In vitro inhibitory effect of triterpenoidal saponins from platycodi radix on pancreatic lipase

Archives of Pharmacal Research

Volumn 28, Issue 2, 2005, Pages 180-185

  Bao, Jun Xu ^a,d   Li, Kun Han ^b   Yi, Nan Zheng ^c   Jeong, Hyun Lee ^a   Chang, Keun Sung ^a  

^a Chungnam National University   (South Korea)

^b PREFECTURAL UNIVERSITY OF KUMAMOTO   (Japan)

^c JILIN AGRICULTURAL UNIVERSITY   (China)

^d DALIAN UNIVERSITY   (China)

Author keywords

Anti obesity; Pancreatic lipase; Platycodi radix; Platycodins

Indexed keywords

ANTIOBESITY AGENT; ENZYME INHIBITOR; PLANT EXTRACT; SAPONIN; TRIACYLGLYCEROL LIPASE; TRITERPENE;

ARTICLE; CARBOHYDRATE ANALYSIS; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; INFRARED SPECTROSCOPY; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; PANCREAS; PLANT ROOT; PLATYCODON; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTI-OBESITY AGENTS; CARBOHYDRATE SEQUENCE; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LIPASE; MOLECULAR SEQUENCE DATA; PANCREAS; PLANT EXTRACTS; PLANT ROOTS; PLATYCODON; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 21844471043     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977712     Document Type: Article

References (32)

