Molecular characterization of a new scorpion venom lipolysis activating peptide: Evidence for disulfide bridge-mediated functional switch of peptides

FEBS Letters

Volumn 580, Issue 30, 2006, Pages 6825-6836

  Zhu, S ^a   Gao, B ^a  

^a INSTITUTE OF ZOOLOGY   (China)

Author keywords

Adipocyte lipolysis; Buthus martensii; Functional switch; Genetic diversity; Heterodimer; Neurotoxin; Sodium channel

Indexed keywords

BUTHUS MARTENSII LIKE VENOM PEPTIDE 1; COMPLEMENTARY DNA; DISULFIDE; HETERODIMER; PEPTIDE; SCORPION VENOM; STRUCTURAL PROTEIN;

ADIPOCYTE; ARTICLE; BUTHUS OCCITANUS TUNETANUS; CHANNEL GATING; GENE IDENTIFICATION; GENE ISOLATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC LINKAGE; GENETIC TRAIT; LIPOLYSIS; MOLECULAR CLONING; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN STRUCTURE; RNA EDITING; SCORPION; TOXIN STRUCTURE;

ADENINE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DISULFIDES; DNA, COMPLEMENTARY; LIPOLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RNA EDITING; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; STRUCTURAL HOMOLOGY, PROTEIN; TRANSCRIPTION, GENETIC;

BUTHUS OCCITANUS TUNETANUS; MESOBUTHUS MARTENSII; SCORPIONES;

EID: 33845441749     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.11.040     Document Type: Article

References (53)

