2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways

Biochemical Pharmacology

Volumn 79, Issue 6, 2010, Pages 825-841

  Ting, C M ^a   Lee, Y M ^a   Wong, C K C ^a   Wong, A S ^b   Lung, H L ^b   Lung, M L ^b   Lo, K W ^c   Wong, R N S ^a   Mak, N K ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

2 Methoxyestradiol; Endoreduplication; MAPK signaling pathways; Mitochondria; Nasopharyngeal carcinoma; Oxidative stress

Indexed keywords

2 METHOXYESTRADIOL; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TUBULIN;

ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMOSOME NUMBER; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; ENDOREDUPLICATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; NASOPHARYNX CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ESTRADIOL; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; OXIDATIVE STRESS; TUBULIN MODULATORS;

EID: 74149083977     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.10.018     Document Type: Article

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