Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice

Neuroscience Letters

Volumn 440, Issue 1, 2008, Pages 44-48

  Gu, Feng ^a   Zhu, Manjie ^a   Shi, Jianting ^a   Hu, Yinghe ^a   Zhao, Zheng ^a  

^a B326 Science Building   (China)

Author keywords

Catalase; Malonaldehyde; Oxidative stress; Presenilin; Protein carbonyl; Superoxide dismutase

Indexed keywords

CATALASE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; PRESENILIN; SUPEROXIDE DISMUTASE;

ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGE FACTORS; ALZHEIMER DISEASE; ANIMALS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PRESENILIN-1; PRESENILIN-2; SPECTROPHOTOMETRY; SUPEROXIDE DISMUTASE;

EID: 45249120152     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.050     Document Type: Article

References (35)

1. Balazs L., and Leon M. Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem. Res. 19 (1994) 1131-1137
2. Beglopoulos V., and Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Trends Pharmacol. Sci. 27 (2006) 33-40
3. Beglopoulos V., Sun X., Saura C.A., Lemere C.A., Kim R.D., and Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J. Biol. Chem. 279 (2004) 46907-46914
4. Berlett B.S., and Stadtman E.R. Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 272 (1997) 20313-20316
5. Butterfield D.A., Drake J., Pocernich C., and Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7 (2001) 548-554
6. Choi J., Forster M.J., McDonald S.R., Weintraub S.T., Carroll C.A., and Gracy R.W. Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. Free Radic. Biol. Med. 36 (2004) 1155-1162
7. Dalle-Donne I., Giustarini D., Colombo R., Rossi R., and Milzani A. Protein carbonylation in human diseases. Trends Mol. Med. 9 (2003) 169-176
8. De Strooper B., Beullens M., Contreras B., Levesque L., Craessaerts K., Cordell B., Moechars D., Bollen M., Fraser P., George-Hyslop P.S., and Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem. 272 (1997) 3590-3598
9. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., and Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391 (1998) 387-390
10. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., and Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398 (1999) 518-522
11. Dong S., Li C., Wu P., Tsien J.Z., and Hu Y. Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur. J. Neurosci. 26 (2007) 101-112
12. Donoviel D.B., Hadjantonakis A.K., Ikeda M., Zheng H., Hyslop P.S., and Bernstein A. Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 13 (1999) 2801-2810
13. Feng R., Rampon C., Tang Y.P., Shrom D., Jin J., Kyin M., Sopher B., Miller M.W., Ware C.B., Martin G.M., Kim S.H., Langdon R.B., Sisodia S.S., and Tsien J.Z. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32 (2001) 911-926
14. Feng R., Wang H., Wang J., Shrom D., Zeng X., and Tsien J.Z. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 8162-8167
15. Gsell W., Conrad R., Hickethier M., Sofic E., Frolich L., Wichart I., Jellinger K., Moll G., Ransmayr G., and Beckmann H. Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J. Neurochem. 64 (1995) 1216-1223
16. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S.P., Wu J.F., and Carney J.M. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65 (1995) 2146-2156
17. Herreman A., Hartmann D., Annaert W., Saftig P., Craessaerts K., Serneels L., Umans L., Schrijvers V., Checler F., Vanderstichele H., Baekelandt V., Dressel R., Cupers P., Huylebroeck D., Zwijsen A., Van Leuven F., and De Strooper B. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 11872-11877
18. Hutton M., and Hardy J. The presenilins and Alzheimer's disease. Hum. Mol. Genet. 6 (1997) 1639-1646
19. Levine R.L., Williams J.A., Stadtman E.R., and Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 233 (1994) 346-357
20. Lovell M.A., Ehmann W.D., Butler S.M., and Markesbery W.R. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45 (1995) 1594-1601
21. Marcus D.L., Strafaci J.A., and Freedman M.L. Differential neuronal expression of manganese superoxide dismutase in Alzheimer's disease. Med. Sci. Monit. 12 (2006) BR8-BR14
22. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23 (1997) 134-147
23. Mohmmad Abdul H., Sultana R., Keller J.N., St Clair D.K., Markesbery W.R., and Butterfield D.A. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. J. Neurochem. 96 (2006) 1322-1335
24. Nabeshi H., Oikawa S., Inoue S., Nishino K., and Kawanishi S. Proteomic analysis for protein carbonyl as an indicator of oxidative damage in senescence-accelerated mice. Free Radic. Res. 40 (2006) 1173-1181
25. Nakajima M., and Shirasawa T. Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro. Neuroscience 125 (2004) 563-568
26. Nakajima M., Miura M., Aosaki T., and Shirasawa T. Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro. J. Neurochem. 78 (2001) 807-814
27. Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E.K., Jones P.K., Ghanbari H., Wataya T., Shimohama S., Chiba S., Atwood C.S., Petersen R.B., and Smith M.A. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60 (2001) 759-767
28. Opazo C., Huang X., Cherny R.A., Moir R.D., Roher A.E., White A.R., Cappai R., Masters C.L., Tanzi R.E., Inestrosa N.C., and Bush A.I. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J. Biol. Chem. 277 (2002) 40302-40308
29. Sato E., Oda N., Ozaki N., Hashimoto S., Kurokawa T., and Ishibashi S. Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse. Mech. Ageing Dev. 86 (1996) 105-114
30. Saura C.A., Choi S.Y., Beglopoulos V., Malkani S., Zhang D., Shankaranarayana Rao B.S., Chattarji S., Kelleher III R.J., Kandel E.R., Duff K., Kirkwood A., and Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42 (2004) 23-36
31. Sayre L.M., Zelasko D.A., Harris P.L., Perry G., Salomon R.G., and Smith M.A. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68 (1997) 2092-2097
32. Shen J., Bronson R.T., Chen D.F., Xia W., Selkoe D.J., Tonegawa S., and Skeletal. CNS defects in presenilin-1-deficient mice. Cell 89 (1997) 629-639
33. Subbarao K.V., Richardson J.S., and Ang L.C. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J. Neurochem. 55 (1990) 342-345
34. Turner B.J., Li Q.X., Laughton K.M., Masters C.L., Lopes E.C., Atkin J.D., and Cheema S.S. Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1. Neurochem. Res. 29 (2004) 2281-2286
35. Yao Y., Chinnici C., Tang H., Trojanowski J.Q., Lee V.M., and Pratico D. Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis. J. Neuroinflamm. 1 (2004) 21