Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

Oncogene

Volumn 30, Issue 18, 2011, Pages 2147-2160

  Kucejova, B ^a,b,c   Sunny, N E ^a   Nguyen, A D ^b   Hallac, R ^b   Fu, X ^a   Pea Llopis S ^a,b,c   Mason, R P ^b   Deberardinis, R J ^b   Xie, X J ^a,c   Debose Boyd, R ^b   Kodibagkar, V D ^b   Burgess, S C ^a   Brugarolas, J ^a,b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Hif; liver steatosis; mitochondrial respiration; Vhl

Indexed keywords

ACYLCARNITINE; CRE RECOMBINASE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1BETA; KETONE; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; VON HIPPEL LINDAU PROTEIN;

ADAPTATION; ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSE OF DEATH; CONTROLLED STUDY; EX VIVO STUDY; FATTY ACID OXIDATION; FATTY LIVER; GENE; GENE DISRUPTION; GENE INACTIVATION; GLUCONEOGENESIS; HOMEOSTASIS; HUMAN; HUMAN TISSUE; HYPOGLYCEMIA; HYPOKETONEMIA; HYPOXIA; IN VIVO STUDY; LIFE EXPECTANCY; LIFESPAN; LIVER PERFUSION; METABOLIC DISORDER; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE PHOSPHORYLATION; OXIMETRY; OXYGEN SENSING; OXYGEN TENSION; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UREA CYCLE; VHL GENE;

ANIMALS; ANOXIA; GLUCONEOGENESIS; HYPOGLYCEMIA; KETONES; LIVER; MICE; OXYGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

ADENOVIRIDAE; MUS;

EID: 79955609641     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.587     Document Type: Article

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