The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae

FEBS Letters

Volumn 580, Issue 26, 2006, Pages 6254-6258

  Abdel Mottaleb, Yousra ^a   Clynen, Elke ^a   Jalali, Amir ^b   Bosmans, Frank ^a   Vatanpour, Hossein ^b   Schoofs, Liliane ^a   Tytgat, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

KTx 8.5; Odonthubuthus doriae; Voltage gated K+ channels

Indexed keywords

AMINO ACID; CYSTEINE; ODONTHOBUTHUS DORIAE POTASSIUM CHANNEL TOXIN; POTASSIUM CHANNEL; SCORPION VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; NONHUMAN; ODOTHOBUTHUS DORIAE; OOCYTE; PRIORITY JOURNAL; PURIFICATION; SCORPION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TOXIN ANALYSIS; XENOPUS LAEVIS;

ANIMALS; ELECTROPHYSIOLOGY; INHIBITORY CONCENTRATION 50; OOCYTES; POTASSIUM; POTASSIUM CHANNELS; SCORPION VENOMS; SEQUENCE ALIGNMENT; TRANSFECTION; XENOPUS LAEVIS;

SCORPIONES; VERTEBRATA; XENOPUS LAEVIS;

EID: 33750595669     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.10.029     Document Type: Article

References (24)

1. + channels. Ann. N. Y. Acad. Sci. 868 (1999) 233-285
2. +-channels. Toxicon 43 8 (2004) 865-875
3. Mouhat S., et al. Diversity of folds in animal toxins acting on ion channels. Biochem. J. 378 Pt 3 (2004) 717-726
4. Zhu S., Gao B., and Tytgat J. Phylogenetic distribution, functional epitopes and evolution of the CSalphabeta superfamily. Cell Mol. Life Sci. 62 19-20 (2005) 2257-2269
5. Tytgat J., et al. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol. Sci. 20 11 (1999) 444-447
6. Abdel-Mottaleb Y., et al. A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily. FEBS Lett. 580 2 (2006) 592-596
7. Jalali A., et al. OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett. 579 19 (2005) 4181-4186
8. Maertens C., et al. Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol. Pharmacol. 70 1 (2006) 405-414
9. Altschul S.F., Madden T.L., Schuffer A.A., Zhang J., Miller W., and Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25 (1997) 3389-3402
10. Guex N., and Peitsch M.C. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18 15 (1997) 2714-2723
11. Peitsch M.C. Protein modeling by E-mail. Bio/Technology 13 (1995) 658-660
12. Schwede T., et al. SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res. 31 13 (2003) 3381-3385
13. Koradi R., Billeter M., and Wuthrich K. MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14 1 (1996) 51-55 29-32
14. Stuhmer W., Stocker M., Sakmann B., Seeburg P., Baumann A., Grupe A., and Pongs O. Potassium channels expressed from rat brain cDNA have delayed rectifier properties. FEBS Lett. 242 1 (1988) 199-206
15. + channel. Int. J. Pept. Protein Res. 48 6 (1996) 514-521
16. + channels. Biochemistry 36 44 (1997) 13473-13482
17. + channels. Eur. J. Biochem. 245 2 (1997) 457-464
18. Buisine E., et al. Characterization of a new family of toxin-like peptides from the venom of the scorpion Leiurus quinquestriatus hebraeus. 1H NMR structure of leiuropeptide II. J. Pept. Res. 49 6 (1997) 545-555
19. Blanc E., et al. Solution structure of P01, a natural scorpion peptide structurally analogous to scorpion toxins specific for apamin-sensitive potassium channel. Proteins 24 3 (1996) 359-369
20. Dauplais M., Lecoq A., Song J., Cotton J., Jamin N., Gilquin B., Roumestand C., Vita C., de Meideros C.L., Rowan E.G., Harvey A.L., and Ménez A. On the convergent evolution of animal toxins: conservation of a dyad of functional residues in potassium channel-blocking toxins with unrelated structures. J. Biol. Chem. 272 (1997) 4302-4309
21. + channels and scorpion toxins. Trends Pharmacol. Sci. 24 5 (2003) 222-227
22. Rasband M.N., et al. Potassium channel distribution, clustering, and function in remyelinating rat axons. J. Neurosci. 18 1 (1998) 36-47
23. Sherratt R.M., Bostock H., and Sears T.A. Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. Nature 283 5747 (1980) 570-572
24. Dudina E.E., et al. OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus. Biochem. Biophys. Res. Commun. 286 5 (2001) 841-847