메뉴 건너뛰기




Volumn 12, Issue 3, 2011, Pages 1533-1562

Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia

Author keywords

Administration methods; Animal experiments; Cerebral ischemia; Estrogen; Stroke

Indexed keywords

ESTRADIOL; ESTROGEN; GROWTH FACTOR; NEUROPROTECTIVE AGENT;

EID: 79953323706     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12031533     Document Type: Review
Times cited : (61)

References (219)
  • 1
    • 0026099937 scopus 로고
    • Sex differences in postischemic neuronal necrosis in gerbils
    • Hall, E.D.; Pazara, K.E.; Linseman, K.L. Sex differences in postischemic neuronal necrosis in gerbils. J. Cereb. Blood Flow Metab. 1991, 11, 292-298.
    • (1991) J. Cereb. Blood Flow Metab , vol.11 , pp. 292-298
    • Hall, E.D.1    Pazara, K.E.2    Linseman, K.L.3
  • 2
    • 0030700217 scopus 로고    scopus 로고
    • Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat
    • Simpkins, J.W.; Rajakumar, G.; Zhang, Y.Q.; Simpkins, C.E.; Greenwald, D.; Yu, C.J.; Bodor, N.; Day, A.L. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J. Neurosurg. 1997, 87, 724-730.
    • (1997) J. Neurosurg , vol.87 , pp. 724-730
    • Simpkins, J.W.1    Rajakumar, G.2    Zhang, Y.Q.3    Simpkins, C.E.4    Greenwald, D.5    Yu, C.J.6    Bodor, N.7    Day, A.L.8
  • 4
    • 73949132798 scopus 로고    scopus 로고
    • The risk of stroke in postmenopausal women receiving hormonal therapy
    • Lobo, R.A. The risk of stroke in postmenopausal women receiving hormonal therapy. Climacteric 2009, 12 (Suppl 1), 81-85.
    • (2009) Climacteric , vol.12 , Issue.1 , pp. 81-85
    • Lobo, R.A.1
  • 6
    • 0035805173 scopus 로고    scopus 로고
    • Deleterious effect of beta-estradiol in a rat model of transient forebrain ischemia
    • Harukuni, I.; Hurn, P.D.; Crain, B.J. Deleterious effect of beta-estradiol in a rat model of transient forebrain ischemia. Brain Res. 2001, 900, 137-142.
    • (2001) Brain Res , vol.900 , pp. 137-142
    • Harukuni, I.1    Hurn, P.D.2    Crain, B.J.3
  • 7
    • 24044548988 scopus 로고    scopus 로고
    • 17beta-estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats
    • Yong, Y.; Xie, H.J.; Zhang, Y.F.; Yang, Q.D.; Liao, D.F.; Yang, H.L.; Yan, P.K.; Liu, Z.J. 17beta-estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats. Brain Res. 2005, 1054, 192-199.
    • (2005) Brain Res , vol.1054 , pp. 192-199
    • Yong, Y.1    Xie, H.J.2    Zhang, Y.F.3    Yang, Q.D.4    Liao, D.F.5    Yang, H.L.6    Yan, P.K.7    Liu, Z.J.8
  • 8
    • 27744529107 scopus 로고    scopus 로고
    • Estradiol Increases Brain Lesions in the Cortex and Lateral Striatum After Transient Occlusion of the Middle Cerebral Artery In Rats: No Effect of Ischemia On Galanin In the Stroke Area But Decreased Levels In the Hippocampus
    • Theodorsson, A.; Theodorsson, E.Estradiol increases brain lesions in the cortex and lateral striatum after transient occlusion of the middle cerebral artery in rats: No effect of ischemia on galanin in the stroke area but decreased levels in the hippocampus. Peptides 2005, 26, 2257-2264.
    • (2005) Peptides , vol.26 , pp. 2257-2264
    • Theodorsson, A.1    Theodorsson, E.2
  • 9
    • 13844267505 scopus 로고    scopus 로고
    • Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation
    • Gordon, K.B.; Macrae, I.M.; Carswell, H.V. Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation. Brain Res. 2005, 1036, 155-162.
    • (2005) Brain Res , vol.1036 , pp. 155-162
    • Gordon, K.B.1    Macrae, I.M.2    Carswell, H.V.3
  • 11
    • 14644435096 scopus 로고    scopus 로고
    • Detrimental effects of 17beta-oestradiol after permanent middle cerebral artery occlusion
    • Bingham, D.; Macrae, I.M.; Carswell, H.V. Detrimental effects of 17beta-oestradiol after permanent middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 2005, 25, 414-420.
    • (2005) J. Cereb. Blood Flow Metab , vol.25 , pp. 414-420
    • Bingham, D.1    Macrae, I.M.2    Carswell, H.V.3
  • 13
    • 67649657689 scopus 로고    scopus 로고
    • Estradiol is A Potent Protective, Restorative, and Trophic Factor After Brain Injury
    • Brown, C.M.; Suzuki, S.; Jelks, K.A.; Wise, P.M.Estradiol is a potent protective, restorative, and trophic factor after brain injury. Semin. Reprod. Med. 2009, 27, 240-249.
    • (2009) Semin. Reprod. Med , vol.27 , pp. 240-249
    • Brown, C.M.1    Suzuki, S.2    Jelks, K.A.3    Wise, P.M.4
  • 14
    • 67349251253 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens following ischemic stroke
    • Suzuki, S.; Brown, C.M.; Wise, P.M. Neuroprotective effects of estrogens following ischemic stroke. Front. Neuroendocrinol. 2009, 30, 201-211.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 201-211
    • Suzuki, S.1    Brown, C.M.2    Wise, P.M.3
  • 15
    • 68249086298 scopus 로고    scopus 로고
    • Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: A systematic analysis
    • Strom, J.O.; Theodorsson, A.; Theodorsson, E. Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: A systematic analysis. J. Cereb. Blood Flow Metab. 2009, 29, 1359-1372.
    • (2009) J. Cereb. Blood Flow Metab , vol.29 , pp. 1359-1372
    • Strom, J.O.1    Theodorsson, A.2    Theodorsson, E.3
  • 16
    • 77951178010 scopus 로고    scopus 로고
    • Different methods for administering 17beta-estradiol to ovariectomized rats result in opposite effects on ischemic brain damage
    • Strom, J.O.; Theodorsson, E.; Holm, L.; Theodorsson, A. Different methods for administering 17beta-estradiol to ovariectomized rats result in opposite effects on ischemic brain damage. BMC Neurosci. 2010, 11, 39.
    • (2010) BMC Neurosci , vol.11 , pp. 39
    • Strom, J.O.1    Theodorsson, E.2    Holm, L.3    Theodorsson, A.4
  • 17
    • 57349170348 scopus 로고    scopus 로고
    • Order of magnitude differences between methods for maintaining physiological 17beta-oestradiol concentrations in ovariectomized rats
    • Strom, J.O.; Theodorsson, E.; Theodorsson, A. Order of magnitude differences between methods for maintaining physiological 17beta-oestradiol concentrations in ovariectomized rats. Scand. J. Clin. Lab. Invest. 2008, 68, 814-822.
    • (2008) ScandJ. Clin. Lab. Invest , vol.68 , pp. 814-822
    • Strom, J.O.1    Theodorsson, E.2    Theodorsson, A.3
  • 19
    • 34447116951 scopus 로고    scopus 로고
    • Role of Signal Transducer and Activator of Transcription-3 In Estradiol-mediated Neuroprotection
    • Dziennis, S.; Jia, T.; Ronnekleiv, O.K.; Hurn, P.D.; Alkayed, N.J. Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection. J. Neurosci. 2007, 27, 7268-7274.
    • (2007) J. Neurosci , vol.27 , pp. 7268-7274
    • Dziennis, S.1    Jia, T.2    Ronnekleiv, O.K.3    Hurn, P.D.4    Alkayed, N.J.5
  • 20
    • 21044445491 scopus 로고    scopus 로고
    • High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats
    • Schreihofer, D.A.; Do, K.D.; Schreihofer, A.M. High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 289, R103-108.
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.289
    • Schreihofer, D.A.1    Do, K.D.2    Schreihofer, A.M.3
  • 21
    • 0348109349 scopus 로고    scopus 로고
    • Estradiol attenuates programmed cell death after stroke-like injury
    • Rau, S.W.; Dubal, D.B.; Bottner, M.; Gerhold, L.M.; Wise, P.M. Estradiol attenuates programmed cell death after stroke-like injury. J. Neurosci. 2003, 23, 11420-11426.
    • (2003) J. Neurosci , vol.23 , pp. 11420-11426
    • Rau, S.W.1    Dubal, D.B.2    Bottner, M.3    Gerhold, L.M.4    Wise, P.M.5
  • 22
    • 0037081302 scopus 로고    scopus 로고
    • Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: Perfusion-dependent and-independent mechanisms
    • He, Z.; He, Y.J.; Day, A.L.; Simpkins, J.W. Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: Perfusion-dependent and-independent mechanisms. J. Neurol. Sci. 2002, 193, 79-87.
    • (2002) J. Neurol. Sci , vol.193 , pp. 79-87
    • He, Z.1    He, Y.J.2    Day, A.L.3    Simpkins, J.W.4
  • 23
    • 33847677305 scopus 로고    scopus 로고
    • Acute pretreatment with estradiol protects against CA1 cell loss and spatial learning impairments resulting from transient global ischemia
    • Sandstrom, N.J.; Rowan, M.H.Acute pretreatment with estradiol protects against CA1 cell loss and spatial learning impairments resulting from transient global ischemia. Horm. Behav. 2007, 51, 335-345.
    • (2007) Horm. Behav , vol.51 , pp. 335-345
    • Sandstrom, N.J.1    Rowan, M.H.2
  • 24
    • 0032487513 scopus 로고    scopus 로고
    • Cerebral vasodilating capacity during forebrain ischemia: Effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase
    • Pelligrino, D.A.; Santizo, R.; Baughman, V.L.; Wang, Q. Cerebral vasodilating capacity during forebrain ischemia: Effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport 1998, 9, 3285-3291.
    • (1998) Neuroreport , vol.9 , pp. 3285-3291
    • Pelligrino, D.A.1    Santizo, R.2    Baughman, V.L.3    Wang, Q.4
  • 25
    • 3242669822 scopus 로고    scopus 로고
    • Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion
    • Saleh, T.M.; Connell, B.J.; Legge, C.; Cribb, A.E. Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion. Brain Res. 2004, 1018, 119-129.
    • (2004) Brain Res , vol.1018 , pp. 119-129
    • Saleh, T.M.1    Connell, B.J.2    Legge, C.3    Cribb, A.E.4
  • 26
    • 33747320467 scopus 로고    scopus 로고
    • Chronic 17beta-estradiol pretreatment and ischemia-induced hippocampal degeneration and memory impairments
    • Plamondon, H.; Morin, A.; Charron, C. Chronic 17beta-estradiol pretreatment and ischemia-induced hippocampal degeneration and memory impairments: A 6-month survival study. Horm. Behav. 2006, 50, 361-369.
    • (2006) A 6-month Survival Study. Horm. Behav , vol.50 , pp. 361-369
    • Plamondon, H.1    Morin, A.2    Charron, C.3
  • 27
    • 7944227783 scopus 로고    scopus 로고
    • 17Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
    • Choi, Y.C.; Lee, J.H.; Hong, K.W.; Lee, K.S. 17Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats. Fundam. Clin. Pharmacol. 2004, 18, 547-557.
