Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

Biochemical Journal

Volumn 436, Issue 2, 2011, Pages 241-251

  Shih, Andrew J ^a   Telesco, Shannon E ^a   Choi, Sung Hee ^b   Lemmon, Mark A ^b   Radhakrishnan, Ravi ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Epidermal growth factor receptor (EGFR); Homology modelling; Kinase activation; Molecular dynamics; Principal component analysis (PCA)

Indexed keywords

DIMER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; HEMATOPOIETIC CELL KINASE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

CONSERVED SEQUENCE; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79953726111     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101791     Document Type: Article

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