Organic nitrates and nitrate resistance in diabetes: The role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate

Experimental Diabetes Research

Volumn 2010, Issue , 2010, Pages

  Daiber, Andreas ^a   Oelze, Matthias ^a   Schuhmacher, Swenja ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIOXIDANT; APOCYNIN; ASCORBIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CHELERYTHRINE; CYCLIC GMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EBSELEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FERRITIN; GLUTATHIONE; GLYCERYL TRINITRATE; HEME OXYGENASE 1; HYDRALAZINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOSORBIDE 5 NITRATE; ISOSORBIDE DINITRATE; NITRATE; NITRIC OXIDE; PENTAERYTHRITYL TETRANITRATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RENIN INHIBITOR; SUPEROXIDE DISMUTASE; THIOCTIC ACID; XANTHINE OXIDASE; VASODILATOR AGENT;

ANGINA PECTORIS; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CIGARETTE SMOKING; CONGESTIVE HEART FAILURE; DIABETES MELLITUS; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; ISCHEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; DIABETIC ANGIOPATHY; DRUG RESISTANCE; METABOLISM; REVIEW;

ANIMALS; ANTIOXIDANTS; DIABETIC ANGIOPATHIES; DRUG RESISTANCE; ENDOTHELIUM, VASCULAR; HUMANS; NITRATES; NITRIC OXIDE; OXIDATIVE STRESS; PENTAERYTHRITOL TETRANITRATE; VASODILATOR AGENTS;

EID: 79952269159     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2010/213176     Document Type: Article

References (139)

