Potassium channels: From scorpion venoms to high-resolution structure

Toxicon

Volumn 39, Issue 6, 2001, Pages 739-748

  Garcia, M L ^a   Gao, Ying Duo ^a   McManus, O B ^a   Kaczorowski, G J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN SUBUNIT; SCORPION VENOM;

AMINO ACID SEQUENCE; BINDING AFFINITY; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

SCORPIONES;

EID: 0035184148     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00214-2     Document Type: Short Survey

References (46)

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3. Refined structure of charybdotoxin: Common motifs in scorpion toxins and insect defensins
4. + channel
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6. + conduction and selectivity
7. Kaliotoxin (1-37) shows structural differences with related potassium channel blockers
8. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus
9. + channels from Leiurus quinquestriatus var. hebraeus venom
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11. Pharmacology of high-conductance calcium-activated potassium channels
12. Charybdotoxin and its effects on potassium channels
13. Purification and reconstitution of the high-conductance calcium-activated potassium channel from tracheal smooth muscle
14. Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels
15. Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle
16. + channel
17. + channel: Peptide and channel residues mediating molecular recognition
18. Transfer of the scorpion toxin receptor to an insensitive potassium channel
19. Agitoxin footprinting the Shaker potassium channel pore
20. v1 family potassium channels. Mapping the domains of high affinity interaction
21. + channels. Functional asymmetries and sidedness of proton activation
22. + channel signature sequence
23. The aromatic binding site for tetraethylammonium ion on potassium channels
24. + channel pore through mutant cycles with a peptide inhibitor
25. 15N triple-resonance nuclear magnetic resonance spectroscopy
26. 1H nuclear magnetic resonance spectroscopy
27. Solution structure of the potassium channel inhibitor agitoxin 2: Caliper for probing channel geometry
28. Determination of the subunit stoichiometry of a voltage-activated potassium channel
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30. + channel
31. + channel by trimethyloxonium
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33. Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor
34. + channel by charybdotoxin and tetraethylammonium
35. + channels from mammalian skeletal muscle
36. + channels
37. + channel
38. Mapping function to structure in a channel-blocking peptide: Electrostatic mutants of charybdotoxin
39. + channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann
40. + channel selectivity filter by mutant cycle-based structure analysis
41. + channels
42. Synthesis and characterization of kaliotoxin
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44. + channel structure from a complete functional map of the molecular surface of charybdotoxin
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46. + channel with quaternary ammonium ions