhibitor in Lagerstroemia speciosa (L.) Pers. (Banaba)]. Yakugaku Zasshi 2003 123 599-605 (Pubitemid 41320960)
14. Tsujita T, Takaku T, Suzuki T. Chestnut astringent skin extract, an alpha-amylase inhibitor, retards carbohydrate absorption in rats and humans. J Nutr Sci Vitaminol 2008 54 82-88 (Pubitemid 351413107)
15. Tormo M A., Gil-Exojo I, de Tejada A R., Campillo J E. White bean amylase inhibitor administered orally reduces glycaemia in type 2 diabetic rats. Br J Nutr 2006 96 539-544
16. Bray G, Ryan D. Drug treatment of the overweight patient. Gastroenterology 2007 132 2239-2252 (Pubitemid 46693746)
17. McClendon K, Riche D, Uwaifo G. Orlistat: current status in clinical therapeutics. Expert Opin Drug Saf 2009 8 727-744
18. Weibel E K., Hadvary P, Hochuli E, Kupfer E, Lengsfeld H. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot 1987 40 1081-1085 (Pubitemid 17141406)
19. Viner R M., Hsia Y, Tomsic T, Wong I C. K. Efficacy and safety of anti-obesity drugs in children and adolescents: systematic review and meta-analysis. Obes Rev 2010 11 593-602
20. Heymsfield S B., Segal K R., Hauptman J, Lucas C P., Boldrin M N., Rissanen A. Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults. Arch Intern Med 2000 160 1321-1326 (Pubitemid 30252779)
21. Torgerson J, Hauptman J, Boldrin M, Sjstrm L. Xenical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004 27 155-161 (Pubitemid 38196725)
22. Slanc P, Doljak B, Kreft S, Lunder M, Janes D, Strukelj B. Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition. Phytother Res 2009 23 874-877
23. Slanc P, Doljak B, Mlinaric A, Strukelj B. Screening of wood damaging fungi and macrofungi for inhibitors of pancreatic lipase. Phytother Res 2004 18 758-762 (Pubitemid 39481697)
24. Bitou N, Ninomiya M, Tsujita T, Okuda H. Screening of lipase inhibitors from marine algae. Lipids 1999 34 441-445 (Pubitemid 29262588)
25. Abete I, Parra M D., Zulet M A., Martinez J A. Different dietary strategies for weight loss in obesity: role of energy and macronutrient content. Nutr Rev 2006 19 5-17 (Pubitemid 44174290)
26. Astrup A. The role of dietary fat in the prevention and treatment of obesity. Efficacy and safety of low-fat diets. Int J Obes 2001 25 46-50
27. Lomba A, Martinez J A., Garcia-Daz D, Paternain L, Marti A, Campion J, Milagro F I. Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters. Mol Genet Metab 2010 101 273-278
28. Lomba A, Milagro F I., Garcia-Daz D F., Campion J, Marzo F, Martinez J A. A high-sucrose isocaloric pair-fed model induces obesity and impairs NDUFB6 gene function in rat adipose tissue. J Nutrigenet Nutrigenomics 2009 2 267-272
29. Hermsdorff H H. M., Volp A C. P., Bressan J. [Macronutrient profile affects diet-induced thermogenesis and energy intake]. Arch Latinoam Nutr 2007 57 33-42
30. Mobbs C, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite 2007 48 135-138 (Pubitemid 46073281)
31. Rolls B J. The role of energy density in the overconsumption of fat. J Nutr 2000 130 268-271
32. Jäger S, Trojan H, Kopp T, Laszczyk M, Scheffler A. Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. Molecules 2009 14 2016-2031
33. Stevenson E, Astbury N, Simpson E, Taylor M, Macdonald I. Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women. J Nutr 2009 139 890-897
34. Armand M. Lipases and lipolysis in the human digestive tract: where do we stand? Curr Opin Clin Nutr Metab Care 2007 10 156-164 (Pubitemid 46220307)
35. Lowe M. The triglyceride lipases of the pancreas. J Lipid Res 2002 43 2007-2016