1. +-channels. Eur. J. Biochem. 264 (1999) 287-300
2. +-channels. Toxicon 43 (2004) 865-875
3. + channels and related peptides: biodiversity, structure-function relationships and evolution. Toxicon 46 (2005) 831-844
4. Goudet C., Chi C.W., and Tytgat J. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon 40 (2002) 1239-1258
5. Soudani N., Gharbi-Chihi J., Srairi-Abid N., Yazidi C.M., Planells R., Margotat A., Torresani J., and Ayeb M.E. Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus. Biochim. Biophys. Acta 1747 (2005) 47-56
6. Catterall W.A. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels. Neuron 26 (2000) 13-25
7. Lopreato G.F., Lu Y., Southwell A., Atkinson N.S., Hillis D.M., Wilcox T.P., and Zakon H.H. Evolution and divergence of sodium channel genes in vertebrates. Proc. Natl. Acad. Sci. USA 98 (2001) 7588-7592
8. Cestéle S., and Catterall W.A. Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. Biochimie 82 (2000) 883-892
9. Lewis R.J., and Garcia M.L. Therapeutic potential of venom peptides. Nat. Rev. Drug Discov. 2 (2003) 790-802
10. He X.L., Li H.M., Zeng Z.H., Liu X.Q., Wang M., and Wang D.C. Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel. J. Mol. Biol. 292 (1999) 125-135
11. Zhu S., Gao B., and Tytgat J. Phylogenetic distribution, functional epitopes and evolution of the CSαβ superfamily. Cell. Mol. Life Sci. 62 (2005) 2257-2269
12. Gordon D., Gilles N., Bertrand D., Molgo J., Nicholson G.M., Sauviat M.P., Benoit E., Shichor I., Lotan I., Gurevitz M., Kallen R.G., and Heinemann S.H. In: Ménez A. (Ed). Perspectives in Molecular Toxinology (2002), Wiley, West Sussex 215-238
13. Gordon D., and Gurevitz M. The selectivity of scorpion α-toxins for sodium channel subtypes is determined by subtle variations at the interaction surface. Toxicon 41 (2003) 125-128
14. Zhu S., Bosmans F., and Tytgat J. Adaptive evolution of scorpion sodium channel toxins. J. Mol. Evol. 8 (2004) 145-153
15. Inceoglu B., Lango J., Wu J., Hawkins P., Southern J., and Hammock B.D. Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). Eur. J. Biochem. 268 (2001) 5407-5413
16. Karbat I., Frolow F., Froy O., Gilles N., Cohen L., Turkov M., Gordon D., and Gurevitz M. Molecular basis of the high insecticidal potency of scorpion α-toxins. J. Biol. Chem. 279 (2004) 31679-31686
17. Gurevitz M., Froy O., Zilberberg N., Turkov M., Strugatsky D., Gershburg E., Lee D., Adams M.E., Tugarinov V., Anglister J., Shaanan B., Loret E., Stankiewicz M., Pelhate M., Gordon D., and Chejanovsky N. Sodium channel modifiers from scorpion venom: structure-activity relationship, mode of action and application. Toxicon 36 (1998) 1671-1682
18. Valdez-Cruz N.A., Batista C.V.F., Zamudio F.Z., Bosmans F., Tytgat J., and Possani L.D. Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus. Eur. J. Biochem. 271 (2004) 4753-4761
19. Céard B., Martin-Eauclaire M., and Bougis P.E. Evidence for a position-specific deletion as an evolutionary link between long and short-chain scorpion toxins. FEBS Lett. 494 (2001) 246-248
20. + channels. Biochem. J. 388 (2005) 455-464
21. + channel toxin from Parabuthus transvaalicus. Eur. J. Biochem. 269 (2002) 5369-5376
22. Inceoglu B., Lango J., Pessah I.N., and Hammock B.D. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus posses divergent biological activity. Toxicon 45 (2005) 727-733
23. Zeng X., Luo F., and Li W. Molecular dissection of venom from Chinese scorpion Mesobuthus martensii: identification and characterization of four novel disulfide-bridged venom peptides. Peptides 27 (2006) 1745-1754
24. Martin-Eauclaire M.F., Ceard B., Bosmans F., Rosso J.P., Tytgat J., and Bougis P.E. New "Birtoxin analogs" from Androctonus australis venom. Biochem. Biophys. Res. Commun. 333 (2005) 524-530
25. Zhu S., and Gao B. Molecular characterization of a possible progenitor sodium channel toxin from the Old World scorpion Mesobuthus martensii. FEBS Lett. 580 (2006) 5979-5987
26. Koslowsky D.J. A historical perspective on RNA editing: how the peculiar and bizarre became mainstream. In: Gott J.M. (Ed). Methods in Molecular Biology (2004), Humana Press Inc., Totowa, NJ 161-197
27. Keegan L.P., Gallo A., and O'Connel M.A. The many roles of an RNA editor. Nat. Genet. 2 (2001) 869-878
28. Hoopengardner B., Bhalla T., Staber C., and Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science 301 (2003) 832-836
29. Zhu S., Darbon H., Dyason K., Verdonck F., and Tytgat J. Evolutionary origin of inhibitor cystine knot peptides. FASEB J. 17 (2003) 1765-1767
30. Eisenberg D., Luthy R., and Bowie J.U. VERIFY3D: assessment of protein models with three-dimensional profiles. Methods Enzymol. 277 (1997) 396-404
31. Sippl M.J. Recognition of errors in three-dimensional structures of proteins. Proteins 17 (1993) 355-362
32. Guex N., and Peitsch M.C. Swiss-Pdb viewer: a fast and easy-to-use PDB viewer for Macintosh and PC. Prot. Data Bank Q. Newslett. 77 (1996) 7
33. Castrignanò T., De Meo P.D., Cozzetto D., Talamo I.G., and Tramontano A. The PMDB protein model database. Nucleic Acids Res. 34 (2006) D306-D309
34. Zhu S., and Li W. Precursors of three unique cysteine-rich peptides from the scorpion Buthus martensii Karsch. Comp. Biochem. Physiol. 131 (2002) 749-756
35. Matsumura H., Ikemura N., Ito Y., and Kuribayashi K. RNA editing-like phenomenon in paramyxovirus V gene mRNA observed in insect cells infected with a recombinant baculovirus. J. Gen. Virol. 80 (1999) 117-123
36. Zaki T.I., and Maruniak J.E. Three polymorphic genes encoding a depressant toxin from the Egyptian scorpion Leiurus quinquestriatus quinquestriatus. Toxicon 41 (2003) 109-113
37. Mueller J.L., Ripoll D.R., Aquadro C.F., and Wolfner M.F. Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid. Proc. Natl. Acad. Sci. USA 101 (2004) 13542-13547
38. Duret L., Guex N., Peitsch M.C., and Bairoch A. New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling. Genome Res. 8 (1998) 348-353
39. Srinivasan K.N., Sivaraja V., Huys I., Sasaki T., Cheng B., Kumar T.K., Sato K., Tytgat J., Yu C., San B.C., Ranganathan S., Bowie H.J., Kini R.M., and Gopalakrishnakone P. κ-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity. J. Biol. Chem. 277 (2002) 30040-30047
40. Cohen L., Karbat I., Gilles N., Ilan N., Benveniste M., Gordon D., and Gurevitz M. Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels. J. Biol. Chem. 280 (2005) 5045-5053
41. Krimm I., Gilles N., Sautière P., Stankiewicz M., Pelhate M., Gordon D., and Lancelin L.M. NMR structures and activity of a novel α-like toxin from the scorpion Leiurus quinquestriatus hebraeus. J. Mol. Biol. 285 (1999) 1749-1763
42. + channel selectivity of the scorpion α-like toxin BmK M1. J. Mol. Biol. 353 (2005) 788-803
43. Hogg P.J. Disulfide bonds as switches for protein function. Trends Biochem. Sci. 28 (2003) 210-214
44. Hu X., Yagi Y., Tanji T., Zhou S., and Ip Y.T. Multimerization and interaction of Toll and Spatzle in Drosophila. Proc. Natl. Acad. Sci. USA 101 (2004) 9369-9374
45. Sun Y.M., Liu W., Zhu R.H., Goudet C., Tytgat J., and Wang D.C. Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis. J. Pept. Res. 60 (2002) 247-256
46. Zhu S., Huys I., Dyason K., Verdonck F., and Tytgat J. Evolutionary trace analysis of scorpion toxins specific for K-channels. PROTEINS 54 (2004) 361-370
47. Gurevitz M., Gordon D., Ben-Natan S., Turkov M., and Froy O. Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival. FASEB J. 15 (2001) 1201-1205
48. Yao J., Chen X., Li H., Zhou Y., Yao L., Wu G., Chen X., Zhang N., Zhou Z., Xu T., Wu H., and Ding J. BmP09, a ̈long chain̈ scorpion peptide blocker of BK channels. J. Biol. Chem. 280 (2005) 14819-14828
49. Blanc V., and Davidson N.O. C-to-U RNA editing: mechanisms leading to genetic diversity. J. Biol. Chem. 278 (2003) 1395-1398
50. Palladino M.J., Keegan L.P., O'Connell M.A., and Reenan R.A. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102 (2000) 437-449
51. + channel transcript. Evolutionary conservation and developmental regulation. Genetics 155 (2000) 1149-1160
52. Song W., Liu Z., Tan J., Nomura Y., and Dong K. RNA editing generates tissue-specific sodium channels with distinct gating properties. J. Biol. Chem. 279 (2004) 32554-32561
53. Liu Z., Song W., and Dong K. Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. Proc. Natl. Acad. Sci. USA 101 (2004) 11862-11867