Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia

Brain Research

Volumn 1008, Issue 2, 2004, Pages 147-154

  Wen, Yi ^a   Yang, Shaohua ^a   Liu, Ran ^a   Perez, Evelyn ^a   Yi, Kun Don ^a   Koulen, Peter ^a   Simpkins, James W ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Disorders of the nervous system; Estrogen; Ischemia; Neuroprotection; NF B; Post ischemic inflammation; Stroke

Indexed keywords

ESTRADIOL; ESTROGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN ACTIVITY; FEMALE; IMMUNE RESPONSE; INFLAMMATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ACTINS; ANIMALS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CELL DEATH; DENSITOMETRY; DNA FRAGMENTATION; ESTRADIOL; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION MEDIATORS; ISCHEMIC ATTACK, TRANSIENT; MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 2442534125     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.02.019     Document Type: Article

References (41)

1. Asthana S., Craft S., Baker L.D., Raskind M.A., Birnbaum R.S., Lofgreen C.P., Veith R.C., Plymate S.R. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology. 24:1999;657-677
2. Atwood W.J., Tornatore C.S., Traub R., Conant K., Drew P.D., Major E.O. Stimulation of HIV type 1 gene expression and induction of NF-kappa B (p50/p65)-binding activity in tumor necrosis factor alpha-treated human fetal glial cells. AIDS Res. Hum. Retrovir. 10:1994;1207-1211
3. Azcoitia I., Garcia-Ovejero D., Chowen J.A., Garcia-Segura L.M. Astroglia play a key role in the neuroprotective actions of estrogen. Prog. Brain Res. 132:2001;469-478
4. Baeuerle P.A., Baltimore D. NF-kappa B: ten years after. Cell. 87:1996;13-20
5. Berti R., Williams A.J., Moffett J.R., Hale S.L., Velarde L.C., Elliott P.J., Yao C., Dave J.R., Tortella F.C. Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury. J. Cereb. Blood Flow Metab. 22:2002;1068-1079
6. Carroll J.E., Howard E.F., Hess D.C., Wakade C.G., Chen Q., Cheng C. Nuclear factor-kappa B activation during cerebral reperfusion: effect of attenuation with N-acetylcysteine treatment. Brain Res. Mol. Brain Res. 56:1998;186-191
7. Carroll J.E., Hess D.C., Howard E.F., Hill W.D. Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury? NeuroReport. 11:2000;R1-R4
8. Christensen H., Boysen G., Johannesen H.H., Christensen E., Bendtzen K. Deteriorating ischaemic stroke. Cytokines, soluble cytokine receptors, ferritin, systemic blood pressure, body temperature, blood glucose, diabetes, stroke severity, and CT infarction-volume as predictors of deteriorating ischaemic stroke. J. Neurol. Sci. 201:2002;1-7
9. Connolly E.S. Jr., Winfree C.J., Springer T.A., Naka Y., Liao H., Yan S.D., Stern D.M., Solomon R.A., Gutierrez-Ramos J.C., Pinsky D.J. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J. Clin. Invest. 97:1996;209-216
10. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22:1999;391-397
11. Dubal D.B., Kashon M.L., Pettigrew L.C., Ren J.M., Finklestein S.P., Rau S.W., Wise P.M. Estradiol protects against ischemic injury. J. Cereb. Blood Flow Metab. 18:1998;1253-1258
12. Dubal D.B., Wilson M.E., Wise P.M. Estradiol: a protective and trophic factor in the brain. J. Alzheimer's Dis. 1:1999;265-274
13. Dudek E.J., Shang F., Taylor A. H(2)O(2)-mediated oxidative stress activates NF-kappa B in lens epithelial cells. Free Radic. Biol. Med. 31:2001;651-658
14. Emsley H.C., Tyrrell P.J. Inflammation and infection in clinical stroke. J. Cereb. Blood Flow Metab. 22:2002;1399-1419
15. Galea E., Santizo R., Feinstein D.L., Adamsom P., Greenwood J., Koenig H.M., Pelligrino D.A. Estrogen inhibits NF kappa B-dependent inflammation in brain endothelium without interfering with I kappa B degradation. NeuroReport. 13:2002;1469-1472
16. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501
