메뉴 건너뛰기




Volumn 22, Issue 11, 2009, Pages 1446-1456

Correlation between KIT expression and KIT mutation in melanoma: A study of 173 cases with emphasis on the acral-lentiginous/mucosal type

Author keywords

Acral lentiginous; Immunohistochemistry; KIT; Melanoma; Mucosal; Mutation

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIT GENE; MAJOR CLINICAL STUDY; MALE; MALIGNANT LENTIGO; MELANOMA; PRIORITY JOURNAL;

EID: 70350668375     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.116     Document Type: Article
Times cited : (167)

References (53)
  • 1
    • 0031927710 scopus 로고    scopus 로고
    • The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis
    • Grichnik JM, Burch JA, Burchette J, et al. The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis. J Invest Dermatol 1998;111:233-238
    • (1998) J Invest Dermatol , vol.111 , pp. 233-238
    • Grichnik, J.M.1    Burch, J.A.2    Burchette, J.3
  • 2
    • 33646155553 scopus 로고    scopus 로고
    • Kit and melanocyte migration
    • Grichnik JM. Kit and melanocyte migration. J Invest Dermatol 2006;126:945-947
    • (2006) J Invest Dermatol , vol.126 , pp. 945-947
    • Grichnik, J.M.1
  • 3
    • 46749158639 scopus 로고    scopus 로고
    • Tyrosine kinase activating mutations in human malignancies: Implications for diagnostic pathology
    • Holden JA, Willmore-Payne C, Layfield LJ. Tyrosine kinase activating mutations in human malignancies: implications for diagnostic pathology. Exp Mol Pathol 2008;85:68-75
    • (2008) Exp Mol Pathol , vol.85 , pp. 68-75
    • Holden, J.A.1    Willmore-Payne, C.2    Layfield, L.J.3
  • 4
    • 33646153073 scopus 로고    scopus 로고
    • Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes
    • Alexeev V, Yoon K. Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes. J Invest Dermatol 2006;126:1102-1110
    • (2006) J Invest Dermatol , vol.126 , pp. 1102-1110
    • Alexeev, V.1    Yoon, K.2
  • 5
    • 0026793058 scopus 로고
    • Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor
    • Natali PG, Nicotra MR, Winkler AB, et al. Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 1992;52:197-201
    • (1992) Int J Cancer , vol.52 , pp. 197-201
    • Natali, P.G.1    Nicotra, M.R.2    Winkler, A.B.3
  • 6
    • 0030765407 scopus 로고    scopus 로고
    • Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression
    • Montone KT, van Belle P, Elenitsas R, et al. Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Mod Pathol 1997;10:939-944
    • (1997) Mod Pathol , vol.10 , pp. 939-944
    • Montone, K.T.1    Van Belle, P.2    Elenitsas, R.3
  • 7
    • 3042808726 scopus 로고    scopus 로고
    • Primary melanoma of the skin and cutaneous melano-matous metastases: Comparative histologic features and immunophenotypes
    • Guerriere-Kovach PM, Hunt EL, Patterson JW, et al. Primary melanoma of the skin and cutaneous melano-matous metastases: comparative histologic features and immunophenotypes. Am J Clin Pathol 2004;122: 70-77
    • (2004) Am J Clin Pathol , vol.122 , pp. 70-77
    • Guerriere-Kovach, P.M.1    Hunt, E.L.2    Patterson, J.W.3
  • 8
    • 16544371910 scopus 로고    scopus 로고
    • Prevalence of KIT expression in human tumors
    • Went PT, Dirnhofer S, Bundi M, et al. Prevalence of KIT expression in human tumors. J Clin Oncol 2004; 22:4514-4522
    • (2004) J Clin Oncol , vol.22 , pp. 4514-4522
    • Went, P.T.1    Dirnhofer, S.2    Bundi, M.3
  • 9
    • 20144378490 scopus 로고    scopus 로고
    • Human malignant melanoma: Detection of BRAF-and c-kit-activating mutations by high-resolution amplicon melting analysis
    • Willmore-Payne C, Holden JA, Tripp S, et al. Human malignant melanoma: detection of BRAF-and c-kit-activating mutations by high-resolution amplicon melting analysis. Hum Pathol 2005;36:486-493
    • (2005) Hum Pathol , vol.36 , pp. 486-493
    • Willmore-Payne, C.1    Holden, J.A.2    Tripp, S.3
  • 10
    • 0038443937 scopus 로고    scopus 로고
