Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)-deficient mice

Journal of Biological Chemistry

Volumn 281, Issue 28, 2006, Pages 19000-19008

  Burgess, Shawn C ^a   Leone, Teresa C ^b   Wende, Adam R ^b   Croce, Michelle A ^b   Chen, Zhouji ^b   Sherry, A Dean ^a   Malloy, Craig R ^a   Finck, Brian N ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; GLUCONEOGENESIS; PHOSPHORYLATION; TRICARBOXYLIC ACID;

CARBOXYLIC ACIDS; ENZYMES; FATTY ACIDS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; OXIDATION;

GENETIC ENGINEERING;

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; DIET RESTRICTION; ENERGY METABOLISM; ENERGY YIELD; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; LIVER; LIVER METABOLISM; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATIVE PHOSPHORYLATION; PEROXISOME; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION;

ANIMALS; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; TRANS-ACTIVATORS; TRICARBOXYLIC ACIDS;

EID: 33745865153     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600050200     Document Type: Article

References (43)

1. Lin, J., Handschin, C., and Spiegelman, B. M. (2005) Cell Metab. 1, 361-370
2. Kelly, D. P., and Scarpulla, R. C. (2004) Genes Dev. 18, 357-368
3. Spiegelman, B. M., and Heinrich, R. (2004) Cell 119, 157-167
4. Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., and Spiegelman, B. M. (1998) Cell 92, 829-839
5. Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., and Montminy, M. (2001) Nature 413, 179-183
6. Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., Newgard, C. B., and Spiegelman, B. M. (2001) Nature 413, 131-138
7. Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J., and Spiegelman, B. M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4012-4017
8. Koo, S. H., Satoh, H., Herzig, S., Lee, C. H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., and Montminy, M. (2004) Nat. Med. 10, 530-534
9. Handschin, C., Lin, J., Rhee, J., Peyer, A. K., Chin, S., Wu, P. H., Meyer, U. A., and Spiegelman, B. M. (2005) Cell 122, 505-515
10. Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., Chen, Z., Holloszy, J. O., Medeiros, D. M., Schmidt, R. E., Saffitz, J. E., Abel, E. D., Semenkovich, C. F., and Kelly, D. P. (2005) PLoS Biol. 3, e101
11. Lin, J., Wu, P. H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C. Y., Mootha, V. K., Jager, S., Vianna, C. R., Reznick, R. M., Cui, L., Manieri, M., Donovan, M. X., Wu, Z., Cooper, M. P., Fan, M. C., Rohas, L. M., Zavacki, A. M., Cinti, S., Shulman, G. I., Lowell, B. B., Krainc, D., and Spiegelman, B. M. (2004) Cell 119, 121-135
12. Bernal-Mizrachi, C., Weng, S., Feng, C., Finck, B. N., Knutsen, R. H., Leone, T. C., Coleman, T., Mecham, R. P., Kelly, D. P., and Semenkovich, C. F. (2003) Nat. Med. 9, 1069-1075
13. Passonneau, J. V., and Lauderdale, V. R. (1974) Anal. Biochem. 60, 405-412
14. Burgess, S. C., Hausler, N., Merritt, M., Jeffrey, F. M. H., Storey, C., Milde, A., Koshy, S., Lindner, J., Magnuson, M. A., Malloy, C. R., and Sherry, A. D. (2004) J. Biol. Chem. 279, 48941-48949
15. Jones, J. G., Solomon, M. A., Cole, S. M., Sherry, A. D., and Malloy, C. R. (2001) Am. J. Physiol. 281, E848-E856
16. Burgess, S. C., Nuss, M., Chandramouli, V., Hardin, D. S., Rice, M., Landau, B. R., Malloy, C. R., and Sherry, A. D. (2003) Anal. Biochem. 318, 321-324
17. Jin, E. S., Jones, J. G., Merritt, M. E., Burgess, S. C., Malloy, C. R., and Sherry, A. D. (2004) Anal. Biochem. 327, 149-155
18. Chandramouli, V., Ekberg, K., Schumann, W. C., Kalhan, S. C., Wahren, J., and Landau, B. R. (1997) Am. J. Physiol. 273, E1209-E1215