    • (2004) Fundam Clin. Pharmacol , vol.18 , pp. 547-557
    • Choi, Y.C.1    Lee, J.H.2    Hong, K.W.3    Lee, K.S.4
  • 28
    • 33846660439 scopus 로고    scopus 로고
    • Involvement of purα gene in neuroprotection effects of estrogen in rat ischemic brain model
    • Yu, S.J.; Kim, J.R.; Lee, C.K.; Kim, J.H.; Kam, K.Y.; Hong, J.H.; Kang, S.G. Involvement of purα gene in neuroprotection effects of estrogen in rat ischemic brain model. Korean J. Genet. 2006, 28, 403-412.
    • (2006) KoreanJ. Genet , vol.28 , pp. 403-412
    • Yu, S.J.1    Kim, J.R.2    Lee, C.K.3    Kim, J.H.4    Kam, K.Y.5    Hong, J.H.6    Kang, S.G.7
  • 29
    • 31444449417 scopus 로고    scopus 로고
    • Acute and chronic estradiol treatments reduce memory deficits induced by transient global ischemia in female rats
    • Gulinello, M.; Lebesgue, D.; Jover-Mengual, T.; Zukin, R.S.; Etgen, A.M. Acute and chronic estradiol treatments reduce memory deficits induced by transient global ischemia in female rats. Horm. Behav. 2006, 49, 246-260.
    • (2006) Horm. Behav , vol.49 , pp. 246-260
    • Gulinello, M.1    Lebesgue, D.2    Jover-Mengual, T.3    Zukin, R.S.4    Etgen, A.M.5
  • 30
    • 11244353244 scopus 로고    scopus 로고
    • Acute effects of 17beta-estradiol on oxidative stress in ischemic rat striatum
    • Kii, N.; Adachi, N.; Liu, K.; Arai, T. Acute effects of 17beta-estradiol on oxidative stress in ischemic rat striatum. J. Neurosurg. Anesthesiol. 2005, 17, 27-32.
    • (2005) J. Neurosurg. Anesthesiol , vol.17 , pp. 27-32
    • Kii, N.1    Adachi, N.2    Liu, K.3    Arai, T.4
  • 31
    • 17044361906 scopus 로고    scopus 로고
    • Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat
    • Littleton-Kearney, M.T.; Klaus, J.A.; Hurn, P.D.Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat. J. Cereb. Blood Flow Metab. 2005, 25, 421-426.
    • (2005) J. Cereb. Blood Flow Metab , vol.25 , pp. 421-426
    • Littleton-Kearney, M.T.1    Klaus, J.A.2    Hurn, P.D.3
  • 32
    • 57349095598 scopus 로고    scopus 로고
    • Substantial discrepancies in 17beta-oestradiol concentrations obtained with three different commercial direct radioimmunoassay kits in rat sera
    • Strom, J.O.; Theodorsson, A.; Theodorsson, E. Substantial discrepancies in 17beta-oestradiol concentrations obtained with three different commercial direct radioimmunoassay kits in rat sera. Scand. J. Clin. Lab. Invest. 2008, 68, 806-813.
    • (2008) Scand. J. Clin. Lab. Invest , vol.68 , pp. 806-813
    • Strom, J.O.1    Theodorsson, A.2    Theodorsson, E.3
  • 34
    • 67349108331 scopus 로고    scopus 로고
    • Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens
    • Simpkins, J.W.; Yi, K.D.; Yang, S.H. Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens. Front. Neuroendocrinol. 2009, 30, 93-105.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 93-105
    • Simpkins, J.W.1    Yi, K.D.2    Yang, S.H.3
  • 35
    • 0030570392 scopus 로고    scopus 로고
    • Estrogen protects primary cortical neurons from glutamate toxicity
    • Singer, C.A.; Rogers, K.L.; Strickland, T.M.; Dorsa, D.M. Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci. Lett. 1996, 212, 13-16.
    • (1996) Neurosci Lett , vol.212 , pp. 13-16
    • Singer, C.A.1    Rogers, K.L.2    Strickland, T.M.3    Dorsa, D.M.4
  • 36
    • 0031552508 scopus 로고    scopus 로고
    • 17Beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors
    • Weaver, C.E., Jr; Park-Chung, M.; Gibbs, T.T.; Farb, D.H. 17Beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res. 1997, 761, 338-341.
    • (1997) Brain Res , vol.761 , pp. 338-341
    • Weaver Jr., C.E.1    Park-Chung, M.2    Gibbs, T.T.3    Farb, D.H.4
  • 38
    • 34248639877 scopus 로고    scopus 로고
    • Oestrogen and stroke: The potential for harm as well as benefit
    • Macrae, I.M.; Carswell, H.V. Oestrogen and stroke: The potential for harm as well as benefit. Biochem. Soc. Trans. 2006, 34, 1362-1365.
    • (2006) Biochem. Soc. Trans , vol.34 , pp. 1362-1365
    • Macrae, I.M.1    Carswell, H.V.2
  • 39
    • 34347323926 scopus 로고    scopus 로고
    • Cerebrovascular effects of oestrogen: Multiplicity of action
    • Duckles, S.P.; Krause, D.N. Cerebrovascular effects of oestrogen: Multiplicity of action. Clin. Exp. Pharmacol. Physiol. 2007, 34, 801-808.
    • (2007) Clin. Exp. Pharmacol. Physiol , vol.34 , pp. 801-808
    • Duckles, S.P.1    Krause, D.N.2
  • 40
    • 38049064386 scopus 로고    scopus 로고
    • More than a decade of estrogen neuroprotection
    • Simpkins, J.W.; Singh, M. More than a decade of estrogen neuroprotection. Alzheimers Dement. 2008, 4, S131-136.
    • (2008) Alzheimers Dement , vol.4
    • Simpkins, J.W.1    Singh, M.2
  • 41
    • 63649135792 scopus 로고    scopus 로고
    • Estradiol rescues neurons from global ischemia-induced cell death Multiple Cellular Pathways of Neuroprotection
    • Lebesgue, D.; Chevaleyre, V.; Zukin, R.S.; Etgen, A.M. Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection. Steroids 2009, 74, 555-561.
    • (2009) Steroids , vol.74 , pp. 555-561
    • Lebesgue, D.1    Chevaleyre, V.2    Zukin, R.S.3    Etgen, A.M.4
  • 42
    • 67449116583 scopus 로고    scopus 로고
    • Neuroprotection by estrogen in the brain: The mitochondrial compartment as presumed therapeutic target
    • Arnold, S.; Beyer, C. Neuroprotection by estrogen in the brain: The mitochondrial compartment as presumed therapeutic target. J. Neurochem. 2009, 110, 1-11.
    • (2009) J. Neurochem , vol.110 , pp. 1-11
    • Arnold, S.1    Beyer, C.2
  • 43
    • 70350304150 scopus 로고    scopus 로고
    • Estrogen therapy:Is time of initiation critical for neuroprotection?
    • Sherwin, B.B. Estrogen therapy: Is time of initiation critical for neuroprotection? Nat. Rev. Endocrinol. 2009, 5, 620-627.
    • (2009) Nat. Rev. Endocrinol , vol.5 , pp. 620-627
    • Sherwin, B.B.1
  • 44
    • 15544377792 scopus 로고    scopus 로고
    • Neuroprotective effect of an antioxidant in ischemic brain injury Involvement of Neuronal Apoptosis
    • Fujimura, M.; Tominaga, T.; Chan, P.H. Neuroprotective effect of an antioxidant in ischemic brain injury: Involvement of neuronal apoptosis. Neurocrit. Care 2005, 2, 59-66.
    • (2005) Neurocrit. Care , vol.2 , pp. 59-66
    • Fujimura, M.1    Tominaga, T.2    Chan, P.H.3
  • 46
    • 0033497678 scopus 로고    scopus 로고
    • Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor-independent antioxidative mechanism
    • Culmsee, C.; Vedder, H.; Ravati, A.; Junker, V.; Otto, D.; Ahlemeyer, B.; Krieg, J.C.; Krieglstein, J.Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor-independent antioxidative mechanism. J. Cereb. Blood Flow Metab. 1999, 19, 1263-1269.
    • (1999) J. Cereb. Blood Flow Metab , vol.19 , pp. 1263-1269
    • Culmsee, C.1    Vedder, H.2    Ravati, A.3    Junker, V.4    Otto, D.5    Ahlemeyer, B.6    Krieg, J.C.7    Krieglstein, J.8
  • 47
    • 0033016186 scopus 로고    scopus 로고
    • Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system
    • Vedder, H.; Anthes, N.; Stumm, G.; Wurz, C.; Behl, C.; Krieg, J.C. Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system. J. Neurochem. 1999, 72, 2531-2538.
    • (1999) J. Neurochem , vol.72 , pp. 2531-2538
    • Vedder, H.1    Anthes, N.2    Stumm, G.3    Wurz, C.4    Behl, C.5    Krieg, J.C.6
  • 48
    • 33746733513 scopus 로고    scopus 로고
    • Mechanisms involved in the protective effect of estradiol-17beta on lipid peroxidation and DNA damage
    • Ayres, S.; Abplanalp, W.; Liu, J.H.; Subbiah, M.T.Mechanisms involved in the protective effect of estradiol-17beta on lipid peroxidation and DNA damage. Am. J. Physiol. 1998, 274, E1002-1008.
    • (1998) Am. J. Physiol , vol.274
    • Ayres, S.1    Abplanalp, W.2    Liu, J.H.3    Subbiah, M.T.4
  • 49
    • 77955550149 scopus 로고    scopus 로고
    • Unchern, S. Comparable attenuation of Abeta(25-35)-induced neurotoxicity by quercitrin and 17beta-estradiol in cultured rat hippocampal neurons
    • Rattanajarasroj, S.; Unchern, S. Comparable attenuation of Abeta(25-35)-induced neurotoxicity by quercitrin and 17beta-estradiol in cultured rat hippocampal neurons. Neurochem. Res. 2010, 35, 1196-1205.
    • (2010) Neurochem. Res , vol.35 , pp. 1196-1205
    • Rattanajarasroj, S.1    Unchern, S.2
  • 50
    • 33745230048 scopus 로고    scopus 로고
    • Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    • Wang, X.; Dykens, J.A.; Perez, E.; Liu, R.; Yang, S.; Covey, D.F.; Simpkins, J.W. Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Mol. Pharmacol. 2006, 70, 395-404.
    • (2006) Mol. Pharmacol , vol.70 , pp. 395-404
    • Wang, X.1    Dykens, J.A.2    Perez, E.3    Liu, R.4    Yang, S.5    Covey, D.F.6    Simpkins, J.W.7
  • 51
    • 0030608841 scopus 로고    scopus 로고
    • 17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron
    • Keller, J.N.; Germeyer, A.; Begley, J.G.; Mattson, M.P. 17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron. J. Neurosci. Res. 1997, 50, 522-530.
    • (1997) J. Neurosci. Res , vol.50 , pp. 522-530
    • Keller, J.N.1    Germeyer, A.2    Begley, J.G.3    Mattson, M.P.4
  • 52
    • 33947694215 scopus 로고    scopus 로고
    • Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds
    • Prokai, L.; Simpkins, J.W. Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds. Pharmacol. Ther. 2007, 114, 1-12.
    • (2007) Pharmacol. Ther , vol.114 , pp. 1-12
    • Prokai, L.1    Simpkins, J.W.2
  • 53
    • 0028971169 scopus 로고
    • 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro
    • Behl, C.; Widmann, M.; Trapp, T.; Holsboer, F. 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem. Biophys. Res. Commun. 1995, 216, 473-482.
    • (1995) Biochem. Biophys. Res. Commun , vol.216 , pp. 473-482
    • Behl, C.1    Widmann, M.2    Trapp, T.3    Holsboer, F.4
  • 54
    • 0344492699 scopus 로고    scopus 로고
    • Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase-amyloid complexes
    • Bonnefont, A.B.; Munoz, F.J.; Inestrosa, N.C. Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase-amyloid complexes. FEBS Lett. 1998, 441, 220-224.
