Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 4, 2008, Pages 1126-1129

  Yoshizumi, Kazuma ^a,b   Murota, Kaeko ^b   Watanabe, Shiro ^c   Tomi, Hironori ^a   Tsuji, Tomoko ^a   Terao, Junji ^b  

^a Central Research Development Laboratory Fancl Corporation   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

3, 4 seco lupane triterpenoid saponin; Acanthopanax sessiliflorus; Chiisanoside; Intestinal absorption; Lipase inhibitor

Indexed keywords

BIOLOGICAL ORGANS; ENZYME INHIBITION; LIPASES; PLANTS (BOTANY);

3, 4-SECO-LUPANE TRITERPENOID SAPONIN; ACANTHOPANAX SESSILIFLORUS; CHIISANOSIDE; INTESTINAL ABSORPTION; LIPASE INHIBITOR;

ANIMALS;

ANTIOBESITY AGENT; CHIISANOSIDE; OIL; OLIGOSACCHARIDE; SAFFLOWER OIL; TRIACYLGLYCEROL; TRITERPENE;

ANIMAL; ARTICLE; BLOOD; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE ABSORPTION; MALE; METABOLISM; MOUSE; SMALL INTESTINE; THIN LAYER CHROMATOGRAPHY;

ANIMALS; ANTI-OBESITY AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; MICE; OILS; OLIGOSACCHARIDES; SAFFLOWER OIL; TRIGLYCERIDES; TRITERPENES;

ACANTHOPANAX; ELEUTHEROCOCCUS SESSILIFLORUS; MUS; RODENTIA;

EID: 43549101667     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70761     Document Type: Article

References (17)

1. Perry, L. M., Acanthopanax species. In "Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses," The MIT Press, Cambridge, Massachusetts, London, p. 41 (1980).
2. Yoshizumi, K., Hirano, K., Ando, H., Hirai, Y., Ida, Y., Tsuji, T., Tanaka, T., Satouchi, K., and Terao, J., Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. J. Agric. Food Chem., 54, 335-341 (2006).
3. Nakai, M., Fukui, Y., Asami, S., Toyoda-Ono, Y., Iwashita, T., Shibata, H., Mitsunaga, T., Hashimoto, F., and Kiso, Y., Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. J. Agric. Food Chem., 53, 4593-4598 (2005).
4. Ikeda, I., Tsuda, K., Suzuki, Y., Kobayashi, M., Unno, T., Tomoyori, H., Goto, H., Kawata, Y., Imaizumi, K., Nozawa, A., and Kakuda, T., Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. J. Nutr., 135, 155-159 (2005).
5. Murase, T., Nagasawa, A., Suzuki, J., Hase, T., and Tokimitsu, I., Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int. J. Obes., 26, 1459-1464 (2002).
6. Harada, U., Chikama, A., Saito, S., Takase, H., Nagao, T., Hase, T., and Tokimitsu, I., Effect of the long-term ingestion of tea catechins on energy expenditure and dietary fat oxidation in healthy subjects. J. Health Sci., 51, 248-252 (2005).
7. Han, L.-K., Zheng, Y.-N., Xu, B.-J., Okuda, H., and Kimura, Y., Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice. J. Nutr., 132, 2241-2245 (2002).
8. Han, L.-K., Kimura, Y., Kawashima, M., Takaku, T., Taniyama, T., Hayashi, T., Zheng, Y.-N., and Okuda, H., Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor. Int. J. Obes., 25, 1459-1464 (2001).
9. Karu, N., Reifen, R., and Kerem, Z., Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J. Agric. Food Chem., 55, 2824-2828 (2007).
10. Kwon, C.-S., Sohn, H. Y., Kim, S. H., Kim, J. H., Son, K. H., Lee, J. S., Lim, J. K., and Kim, J.-S., Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem., 67, 1451-1456 (2003).
11. Oishi, Y., Sakamoto, T., Udagawa, H., Taniguchi, H., Kobayashi-Hattori, K., Ozawa, Y., and Takita, T., Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction. Biosci. Biotechnol. Biochem., 71, 735-740 (2007).
12. Saito, M., Hamazaki, T., Tani, T., and Watanabe, S., Bofutsushosan, a traditional Chinese formulation, inhibits pancreatic lipase activity in vitro and suppresses the elevation of plasma triacylglycerols after oral administration of lipid emulsion. J. Trad. Med., 22, 308-313 (2005).
13. Bligh, E. G., and Dyer, W. J., A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37, 911-917 (1959).
14. Hahn, D.-R., Kasai, R., Kim, J.-H., Taniyasu, S., and Tanaka, O., A new glycosyl ester of a 3, 4-secotriterpene from Korean medicinal plant, Acanthopanax chiisanensis (Araliaceae). Chem. Pharm. Bull., 32, 1244-1247 (1984).
15. Shirasuna, K., Miyakoshi, M., Mimoto, S., Isoda, S., Satoh, Y., Hirai, Y., Ida, Y., and Shoji, J., Lupane triterpenoid glycosyl esters from leaves of Acanthopanax divaricatus. Phytochemistry, 45, 579-584 (1997).
16. Jiang, W., Li, W., Han, L., Liu, L., Zhang, Q., Zhang, S., Nikaido, T., and Koike, K., Biologically active triterpenoid saponins from Acanthopanax senticosus. J. Nat. Prod., 69, 1577-1581 (2006).
17. Lambert, J. D., Lee, M. J., Lu, H., Meng, X., Hong, J. J., Seril, D. N., Sturgill, M. G., and Yang, C. S., Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice. J. Nutr., 133, 4172-4177 (2003).