36. Sugiyama H, Akazome Y, Shoji T, Yamaguchi A, Yasue M, Kanda T. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J Agric Food Chem 2007 55 4604-4609 (Pubitemid 46932661)
37. Neovius M, Johansson K, Rssner S. Head-to-head studies evaluating efficacy of pharmaco-therapy for obesity: a systematic review and meta-analysis. Obes Rev 2008 9 420-427
38. Filippatos T, Derdemezis C, Gazi I, Nakou E, Mikhailidis D, Elisaf M. Orlistat-associated adverse effects and drug interactions: a critical review. Drug Saf 2008 31 53-65
39. Kopelman P, Bryson A, Hickling R, Rissanen A, Rossner S, Toubro S. Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes 2007 31 494-499
40. Melia A T., Koss-Twardy S G., Zhi J. The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers. J Clin Pharmacol 1996 36 647-653 (Pubitemid 26260546)
41. Mutoh M, Nakada N, Matsukuma S, Ohshima S, Yoshinari K, Watanabe J. Panclicins, novel pancreatic lipase inhibitors. I. Taxonomy, fermentation, isolation and biological activity. J Antibiot 1994 47 1369-1375
42. Nonaka Y, Ohtaki H, Ohtsuka E, Kocha T, Fukuda T, Takeuchi T. Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat. J Enzym Inhib 1996 10 57-63 (Pubitemid 26022477)
43. Liu D, Wang F, Liao T, Tang J, Steglich W, Zhu H. Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans. Org Lett 2006 8 5749-5752
44. Weber H K., Zuegg J, Faber K, Pleiss J. Molecular reasons for lipase-sensitivity against acetaldehyde. J Mol Catal B 1997 131-138 (Pubitemid 27276900)
45. Mizutani T, Inatomi S, Inazu A, Kawahara E. Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice. J Nutr Sci Vitaminol 2010 56 48-53
46. Lee J, Song J, Lee J. Optimal extraction conditions of anti-obesity lipase inhibitor from Phellinus linteus and nutritional characteristics of the extracts. Mycobiology 2010 38 58-61
47. Kim J, Kim H, Park H, Youn S, Choi D, Shin C. Development of inhibitors against lipase and alpha-glucosidase from derivatives of monascus pigment. FEMS Microbiol Lett 2007 276 93-98 (Pubitemid 47620462)
48. Jones A, Gu L, Sorrels C, Sherman D, Gerwick W. New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol 2009 13 216-223
49. Bitou N, Ninomiya M, Tsujita T, Okuda H. Screening of lipase inhibitors from marine algae. Lipids 1999 34 441-445 (Pubitemid 29262588)
50. Ben Rebah F, Smaoui S, Frikha F, Gargouri Y, Miled N. Inhibitory effects of tunisian marine algal extracts on digestive lipases. Appl Biochem Biotechnol 2008 151 71-79
51. Matsumoto M, Hosokawa M, Matsukawa N, Hagio M, Shinoki A, Nishimukai M. Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats. Eur J Nutr 2010 49 243-249
52. Gholamhoseinian A, Shahouzehi B, Sharifi-far F. Inhibitory effect of some plant extracts on pancreatic lipase. Int J Pharmacol 2010 6 18-24
53. Gargouri Y, Julien R, Pieroni G, Verger R, Sarda L. Studies on the inhibition of pancreatic and microbial lipases by soybean proteins. J Lipid Res 1984 25 1214-1221 (Pubitemid 15216877)
54. Lairon D, Lafont H, Vigne J L., Nalbone G, Lonardi J, Hauton J C. Effects of dietary fibers and cholestyramine on the activity of pancreatic lipase in vitro. Am J Clin Nutr 1985 42 629-638 (Pubitemid 15245056)
55. Tsujita T, Matsuura Y, Okuda H. Studies on the inhibition of pancreatic and carboxylester lipases by protamine. J Lipid Res 1996 37 1481-1487 (Pubitemid 26249979)
56. Tsujita T, Sumiyoshi M, Takaku T, Momsen W, Lowe M, Brockman H. Inhibition of lipases by epsilon-polylysine. J Lipid Res 2003 44 2278-2286