19. Landau, B. R., Wahren, J., Chandramouli, V., Schumann, W. C., Ekberg, K., and Kalhan, S. C. (1995) J. Clin. Investig. 95, 172-178
20. Jones, J. G., Naidoo, R., Sherry, A. D., Jeffrey, F. M. H., Cottam, G. L., and Malloy, C. R. (1997) FEBS Lett. 412, 131-137
21. Kunst, A., Draeger, B., and Ziegenhorn, J. (1984) in Methods of Enzymatic Analysis (Bergmeyer, H. U., ed) 3rd Ed., pp. 163-172, VCH Verlagsgesllschaft, Weinheim, Germany
22. Williamson, D. H., Mellanby, J., and Krebs, H. A. (1962) Biochem. J. 82, 90-96
23. Stocchi, V., Cucchiarini, L., Canestrari, F., Piacentini, M. P., and Fornaini, G. (1987) Anal. Biochem. 167, 181-190
24. Chen, Z., Fitzgerald, R. L., Averna, M. R., and Schonfeld, G. (2000) J. Biol. Chem. 275, 32807-32815
25. Williamson, D. H., Lund, P., and Krebs, H. A. (1967) Biochem. J. 103, 514-527
26. Mootha, V. K., Lindgren, C. M., Eriksson, K. F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstrale, M., Laurila, E., Houstis, N., Daly, M. J., Patterson, N., Mesirov, J. P., Golub, T. R., Tamayo, P., Spiegelman, B., Lander, E. S., Hirschhorn, J. N., Altshuler, D., and Groop, L. C. (2003) Nat. Genet. 34, 267-273
27. Bandsma, R. H., van Dijk, T. H., Harmsel At, A., Kok, T., Reijngoud, D. J., Staels, B., and Kuipers, F. (2004) J. Biol. Chem. 279, 8930-8937
28. Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., and Kelly, D. P. (2005) Cell Metab. 1, 133-144
29. Tordjman, K., Bernal-Mizrachi, C., Zemany, L., Weng, S., Feng, C., Zhang, F., Leone, T. C., Coleman, T., Kelly, D. P., and Semenkovich, C. F. (2001) J. Clin. Investig. 107, 1025-1034
30. Guerre-Millo, M., Rouault, C., Poulain, P., Andre, J., Poitout, V., Peters, J. M., Gonzalez, F. J., Fruchart, J. C., Reach, G., and Staels, B. (2001) Diabetes 50, 2809-2814
31. Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., and Wahli, W. (1999) J. Clin. Investig. 103, 1489-1498
32. Leone, T. C., Weinheimer, C. J., and Kelly, D. P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7473-7478
33. Kurtz, D. M., Rinaldo, P., Rhead, W. J., Tian, L., Millington, D. S., Vockley, J., Hamm, D. A., Brix, A. E., Lindsey, J. R., Pinkert, C. A., O'Brien, W. E., and Wood, P. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15592-15597
34. Ibdah, J. A., Paul, H., Zhao, Y., Binford, S., Salleng, K., Cline, M., Matern, D., Bennett, M. J., Rinaldo, P., and Strauss, A. W. (2001) J. Clin. Investig. 107, 1403-1409
35. Burton, B. K. (1998) Pediatrics 102, E69
36. Sovik, O. (1989) Acta Paediatr. Scand. 78, 161-170
37. Stanley, C. A. (1987) Advances in pediatrics 34, 59-88
38. She, P., Burgess, S. C., Shiota, M., Flakoll, P., Donahue, E. P., Malloy, C. R., Sherry, A. D., and Magnuson, M. A. (2003) Diabetes 52, 1649-1654
39. Hausler, N., Browning, J., Merritt, M., Storey, C., Milde, A., Jeffrey, F. M., Sherry, A. D., Malloy, C. R., and Burgess, S. C. (2006) Biochem. J. 394, 465-473; Correction (2006) Biochem. J. 395, 663
40. Hakimi, P., Johnson, M. T., Yang, J., Lepage, D. F., Conlon, R. A., Kalhan, S. C., Reshef, L., Tilghman, S. M., and Hanson, R. W. (2005) Nutr. Metab. (Lond) 2, 33
41. Lin, J., Yang, R., Tarr, P. T., Wu, P. H., Handschin, C., Li, S., Yang, W., Pei, L., Uldry, M., Tontonoz, P., Newgard, C. B., and Spiegelman, B. M. (2005) Cell 120, 261-273
42. Koo, S.-H., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., and Montminy, M. (2005) Nature 437, 1109-1111
43. Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., and Muoio, D. M. (2005) J. Biol. Chem. 280, 33588-33598