Molecular diversity and functional evolution of scorpion potassium channel toxins

Molecular and Cellular Proteomics

Volumn 10, Issue 2, 2011, Pages

  Zhu, Shunyi ^a   Peigneur, Steve ^b   Gao, Bin ^a   Luo, Lan ^a   Jin, Di ^a   Zhao, Yong ^a   Tytgat, Jan ^b  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN ALPHA 1; MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN ALPHA 2; MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN ALPHA 3; MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN ALPHA 4; MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN ALPHA 5; MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN BETA 3; MESOBUTHUS EUPEUS POTASSIUM CHANNEL TOXIN BETA 4; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; SCORPION VENOM; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; ERG1 POTASSIUM CHANNEL;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN CELL; IC 50; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCORPION; T LYMPHOCYTE; TOXIN ANALYSIS; ANIMAL; C57BL MOUSE; CHEMISTRY; DROSOPHILA; GENE LIBRARY; GENETICS; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE; OOCYTE; SEQUENCE HOMOLOGY; XENOPUS;

MESOBUTHUS EUPEUS; MESOBUTHUS MARTENSII; SCORPIONES;

AMINO ACID SEQUENCE; ANIMALS; DNA, COMPLEMENTARY; DROSOPHILA; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE LIBRARY; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OOCYTES; POTASSIUM CHANNELS; SCORPION VENOMS; SCORPIONS; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

EID: 79953217737     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M110.002832     Document Type: Article

References (41)