57. Ivanova M, Panaiotov I, Bois A, GArgouri Y, Verger R. Inhibitiion of pancreatic lipase by ovalbumin and -lactoglobulin A at the air-water interface. J Colloid Interface Sci 1990 136 363-374 (Pubitemid 20696406)
58. Gargouri Y, Julien R, Sugihara A, Verger R, Sarda L. Inhibition of pancreatic and microbial lipases by proteins. Biochim Biophys Acta 1984 795 326-331 (Pubitemid 14006620)
59. Han L K., Kimura Y, Okuda H. Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Int J Obes 1999 23 174-179 (Pubitemid 29057513)
60. Tsujita T, Takaichi H, Takaku T, Sawai T, Yoshida N, Hiraki J. Inhibition of lipase activities by basic polysaccharide. J Lipid Res 2007 48 358-365 (Pubitemid 46220602)
61. Knuckles B. Effect of phytate and other myo-inositol phosphate esters on lipase activity. J Food Sci 1988 53 250-252
62. Raghavendra M P., Prakash V. Phenylboronic acid-a potent inhibitor of lipase from Oryza sativa. J Agric Food Chem 2002 50 6037-6041 (Pubitemid 35155332)
63. Ninomiya K, Matsuda H, Shimoda H, Nishida N, Kasajima N, Yoshino T. Carnosic acid, a new class of lipid absorption inhibitor from sage. Bioorg Med Chem Lett 2004 14 1943-1946 (Pubitemid 38410869)
64. Zhao H L., Sim J, Shim S H., Ha Y W., Kang S S., Kim Y S. Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obese rats: evidences for lipase inhibition and calorie intake restriction. Int J Obes 2005 29 983-990 (Pubitemid 41076239)
65. Zhao H, Kim Y. Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. Arch Pharm Res 2004 27 1048-1052
66. Kwon C, Sohn H, Kim S, Kim J, Son K, Lee J. Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci Biotechnol Biochem 2003 67 1451-1456 (Pubitemid 39251780)
67. Won S, Kim S, Kim Y, Lee P, Ryu J, Kim J. Licochalcone A: a lipase inhibitor from the roots of Glycyrrhiza uralensis. Food Res Int 2007 40 1046-1050 (Pubitemid 47241221)
68. Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y. Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol 2006 106 238-244 (Pubitemid 43766196)
69. Kim H, Kang M. Screening of Korean medicinal plants for lipase inhibitory activity. PTR. Phytother Res 2005 19 359-361 (Pubitemid 41098134)
70. Moreno D, Ripoll C, Ilic N, Poulev A, Aubin C, Raskin I. Inhibition of lipid metabolic enzymes using Mangifera indica extracts. J Food Agric Environ 2006 4 21-26 (Pubitemid 43197923)
71. Lei F, Zhang X N., Wang W, Xing D M., Xie W D., Su H. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes 2007 31 1023-1029 (Pubitemid 46842679)
72. Yang H, Kim Y, Bae H, Cho K, Shin J, Kim N, Kim D. Rhei Rhizoma and Chunghyuldan inhibit pancreatic lipase. Nat Prod Sci 2003 9 38-43 (Pubitemid 36427891)
73. Zheng C, Duan Y, Gao J, Ruan Z. Screening for anti-lipase properties of 37 traditional Chinese medicinal herbs. J Chin Med Assoc 2010 73 319-324
74. Yoshikawa M, Shimoda H, Nishida N, Takada M, Matsuda H. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr 2002 132 1819-1824 (Pubitemid 34742862)
75. Terra X, Montagut G, Bustos M, Llopiz N, Ardvol A, Blad C. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. J Nutr Biochem 2009 20 210-218
76. García-Lafuente A, Guillamón E, Villares A, Rostagno M, Martínez J. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009 58 537-552
77. Kawaguchi K, Mizuno T, Aida K, Uchino K. Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas. Biosci Biotechnol Biochem 1997 61 102-104 (Pubitemid 27164853)
78. He F, Pan Q, Shi Y, Duan C. Biosynthesis and genetic regulation of proanthocyanidins in plants. Molecules 2008 13 2674-2692