1. Arai, I., Komatsu, Y., Hirai, Y., Shingu, K., Ida, Y., Yamaura, H., Yamamoto, T., Kuroiwa, Y., Sasaki, K., and Taguchi, S., Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats. Planta Med., 63, 419-424 (1997).
2. Bray, G. A., A concise review on the therapeutics of obesity. Nutrition, 16, 953-960 (2000).
3. Bray, G. A., The underlying basis for obesity: Relationship to cancer. J. Nutr., 132, 3451S-3455S (2002).
4. Choi, S. S., Han, E. J., Lee, T. H., Lee, J. K., Han, K. J., Lee, H. K., and Suh, H. W., Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse. Planta Med., 68, 794-798 (2002).
5. Diego, A. M., Nebojsa, I., Alexander, P., Dawn, L. B., Susan, K. F., and Ilya, R., Inhibitory effects of grape seed extract on lipases. Nutrition, 19, 876-879 (2003).
6. Drent, M. L., Larsson, I., William, O. T., Quaade, F., Czubayko, F., Von Bergmann, K., Strobel, W., and Van der veen, E. A., Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int. J. Obes., 19, 221-226 (1995a).
7. Drent, M. L., Popp, S. C., Ader, H. J., Jansen, J. B., and Van der veen, E. A., Lipase inhibition and hormonal status, body composition and gastrointestinal processing of a lipid high-fat mixed meal in moderately obese subjects. Obes. Res., 3, 573-581 (1995b).
8. Flegal, K. M., Carroll, M. D., Ogden, C. L., and Johnson, C. L., Prevalence and trends in obesity among US adults, 1999-2000. JAMA, 288, 1723-1727 (2002).
9. Han, L. K., Xu, B. J., Kimura, Y., Zheng, Y. N., and Okuda, H., Platycodi Radix affects lipid metabolism in mice with high fat dietinduced obesity. J. Nutr., 130, 2760-2764 (2000).
10. Han, L. K., Kimura, Y., Kawashima, M., Takaku, T., Taniyama, T., Hayashi, T., Zheng, Y. N., and Okuda, H., Anti-obesity effects in rodents of dietary tea saponin, a lipase inhibitor. Int. J. Obes., 25, 1459-1464 (2001).
11. Han, L. K., Zheng, Y. N., Xu, B. J., Okuda, H., and Kimura, Y., Saponins from Platycodi Radix ameliorate high fat dietinduced obesity in mice. J. Nutr., 132, 2241-2245 (2002).
12. Hatano, T., Yamashita, A., and Hashimoto, T., Ito, H., Kubo, N., Yoshiyama, M., Shimura, S., Itoh, Y., Okuda, T., and Yoshida, T., Flavin dimers with lipase inhibitory activity from Cassia nomame. Phytochemistry, 46, 893-900 (1997).
13. Hernell, O., Straggers, J. E., and Carey, M. C., Physical-chemical behavior analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human being. Biochemistry, 29, 2041-2056 (1990).
14. 13C-NMR spectroscopy. Chem. Pharm. Bull., 26, 674-677 (1978).
15. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y., Saponins from roots of Platycodon grandiflorum. Part 2. Isolation and structure of new triterpene glycosides. J. Chem. Soc. Perkin Trans. I., 661-668 (1984).
16. Kawano-Takahashi, Y., Ohminami, H., Okuda, H., Kitagawa, I., Yoshikawa, M., Arichi, S., and Hayashi, T., Effect of soya saponins on gold thioglucose (GTG)-induced obese mice. Int. J. Obes., 10, 293-302 (1986).
17. Kim, K. S., Ezaki, O., Ikemoto, S., and Itakura, H., Effects of Platycodon grandiflorum feeding on serum and liver lipid concentration in rats with diet induced hyperlipidemia. J. Nutr. Sci. Vitaminol., 41, 485-491 (1995).
18. 2 production by platycodin D isolated from the root of Platycodon grandiforum. Planta Med., 67, 362-364 (2001).
19. Kimura, Y., Okuda, H., Arichi, S., and Takemoto, T., Effects of crude saponins of Gynostemma pentaphylium on lipid metabolism. Shoyakugaku Zasshi, 37, 272-275 (1983).
20. Kwon C. S., Sohn, H. Y., Kim, S. H., Kim, J. H., Son, K. H., Lee, J. S., Lim, J. K., and Kim, J. S., Anti-obesity effects of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem., 67, 1451-1456 (2003).
21. Mita, A., Shida, R., Kasai, N., and Shoji, J., Enhancement and suppression in production of IgM-antibody in the mice treated with purified saponins. Biomedicine, 31, 223-227 (1979).
22. Saeki, T., Koike, K., and Nikaido, T., A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis. Planta Med., 65, 428-431 (1999).
23. 3 increase airway mucin release in vivo and in vitro in rats and hamsters. Planta Med., 68, 221-225 (2002).
24. Tada, A., Kaneiwa, Y., Shoji, J., and Shibata, S., Studies on the saponins from roots of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem. Pharm. Bull., 23, 2965-2972 (1975).
25. Tsujitu, T. and Okuda, H., Carboxylestrase in rat and human sera and their relationship to serum acylamidases and cholinesterase. Eur. J. Biochem., 135, 215-220 (1983).
26. Verger, R. Pancreatic lipase. In Borgstorm, B. and Brockman, H. L., (Eds.). Lipase. Elsevier, Amsterdam, The Netherlands, pp. 83-105, (1984).
27. Xu, B. J. Xu, C. L., Cui, M., Liu, M. X., and Zheng, Y. N., Identification on saponins composition of Platycodon grandiflorum applied mass spectral analyses method. J. Jilin Agricultural University, 21, 35-41 (1999).
28. Xu, B. J., Zheng, Y. N., Cui, M., and Song, F. R., Identification of platycodin-D by electrospray mass spectrum. Chinese J. Med. Chem., 10, 193-196 (2000).
29. Xu, B. J., Zheng, Y. N., and Sung, C. K., Quality control and evaluation of Platycodon grandiflorum: Implication for future management. Nat. Prod. Sci., 10(4), 141-151 (2004).
30. Yamamoto, M., Shimura, S., Itoh, Y., Ohsaka, T., Egawa, M., and Inoue, S., Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame herba, on rats fed a highfat diet. Int. J. Obes. Relat. Metab. Disord., 24, 758-764 (2000).
31. Yoshikawa, M., Shimoda, H., Nishida, N., Takada, M., and Matsuda, H., Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J. Nutr., 132, 1819-1824 (2002).
32. Zapf, J., Schoenle, E., Waldvoge, M., Sand, M., and Foresch, E. R., Effects of trypsin treatment of rat adipocyte on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor. Eur. J. Biochem., 133, 605-609 (1981).