1. Shieh, C. C., Coghlan, M., Sullivan, J. P., and Gopalakrishnan, M. (2000) Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol. Rev. 52, 557-594
2. Wulff, H., Castle, N. A., and Pardo, L. A. (2009) Voltage-gated potassium channels as therapeutic targets. Nat. Rev. Drug Discov. 8, 982-1001
3. +-channels. Eur. J. Biochem. 264, 287-300
4. Tytgat, J., Chandy, K. G., Garcia, M. L., Gutman, G. A., Martin-Eauclaire, M. F., van der Walt, J. J., and Possani, L. D. (1999) A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol. Sci. 20, 444-447
5. + channels isolated from Centruroides noxius scorpion venom. FASEB J. 13, 953-962
6. Srinivasan, K. N., Sivaraja, V., Huys, I., Sasaki, T., Cheng, B., Kumar, T. K., Sato, K., Tytgat, J., Yu, C., San, B. C., Ranganathan, S., Bowie, H. J., Kini, R. M., and Gopalakrishnakone, P. (2002) κ-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity. J. Biol. Chem. 277, 30040-30047
7. Bontems, F., Roumestand, C., Gilquin, B., Ménez, A., and Toma, F. (1991) Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins. Science 254, 1521-1523 (Pubitemid 21917495)
8. +-channels. Toxicon 43, 865-875
9. Dauplais, M., Lecoq, A., Song, J., Cotton, J., Jamin, N., Gilquin, B., Roumestand, C., Vita, C., de Medeiros, C. L., Rowan, E. G., Harvey, A. L., and Ménez, A. (1997) On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channelblocking toxins with unrelated structures. J. Biol. Chem. 272, 4302-4309
10. Diego-García, E., Schwartz, E. F., D'Suze, G., González, S. A., Batista, C. V., García, B. I., de la Vega, R. C., and Possani, L. D. (2007) Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of "orphan" components. Peptides 28, 31-37
11. Cao, Z., Xiao, F., Peng, F., Jiang, D., Mao, X., Liu, H., Li, W., Hu, D., and Wang, T. (2003) Expression, purification and functional characterization of a recombinant scorpion venom peptide BmTXKβ. Peptides 24, 187-192 (Pubitemid 36369337)
12. Zhu, S., and Gao, B. (2006) Molecular characterization of a new scorpion venom lipolysis activating peptide: evidence for disulfide bridge-mediated functional switch of peptides. FEBS Lett. 580, 6825-6836 (Pubitemid 44909123)
13. Koradi, R., Billeter, M., and Wüthrich, K. (1996) MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14, 51-55, 29-32
14. Zhu, S., Gao, B., Aumelas, A., del Carmen Rodríguez, M., Lanz-Mendoza, H., Peigneur, S., Diego-Garcia, E., Martin-Eauclaire, M. F., Tytgat, J., and Possani, L. D. (2010) MeuTXKβ1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity. Biochim. Biophys. Acta 1804, 872-883
15. Goudet, C., Chi, C. W., and Tytgat, J. (2002) An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon 40, 1239-1258 (Pubitemid 35239894)
16. + channel determined by construction of multimeric cDNAs. Neuron 9, 861-871
17. + regulatory T cells in mice. Transplantation 82, 1484-1492
18. Corzo, G., Papp, F., Varga, Z., Barraza, O., Espino-Solis, P. G., Rodríguez de la Vega, R. C., Gaspar, R., Panyi, G., and Possani, L. D. (2008) A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus. Biochem. Pharmacol. 76, 1142-1154
19. + channels. Eur. J. Biochem. 245, 457-464
20. Buisine, E., Wieruszeski, J. M., Lippens, G., Wouters, D., Tartar, A., and Sautiere, P. (1997) Characterization of a new family of toxin-like peptides from the venom of the scorpion Leiurus quinquestriatus hebraeus. 1H-NMR structure of leiuropeptide II. J. Pept. Res. 49, 545-555
21. Abdel-Mottaleb, Y., Clynen, E., Jalali, A., Bosmans, F., Vatanpour, H., Schoofs, L., and Tytgat, J. (2006) The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae. FEBS Lett. 580, 6254-6258 (Pubitemid 44679765)
22. Thompson, C. H., Olivetti, P. R., Fuller, M. D., Freeman, C. S., McMaster, D., French, R. J., Pohl, J., Kubanek, J., and McCarty, N. A. (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J. Biol. Chem. 284, 26051-26062
23. Gmachl, M., and Kreil, G. (1995) The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3′-exon. J. Biol. Chem. 270, 12704-12708
24. Gauldie, J., Hanson, J. M., Rumjanek, F. D., Shipolini, R. A., and Vernon, C. A. (1976) The peptide components of bee venom. Eur. J. Biochem. 61, 369-376
25. +-channel blocker from scorpion venom. Biochem. Biophys. Res. Commun. 360, 728-734
26. + channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. Cell. Mol. Life Sci. 65, 187-200
27. Korolkova, Y. V., Kozlov, S. A., Lipkin, A. V., Pluzhnikov, K. A., Hadley, J. K., Filippov, A. K., Brown, D. A., Angelo, K., Strøbaek, D., Jespersen, T., Olesen, S. P., Jensen, B. S., and Grishin, E. V. (2001) An ERG channel inhibitor from the scorpion Buthus eupeus. J. Biol. Chem. 276, 9868-9876
28. Gao, B., Peigneur, S., Tytgat, J., and Zhu, S. (August 14, 2010) A potent potassium channel blocker from Mesobuthus eupeus scorpion venom. Biochimie 10.1016/j.biochi.2010.08.003
29. Possani, L. D., Merino, E., Corona, M., Bolivar, F., and Becerril, B. (2000) Peptides and genes coding for scorpion toxins that affect ion-channels. Biochimie 82, 861-868
30. Han, S., Yi, H., Yin, S. J., Chen, Z. Y., Liu, H., Cao, Z. J., Wu, Y. L., and Li, W. X. (2008) Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J. Biol. Chem. 283, 19058-19065
31. + channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem. J. 385, 95-104
32. Abdel-Mottaleb, Y., Vandendriessche, T., Clynen, E., Landuyt, B., Jalali, A., Vatanpour, H., Schoofs, L., and Tytgat, J. (2008) OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae. Toxicon 51, 1424-1430
33. Takacs, Z., Toups, M., Kollewe, A., Johnson, E., Cuello, L. G., Driessens, G., Biancalana, M., Koide, A., Ponte, C. G., Perozo, E., Gajewski, T. F., Suarez-Kurtz, G., Koide, S., and Goldstein, S. A. (2009) A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc. Natl. Acad. Sci. U.S.A. 106, 22211-22216
34. Regaya, I., Beeton, C., Ferrat, G., Andreotti, N., Darbon, H., De Waard, M., and Sabatier, J. M. (2004) Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J. Biol. Chem. 279, 55690-55696
35. Abbas, N., Belghazi, M., Abdel-Mottaleb, Y., Tytgat, J., Bougis, P. E., and Martin-Eauclaire, M. F. (2008) A new kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes. Biochem. Biophys. Res. Commun. 376, 525-530
36. MacKinnon, R., Cohen, S. L., Kuo, A., Lee, A., and Chait, B. T. (1998) Structural conservation in prokaryotic and eukaryotic potassium channels. Science 280, 106-109
37. Wu, G., Li, Y., Wei, D., He, F., Jiang, S., Hu, G., and Wu, H. (2000) Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch. Biochem. Biophys. Res. Commun. 276, 1148-1154
38. Yin, S. J., Jiang, L., Yi, H., Han, S., Yang, D. W., Liu, M. L., Liu, H., Cao, Z. J., Wu, Y. L., and Li, W. X. (2008) Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. J. Proteome Res. 7, 4890-4897
39. Garcia, M. L., Gao, Y., McManus, O. B., and Kaczorowski, G. J. (2001) Potassium channels: from scorpion venoms to high-resolution structure. Toxicon 39, 739-748 (Pubitemid 32012939)
40. +-channels. Perspect. Drug Discov. Des. 15/16, 15-40
41. + channels. Eur. J. Biochem. 242, 491-498