    • (1998) FEBS Lett , vol.441 , pp. 220-224
    • Bonnefont, A.B.1    Munoz, F.J.2    Inestrosa, N.C.3
  • 56
    • 38649109472 scopus 로고    scopus 로고
    • Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative
    • Prokai-Tatrai, K.; Perjesi, P.; Rivera-Portalatin, N.M.; Simpkins, J.W.; Prokai, L. Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative. Steroids 2008, 73, 280-288.
    • (2008) Steroids , vol.73 , pp. 280-288
    • Prokai-Tatrai, K.1    Perjesi, P.2    Rivera-Portalatin, N.M.3    Simpkins, J.W.4    Prokai, L.5
  • 57
    • 0141884323 scopus 로고    scopus 로고
    • Neuroprotective and neurotoxic effects of estrogens
    • Picazo, O.; Azcoitia, I.; Garcia-Segura, L.M. Neuroprotective and neurotoxic effects of estrogens. Brain Res. 2003, 990, 20-27.
    • (2003) Brain Res , vol.990 , pp. 20-27
    • Picazo, O.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 58
    • 34548294147 scopus 로고    scopus 로고
    • Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model
    • Chen, C.; Hu, Q.; Yan, J.; Lei, J.; Qin, L.; Shi, X.; Luan, L.; Yang, L.; Wang, K.; Han, J.; Nanda, A.; Zhou, C. Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. J. Neurochem. 2007, 102, 1831-1841.
    • (2007) J. Neurochem , vol.102 , pp. 1831-1841
    • Chen, C.1    Hu, Q.2    Yan, J.3    Lei, J.4    Qin, L.5    Shi, X.6    Luan, L.7    Yang, L.8    Wang, K.9    Han, J.10    Nanda, A.11    Zhou, C.12
  • 60
    • 34347335719 scopus 로고    scopus 로고
    • Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in excitotoxicity
    • Diwakar, L.; Kenchappa, R.S.; Annepu, J.; Ravindranath, V. Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in excitotoxicity. Neurochem. Int. 2007, 51, 37-46.
    • (2007) Neurochem. Int , vol.51 , pp. 37-46
    • Diwakar, L.1    Kenchappa, R.S.2    Annepu, J.3    Ravindranath, V.4
  • 61
    • 0037083198 scopus 로고    scopus 로고
    • Differential effects of glucocorticoids and gonadal steroids on glutathione levels in neuronal and glial cell systems
    • Schmidt, A.J.; Krieg, J.C.; Vedder, H. Differential effects of glucocorticoids and gonadal steroids on glutathione levels in neuronal and glial cell systems. J. Neurosci. Res. 2002, 67, 544-550.
    • (2002) J. Neurosci. Res , vol.67 , pp. 544-550
    • Schmidt, A.J.1    Krieg, J.C.2    Vedder, H.3
  • 62
    • 33845188132 scopus 로고    scopus 로고
    • Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS
    • Diwakar, L.; Kenchappa, R.S.; Annepu, J.; Saeed, U.; Sujanitha, R.; Ravindranath, V. Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS. Brain Res. 2006, 1125, 176-184.
    • (2006) Brain Res , vol.1125 , pp. 176-184
    • Diwakar, L.1    Kenchappa, R.S.2    Annepu, J.3    Saeed, U.4    Sujanitha, R.5    Ravindranath, V.6
  • 63
    • 33744955627 scopus 로고    scopus 로고
    • 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells
    • Urata, Y.; Ihara, Y.; Murata, H.; Goto, S.; Koji, T.; Yodoi, J.; Inoue, S.; Kondo, T. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J. Biol. Chem. 2006, 281, 13092-13102.
    • (2006) J. Biol. Chem , vol.281 , pp. 13092-13102
    • Urata, Y.1    Ihara, Y.2    Murata, H.3    Goto, S.4    Koji, T.5    Yodoi, J.6    Inoue, S.7    Kondo, T.8
  • 64
    • 77449136751 scopus 로고    scopus 로고
    • The effects of 17beta estradiol, 17alpha estradiol and progesterone on oxidative stress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia
    • Ozacmak, V.H.; Sayan, H. The effects of 17beta estradiol, 17alpha estradiol and progesterone on oxidative stress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia. Physiol. Res. 2009, 58, 909-912.
    • (2009) Physiol. Res , vol.58 , pp. 909-912
    • Ozacmak, V.H.1    Sayan, H.2
  • 65
    • 44149113049 scopus 로고    scopus 로고
    • Mitochondrial superoxide dismutase activation with 17 beta-estradiol-treated human lens epithelial cells
    • Gottipati, S.; Cammarata, P.R. Mitochondrial superoxide dismutase activation with 17 beta-estradiol-treated human lens epithelial cells. Mol. Vis. 2008, 14, 898-905.
    • (2008) Mol. Vis , vol.14 , pp. 898-905
    • Gottipati, S.1    Cammarata, P.R.2
  • 66
    • 33744514462 scopus 로고    scopus 로고
    • Functional estrogen receptors in the mitochondria of breast cancer cells
    • Pedram, A.; Razandi, M.; Wallace, D.C.; Levin, E.R. Functional estrogen receptors in the mitochondria of breast cancer cells. Mol. Biol. Cell 2006, 17, 2125-2137.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2125-2137
    • Pedram, A.1    Razandi, M.2    Wallace, D.C.3    Levin, E.R.4
  • 67
    • 34547590252 scopus 로고    scopus 로고
    • 17Beta-estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult
    • Tripanichkul, W.; Sripanichkulchai, K.; Duce, J.A.; Finkelstein, D.I. 17Beta-estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult. Brain Res. 2007, 1164, 24-31.
    • (2007) Brain Res , vol.1164 , pp. 24-31
    • Tripanichkul, W.1    Sripanichkulchai, K.2    Duce, J.A.3    Finkelstein, D.I.4
  • 69
    • 38449089795 scopus 로고    scopus 로고
    • Estradiol in vivo regulation of brain mitochondrial proteome
    • Nilsen, J.; Irwin, R.W.; Gallaher, T.K.; Brinton, R.D. Estradiol in vivo regulation of brain mitochondrial proteome. J. Neurosci. 2007, 27, 14069-14077.
    • (2007) J. Neurosci , vol.27 , pp. 14069-14077
    • Nilsen, J.1    Irwin, R.W.2    Gallaher, T.K.3    Brinton, R.D.4
  • 70
    • 44249087833 scopus 로고    scopus 로고
    • Progesterone and estrogen regulate oxidative metabolism in brain mitochondria
    • Irwin, R.W.; Yao, J.; Hamilton, R.T.; Cadenas, E.; Brinton, R.D.; Nilsen, J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology 2008, 149, 3167-3175.
    • (2008) Endocrinology , vol.149 , pp. 3167-3175
    • Irwin, R.W.1    Yao, J.2    Hamilton, R.T.3    Cadenas, E.4    Brinton, R.D.5    Nilsen, J.6
  • 71
    • 34347341696 scopus 로고    scopus 로고
    • Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: Role of estrogen
    • Miller, A.A.; Drummond, G.R.; Mast, A.E.; Schmidt, H.H.; Sobey, C.G. Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: Role of estrogen. Stroke 2007, 38, 2142-2149.
    • (2007) Stroke , vol.38 , pp. 2142-2149
    • Miller, A.A.1    Drummond, G.R.2    Mast, A.E.3    Schmidt, H.H.4    Sobey, C.G.5
  • 72
    • 70449397081 scopus 로고    scopus 로고
    • Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
    • Zhang, Q.G.; Raz, L.; Wang, R.; Han, D.; De Sevilla, L.; Yang, F.; Vadlamudi, R.K.; Brann, D.W. Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. J. Neurosci. 2009, 29, 13823-13836.
    • (2009) J. Neurosci , vol.29 , pp. 13823-13836
    • Zhang, Q.G.1    Raz, L.2    Wang, R.3    Han, D.4    de Sevilla, L.5    Yang, F.6    Vadlamudi, R.K.7    Brann, D.W.8
  • 73
    • 77956180061 scopus 로고    scopus 로고
    • Role of estrogen receptors in pro-oxidative and anti-oxidative actions of estrogens: A perspective
    • Kumar, S.; Lata, K.; Mukhopadhyay, S.; Mukherjee, T.K. Role of estrogen receptors in pro-oxidative and anti-oxidative actions of estrogens: A perspective. Biochim. Biophys. Acta 2010, 1800, 1127-1135.
    • (2010) Biochim. Biophys. Acta , vol.1800 , pp. 1127-1135
    • Kumar, S.1    Lata, K.2    Mukhopadhyay, S.3    Mukherjee, T.K.4
  • 74
    • 74249102890 scopus 로고    scopus 로고
    • Estrogen down-regulates uncoupling proteins and increases oxidative stress in breast cancer
    • Sastre-Serra, J.; Valle, A.; Company, M.M.; Garau, I.; Oliver, J.; Roca, P. Estrogen down-regulates uncoupling proteins and increases oxidative stress in breast cancer. Free Radic. Biol. Med. 2010, 48, 506-512.
    • (2010) Free Radic. Biol. Med , vol.48 , pp. 506-512
    • Sastre-Serra, J.1    Valle, A.2    Company, M.M.3    Garau, I.4    Oliver, J.5    Roca, P.6
  • 75
    • 18244405569 scopus 로고    scopus 로고
    • Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers
    • Felty, Q.; Xiong, W.C.; Sun, D.; Sarkar, S.; Singh, K.P.; Parkash, J.; Roy, D. Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. Biochemistry 2005, 44, 6900-6909.
    • (2005) Biochemistry , vol.44 , pp. 6900-6909
    • Felty, Q.1    Xiong, W.C.2    Sun, D.3    Sarkar, S.4    Singh, K.P.5    Parkash, J.6    Roy, D.7
  • 76
    • 60349094009 scopus 로고    scopus 로고
    • Effects of 17beta-estradiol, and its metabolite, 4-hydroxyestradiol on fertilization, embryo development and oxidative DNA damage in sand dollar (Dendraster excentricus) sperm
    • Rempel, M.A.; Hester, B.; Deharo, H.; Hong, H.; Wang, Y.; Schlenk, D. Effects of 17beta-estradiol, and its metabolite, 4-hydroxyestradiol on fertilization, embryo development and oxidative DNA damage in sand dollar (Dendraster excentricus) sperm. Sci. Total Environ. 2009, 407, 2209-2215.
    • (2009) Sci. Total Environ , vol.407 , pp. 2209-2215
    • Rempel, M.A.1    Hester, B.2    Deharo, H.3    Hong, H.4    Wang, Y.5    Schlenk, D.6
  • 77
    • 49249085799 scopus 로고    scopus 로고
    • Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium
    • Symonds, D.A.; Merchenthaler, I.; Flaws, J.A. Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium. Toxicol. Sci. 2008, 105, 182-187.
    • (2008) Toxicol. Sci , vol.105 , pp. 182-187
    • Symonds, D.A.1    Merchenthaler, I.2    Flaws, J.A.3
  • 78
    • 0037258007 scopus 로고    scopus 로고
    • The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats
    • Pajovic, S.B.; Saicic, Z.S.; Spasic, M.B.; Petrovic, V.M. The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. Physiol. Res. 2003, 52, 189-194.
    • (2003) Physiol. Res , vol.52 , pp. 189-194
    • Pajovic, S.B.1    Saicic, Z.S.2    Spasic, M.B.3    Petrovic, V.M.4
  • 79
    • 0033314054 scopus 로고    scopus 로고
    • Acute effects of estradiol and of diethylstilbestrol: Pro- or antioxidant potential?
