G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane

Biochemical and Biophysical Research Communications

Volumn 346, Issue 3, 2006, Pages 904-910

  Funakoshi, Takeshi ^a,b   Yanai, Akie ^c   Shinoda, Koh ^c   Kawano, Michio M ^b   Mizukami, Yoichi ^a  

^a YAMAGUCHI UNIVERSITY   (Japan)

^b YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Estrogen; G protein coupled receptor 30; Membrane localization

Indexed keywords

EPITOPE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 30; MEMBRANE RECEPTOR; POLYCLONAL ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CELL MEMBRANE; CELL STIMULATION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; FEMALE; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; RAT; TRANSMISSION ELECTRON MICROSCOPY; UTERINE CERVIX CANCER;

ANIMALS; ANTIBODIES; BRAIN; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; ESTROGENS; HUMANS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, IMMUNOELECTRON; RATS; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED;

EID: 33745207541     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.05.191     Document Type: Article

References (42)

1. Civelli O., Nothacker H.P., Saito Y., Wang Z., Lin S.H., and Reinscheid R.K. Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. Trends Neurosci. 24 (2001) 230-237
2. Marchese A., George S.R., Kolakowski Jr. L.F., Lynch K.R., and O'Dowd B.F. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol. Sci. 20 (1999) 370-375
3. Kojima M., Hosoda H., Matsuo H., and Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol. Metab. 12 (2001) 118-122
4. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richarson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 1 page following 696
5. Zhang J.V., Ren P.G., Avsian-Kretchmer O., Luo C.W., Rauch R., Klein C., and Hsueh A.J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310 (2005) 996-999
6. Ribeiro J.A., Sebastiao A.M., and de Mendonca A. Participation of adenosine receptors in neuroprotection. Drug News Perspect. 16 (2003) 80-86
7. Saito Y., Nothacker H.P., Wang Z., Lin S.H., Leslie F., and Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400 (1999) 265-269
8. Monastyrskaya K., Hostettler A., Buergi S., and Draeger A. The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity. J. Biol. Chem. 280 (2005) 7135-7146
9. Manabe T., Noda Y., Mamiya T., Katagiri H., Houtani T., Nishi M., Noda T., Takahashi T., Sugimoto T., Nabeshima T., and Takeshima H. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature 394 (1998) 577-581
10. Reinscheid R.K., Nothacker H.P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma Jr. F.J., and Civelli O. Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science 270 (1995) 792-794
11. Dryer L., and Berghard A. Odorant receptors: a plethora of G-protein-coupled receptors. Trends Pharmacol. Sci. 20 (1999) 413-417
12. Malnic B., Hirono J., Sato T., and Buck L.B. Combinatorial receptor codes for odors. Cell 96 (1999) 713-723
13. Yokomizo T., Kato K., Terawaki K., Izumi T., and Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192 (2000) 421-432
14. Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., Milstien S., and Spiegel S. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 291 (2001) 1800-1803
15. Drews J. Genomic sciences and the medicine of tomorrow. Nat. Biotechnol. 14 (1996) 1516-1518
16. Kimura M., Mizukami Y., Miura T., Fujimoto K., Kobayashi S., and Matsuzaki M. Orphan G protein-coupled receptor, GPR41, induces apoptosis via a p53/Bax pathway during ischemic hypoxia and reoxygenation. J. Biol. Chem. 276 (2001) 26453-26460
17. Takada Y., Kato C., Kondo S., Korenaga R., and Ando J. Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. Biochem. Biophys. Res. Commun. 240 (1997) 737-741
18. Carmeci C., Thompson D.A., Ring H.Z., Francke U., and Weigel R.J. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 45 (1997) 607-617
19. Owman C., Blay P., Nilsson C., and Lolait S.J. Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues. Biochem. Biophys. Res. Commun. 228 (1996) 285-292
