메뉴 건너뛰기




Volumn 12, Issue 3, 2009, Pages 629-636

Supplementation of sk1 from platycodi radix ameliorates obesity and glucose intolerance in mice fed a high-fat diet

Author keywords

Glucose intolerance; Lipid metabolism; Obesity; Platycodi radix; Saponins

Indexed keywords

ANTIOBESITY AGENT; FATTY ACID SYNTHASE; GLUCOKINASE; PLANT EXTRACT; PLATYCODON GRANDIFLORUM EXTRACT; SAPONIN; SK1; UNCLASSIFIED DRUG;

EID: 68149131762     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2008.1234     Document Type: Article
Times cited : (15)

References (38)
  • 1
    • 42649130051 scopus 로고    scopus 로고
    • Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
    • Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, Baile CA: Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci 2008;82:1032-1039.
    • (2008) Life Sci , vol.82 , pp. 1032-1039
    • Yang, J.Y.1    Della-Fera, M.A.2    Rayalam, S.3    Ambati, S.4    Hartzell, D.L.5    Park, H.J.6    Baile, C.A.7
  • 2
    • 0037036968 scopus 로고    scopus 로고
    • Diet and risk of coronary heart diseases and type 2 diabetes
    • Mann JI: Diet and risk of coronary heart diseases and type 2 diabetes. Lancet 2002;360:783-789.
    • (2002) Lancet , vol.360 , pp. 783-789
    • Mann, J.I.1
  • 3
    • 0142120165 scopus 로고    scopus 로고
    • Sugar, hypertriglyceridemia, and cardiovascular disease
    • Fried SK, Rao SP: Sugar, hypertriglyceridemia, and cardiovascular disease. Am J Clin Nutr 2003;78:873S-880S.
    • (2003) Am J Clin Nutr , vol.78
    • Fried, S.K.1    Rao, S.P.2
  • 4
    • 3242741237 scopus 로고    scopus 로고
    • Lee JY, Hwang WI, Lim ST: Antioxidant and anticancer activities of organic extracts from Platycodon grandiflorum A. De Candolle roots. J Ethnopharmacol 2004;93:409-U5.
    • Lee JY, Hwang WI, Lim ST: Antioxidant and anticancer activities of organic extracts from Platycodon grandiflorum A. De Candolle roots. J Ethnopharmacol 2004;93:409-U5.
  • 5
    • 33750688244 scopus 로고    scopus 로고
    • Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum
    • Lee KJ, Kim JY, Choi JH, Kim HG, Chung YC, Roh SH, Jeong HG: Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum. Food Chem Toxicol 2006;44:1890-1896.
    • (2006) Food Chem Toxicol , vol.44 , pp. 1890-1896
    • Lee, K.J.1    Kim, J.Y.2    Choi, J.H.3    Kim, H.G.4    Chung, Y.C.5    Roh, S.H.6    Jeong, H.G.7
  • 6
    • 33646153527 scopus 로고    scopus 로고
    • Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation
    • Kim JY, Hwang YP, Kim DH, Han EH, Chung YC, Roh SH, Jeong HG: Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation. Biosci Biotechnol Biochem 2006;70:858-864.
    • (2006) Biosci Biotechnol Biochem , vol.70 , pp. 858-864
    • Kim, J.Y.1    Hwang, Y.P.2    Kim, D.H.3    Han, E.H.4    Chung, Y.C.5    Roh, S.H.6    Jeong, H.G.7
  • 7
    • 23044468331 scopus 로고    scopus 로고
    • Anti- obese and hypolipidemic effects of platycodin saponins in diet- induced obese rats: Evidences for lipase inhibition and calorie intake restriction
    • Zhao HL, Sim JS, Shim SH, Ha YW, Kang SS, Kim YS: Anti- obese and hypolipidemic effects of platycodin saponins in diet- induced obese rats: evidences for lipase inhibition and calorie intake restriction. Int J Obes 2005;29:983-990.
    • (2005) Int J Obes , vol.29 , pp. 983-990
    • Zhao, H.L.1    Sim, J.S.2    Shim, S.H.3    Ha, Y.W.4    Kang, S.S.5    Kim, Y.S.6
  • 8
    • 0036322011 scopus 로고    scopus 로고
    • Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice
    • Han LK, Zheng YN, Xu BJ, Okuda H, Kimura Y: Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice. J Nutr 2002;132:2241-2245.
    • (2002) J Nutr , vol.132 , pp. 2241-2245
    • Han, L.K.1    Zheng, Y.N.2    Xu, B.J.3    Okuda, H.4    Kimura, Y.5
  • 9
    • 34547401085 scopus 로고    scopus 로고
    • Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats
    • Park YS, Yoon Y, Ahn HS: Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World J Gastroenterol 2007;13:3493-3499.