79. Quesada H, del Bas J M., Pajuelo D, Daz S, Fernandez-Larrea J, Pinent M. Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int J Obes 2009 33 1007-1012
80. Lee Y, Cho E, Tanaka T, Yokozawa T. Inhibitory activities of proanthocyanidins from persimmon against oxidative stress and digestive enzymes related to diabetes. J Nutr Sci Vitaminol 2007 53 287-292 (Pubitemid 47217227)
81. de la Iglesia R, Milagro F I., Campion J, Boque N, Martinez J A. Healthy properties of proanthocyanidins. Biofactors 2010 36 159-168
82. Yamamoto M, Shimura S, Itoh Y, Ohsaka T, Egawa M, Inoue S. Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obes 2000 24 758-764 (Pubitemid 30339274)
83. Ikeda I, Tsuda K, Suzuki Y, Kobayashi M, Unno T, Tomoyori H. Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. J Nutr 2005 135 155-159 (Pubitemid 40194471)
84. Moreno D, Ilic N, Poulev A, Raskin I. Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters. Life Sci 2006 78 2797-2803
85. Han L K., Kimura Y, Kawashima M, Takaku T, Taniyama T, Hayashi T. Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor. Int J Obes 2001 25 1459-1464 (Pubitemid 32977862)
86. Tanaka T, Matsuo Y, Kouno I. Chemistry of secondary polyphenols produced during processing of tea and selected foods. Int J Mol Sci 2009 11 14-34
87. Koo S, Noh S. Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. J Nutr Biochem 2007 18 179-183 (Pubitemid 46216812)
88. Juhel C, Armand M, Pafumi Y, Rosier C, Vandermander J, Lairon D. Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J Nutr Biochem 2000 11 45-51 (Pubitemid 30081719)
89. Bose M, Lambert J, Ju J, Reuhl K, Shapses S, Yang C. The major green tea polyphenol, ()-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J Nutr 2008 138 1677-1683
90. Nakai M, Fukui Y, Asami S, Toyoda-Ono Y, Iwashita T, Shibata H. Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. J Agric Food Chem 2005 53 4593-4598 (Pubitemid 40855493)
91. Toyoda-Ono Y, Yoshimura M, Nakai M, Fukui Y, Asami S, Shibata H. Suppression of postprandial hypertriglyceridemia in rats and mice by oolong tea polymerized polyphenols. Biosci Biotechnol Biochem 2007 71 971-976 (Pubitemid 46650946)
92. Ikeda I. Multifunctional effects of green tea catechins on prevention of the metabolic syndrome. Asia Pac J Clin Nutr 2008 17 273-274
93. Kobayashi M, Ichitani M, Suzuki Y, Unno T, Sugawara T, Yamahira T. Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats. J Agric Food Chem 2009 57 7131-7136
94. Kusano R, Andou H, Fujieda M, Tanaka T, Matsuo Y, Kouno I. Polymer-like polyphenols of black tea and their lipase and amylase inhibitory activities. Chem Pharm Bull 2008 56 266-272 (Pubitemid 351463235)
95. Uchiyama S, Taniguchi Y, Saka A, Yoshida A, Yajima H. Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo. Nutrition 2011 27 287-292
96. Tanaka K, Tamaru S, Nishizono S, Miyata Y, Tamaya K, Matsui T. Hypotriacylglycerolemic and antiobesity properties of a new fermented tea product obtained by tea-rolling processing of third-crop green tea (Camellia sinensis) leaves and Loquat (Eriobotrya japonica) leaves. Biosci Biotechnol Biochem 2010 74 1606-1612
97. Kurihara H, Shibata H, Fukui Y, Kiso Y, Xu J, Yao X. Evaluation of the hypolipemic property of Camellia sinensis var. ptilophylla on postprandial hypertriglyceridemia. J Agric Food Chem 2006 54 4977-4981 (Pubitemid 44140891)
98. Guo Y, Wu G, Su X, Yang H, Zhang J. Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet. Nutr Res 2009 29 656-663