    • Potential use of imatinib mesylate in ocular melanoma and lipo-sarcoma expressing immunohistochemical c-KIT (CD117)
    • Fiorentini G, Rossi S, Lanzanova G, et al. Potential use of imatinib mesylate in ocular melanoma and lipo-sarcoma expressing immunohistochemical c-KIT (CD117). Ann Oncol 2003;14:805
    • (2003) Ann Oncol , vol.14 , pp. 805
    • Fiorentini, G.1    Rossi, S.2    Lanzanova, G.3
  • 11
    • 50249141632 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with metastatic melanoma
    • Kim KB, Eton O, Davis DW, et al. Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer 2008;99:734-740
    • (2008) Br J Cancer , vol.99 , pp. 734-740
    • Kim, K.B.1    Eton, O.2    Davis, D.W.3
  • 12
    • 57049109807 scopus 로고    scopus 로고
    • Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib
    • Quintas-Cardama A, Lazar AJ, Woodman SE, et al. Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib. Nat Clin Pract Oncol 2008;5:737-740
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 737-740
    • Quintas-Cardama, A.1    Lazar, A.J.2    Woodman, S.E.3
  • 13
    • 42949128595 scopus 로고    scopus 로고
    • Major response to imatinib mesylate in KIT-mutated melanoma
    • Hodi FS, Friedlander P, Corless CL, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol 2008;26:2046-2051
    • (2008) J Clin Oncol , vol.26 , pp. 2046-2051
    • Hodi, F.S.1    Friedlander, P.2    Corless, C.L.3
  • 14
    • 52049089936 scopus 로고    scopus 로고
    • Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases
    • Heinrich MC, Joensuu H, Demetri GD, et al. Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases. Clin Cancer Res 2008;14:2717-2725
    • (2008) Clin Cancer Res , vol.14 , pp. 2717-2725
    • Heinrich, M.C.1    Joensuu, H.2    Demetri, G.D.3
  • 15
    • 47249099056 scopus 로고    scopus 로고
    • Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
    • Lutzky J, Bauer J, Bastian BC. Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res 2008;21:492-493
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 492-493
    • Lutzky, J.1    Bauer, J.2    Bastian, B.C.3
  • 16
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin JA, Busam K, Pinkel D, et al. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006;24:4340-4346
    • (2006) J Clin Oncol , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3
  • 17
    • 58149260596 scopus 로고    scopus 로고
    • KIT gene mutations and copy number in melanoma subtypes
    • Beadling C, Jacobson-Dunlop E, Hodi FS, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008;14:6821-6828
    • (2008) Clin Cancer Res , vol.14 , pp. 6821-6828
    • Beadling, C.1    Jacobson-Dunlop, E.2    Hodi, F.S.3
  • 18
    • 34250335270 scopus 로고    scopus 로고
    • L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition
    • Antonescu CR, Busam KJ, Francone TD, et al. L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. Int J Cancer 2007;121: 257-264
    • (2007) Int J Cancer , vol.121 , pp. 257-264
    • Antonescu, C.R.1    Busam, K.J.2    Francone, T.D.3
  • 19
    • 59449085455 scopus 로고    scopus 로고
    • Imatinib targeting of KIT-mutant oncoprotein in melanoma
    • Jiang X, Zhou J, Yuen NK, et al. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res 2008;14:7726-7732
    • (2008) Clin Cancer Res , vol.14 , pp. 7726-7732
    • Jiang, X.1    Zhou, J.2    Yuen, N.K.3
  • 20
    • 20844460619 scopus 로고    scopus 로고
    • A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
    • Chen LL, Trent JC, Wu EF, et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 2004;64:5913-5919
    • (2004) Cancer Res , vol.64 , pp. 5913-5919
    • Chen, L.L.1    Trent, J.C.2    Wu, E.F.3
  • 21
    • 0026518279 scopus 로고
    • Loss of c-kit expression in cultured melanoma cells
    • Lassam N, Bickford S. Loss of c-kit expression in cultured melanoma cells. Oncogene 1992;7:51-56
    • (1992) Oncogene , vol.7 , pp. 51-56
    • Lassam, N.1    Bickford, S.2
  • 22
    • 0027102715 scopus 로고
    • C-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas
