Predicting resistance mutations using protein design algorithms

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 31, 2010, Pages 13707-13712

  Frey, Kathleen M ^a   Georgiev, Ivelin ^b,d   Donald, Bruce R ^b,c   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b Duke University   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

DHFR; K* design algorithm; MRSA; Negative design algorithm

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; GENE MUTATION; GENETIC ALGORITHM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; ALGORITHM; ANTIBIOTIC RESISTANCE; BIOCATALYSIS; BIOMETRY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ALGORITHMS; BIOCATALYSIS; BIOMETRY; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 77956377719     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002162107     Document Type: Article

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