17. Green P.S., Simpkins J.W. Neuroprotective effects of estrogens: potential mechanisms of action. Int. J. Dev. Neurosci. 18:2000;347-358
18. He Z., He Y.J., Day A.L., Simpkins J.W. Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: perfusion-dependent and -independent mechanisms. J. Neurol. Sci. 193:2002;79-87
19. Lindamer L.A., Lohr J.B., Harris M.J., McAdams L.A., Jeste D.V. Gender-related clinical differences in older patients with schizophrenia. J. Clin. Psychiatry. 60:1999;61-67. (quiz 68-69)
20. Lo E.H., Dalkara T., Moskowitz M.A. Mechanisms, challenges and opportunities in stroke. Nat. Rev., Neurosci. 4:2003;399-415
21. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-91
22. Maruyama S., Fujimoto N., Asano K., Ito A. Suppression by estrogen receptor beta of AP-1 mediated transactivation through estrogen receptor alpha. J. Steroid Biochem. Mol. Biol. 78:2001;177-184
23. Matthews J.R., Hay R.T. Regulation of the DNA binding activity of NF-kappa B. Int. J. Biochem. Cell Biol. 27:1995;865-879
24. Mattson M.P., Camandola S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107:2001;247-254
25. Mattson M.P., Goodman Y., Luo H., Fu W., Furukawa K. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49:1997;681-697
26. Mattson M.P., Culmsee C., Yu Z., Camandola S. Roles of nuclear factor kappaB in neuronal survival and plasticity. J. Neurochem. 74:2000;443-456
27. Menzies S.A., Hoff J.T., Betz A.L. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery. 31:1992;100-106. (discussion 106-107)
28. Moynagh P.N., Williams D.C., O'Neill L.A. Interleukin-1 activates transcription factor NF kappa B in glial cells. Biochem. J. 294(Pt. 2):1993;343-347
29. O'Neill L.A., Kaltschmidt C. NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20:1997;252-258
30. Paganini-Hill A., Ross R.K., Henderson B.E. Postmenopausal oestrogen treatment and stroke: a prospective study. BMJ. 297:1988;519-522
31. Pelligrino D.A., Galea E. Estrogen and cerebrovascular physiology and pathophysiology. Jpn. J. Pharmacol. 86:2001;137-158
32. Persky A.M., Green P.S., Stubley L., Howell C.O., Zaulyanov L., Brazeau G.A., Simpkins J.W. Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro. Proc. Soc. Exp. Biol. Med. 223:2000;59-66
33. Rupec R.A., Baeuerle P.A. The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B. Eur. J. Biochem. 234:1995;632-640
34. Rusa R., Alkayed N.J., Crain B.J., Traystman R.J., Kimes A.S., London E.D., Klaus J.A., Hurn P.D. 17beta-estradiol reduces stroke injury in estrogen-deficient female animals. Stroke. 30:1999;1665-1670
35. Schneider A., Martin-Villalba A., Weih F., Vogel J., Wirth T., Schwaninger M. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat. Med. 5:1999;554-559
36. Seeman M.V. Psychopathology in women and men: focus on female hormones. Am. J. Psychiatry. 154:1997;1641-1647
37. Shepherd J.E. Effects of estrogen on cognition mood, and degenerative brain diseases. J. Am. Pharm. Assoc. (Wash.). 41:2001;221-228
38. Simpkins J.W., Rajakumar G., Zhang Y.Q., Simpkins C.E., Greenwald D., Yu C.J., Bodor N., Day A.L. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J. Neurosurg. 87:1997;724-730
39. Williams A.J., Hale S.L., Moffett J.R., Dave J.R., Elliott P.J., Adams J., Tortella F.C. Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-kappaB activation, gliosis, and leukocyte infiltration. J. Cereb. Blood Flow Metab. 23:2003;75-87
40. Wise P.M., Dubal D.B., Wilson M.E., Rau S.W., Bottner M. Minireview: neuroprotective effects of estrogen - new insights into mechanisms of action. Endocrinology. 142:2001;969-973
41. Yang S.H., He Z., Wu S.S., He Y.J., Cutright J., Millard W.J., Day A.L., Simpkins J.W. 17-beta estradiol can reduce secondary ischemic damage and mortality of subarachnoid hemorrhage. J. Cereb. Blood Flow Metab. 21:2001;174-181