99. Martins F, Noso T, Porto V, Curiel A, Gambero A, Bastos D H. M. Maté tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice. Obesity 2010 18 42-47
100. Sugimoto S, Nakamura S, Yamamoto S, Yamashita C, Oda Y, Matsuda H. Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of Ilex paraguariensis. Chem Pharm Bull 2009 57 257-261
101. Yoshikawa M, Shimoda H, Nishida N, Takada M, Matsuda H. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr 2002 132 1819-1824 (Pubitemid 34742862)
102. Akase T, Shimada T, Harasawa Y, Akase T, Ikeya Y, Nagai E. Preventive effects of Salacia reticulata on obesity and metabolic disorders in TSOD mice. Evid Based Complement Alternat Med
103. Zhang J, Kang M, Kim M, Kim M, Song J, Lee Y. Pancreatic lipase inhibitory activity of Taraxacum officinale in vitro and in vivo. Nutr Res Pract 2008 2 200-203
104. Zhao J, Pang Y, Dixon R. The mysteries of proanthocyanidin transport and polymerization. Plant Physiol 2010 153 1-18
105. McDougall G J., Kulkarni N N., Stewart D. Berry polyphenols inhibit pancreatic lipase activity in vitro. J Food Chem 2009 115 193-199
106. Sparg S G., Light M E., van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmacol 2004 94 219-243 (Pubitemid 39119924)
107. Vincken J, Heng L, de Groot A, Gruppen H. Saponins, classification and occurrence in the plant kingdom. Phytochemistry 2007 68 275-297 (Pubitemid 46108037)
108. Haralampidis K, Trojanowska M, Osbourn A. Biosynthesis of triterpenoid saponins in plants. Adv Biochem Eng Biotechnol 2002 75 31
109. Karu N, Reifen R, Kerem Z. Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J Agric Food Chem 2007 55 2824-2828 (Pubitemid 46668284)
110. Kimura H, Ogawa S, Jisaka M, Kimura Y, Katsube T, Yokota K. Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity. J Pharm Biomed Anal 2006 41 1657-1665 (Pubitemid 44247464)
111. Hu J, Zhu X, Han L, Saito M, Sun Y, Yoshikawa M. Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae). Chem Pharm Bull 2008 56 12-16
112. Kimura H, Ogawa S, Katsube T, Jisaka M, Yokota K. Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata BLUME) after treatment with wood ashes. J Agric Food Chem 2008 56 4783-4788 (Pubitemid 351999411)
113. Song M, Lv N, Kim E, Kwon K, Yoo Y, Kim J. Antiobesity activity of aqueous extracts of Rhizoma Dioscoreae tokoronis on high-fat diet-induced obesity in mice. J Med Food 2009 12 304-309
114. Li F, Li W, Fu H, Zhang Q, Koike K. Pancreatic lipase-inhibiting triterpenoid saponins from fruits of Acanthopanax senticosus. Chem Pharm Bull 2007 55 1087-1089 (Pubitemid 47026552)
115. Jiang W, Li W, Han L, Liu L, Zhang Q, Zhang S. Biologically active triterpenoid saponins from Acanthopanax senticosus. J Nat Prod 2006 69 1577-1581 (Pubitemid 46031808)
116. Yoshizumi K, Hirano K, Ando H, Hirai Y, Ida Y, Tsuji T. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. J Agric Food Chem 2006 54 335-341
117. Lee I, Lee J, Baek N, Kim D. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. Biol Pharm Bull 2005 28 2106-2110 (Pubitemid 41634260)
118. Sheng L, Qian Z, Zheng S, Xi L. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. Eur J Pharmacol 2006 543 116-122 (Pubitemid 44092692)
119. Zheng Q, Li W, Han L, Koike K. Pancreatic lipase-inhibiting triterpenoid saponins from Gypsophila oldhamiana. Chem Pharm Bull 2007 55 646-650 (Pubitemid 46570848)
120. Han L, Zheng Y, Yoshikawa M, Okuda H, Kimura Y. Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complement Alternat Med 2005 5 9
