Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress

Annals of Neurology

Volumn 32, Issue 1 S, 1992, Pages S22-S27

  Floyd, Robert A ^a   Carney, John M ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; HYDROXYL RADICAL;

AGING; BRAIN ISCHEMIA; BRAIN PROTECTION; CONFERENCE PAPER; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME INACTIVATION; GERBIL; HYDROXYLATION; IRON STORAGE; NEUROLOGIC DISEASE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REPERFUSION INJURY; TISSUE INJURY;

ANIMAL; BRAIN; DNA; FREE RADICALS; HUMAN; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; REPERFUSION INJURY; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026647763     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410320706     Document Type: Article

References (20)

1. Role of oxygen free radicals in carcinogenesis and brain ischemia
2. Reversal of agerelated increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin‐trapping compound N‐tert‐butyl‐α‐phenylnitrone
3. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion‐induced injury to gerbil brain
4. Ascorbate/iron mediation of hydroxyl free radical damage to pBR322 plasmid DNA
5. Characterization of hydroxyl free radical mediated damage to plasmid pBR322 DNA
6. Mutagenesis by the autoxidation of iron with isolated DNA
7. Mutation spectrum of copper‐induced DNA damage
8. Conditions influencing yield and analysis of 8‐hydroxy‐2′‐deoxyguanosine in oxidatively damaged DNA
9. Metal‐catalyzed oxidation of proteins
10. Metal ion catalyzed oxidation of proteins: biochemical mechanism and biological consequences. J Free
11. Determination of carbonyl content in oxidatively modified proteins
12. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases
13. Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron
14. Iron‐induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes
15. Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats
16. Oxygen free radical involvement in ischemia and reperfusion injury to brain
17. Age influence on oxidative events during brain ischemia/reperfusion
18. Oxidative damage to behavior during agin 5
19. Excretion, metabolism and tissue distribution of a spin trapping agent, α‐phenyl‐N‐butyl‐nitrone (PBN) in rats
20. Excess brain protein oxidation and enzyme dysfunction in normal aging in Alzheimer's disease