Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 3, 2007, Pages 735-740

  Oishi, Yuichi ^a   Sakamoto, Tatsuaki ^a   Udagawa, Haruhide ^a   Taniguchi, Hironobu ^b   Kobayashi Hattori, Kazuo ^a   Ozawa, Yoshio ^c   Takita, Toshichika ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^b Toita Women's College   (Japan)

^c TAKASAKI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Blood glucose; Momordica charantia; Rats; Saponin fraction; Serum neutral fat

Indexed keywords

BACTERIA; BLOOD; ENZYME INHIBITION; OILS AND FATS; PROTEINS; SUGAR (SUCROSE);

BLOOD GLUCOSE; MOMORDICA CHARANTIA; SAPONIN FRACTION; SERUM NEUTRAL FAT;

GLUCOSE;

ANTIDIABETIC AGENT; BUTANOL; CORN OIL; LIPID; SAPONIN; SUCROSE; TRIACYLGLYCEROL LIPASE;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; ISOLATION AND PURIFICATION; MALE; METABOLISM; MOMORDICA CHARANTIA; RAT; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BUTANOLS; CORN OIL; HYPOGLYCEMIC AGENTS; LIPASE; LIPIDS; MALE; MOMORDICA CHARANTIA; RATS; RATS, WISTAR; SAPONINS; SUCROSE;

MOMORDICA CHARANTIA; RATTUS; ZEA MAYS;

EID: 33947579413     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60570     Document Type: Article

References (24)

1. Zimmet, P., Alberti, K. G., and Shaw, J., Global and societal implications of the diabetes epidemic. Nature, 414, 782-787 (2001).
2. Grover, J. K., Yadav, S., and Vats, V., Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol., 81, 81-100 (2002).
3. Shapiro, K., and Gong, W. C., Natural products used for diabetes. J. Am. Pharm. Assoc., 42, 217-226 (2002).
4. Ahmed, I., Lakhani, M. S., Gillett, M., John, A., and Raza, H., Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract., 51, 155-161 (2001).
5. Ali, L., Khan, A. K., Mamun, M. I., Mosihuzzaman, M., Nahar, N., Nur-e-Alam, M., and Rokeya, B., Studies on hypoglycemic effects of fruit pulp, seed, and whole plant of Momordica charantia on normal and diabetic model rats. Planta Med., 59, 408-412 (1993).
6. Meir, P., and Yaniv, Z., An in vitro study on the effects of Momordica charantia on glucose uptake and glucose metabolism in rats. Planta Med., 33, 12-16 (1985).
7. Ahmed, I., Adeghate, E., Cummings, E., Sharma, A. K., and Singh, J., Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol. Cell Biochem., 261, 63-70 (2004).
8. Chen, Q., Chan, L. L., and Li, E. T., Bitter Melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J. Nutr., 133, 1088-1093 (2003).
9. Virdi, J., Sivakami, S., Shahani, S., Suthar, A. C., Banavalikar, M. M., and Biyani, M. K., Antihyperglycemic effects of three extracts from Momordica charantia. J. Ethnopharmacol., 88, 107-111 (2003).
10. Rao, A. V., and Gurfinkel, D. M., The bioactivity of saponins: triterpenoid and steroidal glycosides. Drug Metabol. Drug Interact., 17, 211-235 (2000).
11. Han, L. K., Xu, B. J., Kimura, Y., Zheng, Y., and Okuda, H., Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. J. Nutr., 130, 2760-2764 (2000).
12. Han, L. K., Zheng, Y. N., Xu, B. J., Okuda, H., and Kimura, Y., Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice. J. Nutr., 132, 2241-2245 (2002).
13. Han, L. K., Zheng, Y. N., Yoshikawa, M., Okuda, H., and Kimura, Y., Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complement. Altern. Med., 5, 9 (2005).
14. Zhao, H. L., Sim, J. S., Shim, S. H., Ha, Y. W., Kang, S. S., and Kim, Y. S., Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obese rats: evidences for lipase inhibition and calorie intake restriction. Int. J. Obes., 29, 983-990 (2005).
15. Konishi, Y., Aitani, M., and Nakatani, N., Effects of bay m 1099, an α-glucosidase inhibitor, on starch degradation in germinating mung beans. Biosci. Biotechnol. Biochem., 62, 142-144 (1998).
16. Matsuda, H., Murakami, T., Yashiro, K., Yamahara, J., and Yoshikawa, M., Antidiabetic principles of natural medicines. IV. Aldose reductase and α-glucosidase inhibitors from the roots of Salacia oblonga Wall. (Celastraceae): structure of a new friedelane-type triterpene, Kotalagenin 16-Acetate. Chem. Pharm. Bull., 47, 1725-1729 (1999).
17. Murakami, T., Emoto, A., Matsuda, H., and Yoshikawa, M., Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosidesa, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L. Chem. Pharm. Bull., 49, 54-63 (2001).
18. Yoshikawa, M., Murakami, T., Matsuda, H., Ueno, T., Kadoya, M., Yamahara, J., and Murakami, N., Bioactive saponins and glycosides. II. Senegae Radix. (2): chemical structures, hypoglycemic activity, and ethanol absorption-inhibitory effect of E-senegasaponin c, Z-senegasaponin c, and Z-senegins II, III, and IV. Chem. Pharm. Bull., 44, 1305-1313 (1996).
19. Yoshikawa, M., Murakami, T., Harada, E., Murakami, N., Yamahara, J., and Matsuda, H., Bioactive saponins and glycosides. VII. On the hypoglycemic principles from the root cortex of Aralia elata Seem.: structure related hypoglycemic activity of oleanolic acid oligoglycoside. Chem. Pharm. Bull., 44, 1923-1927 (1996).
20. Samane, S., Noël, J., Charrouf, Z., Amarouch, H., and Haddad, P. S., Insulin-sensitizing and anti-proliferative effects of Argania spinosa seed extracts. Evid. Based Complement. Altern. Med., 3, 317-327 (2006).
21. Capeau, J., Insulin signaling: mechanisms altered in insulin resistance. Med. Sci. (Paris), 19, 834-839 (2003).
22. Carlsen, J., Christiansen, K., and Vinten, J., Insulin stimulated glycogen synthesis in isolated rat hepatocytes: effect of protein kinase inhibitors. Cell. Signal., 9, 447-450 (1997).
23. Itoh, T., Kita, N., Kurokawa, Y., Kobayashi, M., Horio, F., and Furuichi, Y., Suppressive effect of a hot water extract of adzuki beans (Vigna angularis) on hyperglycemia after sucrose loading in mice and diabetic rats. Biosci. Biotechnol. Biochem., 68, 2421-2426 (2004).
24. Ikeda, I., Tsuda, K., Suzuki, Y., Kobayashi, M., Unno, T., Tomoyori, H., Goto, H., Kawata, Y., Imaizumi, K., Nozawa, A., and Kakuda, T., Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. J. Nutr., 135, 155-159 (2005).