A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 52, 2009, Pages 22211-22216

  Takacs, Zoltan ^a   Toups, Megan ^a   Kollewe, Astrid ^a   Johnson, Erik ^a   Cuello, Luis G ^b   Driessens, Gregory ^c   Biancalana, Matthew ^b   Koide, Akiko ^b   Ponte, Cristiano G ^d   Perozo, Eduardo ^b   Gajewski, Thomas F ^c   Suarez Kurtz, Guilherme ^e   Koide, Shohei ^b   Goldstein, Steve A N ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b THE UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d Instituto Federal do Rio de Janeiro   (Brazil)

^e INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

Animal venom; Moka1; Mokatoxin; Peptide toxin; Phage display

Indexed keywords

IMMUNOMODULATING AGENT; MOKATOXIN 1; NEUROTOXIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.3; SCORPION VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CD3+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS REACTION; CYTOKINE RELEASE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL MOTILITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; T LYMPHOCYTE ACTIVATION; TOXIN SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; CYTOKINES; DRUG DESIGN; FEMALE; HUMANS; KV1.3 POTASSIUM CHANNEL; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROTOXINS; OOCYTES; PEPTIDE LIBRARY; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; PROTEIN ENGINEERING; RATS; RECOMBINANT PROTEINS; SCORPION VENOMS; T-LYMPHOCYTES; XENOPUS LAEVIS;

ANIMALIA; SCORPIONES;

EID: 76049087915     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910123106     Document Type: Article

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