    • Genc S.; Gurdol, F.; Oner-Iyidogan, Y.; Suzme, R. Acute effects of estradiol and of diethylstilbestrol: Pro- or antioxidant potential? Res. Commun. Mol. Pathol. Pharmacol. 1999, 105, 253-261.
    • (1999) Res. Commun. Mol. Pathol. Pharmacol , vol.105 , pp. 253-261
    • Genc, S.1    Gurdol, F.2    Oner-Iyidogan, Y.3    Suzme, R.4
  • 80
    • 74149083977 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways
    • Ting, C.M.; Lee, Y.M.; Wong, C.K.; Wong, A.S.; Lung, H.L.; Lung, M.L.; Lo, K.W.; Wong, R.N.; Mak, N.K. 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways. Biochem. Pharmacol. 2010, 79, 825-841.
    • (2010) Biochem. Pharmacol , vol.79 , pp. 825-841
    • Ting, C.M.1    Lee, Y.M.2    Wong, C.K.3    Wong, A.S.4    Lung, H.L.5    Lung, M.L.6    Lo, K.W.7    Wong, R.N.8    Mak, N.K.9
  • 81
    • 65549104414 scopus 로고    scopus 로고
    • 4-hydroxyestradiol Induces Anchorage-independent Growth of Human Mammary Epithelial Cells Via Activation of IkappaB Kinase: Potential Role of Reactive Oxygen Species
    • Park, S.A.; Na, H.K.; Kim, E.H.; Cha, Y.N.; Surh, Y.J.4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species. Cancer Res. 2009, 69, 2416-2424.
    • (2009) Cancer Res , vol.69 , pp. 2416-2424
    • Park, S.A.1    Na, H.K.2    Kim, E.H.3    Cha, Y.N.4    Surh, Y.J.5
  • 82
    • 34347398891 scopus 로고    scopus 로고
    • Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol
    • She, M.R.; Li, J.G.; Guo, K.Y.; Lin, W.; Du, X.; Niu, X.Q. Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol. Acta Pharmacol. Sin. 2007, 28, 1037-1044.
    • (2007) Acta Pharmacol.Sin , vol.28 , pp. 1037-1044
    • She, M.R.1    Li, J.G.2    Guo, K.Y.3    Lin, W.4    Du, X.5    Niu, X.Q.6
  • 83
    • 77952513645 scopus 로고    scopus 로고
    • Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells
    • Jin, R.; Yang, G.; Li, G. Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells. J. Leukoc. Biol. 2010, 87, 779-789.
    • (2010) J. Leukoc. Biol , vol.87 , pp. 779-789
    • Jin, R.1    Yang, G.2    Li, G.3
  • 85
    • 0028958354 scopus 로고
    • Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats
    • discussion 681
    • Yamasaki, Y.; Matsuura, N.; Shozuhara, H.; Onodera, H.; Itoyama, Y.; Kogure, K. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 1995, 26, 676-680; discussion 681.
    • (1995) Stroke , vol.26 , pp. 676-680
    • Yamasaki, Y.1    Matsuura, N.2    Shozuhara, H.3    Onodera, H.4    Itoyama, Y.5    Kogure, K.6
  • 87
    • 0142153881 scopus 로고    scopus 로고
    • Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat
    • Mulcahy, N.J.; Ross, J.; Rothwell, N.J.; Loddick, S.A. Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br. J. Pharmacol. 2003, 140, 471-476.
    • (2003) Br. J. Pharmacol , vol.140 , pp. 471-476
    • Mulcahy, N.J.1    Ross, J.2    Rothwell, N.J.3    Loddick, S.A.4
  • 88
    • 0029865092 scopus 로고    scopus 로고
    • Peripheral administration of interleukin-1 receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat
    • Relton, J.K.; Martin, D.; Thompson, R.C.; Russell, D.A. Peripheral administration of interleukin-1 receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat. Exp. Neurol. 1996, 138, 206-213.
    • (1996) Exp.Neurol , vol.138 , pp. 206-213
    • Relton, J.K.1    Martin, D.2    Thompson, R.C.3    Russell, D.A.4
  • 89
    • 0031051349 scopus 로고    scopus 로고
    • Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction In Mice
    • Nawashiro, H.; Martin, D.; Hallenbeck, J.M.Inhibition of tumor necrosis factor and amelioration of brain infarction in mice. J. Cereb. Blood Flow Metab. 1997, 17, 229-232.
    • (1997) J. Cereb. Blood Flow Metab , vol.17 , pp. 229-232
    • Nawashiro, H.1    Martin, D.2    Hallenbeck, J.M.3
  • 91
    • 0029744418 scopus 로고    scopus 로고
    • Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat
    • Loddick, S.A.; Rothwell, N.J. Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J. Cereb. Blood Flow Metab. 1996, 16, 932-940.
    • (1996) J. Cereb. Blood Flow Metab , vol.16 , pp. 932-940
    • Loddick, S.A.1    Rothwell, N.J.2
  • 92
    • 0033816278 scopus 로고    scopus 로고
    • Effects of estrogen on leukocyte adhesion after transient forebrain ischemia
    • Santizo, R.A.; Anderson, S.; Ye, S.; Koenig, H.M.; Pelligrino, D.A. Effects of estrogen on leukocyte adhesion after transient forebrain ischemia. Stroke 2000, 31, 2231-2235.
    • (2000) Stroke , vol.31 , pp. 2231-2235
    • Santizo, R.A.1    Anderson, S.2    Ye, S.3    Koenig, H.M.4    Pelligrino, D.A.5
  • 93
    • 85047692733 scopus 로고    scopus 로고
    • Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors
    • Mori, M.; Tsukahara, F.; Yoshioka, T.; Irie, K.; Ohta, H. Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors. Life Sci. 2004, 75, 599-609.
    • (2004) Life Sci , vol.75 , pp. 599-609
    • Mori, M.1    Tsukahara, F.2    Yoshioka, T.3    Irie, K.4    Ohta, H.5
  • 94
    • 0033588352 scopus 로고    scopus 로고
    • Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo: Possible mechanisms for gender differences in atherosclerosis
    • Nathan, L.; Pervin, S.; Singh, R.; Rosenfeld, M.; Chaudhuri, G. Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo: Possible mechanisms for gender differences in atherosclerosis. Circ. Res. 1999, 85, 377-385.
    • (1999) Circ. Res , vol.85 , pp. 377-385
    • Nathan, L.1    Pervin, S.2    Singh, R.3    Rosenfeld, M.4    Chaudhuri, G.5
  • 95
    • 34347244941 scopus 로고    scopus 로고
    • Timing of Estrogen Therapy After Ovariectomy Dictates the Efficacy of Its Neuroprotective and Antiinflammatory Actions
    • Suzuki, S.; Brown, C.M.; Dela Cruz, C.D.; Yang, E.; Bridwell, D.A.; Wise, P.M.Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc. Natl. Acad. Sci. USA 2007, 104, 6013-6018.
    • (2007) Proc. Natl. Acad. Sci , vol.104 , pp. 6013-6018
    • Suzuki, S.1    Brown, C.M.2    Dela, C.C.D.3    Yang, E.4    Bridwell, D.A.5    Wise, P.M.6
  • 96
    • 34547291144 scopus 로고    scopus 로고
    • Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion
    • Chiappetta, O.; Gliozzi, M.; Siviglia, E.; Amantea, D.; Morrone, L.A.; Berliocchi, L.; Bagetta, G.; Corasaniti, M.T. Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion. Int. Rev. Neurobiol. 2007, 82, 357-372.
    • (2007) Int. Rev. Neurobiol , vol.82 , pp. 357-372
    • Chiappetta, O.1    Gliozzi, M.2    Siviglia, E.3    Amantea, D.4    Morrone, L.A.5    Berliocchi, L.6    Bagetta, G.7    Corasaniti, M.T.8
  • 97
    • 0042886042 scopus 로고    scopus 로고
    • Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals
    • Nordell, V.L.; Scarborough, M.M.; Buchanan, A.K.; Sohrabji, F. Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals. Neurobiol. Aging 2003, 24, 733-743.
    • (2003) Neurobiol. Aging , vol.24 , pp. 733-743
    • Nordell, V.L.1    Scarborough, M.M.2    Buchanan, A.K.3    Sohrabji, F.4
  • 98
    • 34548446441 scopus 로고    scopus 로고
    • Effects of estrogen against LPS-induced inflammation and toxicity in primary rat glial and neuronal cultures
    • Tenenbaum, M.; Azab, A.N.; Kaplanski, J. Effects of estrogen against LPS-induced inflammation and toxicity in primary rat glial and neuronal cultures. J. Endotoxin Res. 2007, 13, 158-166.
    • (2007) J. Endotoxin Res , vol.13 , pp. 158-166
    • Tenenbaum, M.1    Azab, A.N.2    Kaplanski, J.3
  • 100
    • 41949104261 scopus 로고    scopus 로고
    • Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    • Lewis, D.K.; Johnson, A.B.; Stohlgren, S.; Harms, A.; Sohrabji, F. Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats. J. Neuroimmunol. 2008, 195, 47-59.
    • (2008) J. Neuroimmunol , vol.195 , pp. 47-59
    • Lewis, D.K.1    Johnson, A.B.2    Stohlgren, S.3    Harms, A.4    Sohrabji, F.5
  • 101
    • 0030922247 scopus 로고    scopus 로고
    • Repression of interleukin-6 gene expression by 17beta-estradiol: Inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor
    • Ray, P.; Ghosh, S.K.; Zhang, D.H.; Ray, A. Repression of interleukin-6 gene expression by 17beta-estradiol: Inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. FEBS Lett. 1997, 409, 79-85.
    • (1997) FEBS Lett , vol.409 , pp. 79-85
    • Ray, P.1    Ghosh, S.K.2    Zhang, D.H.3    Ray, A.4
  • 102
    • 1942437403 scopus 로고    scopus 로고
    • Estrogen suppresses IL-1beta-mediated induction of COX-2 pathway in rat cerebral blood vessels
    • Ospina, J.A.; Brevig, H.N.; Krause, D.N.; Duckles, S.P. Estrogen suppresses IL-1beta-mediated induction of COX-2 pathway in rat cerebral blood vessels. Am. J. Physiol. Heart Circ. Physiol. 2004, 286, H2010-2019.
    • (2004) Am. J. Physiol. Heart Circ. Physiol , vol.286
    • Ospina, J.A.1    Brevig, H.N.2    Krause, D.N.3    Duckles, S.P.4
  • 104
    • 51749112880 scopus 로고    scopus 로고
    • Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases
    • Vegeto, E.; Benedusi, V.; Maggi, A. Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases. Front. Neuroendocrinol. 2008, 29, 507-519.
    • (2008) Front. Neuroendocrinol , vol.29 , pp. 507-519
    • Vegeto, E.1    Benedusi, V.2    Maggi, A.3
  • 106
    • 0032694582 scopus 로고    scopus 로고
    • Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD
    • Srivastava, S.; Weitzmann, M.N.; Cenci, S.; Ross, F.P.; Adler, S.; Pacifici, R. Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J. Clin. Invest. 1999, 104, 503-513.
    • (1999) J. Clin. Invest , vol.104 , pp. 503-513
    • Srivastava, S.1    Weitzmann, M.N.2    Cenci, S.3    Ross, F.P.4    Adler, S.5    Pacifici, R.6
  • 107
    • 67651241236 scopus 로고    scopus 로고
    • Inflammation and epithelial alterations in rat prostate: Impact of the androgen to oestrogen ratio
    • Yatkin, E.; Bernoulli, J.; Talvitie, E.M.; Santti, R. Inflammation and epithelial alterations in rat prostate: Impact of the androgen to oestrogen ratio. Int. J. Androl. 2009, 32, 399-410.