    • (2007) World J Gastroenterol , vol.13 , pp. 3493-3499
    • Park, Y.S.1    Yoon, Y.2    Ahn, H.S.3
  • 10
    • 33646153996 scopus 로고    scopus 로고
    • Platycodin D-induced apoptosis through nuclear factor-κB activation in immortalized keratinocytes
    • Ahn KS, Hahn BS, Kwack K, Lee EB, Kim YS: Platycodin D-induced apoptosis through nuclear factor-κB activation in immortalized keratinocytes. Eur J Pharmacol 2006;537:1-11.
    • (2006) Eur J Pharmacol , vol.537 , pp. 1-11
    • Ahn, K.S.1    Hahn, B.S.2    Kwack, K.3    Lee, E.B.4    Kim, Y.S.5
  • 12
    • 0034845702 scopus 로고    scopus 로고
    • Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells
    • Han SB, Park SH, Lee KH, Lee CW, Lee SH, Kim HC, Kim YS, Lee HS, Kim SH: Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Int Immunopharmacol 2001;1:1969-1978.
    • (2001) Int Immunopharmacol , vol.1 , pp. 1969-1978
    • Han, S.B.1    Park, S.H.2    Lee, K.H.3    Lee, C.W.4    Lee, S.H.5    Kim, H.C.6    Kim, Y.S.7    Lee, H.S.8    Kim, S.H.9
  • 14
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997;389:610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 15
    • 0032698074 scopus 로고    scopus 로고
    • Initiation of hyperinsulinemia and hyperleptinemia is diet dependent in C57BL/6 mice
    • Harte RA, Kirk EA, Rosenfeld ME, LeBoeuf RC: Initiation of hyperinsulinemia and hyperleptinemia is diet dependent in C57BL/6 mice. Horm Metab Res 1999;31:570-575.
    • (1999) Horm Metab Res , vol.31 , pp. 570-575
    • Harte, R.A.1    Kirk, E.A.2    Rosenfeld, M.E.3    LeBoeuf, R.C.4
  • 16
    • 1642468898 scopus 로고
    • Report of Ad Hoc Committee on Standards for Nutritional Studies
    • American Institute of Nutrition
    • American Institute of Nutrition: Report of Ad Hoc Committee on Standards for Nutritional Studies. J Nutr 1980;110:1717-1726.
    • (1980) J Nutr , vol.110 , pp. 1717-1726
  • 17
    • 0017375321 scopus 로고
    • Report of the American Institute of Nutrition. Ad Hoc Committee on Standards for Nutritional Studies
    • American Institute of Nutrition
    • American Institute of Nutrition: Report of the American Institute of Nutrition. Ad Hoc Committee on Standards for Nutritional Studies. J Nutr 1977;107:1340-1348.
    • (1977) J Nutr , vol.107 , pp. 1340-1348
  • 19
    • 0030994947 scopus 로고    scopus 로고
    • The homeostasis model in the San Antonio Heart Study
    • Haffner SM, Miettinen H, Stern MP: The homeostasis model in the San Antonio Heart Study. Diabetes Care 1997;20:1087-1092.
    • (1997) Diabetes Care , vol.20 , pp. 1087-1092
    • Haffner, S.M.1    Miettinen, H.2    Stern, M.P.3
  • 20
    • 70449158340 scopus 로고
    • A simple method for isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Sloan-Stanley GH: A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloan-Stanley, G.H.3
  • 21
    • 0015911095 scopus 로고
    • Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A
    • Hulcher FH, Oleson WH: Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J Lipid Res 1973;14:625-631.
    • (1973) J Lipid Res , vol.14 , pp. 625-631
    • Hulcher, F.H.1    Oleson, W.H.2
  • 22
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 24
    • 0019742075 scopus 로고
    • Assay of peroxisomal β-oxidation of fatty acids
    • Lazarow PB: Assay of peroxisomal β-oxidation of fatty acids. Methods Enzymol 1981;72:315-319.
    • (1981) Methods Enzymol , vol.72 , pp. 315-319
    • Lazarow, P.B.1
  • 25
    • 0023154010 scopus 로고
    • Factors underlying significant under- estimations of glucokinase activity in crude liver extract: Physiological implications of higher cellular activity
    • Davidson AL, Arion WJ: Factors underlying significant under- estimations of glucokinase activity in crude liver extract: physiological implications of higher cellular activity. Arch Biochem Biophys 1987;253:156-167.
    • (1987) Arch Biochem Biophys , vol.253 , pp. 156-167
    • Davidson, A.L.1    Arion, W.J.2
  • 26
    • 0020537898 scopus 로고
    • Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat
    • Newgard CB, Hirsch LJ, Foster DW, McGarry DJ: Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. J Biol Chem 1983;258:8046-8052.
    • (1983) J Biol Chem , vol.258 , pp. 8046-8052
    • Newgard, C.B.1    Hirsch, L.J.2    Foster, D.W.3    McGarry, D.J.4
  • 27
    • 0023683758 scopus 로고
    • Determination of glucose-6-phosphatase activity using the glucose dehydrogenase- coupled reaction
    • Alegre M, Ciudad CJ, Fillat C, Guinovart JJ: Determination of glucose-6-phosphatase activity using the glucose dehydrogenase- coupled reaction. Anal Biochem 1988;173:185-189.
    • (1988) Anal Biochem , vol.173 , pp. 185-189
    • Alegre, M.1    Ciudad, C.J.2    Fillat, C.3    Guinovart, J.J.4
  • 28
    • 31044449046 scopus 로고    scopus 로고
    • Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)
    • Bolleddula J, Karl Olson L, Schutzki RE, Tai MH, Nair MG: Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 2006;54:243-248.
    • (2006) J Agric Food Chem , vol.54 , pp. 243-248
    • Bolleddula, J.1    Karl Olson, L.2    Schutzki, R.E.3    Tai, M.H.4    Nair, M.G.5
  • 29
    • 0033735626 scopus 로고    scopus 로고
    • Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity
    • Han LK, Xu BJ, Kimura Y, Zheng YN, Okuda H: Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. J Nutr 2000;130:2760-2764.
    • (2000) J Nutr , vol.130 , pp. 2760-2764
    • Han, L.K.1    Xu, B.J.2    Kimura, Y.3    Zheng, Y.N.4    Okuda, H.5
  • 30
    • 10344228731 scopus 로고    scopus 로고
    • Dysfunctional fat cells, lipotoxicity and type 2 diabetes
    • DeFronzo RA: Dysfunctional fat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract 2004;143:9-21.
    • (2004) Int J Clin Pract , vol.143 , pp. 9-21
    • DeFronzo, R.A.1
  • 31
    • 4344685089 scopus 로고    scopus 로고
    • Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats
    • Kim HK, Choi S, Choi H: Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. J Nutr Biochem 2004;15:485-492.
    • (2004) J Nutr Biochem , vol.15 , pp. 485-492
    • Kim, H.K.1    Choi, S.2    Choi, H.3
  • 32
    • 33646012970 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase by polyphenols
    • Tian WX: Inhibition of fatty acid synthase by polyphenols. Curr Med Chem 2006;13:967-977.
    • (2006) Curr Med Chem , vol.13 , pp. 967-977
    • Tian, W.X.1
  • 33
    • 0031944573 scopus 로고    scopus 로고
    • The effect of dietary vitamin E supply and a moderately oxidized oil on activities of hepatic lipogenic enzymes in rats
    • Eder K, Kirchgessner M: The effect of dietary vitamin E supply and a moderately oxidized oil on activities of hepatic lipogenic enzymes in rats. Lipids 1998;33:277-283.
    • (1998) Lipids , vol.33 , pp. 277-283
    • Eder, K.1    Kirchgessner, M.2
  • 34
    • 0034989210 scopus 로고    scopus 로고
    • Differential effects of diets that provide different lipid sources on hepatic lipogenic activities in rats under ad libitum or restricted feeding
    • Portillo MP, Chavarri M, Duran D, Rodriguez VM, Macarulla MT: Differential effects of diets that provide different lipid sources on hepatic lipogenic activities in rats under ad libitum or restricted feeding. Nutrition 2001;17:467-473.
    • (2001) Nutrition , vol.17 , pp. 467-473
    • Portillo, M.P.1    Chavarri, M.2    Duran, D.3    Rodriguez, V.M.4    Macarulla, M.T.5
  • 37
    • 0031786715 scopus 로고    scopus 로고
    • Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice
    • Ahren B, Scheurink AJ: Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice. Eur J Endocrinol 1998;139:461-467.
    • (1998) Eur J Endocrinol , vol.139 , pp. 461-467
    • Ahren, B.1    Scheurink, A.J.2
  • 38
    • 0036254607 scopus 로고    scopus 로고
    • Insulin resistance in type 2 diabetes: Role of fatty acid
    • Amer P: Insulin resistance in type 2 diabetes: role of fatty acid. Diabetes Metab Res Rev 2002;18(Suppl 2):S5-S9.
    • (2002) Diabetes Metab Res Rev , vol.18 , Issue.SUPPL. 2
    • Amer, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.