121. Lee Y, Cha B, Yamaguchi K, Choi S, Yonezawa T, Teruya T. Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice. Cytotechnology 2010 62 367-376
122. Liu W, Zheng Y, Han L, Wang H, Saito M, Ling M. Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice. Phytomedicine 2008 15 1140-1145
123. Xu B, Han L, Zheng Y, Lee J, Sung C. In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase. Arch Pharm Res 2005 28 180-185
124. Zhao H, Kim Y. Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. Arch Pharm Res 2004 27 968-972
125. Han L, Zheng Y, Xu B, Okuda H, Kimura Y. Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. J Nutr 2002 132 2241-2245 (Pubitemid 34851657)
126. Kim J, Moon K, Seo K, Park K, Choi M, Do G. Supplementation of SK1 from Platycodi radix ameliorates obesity and glucose intolerance in mice fed a high-fat diet. J Med Food 2009 12 629-636
127. Morikawa T, Xie Y, Asao Y, Okamoto M, Yamashita C, Muraoka O. Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak. Phytochemistry 2009 70 1166-1172
128. Zheng Q, Koike K, Han L, Okuda H, Nikaido T. New biologically active triterpenoid saponins from Scabiosa tschiliensis. J Nat Prod 2004 67 604-613 (Pubitemid 38533932)
129. Guo T, Liu Q, Wang P, Zhang L, Zhang W, Li Y. Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase. Carbohydr Res 2009 344 1167-1174
130. Yoshikawa M, Morikawa T, Yamamoto K, Kato Y, Nagatomo A, Matsuda H. Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis). J Nat Prod 2005 68 1360-1365 (Pubitemid 41499430)
131. Jäger S, Laszczyk M, Scheffler A. A preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (Betulae alba cortex). Molecules 2008 13 3224-3235
132. Kim S, Park K. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacol Res 2003 48 511-513 (Pubitemid 37101210)
133. Chantre P, Lairon D. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 2002 9 3-8 (Pubitemid 34184203)
134. Lee Y, Chung H, Kwak H, Yoon S. The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women. Biochem Biophys Res Commun 2008 375 44-48
135. Sugiyama H, Akazome Y, Shoji T, Yamaguchi A, Yasue M, Kanda T. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J Agric Food Chem 2007 55 4604-4609 (Pubitemid 46932661)
136. Moreno D, Ilic N, Poulev A, Raskin I. Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters. Life Sci 2006 78 2797-2803
137. He R, Chen L, Lin B, Matsui Y, Yao X, Kurihara H. Beneficial effects of oolong tea consumption on diet-induced overweight and obese subjects. Chin J Integr Med 2009 15 34-41
138. Sharma N, Sharma V, Seo S. Screening of some medicinal plants for anti-lipase activity. J Ethnopharmacol 2005 97 453-456 (Pubitemid 40312318)
139. Möller N, Roos N, Schrezenmeir J. Lipase inhibitory activity in alcohol extracts of worldwide occurring plants and propolis. Phytother Res 2009 23 585-586
140. Kobayashi K, Ihara S, Kobata A, Itoh K, Kusunoki N, Yoshizaki F. Inhibitory effect of Myrica bark on lipase activity in mouse plasma and gastrointestinal tract. J Med Food 2008 11 289-293 (Pubitemid 351948175)
141. Kobayashi K, Yamada K, Murata T, Hasegawa T, Takano F, Koga K. Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal. Planta Med 2008 74 1716-1719
142. Birari R, Roy S, Singh A, Bhutani K. Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves. Nat Prod Commun 2009 4 1089-1092
143. Ekanem A P., Wang M, Simon J E., Moreno D A. Antiobesity properties of two African plants (Afromomum meleguetta and Spilanthes acmella) by pancreatic lipase inhibition. Phytother Res 2007 21 1253-1255