    • (2009) Int. J. Androl , vol.32 , pp. 399-410
    • Yatkin, E.1    Bernoulli, J.2    Talvitie, E.M.3    Santti, R.4
  • 108
    • 0034101631 scopus 로고    scopus 로고
    • Mediation of the immunomodulatory effect of beta-estradiol on inflammatory responses by inhibition of recruitment and activation of inflammatory cells and their gene expression of TNF-alpha and IFN-gamma
    • Salem, M.L.; Hossain, M.S.; Nomoto, K. Mediation of the immunomodulatory effect of beta-estradiol on inflammatory responses by inhibition of recruitment and activation of inflammatory cells and their gene expression of TNF-alpha and IFN-gamma. Int. Arch. Allergy Immunol. 2000, 121, 235-245.
    • (2000) Int. Arch. Allergy Immunol , vol.121 , pp. 235-245
    • Salem, M.L.1    Hossain, M.S.2    Nomoto, K.3
  • 109
    • 2442534125 scopus 로고    scopus 로고
    • Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    • Wen, Y.; Yang, S.; Liu, R.; Perez, E.; Yi, K.D.; Koulen, P.; Simpkins, J.W. Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia. Brain Res. 2004, 1008, 147-154.
    • (2004) Brain Res , vol.1008 , pp. 147-154
    • Wen, Y.1    Yang, S.2    Liu, R.3    Perez, E.4    Yi, K.D.5    Koulen, P.6    Simpkins, J.W.7
  • 110
    • 1642308662 scopus 로고    scopus 로고
    • Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice
    • Lei, D.L.; Long, J.M.; Hengemihle, J.; O'Neill, J.; Manaye, K.F.; Ingram, D.K.; Mouton, P.R. Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice. Neuroscience 2003, 121, 659-666.
    • (2003) Neuroscience , vol.121 , pp. 659-666
    • Lei, D.L.1    Long, J.M.2    Hengemihle, J.3    O'Neill, J.4    Manaye, K.F.5    Ingram, D.K.6    Mouton, P.R.7
  • 111
    • 41149167594 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury
    • Brown, C.M.; Dela Cruz, C.D.; Yang, E.; Wise, P.M.Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury. Exp. Neurol. 2008, 210, 782-787.
    • (2008) Exp. Neurol , vol.210 , pp. 782-787
    • Brown, C.M.1    Dela, C.C.D.2    Yang, E.3    Wise, P.M.4
  • 113
    • 3242792686 scopus 로고    scopus 로고
    • Estrogen replacement treatment in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules
    • Xu, H.L.; Baughman, V.L.; Pelligrino, D.A. Estrogen replacement treatment in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules. Stroke 2004, 35, 1974-1978.
    • (2004) Stroke , vol.35 , pp. 1974-1978
    • Xu, H.L.1    Baughman, V.L.2    Pelligrino, D.A.3
  • 114
    • 18644374888 scopus 로고    scopus 로고
    • Rivest, S. Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain
    • Soucy, G.; Boivin, G.; Labrie, F.; Rivest, S. Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain. J. Immunol. 2005, 174, 6391-6398.
    • (2005) J. Immunol , vol.174 , pp. 6391-6398
    • Soucy, G.1    Boivin, G.2    Labrie, F.3
  • 115
    • 25144480743 scopus 로고    scopus 로고
    • Estrogen's effects on central and circulating immune cells vary with reproductive age
    • Johnson, A.B.; Sohrabji, F. Estrogen's effects on central and circulating immune cells vary with reproductive age. Neurobiol. Aging 2005, 26, 1365-1374.
    • (2005) Neurobiol. Aging , vol.26 , pp. 1365-1374
    • Johnson, A.B.1    Sohrabji, F.2
  • 116
    • 0036784959 scopus 로고    scopus 로고
    • Long-term estrogen therapy worsens the behavioral and neuropathological consequences of chronic brain inflammation
    • Marriott, L.K.; Hauss-Wegrzyniak, B.; Benton, R.S.; Vraniak, P.D.; Wenk, G.L. Long-term estrogen therapy worsens the behavioral and neuropathological consequences of chronic brain inflammation. Behav. Neurosci. 2002, 116, 902-911.
    • (2002) Behav. Neurosci , vol.116 , pp. 902-911
    • Marriott, L.K.1    Hauss-Wegrzyniak, B.2    Benton, R.S.3    Vraniak, P.D.4    Wenk, G.L.5
  • 117
    • 33749033087 scopus 로고    scopus 로고
    • Estradiol Reduces Activity of the Blood-brain Barrier Na-K-Cl Cotransporter and Decreases Edema Formation In Permanent Middle Cerebral Artery Occlusion
    • O'Donnell, M.E.; Lam, T.I.; Tran, L.Q.; Foroutan, S.; Anderson, S.E. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 2006, 26, 1234-1249.
    • (2006) Blood Flow Metab , vol.26 , pp. 1234-1249
    • O'Donnell, M.E.1    Lam, T.I.2    Tran, L.Q.3    Foroutan, S.4    Anderson, S.E.5
  • 118
    • 33749321675 scopus 로고    scopus 로고
    • Influence of sex steroid hormones on cerebrovascular function
    • Krause, D.N.; Duckles, S.P.; Pelligrino, D.A. Influence of sex steroid hormones on cerebrovascular function. J. Appl. Physiol. 2006, 101, 1252-1261.
    • (2006) J. Appl. Physiol , vol.101 , pp. 1252-1261
    • Krause, D.N.1    Duckles, S.P.2    Pelligrino, D.A.3
  • 119
    • 0033806888 scopus 로고    scopus 로고
    • Estradiol protects against ischemic brain injury in middle-aged rats
    • Wise, P.M.; Dubal, D.B. Estradiol protects against ischemic brain injury in middle-aged rats. Biol. Reprod. 2000, 63, 982-985.
    • (2000) Biol Reprod , vol.63 , pp. 982-985
    • Wise, P.M.1    Dubal, D.B.2
  • 120
    • 0035118001 scopus 로고    scopus 로고
    • Neuroprotective effects of estradiol in middle-aged female rats
    • Dubal, D.B.; Wise, P.M. Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology 2001, 142, 43-48.
    • (2001) Endocrinology , vol.142 , pp. 43-48
    • Dubal, D.B.1    Wise, P.M.2
  • 121
    • 4944246436 scopus 로고    scopus 로고
    • Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats
    • Toung, T.J.; Chen, T.Y.; Littleton-Kearney, M.T.; Hurn, P.D.; Murphy, S.J.Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats. J. Cereb. Blood Flow Metab. 2004, 24, 1160-1166.
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , pp. 1160-1166
    • Toung, T.J.1    Chen, T.Y.2    Littleton-Kearney, M.T.3    Hurn, P.D.4    Murphy, S.J.5
  • 122
    • 0033976986 scopus 로고    scopus 로고
    • Neuroprotective effects of female gonadal steroids in reproductively senescent female rats
    • Alkayed, N.J.; Murphy, S.J.; Traystman, R.J.; Hurn, P.D.; Miller, V.M. Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 2000, 31, 161-168.
    • (2000) Stroke , vol.31 , pp. 161-168
    • Alkayed, N.J.1    Murphy, S.J.2    Traystman, R.J.3    Hurn, P.D.4    Miller, V.M.5
  • 123
    • 0033755647 scopus 로고    scopus 로고
    • Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus
    • Toung, T.K.; Hurn, P.D.; Traystman, R.J.; Sieber, F.E. Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus. Stroke 2000, 31, 2701-2706.
    • (2000) Stroke , vol.31 , pp. 2701-2706
    • Toung, T.K.1    Hurn, P.D.2    Traystman, R.J.3    Sieber, F.E.4
  • 124
    • 66049147738 scopus 로고    scopus 로고
    • The complexity of neurobiological processes in acute ischemic stroke
    • Brouns, R.; De Deyn, P.P. The complexity of neurobiological processes in acute ischemic stroke. Clin. Neurol. Neurosurg. 2009, 111, 483-495.
    • (2009) Clin. Neurol. Neurosurg , vol.111 , pp. 483-495
    • Brouns, R.1    de Deyn, P.P.2
  • 125
    • 0027731282 scopus 로고
    • Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat
    • Brann, D.W.; Zamorano, P.L.; Chorich, L.P.; Mahesh, V.B. Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat. Neuroendocrinology 1993, 58, 666-672.
    • (1993) Neuroendocrinology , vol.58 , pp. 666-672
    • Brann, D.W.1    Zamorano, P.L.2    Chorich, L.P.3    Mahesh, V.B.4
  • 126
    • 0031051384 scopus 로고    scopus 로고
    • Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: Correlation with dendritic spine density
    • Woolley, C.S.; Weiland, N.G.; McEwen, B.S.; Schwartzkroin, P.A. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: Correlation with dendritic spine density. J. Neurosci. 1997, 17, 1848-1859.
    • (1997) J. Neurosci , vol.17 , pp. 1848-1859
    • Woolley, C.S.1    Weiland, N.G.2    McEwen, B.S.3    Schwartzkroin, P.A.4
  • 127
    • 0026760870 scopus 로고
    • Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus
    • Weiland, N.G. Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus. Endocrinology 1992, 131, 662-668.
    • (1992) Endocrinology , vol.131 , pp. 662-668
    • Weiland, N.G.1
  • 128
    • 0027445017 scopus 로고
    • Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat
    • Woolley, C.S.; McEwen, B.S.Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J. Comp. Neurol. 1993, 336, 293-306.
    • (1993) J. Comp. Neurol , vol.336 , pp. 293-306
    • Woolley, C.S.1    McEwen, B.S.2
  • 129
    • 0026627947 scopus 로고
    • Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat
    • Woolley, C.S.; McEwen, B.S. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J. Neurosci. 1992, 12, 2549-2554.
    • (1992) J. Neurosci , vol.12 , pp. 2549-2554
    • Woolley, C.S.1    McEwen, B.S.2
  • 130
    • 0033015464 scopus 로고    scopus 로고
    • Estradiol increases spine density and NMDA-dependent Ca2+ transients in spines of CA1 pyramidal neurons from hippocampal slices
    • Pozzo-Miller, L.D.; Inoue, T.; Murphy, D.D. Estradiol increases spine density and NMDA-dependent Ca2+ transients in spines of CA1 pyramidal neurons from hippocampal slices. J. Neurophysiol. 1999, 81, 1404-1411.
    • (1999) J. Neurophysiol , vol.81 , pp. 1404-1411
    • Pozzo-Miller, L.D.1    Inoue, T.2    Murphy, D.D.3
  • 131
    • 0026060767 scopus 로고
    • Estradiol replacement to female rats facilitates dorsal hippocampal but not ventral hippocampal kindled seizure acquisition
    • Buterbaugh, G.G.; Hudson, G.M. Estradiol replacement to female rats facilitates dorsal hippocampal but not ventral hippocampal kindled seizure acquisition. Exp. Neurol. 1991, 111, 55-64.
    • (1991) Exp. Neurol , vol.111 , pp. 55-64
    • Buterbaugh, G.G.1    Hudson, G.M.2
  • 132
    • 0028879385 scopus 로고
    • LTP varies across the estrous cycle: Enhanced synaptic plasticity in proestrus rats
    • Warren, S.G.; Humphreys, A.G.; Juraska, J.M.; Greenough, W.T. LTP varies across the estrous cycle: enhanced synaptic plasticity in proestrus rats. Brain Res. 1995, 703, 26-30.
    • (1995) Brain Res , vol.703 , pp. 26-30
    • Warren, S.G.1    Humphreys, A.G.2    Juraska, J.M.3    Greenough, W.T.4
  • 133
    • 0032589256 scopus 로고    scopus 로고
    • 17Beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation
    • Foy, M.R.; Xu, J.; Xie, X.; Brinton, R.D.; Thompson, R.F.; Berger, T.W. 17Beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J. Neurophysiol. 1999, 81, 925-929.
