Analysis of somatic mutations in cancer: Molecular mechanisms of activation in the ErbB family of receptor tyrosine kinases

Cancers

Volumn 3, Issue 1, 2011, Pages 1195-1231

  Shih, Andrew J ^a   Telesco, Shannon E ^a   Radhakrishnan, Ravi ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

ErbB EGFR HER kinase; ERK Akt activation; Multiscale modeling; Somatic mutation

Indexed keywords

BEVACIZUMAB; CETUXIMAB; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GEFITINIB; IMATINIB; LAPATINIB; NILOTINIB; PANITUMUMAB; PAZOPANIB; PEGAPTANIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; RANIBIZUMAB; SORAFENIB; STEM CELL FACTOR RECEPTOR; SUNITINIB; TRASTUZUMAB; VASCULOTROPIN RECEPTOR 2;

BREAST CANCER; CANCER RESISTANCE; CARCINOGENESIS; COLON CANCER; DIGESTIVE SYSTEM CANCER; DIMERIZATION; DRUG EFFICACY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; KIDNEY CANCER; LEUKEMIA; LUNG CANCER; MOLECULAR INTERACTION; MUTANT; NEOPLASM; NEUROBLASTOMA; OVARY CANCER; PROSTATE CANCER; REVIEW; SIGNAL TRANSDUCTION; SKIN CANCER; SOMATIC MUTATION; THYROID CANCER;

EID: 79953684580     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3011195     Document Type: Review

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