20. Filardo E.J., Quinn J.A., Bland K.I., and Frackelton Jr. A.R. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol. Endocrinol. 14 (2000) 1649-1660
21. Maggiolini M., Vivacqua A., Fasanella G., Recchia A.G., Sisci D., Pezzi V., Montanaro D., Musti A.M., Picard D., and Ando S. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J. Biol. Chem. 279 (2004) 27008-27016
22. Hasbi A., O'Dowd B.F., and George S.R. A g protein-coupled receptor for estrogen: the end of the search?. Mol. Interv. 5 (2005) 158-161
23. Rae J.M., and Johnson M.D. What does an orphan G-protein-coupled receptor have to do with estrogen?. Breast Cancer Res. 7 (2005) 243-244
24. Dowsett M., Folkerd E., Doody D., and Haynes B. The biology of steroid hormones and endocrine treatment of breast cancer. Breast 14 (2005) 452-457
25. Dubey R.K., Imthurn B., Barton M., and Jackson E.K. Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen. Cardiovasc Res. 66 (2005) 295-306
26. Brubaker K.D., and Gay C.V. Estrogen stimulates protein tyrosine phosphorylation and Src kinase activity in avian osteoclasts. J. Cell Biochem. 76 (1999) 206-216
27. Karpuzoglu E., Fenaux J.B., Phillips R.A., Lengi A.J., Elvinger F., and Ansar Ahmed S. Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-gamma. Endocrinology 147 (2006) 662-671
28. Morley P., Whitfield J.F., Vanderhyden B.C., Tsang B.K., and Schwartz J.L. A new, nongenomic estrogen action: the rapid release of intracellular calcium. Endocrinology 131 (1992) 1305-1312
29. Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., and Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307 (2005) 1625-1630
30. Thomas P., Pang Y., Filardo E.J., and Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 (2005) 624-632
31. Mizukami Y., Sumimoto H., Isobe R., Minakami S., and Takeshige K. omega-Oxidation of lipoxin B4 by rat liver. Identification of an omega-carboxy metabolite of lipoxin B4. Eur. J. Biochem. 224 (1994) 959-965
32. Mizukami Y., Iwamatsu A., Aki T., Kimura M., Nakamura K., Nao T., Okusa T., Matsuzaki M., Yoshida K., and Kobayashi S. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J. Biol. Chem. 279 (2004) 50120-50131
33. Mizukami Y., Kobayashi S., Uberall F., Hellbert K., Kobayashi N., and Yoshida K. Nuclear mitogen-activated protein kinase activation by protein kinase czeta during reoxygenation after ischemic hypoxia. J. Biol. Chem. 275 (2000) 19921-19927
34. Shinoda K., Nagano M., and Osawa Y. Neuronal aromatase expression in preoptic, strial, and amygdaloid regions during late prenatal and early postnatal development in the rat. J. Comp. Neurol. 343 (1994) 113-129
35. O'Dowd B.F., Nguyen T., Marchese A., Cheng R., Lynch K.R., Heng H.H., Kolakowski Jr. L.F., and George S.R. Discovery of three novel G-protein-coupled receptor genes. Genomics 47 (1998) 310-313
36. Feng Y., and Gregor P. Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. Biochem. Biophys. Res. Commun. 231 (1997) 651-654
37. Haynes M.P., Sinha D., Russell K.S., Collinge M., Fulton D., Morales-Ruiz M., Sessa W.C., and Bender J.R. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ. Res. 87 (2000) 677-682
38. Vivacqua A., Bonofiglio D., Recchia A.G., Musti A.M., Picard D., Ando S., and Maggiolini M. The G protein-coupled receptor gpr30 mediates the proliferative effects induced by 17{rbeta}-estradiol and hydroxytamoxifen in endometrial cancer cells. Mol. Endocrinol. (2005)
39. Filardo E.J., and Thomas P. GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol. Metab. 16 (2005) 362-367
40. Ahola T.M., Manninen T., Alkio N., and Ylikomi T. G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells. Endocrinology 143 (2002) 3376-3384
41. Ahola T.M., Purmonen S., Pennanen P., Zhuang Y.H., Tuohimaa P., and Ylikomi T. Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells. Eur. J. Biochem. 269 (2002) 2485-2490
42. Song L., De Sarno P., and Jope R.S. Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J. Biol. Chem. 277 (2002) 44701-44708