Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats

Stroke

Volumn 30, Issue 3, 1999, Pages 630-637

  Wang, Qiong ^a   Santizo, Roberto ^a   Baughman, Verna L ^a   Pelligrino, Dale A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cerebral blood flow; Cerebral ischemia, global; Estradiol; Rats

Indexed keywords

ESTRADIOL; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; HIPPOCAMPUS; LASER DOPPLER FLOWMETRY; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; REPERFUSION; TRANSIENT ISCHEMIC ATTACK;

EID: 0033004253     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.3.630     Document Type: Article

References (37)

1. Pelligrino DA, Santizo R, Baughman VL, Wang Q. Cerebral vasodilating capacity during transient forebrain ischemia: the effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport. 1998;9:3285-3291.
2. Hayashi T, Yamada K, Esaki T, Muto E, Chaudhuri G, Iguchi A. Physiological concentrations of 17 beta-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system. J Cardiovasc Pharmacol. 1998;31:292-298.
3. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD. Gender-linked brain injury in experimental stroke. Stroke. 1998;29: 159-165.
4. Hurn PD, Littleton-Kearney MT, Kirsch JR, Dharmarajan AM, Traystman RJ. Postischemic cerebral blood flow recovery in the female: effect of 17 beta-estradiol. J Cereb Blood Flow Metab. 1995;15: 666-672.
5. Sudo S, Wen TC, Desaki J, Matsuda S, Tanaka J, Arai T, Maeda N, Sakanaka M. Beta-estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil. Neurosci Res. 1997;29:345-354.
6. Kondo Y, Suzuki K, Sakuma Y. Estrogen alleviates cognitive dysfunction following transient brain ischemia in ovariectomized gerbils. Neurosci Lett. 1997;238:45-48.
7. Simpkins JW, Rajakamar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg. 1997;87:724-730.
8. Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW. Effects of gender and estradiol treatment on focal brain ischemia. Brain Res. 1998;784: 321-324.
9. Goodman YD, Bruce AJ, Cheng B, Mattson MP. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta- peptide toxicity in hippocampal neurons. J Neurochem. 1996;66:1836-1844.
10. Regan RF, Guo YP. Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures. Brain Res. 1997;764:133-140.
11. Pelligrino DA, Gay RL, Baughman VL, Wang Q. Nitric oxide synthase inhibition modulates N-methyl-D-aspartate-induced changes in cerebral blood flow and EEG activity. Am J Physiol. 1996;271:H990-H995.
12. Hoffman WE, Braucher E, Pelligrino DA, Thomas C, Albrecht RF, Miletich DJ. Brain lactate and neurologic outcome following incomplete ischemia in fasted, nonfasted, and glucose-loaded rats. Anesthesiology. 1990;72:1045-1050.
13. Hoffman WE, Miletich DJ, Albrecht RF, Anderson S. Regional cerebral blood flow measurement in rats with radioactive microspheres. Life Sci. 1983;33:1075-1080.
14. Reimers TJ, Lamb SV, Bartlett SA, Matamoros RA, Cowan RG, Engle JS. Effects of hemolysis and storage on quantification of hormones in blood samples from dogs, cattle, and horses. Am J Vet Res. 1991;52: 1075-1080.
15. Hoffman WE, Pelligrino D, Werner C, Kochs E, Albrecht RF, Schulte am Esch J. Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats. Anesthesiology. 1992; 76:755-762.
16. Pelligrino DA, Wang Q, Baughman VL. 17 β-Estradiol treatment in ovariectomized rats: effects on nitric oxide (NO)-dependent arteriolar dilation and NO synthase activity and expression in the brain. J Cereb Blood Flow Metab. 1997;17(suppl 1):S393. Abstract.
17. Siesjo BK, Katsura KI, Zhao Q, Folbergrova J, Pahlmark K, Siesjo P, Smith ML. Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma. 1995;12:943-956.
18. Holschneider DP, Scremin OU. Effects of ovariectomy on cerebral blood flow of rats. Neuroendocrinology. 1998;67:260-268.
19. Clark WM, Lauten JD, Lessov N, Woodward W, Coull BM. Time course of ICAM-1 expression and leukocyte subset infiltration in rat forebrain ischemia. Mol Chem Neuropathol. 1995;26:213-230.
20. Kondo Y, Asanuma M, Nishibayashi S, Iwata E, Ogawa N. Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain. Brain Res. 1997;772:37-44.
21. Endoh M, Maiese K, Wagner J. Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Res. 1994;651:92-100.
22. Gerhart DZ, Leino RL, Taylor WE, Borson ND, Drewes LR. GLUT1 and GLUT3 gene expression in gerbil brain following brief ischemia: an in situ hybridization study. Mol Brain Res. 1994;25:313-322.
23. McCall AL, Moholtsiebert M, Vanbueren A, Cherry NJ, Lessov N, Tiffany N, Thompson M, Downes H, Woodward WR. Progressive hippocampal loss of immunoreactive GLUT3, the neuron-specific glucose transporter, after global forebrain ischemia in the rat. Brain Res. 1995;670:29-38.
24. Schmidtkastner R, Fliss H, Hakim AM. Subtle neuronal death in striatum after short forebrain ischemia in rats detected by in situ end-labeling for DNA damage. Stroke. 1997;28:163-169.
25. Caulinglaser T, Watson CA, Pardi R, Bender JR. Effects of 17 beta- estradiol on cytokine-induced endothelial cell adhesion molecule expression. J Clin Invest. 1996;98:36-42.
26. Green PS, Gordon K, Simpkins JW. Phenolic a ring requirement for the neuroprotective effects of steroids. J Steroid Biochem Mol Biol. 1997;63: 229-235.
27. Ayres S, Abplanalp W, Liu JH, Subbiah MR. Mechanisms involved in the protective effect of estradiol-17 beta on lipid peroxidation and DNA damage. Am J Physiol. 1998;274:E1002-E1008.
28. Shi J, Zhang YQ, Simpkins JW. Effects of 17 beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats. Exp Brain Res. 1997;117:200-206.
29. Mattson MP, Robinson N, Guo Q. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1. Neuroreport. 1997;8:3817-3821.
30. Garcia-Segura LM, Cardona-Gomez P, Naftolin F, Chowen JA. Estradiol upregulates Bcl-2 expression in adult brain neurons. Neuroreport. 1998; 9:593-597.
31. Wong M, Thompson TL, Moss RL. Nongenomic actions of estrogen in the brain: physiological significance and cellular mechanisms. Crit Rev Neurobiol. 1996;10:189-203.
32. Toung TK, Traystman RJ, Hurn PD. Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke. 1998;29:1666-1670.
33. Green PS, Gridley KE, Simpkins JW. Nuclear estrogen receptor- independent neuroprotection by estratrienes: a novel interaction with glutathione. Neuroscience. 1998;84:7-10.
34. Kume-Kick J, Rice ME. Estrogen-dependent modulation of rat brain ascorbate levels and ischemia-induced ascorbate loss. Brain Res. 1998; 803:105-113.
35. Singer CA, Rogers KL, Strickland TM, Dorsa DM. Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci Lett. 1996; 212:13-16.
36. Gonzalez-Vidal MD, Cervera-Gaviria M, Ruelas R, Escobar A, Morali G, Cervantes M. Progesterone: protective effects on the cat hippocampal neuronal damage due to acute global cerebral ischemia. Arch Med Res. 1998;29:117-124.
37. Jiang N, Chopp M, Stein DG, Feit H. Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res. 1996;735:101-107.