    • (1999) J. Neurophysiol , vol.81 , pp. 925-929
    • Foy, M.R.1    Xu, J.2    Xie, X.3    Brinton, R.D.4    Thompson, R.F.5    Berger, T.W.6
  • 134
    • 0019308728 scopus 로고
    • Gonadal steroids: Effects on excitability of hippocampal pyramidal cells
    • Teyler, T.J.; Vardaris, R.M.; Lewis, D.; Rawitch, A.B. Gonadal steroids: Effects on excitability of hippocampal pyramidal cells. Science 1980, 209, 1017-1018.
    • (1980) Science , vol.209 , pp. 1017-1018
    • Teyler, T.J.1    Vardaris, R.M.2    Lewis, D.3    Rawitch, A.B.4
  • 135
    • 0023265121 scopus 로고
    • Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum
    • Smith, S.S.; Waterhouse, B.D.; Woodward, D.J. Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum. Brain Res. 1987, 422, 40-51.
    • (1987) Brain Res , vol.422 , pp. 40-51
    • Smith, S.S.1    Waterhouse, B.D.2    Woodward, D.J.3
  • 136
    • 0141543841 scopus 로고    scopus 로고
    • Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha
    • Sato, K.; Matsuki, N.; Ohno, Y.; Nakazawa, K. Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha. J. Neurochem. 2003, 86, 1498-1505.
    • (2003) J. Neurochem , vol.86 , pp. 1498-1505
    • Sato, K.1    Matsuki, N.2    Ohno, Y.3    Nakazawa, K.4
  • 137
    • 0029969410 scopus 로고    scopus 로고
    • 17Beta-Estradiol potentiates kainate-induced currents via activation of the cAMP cascade
    • Gu, Q.; Moss, R.L. 17Beta-Estradiol potentiates kainate-induced currents via activation of the cAMP cascade. J. Neurosci. 1996, 16, 3620-3629.
    • (1996) J. Neurosci , vol.16 , pp. 3620-3629
    • Gu, Q.1    Moss, R.L.2
  • 138
    • 0022453715 scopus 로고
    • Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells
    • Johansen, F.F.; Jorgensen, M.B.; Diemer, N.H. Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells. Brain Res. 1986, 377, 344-347.
    • (1986) Brain Res , vol.377 , pp. 344-347
    • Johansen, F.F.1    Jorgensen, M.B.2    Diemer, N.H.3
  • 139
    • 0022485247 scopus 로고
    • Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells
    • Onodera, H.; Sato, G.; Kogure, K. Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells. Neurosci. Lett. 1986, 68, 169-174.
    • (1986) Neurosci. Lett , vol.68 , pp. 169-174
    • Onodera, H.1    Sato, G.2    Kogure, K.3
  • 140
    • 0021916489 scopus 로고
    • Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path
    • Wieloch, T.; Lindvall, O.; Blomqvist, P.; Gage, F.H. Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path. Neurol. Res. 1985, 7, 24-26.
    • (1985) Neurol. Res , vol.7 , pp. 24-26
    • Wieloch, T.1    Lindvall, O.2    Blomqvist, P.3    Gage, F.H.4
  • 141
    • 0032913843 scopus 로고    scopus 로고
    • Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors
    • Ito, H.; Watanabe, Y.; Isshiki, A.; Uchino, H. Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. Acta Anaesthesiol. Scand. 1999, 43, 153-162.
    • (1999) Acta Anaesthesiol. Scand , vol.43 , pp. 153-162
    • Ito, H.1    Watanabe, Y.2    Isshiki, A.3    Uchino, H.4    Uchino, H.5
  • 142
    • 0031944456 scopus 로고    scopus 로고
    • Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]
    • Schwartz-Bloom, R.D.; McDonough, K.J.; Chase, P.J.; Chadwick, L.E.; Inglefield, J.R.; Levin, E.D. Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]. J. Cereb. Blood Flow Metab. 1998, 18, 548-558.
    • (1998) J. Cereb. Blood Flow Metab , vol.18 , pp. 548-558
    • Schwartz-Bloom, R.D.1    McDonough, K.J.2    Chase, P.J.3    Chadwick, L.E.4    Inglefield, J.R.5    Levin, E.D.6
  • 143
    • 0029924284 scopus 로고    scopus 로고
    • Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons
    • Goodman, Y.; Bruce, A.J.; Cheng, B.; Mattson, M.P. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons. J. Neurochem. 1996, 66, 1836-1844.
    • (1996) J. Neurochem , vol.66 , pp. 1836-1844
    • Goodman, Y.1    Bruce, A.J.2    Cheng, B.3    Mattson, M.P.4
  • 144
    • 0033298546 scopus 로고    scopus 로고
    • Gonadal hormones affect neuronal vulnerability to excitotoxin-induced degeneration
    • Azcoitia, I.; Fernandez-Galaz, C.; Sierra, A.; Garcia-Segura, L.M. Gonadal hormones affect neuronal vulnerability to excitotoxin-induced degeneration. J. Neurocytol. 1999, 28, 699-710.
    • (1999) J. Neurocytol , vol.28 , pp. 699-710
    • Azcoitia, I.1    Fernandez-Galaz, C.2    Sierra, A.3    Garcia-Segura, L.M.4
  • 145
    • 0035906427 scopus 로고    scopus 로고
    • 17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: A New Neuroprotective Pathway
    • Mendelowitsch, A.; Ritz, M.F.; Ros, J.; Langemann, H.; Gratzl, O. 17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: A new neuroprotective pathway. Brain Res. 2001, 901, 230-236.
    • (2001) Brain Res , vol.901 , pp. 230-236
    • Mendelowitsch, A.1    Ritz, M.F.2    Ros, J.3    Langemann, H.4    Gratzl, O.5
  • 146
    • 0037123750 scopus 로고    scopus 로고
    • 17Beta-estradiol treatment retards excitotoxic delayed degeneration in substantia nigra reticulata neurons
    • DeGiorgio, L.A.; Attardi, B.; Shimizu, Y.; Ogata, M.; Volpe, B.T. 17Beta-estradiol treatment retards excitotoxic delayed degeneration in substantia nigra reticulata neurons. Brain Res. 2002, 936, 15-20.
    • (2002) Brain Res , vol.936 , pp. 15-20
    • Degiorgio, L.A.1    Attardi, B.2    Shimizu, Y.3    Ogata, M.4    Volpe, B.T.5
  • 147
    • 0036882776 scopus 로고    scopus 로고
    • 17Beta-estradiol effect on the extracellular concentration of amino acids in the glutamate excitotoxicity model in the rat
    • Ritz, M.F.; Schmidt, P.; Mendelowitsch, A. 17Beta-estradiol effect on the extracellular concentration of amino acids in the glutamate excitotoxicity model in the rat. Neurochem. Res. 2002, 27, 1677-1683.
    • (2002) Neurochem.Res , vol.27 , pp. 1677-1683
    • Ritz, M.F.1    Schmidt, P.2    Mendelowitsch, A.3
  • 148
    • 4444229212 scopus 로고    scopus 로고
    • Acute effects of 17beta-estradiol on the extracellular concentration of excitatory amino acids and energy metabolites during transient cerebral ischemia in male rats
    • Ritz, M.F.; Schmidt, P.; Mendelowitsch, A. Acute effects of 17beta-estradiol on the extracellular concentration of excitatory amino acids and energy metabolites during transient cerebral ischemia in male rats. Brain Res. 2004, 1022, 157-163.
    • (2004) Brain Res , vol.1022 , pp. 157-163
    • Ritz, M.F.1    Schmidt, P.2    Mendelowitsch, A.3
  • 149
    • 57549105460 scopus 로고    scopus 로고
    • Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model
    • Zhang, H.; Xie, M.; Schools, G.P.; Feustel, P.F.; Wang, W.; Lei, T.; Kimelberg, H.K.; Zhou, M. Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res. 2009, 1247, 196-211.
    • (2009) Brain Res , vol.1247 , pp. 196-211
    • Zhang, H.1    Xie, M.2    Schools, G.P.3    Feustel, P.F.4    Wang, W.5    Lei, T.6    Kimelberg, H.K.7    Zhou, M.8
  • 150
    • 10344234703 scopus 로고    scopus 로고
    • Apoptosis in cerebral ischemia: Executional and regulatory signaling mechanisms
    • Zhang, F.; Yin, W.; Chen, J. Apoptosis in cerebral ischemia: Executional and regulatory signaling mechanisms. Neurol. Res. 2004, 26, 835-845.
    • (2004) Neurol. Res , vol.26 , pp. 835-845
    • Zhang, F.1    Yin, W.2    Chen, J.3
  • 152
    • 65549098614 scopus 로고    scopus 로고
    • Apoptotic mechanisms after cerebral ischemia
    • Broughton, B.R.; Reutens, D.C.; Sobey, C.G. Apoptotic mechanisms after cerebral ischemia. Stroke 2009, 40, e331-339.
    • (2009) Stroke , vol.40
    • Broughton, B.R.1    Reutens, D.C.2    Sobey, C.G.3
  • 153
    • 0030808462 scopus 로고    scopus 로고
    • Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant -apoptotic{norm of matrix} pattern of gene induction
    • Estus, S.; Tucker, H.M.; van Rooyen, C.; Wright, S.; Brigham, E.F.; Wogulis, M.; Rydel, R.E. Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant -apoptotic{norm of matrix} pattern of gene induction. J. Neurosci. 1997, 17, 7736-7745.
    • (1997) J. Neurosci , vol.17 , pp. 7736-7745
    • Estus, S.1    Tucker, H.M.2    van Rooyen, C.3    Wright, S.4    Brigham, E.F.5    Wogulis, M.6    Rydel, R.E.7
  • 154
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus, S.; Zaks, W.J.; Freeman, R.S.; Gruda, M.; Bravo, R.; Johnson, E.M., Jr. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 1994, 127, 1717-1727.
    • (1994) J. Cell Biol , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson Jr., E.M.6
  • 155
    • 0344874576 scopus 로고    scopus 로고
    • Estradiol differentially regulates c-Fos after focal cerebral ischemia
    • Rau, S.W.; Dubal, D.B.; Bottner, M.; Wise, P.M. Estradiol differentially regulates c-Fos after focal cerebral ischemia. J. Neurosci. 2003, 23, 10487-10494.
    • (2003) J. Neurosci , vol.23 , pp. 10487-10494
    • Rau, S.W.1    Dubal, D.B.2    Bottner, M.3    Wise, P.M.4
  • 159
    • 0033178294 scopus 로고    scopus 로고
    • Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors
    • Dubal, D.B.; Shughrue, P.J.; Wilson, M.E.; Merchenthaler, I.; Wise, P.M. Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors. J. Neurosci. 1999, 19, 6385-6393.
    • (1999) J. Neurosci , vol.19 , pp. 6385-6393
    • Dubal, D.B.1    Shughrue, P.J.2    Wilson, M.E.3    Merchenthaler, I.4    Wise, P.M.5
  • 160
    • 0037088929 scopus 로고    scopus 로고
    • Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1
    • Jover, T.; Tanaka, H.; Calderone, A.; Oguro, K.; Bennett, M.V.; Etgen, A.M.; Zukin, R.S. Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1. J. Neurosci. 2002, 22, 2115-2124.
    • (2002) J. Neurosci , vol.22 , pp. 2115-2124
    • Jover, T.1    Tanaka, H.2    Calderone, A.3    Oguro, K.4    Bennett, M.V.5    Etgen, A.M.6    Zukin, R.S.7
  • 161
    • 0032997908 scopus 로고    scopus 로고
    • Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: Relevance to Alzheimer's disease
    • Pike, C.J. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: Relevance to Alzheimer's disease. J. Neurochem. 1999, 72, 1552-1563.