144. Shin J, Han M, Song M, Baek N, Kim D. 5-Hydroxy-7-(4-hydroxy-3- methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum. Biol Pharm Bull 2004 27 138-140 (Pubitemid 41656693)
145. Shin J, Han M, Kim D. 3-Methylethergalangin isolated from Alpinia officinarum inhibits pancreatic lipase. Biol Pharm Bull 2003 26 854-857 (Pubitemid 39655308)
146. Jang D, Lee G, Kim J, Lee Y, Kim J, Kim Y. A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. Arch Pharm Res 2008 31 666-670
147. Han L, Sumiyoshi M, Zhang J, Liu M, Zhang X, Zheng Y. Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals. Phytother Res 2003 17 1188-1194 (Pubitemid 38057177)
148. Tucci S A., Boyland E J., Halford J C. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes Metab Syndr Obes 2010 3 125-143
149. Osbourn A. Saponins in cereals. Phytochemistry 2003 62 1-4 (Pubitemid 36869760)
150. Han L, Nose R, Li W, Gong X, Zheng Y, Yoshikawa M. Reduction of fat storage in mice fed a high-fat diet long term by treatment with saponins prepared from Kochia scoparia fruit. Phytother Res 2006 20 877-882 (Pubitemid 44606485)
151. Oishi Y, Sakamoto T, Udagawa H, Taniguchi H, Kobayashi-Hattori K, Ozawa Y. Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction. Biosci Biotechnol Biochem 2007 71 735-740 (Pubitemid 46481449)
152. Chang X, Li W, Jia Z, Satou T, Fushiya S, Koike K. Biologically active triterpenoid saponins from Ardisia japonica. J Nat Prod 2007 70 179-187 (Pubitemid 46447627)
153. Kimura H, Ogawa S, Katsube T, Jisaka M, Yokota K. Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata BLUME) after treatment with wood ashes. J Agric Food Chem 2008 56 4783-4788 (Pubitemid 351999411)
154. Yamamoto M, Shimura S, Itoh Y, Ohsaka T, Egawa M, Inoue S. Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obes 2000 24 758-764 (Pubitemid 30339274)
155. Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Alternat Med 2006 6 9
156. Kurihara H, Asami S, Shibata H, Fukami H, Tanaka T. Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice. Biol Pharm Bull 2003 26 383-385 (Pubitemid 39663631)
157. Kwon C, Sohn H, Kim S, Kim J, Son K, Lee J. Anti-obesity effect of Dioscorea nipponic a Makino with lipase-inhibitory activity in rodents. Biosci Biotechnol Biochem 2003 67 1451-1456 (Pubitemid 39251780)
158. Cha Y, Rhee S, Heo Y. Acanthopanax senticosus extract prepared from cultured cells decreases adiposity and obesity indices in C57BL/6J mice fed a high fat diet. J Med Food 2004 7 422-429 (Pubitemid 40095841)
159. Yoshizumi K, Murota K, Watanabe S, Tomi H, Tsuji T, Terao J. Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents. Biosci Biotechnol Biochem 2008 72 1126-1129 (Pubitemid 351679374)
160. Yajima H, Noguchi T, Ikeshima E, Shiraki M, Kanaya T, Tsuboyama-Kasaoka N. Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents. Int J Obes 2005 29 991-997 (Pubitemid 41076240)
161. Sugiyama H, Akazome Y, Shoji T, Yamaguchi A, Yasue M, Kanda T. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J Agric Food Chem 2007 55 4604-4609 (Pubitemid 46932661)
162. Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y. Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol 2006 106 238-244 (Pubitemid 43766196)
163. Harach T, Aprikian O, Monnard I, Moulin J, Membrez M, Bolor J. Rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and liver steatosis in mice fed a high-fat diet. Planta Med 2010 76 566-571