Apolipoprotein E: Structure, function, and possible roles in Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 777, Issue , 1996, Pages 139-145

  Mahley, R W ^a,b,c   Nathan, B P ^a   Pitas, R E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; TAU PROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ALZHEIMER DISEASE; CONFERENCE PAPER; CYTOSKELETON; HUMAN; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PERIPHERAL NERVOUS SYSTEM; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION;

MURINAE;

EID: 0029924266     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb34412.x     Document Type: Article

References (24)

1. MAHLEY, R. W. 1988. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
2. ELSHOURBAGY, N. A., W. S. LIAO, R. W. MAHLEY & J. M. TAYLOR. 1985. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc. Natl. Acad. Sci. USA 82:203-207.
3. BOYLES, J. K., R. E. PITAS, E. WILSON, R. W. MAHLEY & J. M. TAYLOR. 1985. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J. Clin. Invest. 76:1501-1513.
4. PITAS, R. E., J. K. BOYLES, S. H. LEE, D. FOSS & R. W. MAHLEY. 1987. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim. Biophys. Acta. 917:148-161.
5. PITAS, R. E., J. K. BOYLES, S. H. LEE, D. Y. HUI & K. H. WEISGRABER. 1987. Lipoproteins and their receptors in the central nervous system: Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J. Biol. Chem. 262:14352-14360.
6. HANDELMANN, G. E., J. K. BOYLES, K. H. WEISGRABER, R. W. MAHLEY & R. E. PITAS. 1992. Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. J. Lipid Res. 33:1677-1688.
7. MÜLLER, H. W., P. J. GEBICKE-HÄRTER, D. H. HANGEN & E. M. SHOOTER. 1985. A specific 37,000-dalton protein that accumulates in regenerating but not in nonregenerating mammalian nerves. Science 228:499-501.
8. IGNATIUS, M. J., P. J. GEBICKE-HÄRTER, J. H. P. SKENE, J. W. SCHILLING, K. H. WEISGRABER, R. W. MAHLEY & E. M. SHOOTER. 1986. Expression of apolipoprotein E during nerve degeneration and regeneration. Proc. Natl. Acad. Sci. USA 83:1125-1129.
9. BOYLES, J. K., C. D. ZOELLNER, L J. ANDERSON, L. M. KOSIK, R. E. PITAS, K. H. WEISGRABER, D. Y. HUI, R. W. MAHLEY, P. J. GEBICKE-HAERTER, M. J. IGNATIUS & E. M. SHOOTER. 1989. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J. Clin. Invest. 83: 1015-1031.
10. IGNATIUS, M. J., E. M. SHOOTER, R. E. PITAS & R. W. MAHLEY. 1987. Lipoprotein uptake by neuronal growth cones in vitro. Science 236:959-962.
11. SAUNDERS, A. M., W. J. STRITTMATTER, D. SCHMECHEL, P. H. ST. GEORGE-HYSLOP, M. A. PERICAK-VANCE, S. H. JOO, B. L. ROSI, J. F. GUSELLA, D. R. CRAPPER-MACLACHLAN, M. J. ALBERTS, C. HULETTE, B. CRAIN, D. GOLDGABER & A. D. ROSES. 1993. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467-1472.
12. CORDER, E. H., A. M. SAUNDERS, W. J. STRITTMATTER, D. E. SCHMECHEL, P. C. GASKELL, G. W. SMALL, A. D. ROSES, J. L. HAINES & M. A. PERICAK-VANCE. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
13. MCKHANN, G., D. DRACHMAN, M. FOLSTEIN, R. KATZMAN, D. PRICE & E. M. STADLAN. 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
14. SELKOE, D. J. 1991. The molecular pathology of Alzheimer's disease. Neuron 6:487-498.
15. CROWTHER, R. A. 1993. Tau protein and paired helical filaments of Alzheimer's disease. Curr. Opin. Struct. Biol. 3:202-206.
16. ROSES, A. D. 1994. The Alzheimer diseases. Curr. Neurol. 14:111-141.
17. WEISGRABER, K. H., A. D. ROSES & W. J. STRITTMATTER. 1994. The role of apolipoprotein E in the nervous system. Curr. Opin. Lipidol. 5:110-116.
18. WEISGRABER, K. H., R. E. PITAS & R. W. MAHLEY. 1994. Lipoproteins, neurobiology, and Alzheimer's disease: Structure and function of apolipoprotein E. Curr. Opin. Struct. Biol. 4:507-515.
19. STRITTMATTER, W. J., A. M. SAUNDERS, D. SCHMECHEL, M. PERICAK-VANCE, J. ENGHILD, G. S. SALVESEN & A. D. ROSES. 1993. Apolipoprotein E: High avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:1977-1981.
20. STRITTMATTER, W. J., K. H. WEISGRABER, D. Y. HUANG, L.-M. DONG, G. S. SALVESEN, M. PERICAK-VANCE, D. SCHMECHEL, A. M. SAUNDERS, D. GOLDGABER & A. D. ROSES. 1993. Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:8098-8102.
21. SANAN, D. A., K. H. WEISGRABER, S. J. RUSSELL, R. W. MAHLEY, D. HUANG, A. SAUNDERS, D. SCHMECHEL, T. WISNIEWSKI, B. FRANGIONE, A. D. ROSES & W. J. STRITTMATTER. 1994. Apolipoprotein E associates with β amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J. Clin. Invest. 94:860-869.
22. STRITTMATTER, W. J., K. H. WEISGRABER, M. GOEDERT, A. M. SAUNDERS, D. HUANG, E. H. CORDER, L.-M. DONG, R. JAKES, M. J. ALBERTS, J. R. GILBERT, S.-H. HAN, C. HULETTE, G. EINSTEIN, D. E. SCHMECHEL, M. A. PERICAK-VANCE & A. D. ROSES. 1994. Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp. Neurol. 125:163-171.
23. NATHAN, B. P., S. BELLOSTA, D. A. SANAN, K. H. WEISGRABER, R. W. MAHLEY & R. E. PITAS. 1994. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264:850-852.
24. NATHAN, B. P., S. BELLOSTA, R. W. MAHLEY & R. E. PITAS. 1994. Apolipoprotein E3- and E4-induced differences in neurite outgrowth are associated with differences in the subcellular localization of apolipoprotein E. Soc. Neurosci. 20: 1033. (Abstr.)