    • (1999) J. Neurochem , vol.72 , pp. 1552-1563
    • Pike, C.J.1
  • 162
    • 0032479933 scopus 로고    scopus 로고
    • Modulation of Bcl-2 expression: A potential component of estrogen protection in NT2 neurons
    • Singer, C.A.; Rogers, K.L.; Dorsa, D.M. Modulation of Bcl-2 expression: A potential component of estrogen protection in NT2 neurons. Neuroreport 1998, 9, 2565-2568.
    • (1998) Neuroreport , vol.9 , pp. 2565-2568
    • Singer, C.A.1    Rogers, K.L.2    Dorsa, D.M.3
  • 163
  • 164
    • 51849120763 scopus 로고    scopus 로고
    • Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation
    • Yune, T.Y.; Park, H.G.; Lee, J.Y.; Oh, T.H. Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. J. Neurotrauma 2008, 25, 1121-1131.
    • (2008) J. Neurotrauma , vol.25 , pp. 1121-1131
    • Yune, T.Y.1    Park, H.G.2    Lee, J.Y.3    Oh, T.H.4
  • 165
    • 59449094490 scopus 로고    scopus 로고
    • Estrogen Affects Levels of Bcl-2 Protein and MRNA in Medial Amygdala of Ovariectomized Rats
    • Fan, L.; Pandey, S.C.; Cohen, R.S.Estrogen affects levels of Bcl-2 protein and mRNA in medial amygdala of ovariectomized rats. J. Neurosci. Res. 2008, 86, 3655-3664.
    • (2008) J. Neurosci. Res , vol.86 , pp. 3655-3664
    • Fan, L.1    Pandey, S.C.2    Cohen, R.S.3
  • 166
    • 41549137723 scopus 로고    scopus 로고
    • Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax
    • Sharma, K.; Mehra, R.D. Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax. Brain Res. 2008, 1204, 1-15.
    • (2008) Brain Res , vol.1204 , pp. 1-15
    • Sharma, K.1    Mehra, R.D.2
  • 167
    • 0033152867 scopus 로고    scopus 로고
    • Estrogen and NGF synergistically protect terminally differentiated, ERalpha-transfected PC12 cells from apoptosis
    • Gollapudi, L.; Oblinger, M.M. Estrogen and NGF synergistically protect terminally differentiated, ERalpha-transfected PC12 cells from apoptosis. J. Neurosci. Res. 1999, 56, 471-481.
    • (1999) J. Neurosci. Res , vol.56 , pp. 471-481
    • Gollapudi, L.1    Oblinger, M.M.2
  • 169
    • 0037646999 scopus 로고    scopus 로고
    • 17Beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection
    • Lee, S.Y.; Andoh, T.; Murphy, D.L.; Chiueh, C.C. 17Beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection. FASEB J. 2003, 17, 947-948.
    • (2003) FASEB J , vol.17 , pp. 947-948
    • Lee, S.Y.1    Andoh, T.2    Murphy, D.L.3    Chiueh, C.C.4
  • 170
    • 26444580828 scopus 로고    scopus 로고
    • Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release
    • Zhang, Y.; Bhavnani, B.R. Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC Neurosci. 2005, 6, 13.
    • (2005) BMC Neurosci , vol.6 , pp. 13
    • Zhang, Y.1    Bhavnani, B.R.2
  • 171
    • 0029157380 scopus 로고
    • Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells
    • Teixeira, C.; Reed, J.C.; Pratt, M.A. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res. 1995, 55, 3902-3907.
    • (1995) Cancer Res , vol.55 , pp. 3902-3907
    • Teixeira, C.1    Reed, J.C.2    Pratt, M.A.3
  • 174
    • 56449097523 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke
    • Hansen, T.M.; Moss, A.J.; Brindle, N.P. Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke. Curr. Neurovasc. Res. 2008, 5, 236-245.
    • (2008) Curr. Neurovasc. Res , vol.5 , pp. 236-245
    • Hansen, T.M.1    Moss, A.J.2    Brindle, N.P.3
  • 176
    • 0027503073 scopus 로고
    • Gonadal steroids as promoting factors in axonal regeneration
    • Jones, K.J. Gonadal steroids as promoting factors in axonal regeneration. Brain Res. Bull. 1993, 30, 491-498.
    • (1993) Brain Res. Bull , vol.30 , pp. 491-498
    • Jones, K.J.1
  • 177
    • 33847770454 scopus 로고    scopus 로고
    • Cross-talk between IGF-I and estradiol in the brain: Focus on neuroprotection
    • Garcia-Segura, L.M.; Sanz, A.; Mendez, P. Cross-talk between IGF-I and estradiol in the brain: Focus on neuroprotection. Neuroendocrinology 2006, 84, 275-279.
    • (2006) Neuroendocrinology , vol.84 , pp. 275-279
    • Garcia-Segura, L.M.1    Sanz, A.2    Mendez, P.3
  • 178
    • 0028343330 scopus 로고
    • Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats
    • Duenas, M.; Luquin, S.; Chowen, J.A.; Torres-Aleman, I.; Naftolin, F.; Garcia-Segura, L.M. Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats. Neuroendocrinology 1994, 59, 528-538.
    • (1994) Neuroendocrinology , vol.59 , pp. 528-538
    • Duenas, M.1    Luquin, S.2    Chowen, J.A.3    Torres-Aleman, I.4    Naftolin, F.5    Garcia-Segura, L.M.6
  • 179
    • 0034727891 scopus 로고    scopus 로고
    • Region- and peptide-specific regulation of the neurotrophins by estrogen
    • Jezierski, M.K.; Sohrabji, F. Region- and peptide-specific regulation of the neurotrophins by estrogen. Brain Res. Mol. Brain Res. 2000, 85, 77-84.
    • (2000) Brain Res. Mol. Brain Res , vol.85 , pp. 77-84
    • Jezierski, M.K.1    Sohrabji, F.2
  • 180
    • 0032873614 scopus 로고    scopus 로고
    • Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain
    • Gibbs, R.B. Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain Res. 1999, 844, 20-27.
    • (1999) Brain Res , vol.844 , pp. 20-27
    • Gibbs, R.B.1
  • 181
    • 0028843912 scopus 로고
    • Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor
    • Sohrabji, F.; Miranda, R.C.; Toran-Allerand, C.D. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 1995, 92, 11110-11114.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11110-11114
    • Sohrabji, F.1    Miranda, R.C.2    Toran-Allerand, C.D.3
  • 182
    • 18844376360 scopus 로고    scopus 로고
    • Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: Involvement of nonclassical genomic signaling pathways
    • Dhandapani, K.M.; Wade, F.M.; Mahesh, V.B.; Brann, D.W. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: Involvement of nonclassical genomic signaling pathways. Endocrinology 2005, 146, 2749-2759.
    • (2005) Endocrinology , vol.146 , pp. 2749-2759
    • Dhandapani, K.M.1    Wade, F.M.2    Mahesh, V.B.3    Brann, D.W.4
  • 183
    • 0034718502 scopus 로고    scopus 로고
    • Regulation of Vascular Endothelial Growth Factor (VEGF) Gene Transcription By Estrogen Receptors Alpha and Beta
    • Mueller, M.D.; Vigne, J.L.; Minchenko, A.; Lebovic, D.I.; Leitman, D.C.; Taylor, R.N.Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc. Natl. Acad. Sci. USA 2000, 97, 10972-10977.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10972-10977
    • Mueller, M.D.1    Vigne, J.L.2    Minchenko, A.3    Lebovic, D.I.4    Leitman, D.C.5    Taylor, R.N.6
  • 184
    • 0030292973 scopus 로고    scopus 로고
    • Estrogen induction of TGF-alpha is mediated by an estrogen response element composed of two imperfect palindromes
    • El-Ashry, D.; Chrysogelos, S.A.; Lippman, M.E.; Kern, F.G. Estrogen induction of TGF-alpha is mediated by an estrogen response element composed of two imperfect palindromes. J. Steroid Biochem. Mol. Biol. 1996, 59, 261-269.
    • (1996) J. Steroid Biochem. Mol. Biol , vol.59 , pp. 261-269
    • El-Ashry, D.1    Chrysogelos, S.A.2    Lippman, M.E.3    Kern, F.G.4
  • 185
    • 0026047799 scopus 로고
    • Estrogen-enhanced neurite growth: Evidence for a selective induction of Tau and stable microtubules
    • Ferreira, A.; Caceres, A. Estrogen-enhanced neurite growth: Evidence for a selective induction of Tau and stable microtubules. J. Neurosci. 1991, 11, 392-400.
    • (1991) J. Neurosci , vol.11 , pp. 392-400
    • Ferreira, A.1    Caceres, A.2
  • 186
    • 0342803689 scopus 로고    scopus 로고
    • Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice
    • Singh, M.; Setalo G., Jr.; Guan, X.; Frail, D.E.; Toran-Allerand, C.D. Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J. Neurosci. 2000, 20, 1694-1700.
    • (2000) J. Neurosci , vol.20 , pp. 1694-1700
    • Singh, M.1    Setalo Jr., G.2    Guan, X.3    Frail, D.E.4    Toran-Allerand, C.D.5
  • 187
    • 0037430850 scopus 로고    scopus 로고
    • Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res
    • Mendez, P.; Azcoitia, I.; Garcia-Segura, L.M. Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res. Mol. Brain Res. 2003, 112, 170-176.
    • (2003) Mol. Brain Res , vol.112 , pp. 170-176
    • Mendez, P.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 188
    • 0347629016 scopus 로고    scopus 로고
    • Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxdopamine lesions
    • Quesada, A.; Micevych, P.E.Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxdopamine lesions. J. Neurosci. Res. 2004, 75, 107-116.
    • (2004) J. Neurosci. Res , vol.75 , pp. 107-116
    • Quesada, A.1    Micevych, P.E.2
  • 189
    • 0033573273 scopus 로고    scopus 로고
    • Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling
    • Azcoitia, I.; Sierra, A.; Garcia-Segura, L.M. Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling. J. Neurosci. Res. 1999, 58, 815-822.
    • (1999) J. Neurosci. Res , vol.58 , pp. 815-822
    • Azcoitia, I.1    Sierra, A.2    Garcia-Segura, L.M.3
  • 190
    • 33847062554 scopus 로고    scopus 로고
    • MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia
    • Jover-Mengual, T.; Zukin, R.S.; Etgen, A.M. MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007, 148, 1131-1143.
    • (2007) Endocrinology , vol.148 , pp. 1131-1143
    • Jover-Mengual, T.1    Zukin, R.S.2    Etgen, A.M.3
  • 191
    • 70949097002 scopus 로고    scopus 로고
    • Oestradiol and insulin-like growth factor-1 reduce cell loss after global ischaemia in middle-aged female rats
    • Traub, M.L.; De Butte-Smith, M.; Zukin, R.S.; Etgen, A.M. Oestradiol and insulin-like growth factor-1 reduce cell loss after global ischaemia in middle-aged female rats. J. Neuroendocrinol. 2009, 21, 1038-1044.
    • (2009) J. Neuroendocrinol , vol.21 , pp. 1038-1044
    • Traub, M.L.1    De Butte-Smith, M.2    Zukin, R.S.3    Etgen, A.M.4
  • 192
    • 0027287662 scopus 로고
    • Estrogen modulates the growth-associated protein GAP-43 (Neuromodulin) mRNA in the rat preoptic area and basal hypothalamus
    • Shughrue, P.J.; Dorsa, D.M. Estrogen modulates the growth-associated protein GAP-43 (Neuromodulin) mRNA in the rat preoptic area and basal hypothalamus. Neuroendocrinology 1993, 57, 439-447.