    • Funasaka Y, Boulton T, Cobb M, et al. c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Mol Biol Cell 1992;3:197-209
    • (1992) Mol Biol Cell , vol.3 , pp. 197-209
    • Funasaka, Y.1    Boulton, T.2    Cobb, M.3
  • 23
    • 0141958794 scopus 로고    scopus 로고
    • Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array
    • Shen SS, Zhang PS, Eton O, et al. Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array. J Cutan Pathol 2003;30:539-547
    • (2003) J Cutan Pathol , vol.30 , pp. 539-547
    • Shen, S.S.1    Zhang, P.S.2    Eton, O.3
  • 24
    • 2942550604 scopus 로고    scopus 로고
    • Immunohistochemical determination of HER-2/neu overexpression in malignant melanoma reveals no prognostic value, while c-Kit (CD117) overexpression exhibits potential therapeutic implications
    • Potti A, Hille RC, Koch M. Immunohistochemical determination of HER-2/neu overexpression in malignant melanoma reveals no prognostic value, while c-Kit (CD117) overexpression exhibits potential therapeutic implications. J Carcinog 2003;2:8
    • (2003) J Carcinog , vol.2 , pp. 8
    • Potti, A.1    Hille, R.C.2    Koch, M.3
  • 25
    • 33745796354 scopus 로고    scopus 로고
    • Anorectal malignant melanoma: Morphologic and immunohistochemical features
    • Chute DJ, Cousar JB, Mills SE. Anorectal malignant melanoma: morphologic and immunohistochemical features. Am J Clin Pathol 2006;126:93-100
    • (2006) Am J Clin Pathol , vol.126 , pp. 93-100
    • Chute, D.J.1    Cousar, J.B.2    Mills, S.E.3
  • 26
    • 44949137352 scopus 로고    scopus 로고
    • Malignant blue nevus with lymph node metastases
    • Zyrek-Betts J, Micale M, Lineen A, et al. Malignant blue nevus with lymph node metastases. J Cutan Pathol 2008;35:651-657
    • (2008) J Cutan Pathol , vol.35 , pp. 651-657
    • Zyrek-Betts, J.1    Micale, M.2    Lineen, A.3
  • 27
    • 23744512047 scopus 로고    scopus 로고
    • An immunohisto-chemical evaluation of c-kit (CD-117) expression in malignant melanoma, and results of imatinib mesylate (Gleevec) therapy in three patients
    • Alexis JB, Martinez AE, Lutzky J. An immunohisto-chemical evaluation of c-kit (CD-117) expression in malignant melanoma, and results of imatinib mesylate (Gleevec) therapy in three patients. Melanoma Res 2005;15:283-285
    • (2005) Melanoma Res , vol.15 , pp. 283-285
    • Alexis, J.B.1    Martinez, A.E.2    Lutzky, J.3
  • 28
    • 0036319991 scopus 로고    scopus 로고
    • Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution
    • Hornick JL, Fletcher CD. Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution. Am J Clin Pathol 2002; 117:188-193
    • (2002) Am J Clin Pathol , vol.117 , pp. 188-193
    • Hornick, J.L.1    Fletcher, C.D.2
  • 29
    • 0027197555 scopus 로고
    • KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells
    • Zakut R, Perlis R, Eliyahu S, et al. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 1993;8: 2221-2229
    • (1993) Oncogene , vol.8 , pp. 2221-2229
    • Zakut, R.1    Perlis, R.2    Eliyahu, S.3
  • 30
    • 0032479996 scopus 로고    scopus 로고
    • Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
    • DOI 10.1093/emboj/17.15.4358
    • Huang S, Jean D, Luca M, et al. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J 1998;17: 4358-4369 (Pubitemid 28362626)
    • (1998) EMBO Journal , vol.17 , Issue.15 , pp. 4358-4369
    • Huang, S.1    Jean, D.2    Luca, M.3    Tainsky, M.A.4    Bar-Eli, M.5
  • 31
    • 0034685648 scopus 로고    scopus 로고
    • Melanin binds reversibly to thermostable DNA polymerase and inhibits its activity
    • Eckhart L, Bach J, Ban J, et al. Melanin binds reversibly to thermostable DNA polymerase and inhibits its activity. Biochem Biophys Res Commun 2000;271: 726-730
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 726-730
    • Eckhart, L.1    Bach, J.2    Ban, J.3
  • 32
    • 0031688927 scopus 로고    scopus 로고
    • Bovine serum albumin reverses inhibition of RT-PCR by melanin
