Somatic mutations of ErbB4: Selective loss-of-function phenotype affecting signal transduction pathways in cancer

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 5582-5591

  Tvorogov, Denis ^a   Sundvall, Maria ^a   Kurppa, Kari ^a   Hollmén, Maija ^a,b   Repo, Susanna ^b,d   Johnson, Mark S ^b   Elenius, Klaus ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER DRUG; CANCER-ASSOCIATED MUTATIONS; CLINICAL USE; CODING REGION; EPIDERMAL GROWTH FACTOR RECEPTORS; KINASE ACTIVITY; MAMMARY CARCINOMA CELL; NEUREGULIN; NON SMALL CELL LUNG CANCER; SIGNAL TRANSDUCTION PATHWAYS; SOMATIC MUTATION; STRUCTURAL FEATURE; WILD TYPES;

SIGNAL TRANSDUCTION;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT5 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DIFFERENTIATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SOMATIC MUTATION; STOMACH CANCER; WILD TYPE; ANIMAL; CELL PROLIFERATION; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CULTURE TECHNIQUE; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MUTATION; PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; IMMUNOPRECIPITATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MUTATION; PHENOTYPE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 65549104656     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805438200     Document Type: Article

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