    • (1993) Neuroendocrinology , vol.57 , pp. 439-447
    • Shughrue, P.J.1    Dorsa, D.M.2
  • 193
    • 0032937824 scopus 로고    scopus 로고
    • Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures
    • Teter, B.; Harris-White, M.E.; Frautschy, S.A.; Cole, G.M. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience 1999, 91, 1009-1016.
    • (1999) Neuroscience , vol.91 , pp. 1009-1016
    • Teter, B.1    Harris-White, M.E.2    Frautschy, S.A.3    Cole, G.M.4
  • 194
    • 0031215052 scopus 로고    scopus 로고
    • Estrogen regulates neurofilament gene expression in adult female rat dorsal root ganglion neurons
    • Scoville, S.A.; Bufton, S.M.; Liuzzi, F.J. Estrogen regulates neurofilament gene expression in adult female rat dorsal root ganglion neurons. Exp. Neurol. 1997, 146, 596-599.
    • (1997) Exp. Neurol , vol.146 , pp. 596-599
    • Scoville, S.A.1    Bufton, S.M.2    Liuzzi, F.J.3
  • 196
    • 0036155935 scopus 로고    scopus 로고
    • Cerebral thrombosis and microcirculation of the rat during the oestrous cycle and after ovariectomy
    • Ono, H.; Sasaki, Y.; Bamba, E.; Seki, J.; Giddings, J.C.; Yamamoto, J. Cerebral thrombosis and microcirculation of the rat during the oestrous cycle and after ovariectomy. Clin. Exp. Pharmacol. Physiol. 2002, 29, 73-78.
    • (2002) Clin. Exp. Pharmacol. Physiol , vol.29 , pp. 73-78
    • Ono, H.1    Sasaki, Y.2    Bamba, E.3    Seki, J.4    Giddings, J.C.5    Yamamoto, J.6
  • 197
    • 0036007497 scopus 로고    scopus 로고
    • 17Beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase
    • Ospina, J.A.; Krause, D.N.; Duckles, S.P. 17Beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. Stroke 2002, 33, 600-605.
    • (2002) Stroke , vol.33 , pp. 600-605
    • Ospina, J.A.1    Krause, D.N.2    Duckles, S.P.3
  • 198
    • 0038677091 scopus 로고    scopus 로고
    • 17Beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation
    • Ospina, J.A.; Duckles, S.P.; Krause, D.N. 17Beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H241-250.
    • (2003) Am. J. Physiol. Heart Circ. Physiol , vol.285
    • Ospina, J.A.1    Duckles, S.P.2    Krause, D.N.3
  • 199
    • 0141926417 scopus 로고    scopus 로고
    • Estrogen-induced augmentation of endothelium-dependent nitric oxide-mediated vasodilation in isolated rat cerebral small arteries
    • Momoi, H.; Ikomi, F.; Ohhashi, T. Estrogen-induced augmentation of endothelium-dependent nitric oxide-mediated vasodilation in isolated rat cerebral small arteries. Jpn. J. Physiol. 2003, 53, 193-203.
    • (2003) Jpn.J. Physiol , vol.53 , pp. 193-203
    • Momoi, H.1    Ikomi, F.2    Ohhashi, T.3
  • 200
    • 0034749928 scopus 로고    scopus 로고
    • Selected contribution: Cerebrovascular nos and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha
    • discussion 2389-2390
    • Geary, G.G.; McNeill, A.M.; Ospina, J.A.; Krause, D.N.; Korach, K.S.; Duckles, S.P. Selected contribution: Cerebrovascular nos and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha. J. Appl. Physiol. 2001, 91, 2391-2399; discussion 2389-2390.
    • (2001) J. Appl. Physiol , vol.91 , pp. 2391-2399
    • Geary, G.G.1    McNeill, A.M.2    Ospina, J.A.3    Krause, D.N.4    Korach, K.S.5    Duckles, S.P.6
  • 201
    • 0032860804 scopus 로고    scopus 로고
    • Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels
    • McNeill, A.M.; Kim, N.; Duckles, S.P.; Krause, D.N.; Kontos, H.A. Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke 1999, 30, 2186-2190.
    • (1999) Stroke , vol.30 , pp. 2186-2190
    • McNeill, A.M.1    Kim, N.2    Duckles, S.P.3    Krause, D.N.4    Kontos, H.A.5
  • 202
    • 0033867277 scopus 로고    scopus 로고
    • Gonadal hormones affect diameter of male rat cerebral arteries through endothelium-dependent mechanisms
    • Geary, G.G.; Krause, D.N.; Duckles, S.P. Gonadal hormones affect diameter of male rat cerebral arteries through endothelium-dependent mechanisms. Am. J. Physiol. Heart Circ. Physiol. 2000, 279, H610-618.
    • (2000) Am. J. Physiol. Heart Circ. Physiol , vol.279
    • Geary, G.G.1    Krause, D.N.2    Duckles, S.P.3
  • 203
    • 0034607151 scopus 로고    scopus 로고
    • Nitric-oxide-dependent pial arteriolar dilation in the female rat: Effects of chronic estrogen depletion and repletion
    • Pelligrino, D.A.; Ye, S.; Tan, F.; Santizo, R.A.; Feinstein, D.L.; Wang, Q. Nitric-oxide-dependent pial arteriolar dilation in the female rat: Effects of chronic estrogen depletion and repletion. Biochem. Biophys. Res. Commun. 2000, 269, 165-171.
    • (2000) Biochem. Biophys. Res. Commun , vol.269 , pp. 165-171
    • Pelligrino, D.A.1    Ye, S.2    Tan, F.3    Santizo, R.A.4    Feinstein, D.L.5    Wang, Q.6
  • 204
    • 1642362646 scopus 로고    scopus 로고
    • 17Beta-estradiol increases endothelial nitric oxide synthase mRNA copy number in cerebral blood vessels: Quantification by real-time polymerase chain reaction
    • Stirone, C.; Chu, Y.; Sunday, L.; Duckles, S.P.; Krause, D.N. 17Beta-estradiol increases endothelial nitric oxide synthase mRNA copy number in cerebral blood vessels: Quantification by real-time polymerase chain reaction. Eur. J. Pharmacol. 2003, 478, 35-38.
    • (2003) Eur. J. Pharmacol , vol.478 , pp. 35-38
    • Stirone, C.1    Chu, Y.2    Sunday, L.3    Duckles, S.P.4    Krause, D.N.5
  • 205
    • 33750879820 scopus 로고    scopus 로고
    • Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries
    • Geary, G.G.; Krause, D.N.; Duckles, S.P. Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am. J. Physiol. 1998, 275, H292-300.
    • (1998) Am. J. Physiol , vol.275
    • Geary, G.G.1    Krause, D.N.2    Duckles, S.P.3
  • 206
    • 0033851027 scopus 로고    scopus 로고
    • Estrogen reduces mouse cerebral artery tone through endothelial NOS- and cyclooxygenase-dependent mechanisms
    • Geary, G.G.; Krause, D.N.; Duckles, S.P.Estrogen reduces mouse cerebral artery tone through endothelial NOS- and cyclooxygenase-dependent mechanisms. Am. J. Physiol. Heart Circ. Physiol. 2000, 279, H511-519.
    • (2000) Heart Circ. Physiol , vol.279
    • Geary, G.G.1    Krause, D.N.2    Duckles, S.P.3
  • 207
    • 33751264957 scopus 로고    scopus 로고
    • Estrogen regulates myogenic tone in pressurized cerebral arteries by enhanced basal release of nitric oxide
    • Skarsgard, P.; van Breemen, C.; Laher, I. Estrogen regulates myogenic tone in pressurized cerebral arteries by enhanced basal release of nitric oxide. Am. J. Physiol. 1997, 273, H2248-2256.
    • (1997) Am. J. Physiol , vol.273
    • Skarsgard, P.1    van Breemen, C.2    Laher, I.3
  • 208
    • 3042683996 scopus 로고    scopus 로고
    • Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: Comparison with 17beta-estradiol
    • Sobey C.G.; Weiler, J.M.; Boujaoude, M.; Woodman, O.L. Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: Comparison with 17beta-estradiol. J. Pharmacol. Exp. Ther. 2004, 310, 135-140.
    • (2004) J. Pharmacol. Exp. Ther , vol.310 , pp. 135-140
    • Sobey, C.G.1    Weiler, J.M.2    Boujaoude, M.3    Woodman, O.L.4
  • 211
    • 0034745252 scopus 로고    scopus 로고
    • Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke
    • McCullough, L.D.; Alkayed, N.J.; Traystman, R.J.; Williams, M.J.; Hurn, P.D. Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke. Stroke 2001, 32, 796-802.
    • (2001) Stroke , vol.32 , pp. 796-802
    • McCullough, L.D.1    Alkayed, N.J.2    Traystman, R.J.3    Williams, M.J.4    Hurn, P.D.5
  • 213
    • 21944451544 scopus 로고    scopus 로고
    • Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination
    • Coma, M.; Guix, F.X.; Uribesalgo, I.; Espuna, G.; Sole, M.; Andreu, D.; Munoz, F.J. Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. Brain 2005, 128, 1613-1621.
    • (2005) Brain , vol.128 , pp. 1613-1621
    • Coma, M.1    Guix, F.X.2    Uribesalgo, I.3    Espuna, G.4    Sole, M.5    Andreu, D.6    Munoz, F.J.7
  • 214
    • 1642570319 scopus 로고    scopus 로고
    • Nitric oxide, oxidants, and protein tyrosine nitration
    • Radi, R. Nitric oxide, oxidants, and protein tyrosine nitration. Proc. Natl. Acad. Sci. USA 2004, 101, 4003-4008.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4003-4008
    • Radi, R.1
  • 215
    • 0033004253 scopus 로고    scopus 로고
    • Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats
    • Wang, Q.; Santizo, R.; Baughman, V.L.; Pelligrino, D.A.; Iadecola, C. Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats. Stroke 1999, 30, 630-637.
    • (1999) Stroke , vol.30 , pp. 630-637
    • Wang, Q.1    Santizo, R.2    Baughman, V.L.3    Pelligrino, D.A.4    Iadecola, C.5
  • 216
  • 217
    • 0035068026 scopus 로고    scopus 로고
    • Estrogens decrease reperfusion-associated cortical ischemic damage: An MRI Analysis In a Transient Focal Ischemia Model
    • Shi, J.; Bui, J.D.; Yang, S.H.; He, Z.; Lucas, T.H.; Buckley, D.L.; Blackband, S.J.; King, M.A.; Day, A.L.; Simpkins, J.W. Estrogens decrease reperfusion-associated cortical ischemic damage: An MRI analysis in a transient focal ischemia model. Stroke 2001, 32, 987-992.
    • (2001) Stroke , vol.32 , pp. 987-992
    • Shi, J.1    Bui, J.D.2    Yang, S.H.3    He, Z.4    Lucas, T.H.5    Buckley, D.L.6    Blackband, S.J.7    King, M.A.8    Day, A.L.9    Simpkins, J.W.10
  • 219
    • 0242636873 scopus 로고    scopus 로고
    • Estradiol increases pre- and post-synaptic proteins in the CA1 region of the hippocampus in female rhesus macaques (Macaca mulatta)
    • Choi, J.M.; Romeo, R.D.; Brake, W.G.; Bethea, C.L.; Rosenwaks, Z.; McEwen, B.S. Estradiol increases pre- and post-synaptic proteins in the CA1 region of the hippocampus in female rhesus macaques (Macaca mulatta). Endocrinology 2003, 144, 4734-4738.
    • (2003) Endocrinology , vol.144 , pp. 4734-4738
    • Choi, J.M.1    Romeo, R.D.2    Brake, W.G.3    Bethea, C.L.4    Rosenwaks, Z.5    McEwen, B.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.