Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kvl.3 channels

Journal of Proteome Research

Volumn 7, Issue 11, 2008, Pages 4890-4897

  Yin, Shi Jin ^a   Jiang, Ling ^b   Yi, Hong ^a   Han, Song ^c   Yang, Dai Wen ^b   Liu, Mai Li ^a   Liu, Hui ^a   Cao, Zhi Jian ^a   Wu, Ying Liang ^a   Li, Wen Xin ^a  

^a WUHAN UNIVERSITY   (China)

^b Wuhan National Laboratory for Optoelectronics   (China)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

ADWX 1 peptide selectivity; Channel turret; Kv1.1 channel; Kv1.3 channel; Structural basis

Indexed keywords

ADWX 1 PEPTIDE INHIBITOR; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.3; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; AMINO ACID; DISULFIDE; OLIGOPEPTIDE; POTASSIUM CHANNEL BLOCKING AGENT;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DOSE RESPONSE; DRUG ANTAGONISM; GENETICS; HYDROGEN BOND; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; COMPUTER SIMULATION; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN BONDING; KV1.1 POTASSIUM CHANNEL; KV1.3 POTASSIUM CHANNEL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 58149377754     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr800494a     Document Type: Article

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