Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors

Journal of Biological Chemistry

Volumn 278, Issue 17, 2003, Pages 15435-15440

  Blencke, Stephanie ^a   Ullrich, Axel ^b   Daub, Henrik ^a  

^a Axxima Pharmaceuticals AG   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; GROWTH KINETICS;

CELL MUTATION;

ENZYMES;

BCR ABL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; IMATINIB; ISOLEUCINE; METHIONINE; PROTEIN TYROSINE KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; THREONINE;

ADVANCED CANCER; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CANCER THERAPY; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG SELECTIVITY; GENE MUTATION; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; MAP KINASE SIGNALING SYSTEM; PIPERAZINES; POINT MUTATION; PROTEIN-TYROSINE KINASES; PYRIMIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; THREONINE; TRANSFECTION;

ANIMALIA;

EID: 0037674323     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211158200     Document Type: Article

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