    • Giambernardi TA, Rodeck U, Klebe RJ. Bovine serum albumin reverses inhibition of RT-PCR by melanin. Biotechniques 1998;25:564-566
    • (1998) Biotechniques , vol.25 , pp. 564-566
    • Giambernardi, T.A.1    Rodeck, U.2    Klebe, R.J.3
  • 33
    • 37549021543 scopus 로고    scopus 로고
    • C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma
    • Rivera RS, Nagatsuka H, Gunduz M, et al. C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 2008;452:27-32
    • (2008) Virchows Arch , vol.452 , pp. 27-32
    • Rivera, R.S.1    Nagatsuka, H.2    Gunduz, M.3
  • 34
    • 25144520884 scopus 로고    scopus 로고
    • Prognostic role of E2F1 and members of the CDKN2A network in gastrointestinal stromal tumors
    • Haller F, Gunawan B, von Heydebreck A, et al. Prognostic role of E2F1 and members of the CDKN2A network in gastrointestinal stromal tumors. Clin Cancer Res 2005;11:6589-6597
    • (2005) Clin Cancer Res , vol.11 , pp. 6589-6597
    • Haller, F.1    Gunawan, B.2    Von Heydebreck, A.3
  • 35
    • 0032953812 scopus 로고    scopus 로고
    • Mutations in exon 11 of c-Kit occur preferentially in malignant vs benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
    • Lasota J, Jasinski M, Sarlomo-Rikala M, et al. Mutations in exon 11 of c-Kit occur preferentially in malignant vs benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol 1999;154:53-60
    • (1999) Am J Pathol , vol.154 , pp. 53-60
    • Lasota, J.1    Jasinski, M.2    Sarlomo-Rikala, M.3
  • 36
    • 33746401591 scopus 로고    scopus 로고
    • KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
    • Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006;42:1093-1103
    • (2006) Eur J Cancer , vol.42 , pp. 1093-1103
    • Debiec-Rychter, M.1    Sciot, R.2    Le Cesne, A.3
  • 37
    • 46849106059 scopus 로고    scopus 로고
    • Unlucky number 13? Differential effects of KIT exon 13 mutation in gastrointestinal stromal tumors
    • McAuliffe JC, Wang WL, Pavan GM, et al. Unlucky number 13? Differential effects of KIT exon 13 mutation in gastrointestinal stromal tumors. Mol Oncol 2008;2:161-163
    • (2008) Mol Oncol , vol.2 , pp. 161-163
    • McAuliffe, J.C.1    Wang, W.L.2    Pavan, G.M.3
  • 38
    • 41149170835 scopus 로고    scopus 로고
    • Clinicopatho-logic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: A multicenter study on 54 cases
    • Lasota J, Corless CL, Heinrich MC, et al. Clinicopatho-logic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases. Mod Pathol 2008; 21:476-484
    • (2008) Mod Pathol , vol.21 , pp. 476-484
    • Lasota, J.1    Corless, C.L.2    Heinrich, M.C.3
  • 39
    • 34247867856 scopus 로고    scopus 로고
    • Characterization of tyrosine kinase i domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastro-intestinal stromal tumor
    • Kinoshita K, Hirota S, Isozaki K, et al. Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastro-intestinal stromal tumor. Am J Gastroenterol 2007; 102:1134-1136
    • (2007) Am J Gastroenterol , vol.102 , pp. 1134-1136
    • Kinoshita, K.1    Hirota, S.2    Isozaki, K.3
  • 40
    • 34848816032 scopus 로고    scopus 로고
    • Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors
    • Desai J, Shankar S, Heinrich MC, et al. Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res 2007;13:5398-5405
    • (2007) Clin Cancer Res , vol.13 , pp. 5398-5405
    • Desai, J.1    Shankar, S.2    Heinrich, M.C.3
  • 41
    • 0032104728 scopus 로고    scopus 로고
    • In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation
    • Beghini A, Cairoli R, Morra E, et al. In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation. Blood Cells Mol Dis 1998;24: 262-270
    • (1998) Blood Cells Mol Dis , vol.24 , pp. 262-270
    • Beghini, A.1    Cairoli, R.2    Morra, E.3
  • 42
    • 33845961736 scopus 로고    scopus 로고
    • C-kit Asp-816-Val mutation analysis in patients with mastocytosis
    • Verzijl A, Heide R, Oranje AP, et al. C-kit Asp-816-Val mutation analysis in patients with mastocytosis. Dermatology 2007;214:15-20
    • (2007) Dermatology , vol.214 , pp. 15-20
    • Verzijl, A.1    Heide, R.2    Oranje, A.P.3
  • 43
    • 0038731316 scopus 로고    scopus 로고
    • Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant
    • Frost MJ, Ferrao PT, Hughes TP, et al. Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant. Mol Cancer Ther 2002;1:1115-1124
    • (2002) Mol Cancer Ther , vol.1 , pp. 1115-1124
    • Frost, M.J.1    Ferrao, P.T.2    Hughes, T.P.3
  • 44
    • 0032983371 scopus 로고    scopus 로고
    • Activating c-kit gene mutations in human germ cell tumors
    • Tian Q, Frierson Jr HF, Krystal GW, et al. Activating c-kit gene mutations in human germ cell tumors. Am J Pathol 1999;154:1643-1647
    • (1999) Am J Pathol , vol.154 , pp. 1643-1647
    • Tian, Q.1    Frierson Jr, H.F.2    Krystal, G.W.3
  • 45
    • 14944352767 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
    • Debiec-Rychter M, Cools J, Dumez H, et al. Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastro-enterology 2005;128:270-279
    • (2005) Gastro-enterology , vol.128 , pp. 270-279
    • Debiec-Rychter, M.1    Cools, J.2    Dumez, H.3
  • 46
    • 20344393896 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
    • Antonescu CR, Besmer P, Guo T, et al. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res 2005;11:4182-4190
    • (2005) Clin Cancer Res , vol.11 , pp. 4182-4190
    • Antonescu, C.R.1    Besmer, P.2    Guo, T.3
  • 47
    • 0032523833 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
    • Bastian BC, LeBoit PE, Hamm H, et al. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 1998;58:2170-2175
    • (1998) Cancer Res , vol.58 , pp. 2170-2175
    • Bastian, B.C.1    Leboit, P.E.2    Hamm, H.3
  • 48
    • 48649085443 scopus 로고    scopus 로고
    • Identification of a novel subgroup of melanomas with KIT/ cyclin-dependent kinase-4 overexpression
    • Smalley KS, Contractor R, Nguyen TK, et al. Identification of a novel subgroup of melanomas with KIT/ cyclin-dependent kinase-4 overexpression. Cancer Res 2008;68:5743-5752
    • (2008) Cancer Res , vol.68 , pp. 5743-5752
    • Smalley, K.S.1    Contractor, R.2    Nguyen, T.K.3
  • 49
    • 3843116637 scopus 로고    scopus 로고
    • Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis
    • Lefevre G, Glotin AL, Calipel A, et al. Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis. J Biol Chem 2004; 279:31769-31779
    • (2004) J Biol Chem , vol.279 , pp. 31769-31779
    • Lefevre, G.1    Glotin, A.L.2    Calipel, A.3
  • 50
    • 58849127864 scopus 로고    scopus 로고
    • Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate
    • Hofmann UB, Kauczok-Vetter CS, Houben R, et al. Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate. Clin Cancer Res 2009;15:324-329
    • (2009) Clin Cancer Res , vol.15 , pp. 324-329
    • Hofmann, U.B.1    Kauczok-Vetter, C.S.2    Houben, R.3
  • 51
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V, et al. Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 2006;106:2005-2011
    • (2006) Cancer , vol.106 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3
  • 52
    • 21044460131 scopus 로고    scopus 로고
    • Lack of clinical efficacy of imatinib in metastatic melanoma
    • Ugurel S, Hildenbrand R, Zimpfer A, et al. Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer 2005;92:1398-1405
    • (2005) Br J Cancer , vol.92 , pp. 1398-1405
    • Ugurel, S.1    Hildenbrand, R.2    Zimpfer, A.3
  • 53
    • 33645405597 scopus 로고    scopus 로고
    • Analysis of protein tyrosine kinases expression in the melanoma metas-tases of patients treated with Imatinib Mesylate (STI571, Gleevec)
    • Ivan D, Niveiro M, Diwan AH, et al. Analysis of protein tyrosine kinases expression in the melanoma metas-tases of patients treated with Imatinib Mesylate (STI571, Gleevec). J Cutan Pathol 2006;33:280-285
    • (2006) J Cutan Pathol , vol.33 , pp. 280-285
    • Ivan, D.1    Niveiro, M.2    Diwan, A.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.