1. de Vriese A. S., Verbeuren T. J., van de Voorde J., Lameire N. H., Vanhoutte P. M., Endothelial dysfunction in diabetes British Jou (Pubitemid 30453529)
2. Keaney J. F. Jr., Loscalzo J., Diabetes, oxidative stress, and platelet activation Circulation 1999 99 2 189 191 (Pubitemid 29056355)
3. Lipinski B., Pathophysiology of oxidative stress in diabetes mellitus Journal of Diabetes and Its Complications 2001 15 4 203 210 (Pubitemid 33714181)
4. Griendling K. K., FitzGerald G. A., Oxidative stress and cardiovascular injurypart II: animal and human studies Circulation 2003 108 17 2034 2040 (Pubitemid 37337574)
5. Heitzer T., Schlinzig T., Krohn K., Meinertz T., Mnzel T., Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease Circulation 2001 104 22 2673 2678 (Pubitemid 33108132)
6. Pricci F., Leto G., Amadio L., Iacobini C., Cordone S., Catalano S., Zicari A., Sorcini M., Di Mario U., Pugliese G., Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C Free Radical Biology and Medicine 2003 35 6 683 694 (Pubitemid 37101135)
7. Yu Y., Lyons T. J., A lethal tetrad in diabetes: hyperglycemia, dyslipidemia, oxidative stress, and endothelial dysfunction American Journal of the Medical Sciences 2005 330 5 227 232 (Pubitemid 41689451)
8. Wenzel P., Schulz E., Oelze M., Mller J., Schuhmacher S., Alhamdani M. S. S., Debrezion J., Hortmann M., Reifenberg K., Fleming I., Mnzel T., Daiber A., AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats Free Radical Biology and Medicine 2008 45 5 619 626
9. Johnston G. D., Ulster says 'NO'; explosion, resistance and tolerance: nitric oxide and the actions of organic nitrates Ulster Medical Journal 1998 67 2 79 90 (Pubitemid 29003541)
10. Uitto J., Perejda A. J., Grant G. A., Rowold E. A., Kilo C., Williamson J. R., Glycosylation of human glomerular basement membrane collagen: increased content of hexose in ketoamine linkage and unaltered hydroxylysine-O-glycosides in patients with diabetes Connective Tissue Research 1982 10 3-4 287 296 (Pubitemid 13202022)
11. Bucala R., Tracey K. J., Cerami A., Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes Journal of Clinical Investigation 1991 87 2 432 438
12. Taylor P. D., Poston L., The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery British Journal of Pharmacology 1994 113 3 801 808 (Pubitemid 24326818)
13. Hink U., Li H., Mollnau H., Oelze M., Matheis E., Hartmann M., Skatchkov M., Thaiss F., Stahl R. A., Warnholtz A., Meinertz T., Griendling K., Harrison D. G., Forstermann U., Munzel T., Mechanisms underlying endothelial dysfunction in diabetes mellitus Circulation Research 2001 88 2 E14 E22
14. Barnett A. H., Bain S. C., Bouter P., Karlberg B., Madsbad S., Jervell J., Mustonen J., Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy New England Journal of Medicine 2004 351 19 1952 1961 (Pubitemid 39447136)
15. Crespo M. J., Dunbar D. C., Enalapril improves vascular and cardiac function in streptozotocin-diabetic rats Cellular and Molecular Biology 2003 49 8 1311 1318
16. Ceriello A., Assaloni R., da Ros R., Maier A., Piconi L., Quagliaro L., Esposito K., Giugliano D., Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients Circulation 2005 111 19 2518 2524 (Pubitemid 40696141)
17. Ishii H., Koya D., King G. L., Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus Journal of Molecular Medicine 1998 76 1 21 31 (Pubitemid 28085058)
18. Koya D., King G. L., Protein kinase C activation and the development of diabetic complications Diabetes 1998 47 6 859 866 (Pubitemid 28255657)
19. Inoguchi T., Li P., Umeda F., Yu H. Y., Kakimoto M., Imamura M., Aoki T., Etoh T., Hashimoto T., Naruse M., Sano H., Utsumi H., Nawata H., High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells Diabetes 2000 49 11 1939 1945
20. Harrison D. G., Cai H., Landmesser U., Griendling K. K., Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease Journal of the Renin-Angiotensin-Aldosterone System 2003 4 2 51 61 (Pubitemid 36790175)
21. Oak J. H., Cai H., Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice Diabetes 2007 56 1 118 126
22. Nosadini R., Tonolo G., The role of the renin angiotensin hormonal system in the metabolic syndrome and type 2 diabetes Nutrition, Metabolism and Cardiovascular Diseases 2004 14 2 88 93 (Pubitemid 38813709)
23. Fonarow G. C., An approach to heart failure and diabetes mellitus American Journal of Cardiology 2005 96 4A 47E 52E (Pubitemid 41140370)
24. Heitzer T., Krohn K., Albers S., Meinertz T., Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus Diabetologia 2000 43 11 1435 1438
25. Brodsky S. V., Gealekman O., Chen J., Zhang F., Togashi N., Crabtree M., Gross S. S., Nasjletti A., Goligorsky M. S., Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen Circulation Research 2004 94 3 377 384 (Pubitemid 38240730)
26. Xu J., Xie Z., Reece R., Pimental D., Zou M. H., Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 12 2688 2695
27. Desco M. C., Asensi M., Mrquez R., Martnez-Valls J., Vento M., Pallard F. V., Sastre J., Via J., Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol Diabetes 2002 51 4 1118 1124 (Pubitemid 34438358)
28. Heitzer T., Finckh B., Albers S., Krohn K., Kohlschtter A., Meinertz T., Beneficial effects of -lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress Free Radical Biology and Medicine 2001 31 1 53 61 (Pubitemid 32568424)
29. Ye G., Metreveli N. S., Donthi R. V., Xia S., Xu M., Carlson E. C., Epstein P. N., Catalase protects cardiomyocyte function in models of Type 1 and Type 2 diabetes Diabetes 2004 53 5 1336 1343 (Pubitemid 38569021)
30. Nassar T., Kadery B., Lotan C., Da'as N., Kleinman Y., Haj-Yehia A., Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats European Journal of Pharmacology 2002 436 1-2 111 118 (Pubitemid 34142405)
31. Abraham N. G., Kappas A., Pharmacological and clinical aspects of heme oxygenase Pharmacological Reviews 2008 60 1 79 127 (Pubitemid 351439218)
32. Mnzel T., Daiber A., Mlsch A., Explaining the phenomenon of nitrate tolerance Circulation Research 2005 97 7 618 628 (Pubitemid 41416330)
33. Abrams J., Beneficial actions of nitrates in cardiovascular disease American Journal of Cardiology 1996 77 13 31C 37C
34. Daiber A., Wenzel P., Oelze M., Mnzel T., New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance Clinical Research in Cardiology 2008 97 1 12 20
35. Kleschyov A. L., Oelze M., Daiber A., Huang Y., Mollnau H., Schulz E., Sydow K., Fichtlscherer B., Mlsch A., Mnzel T., Does nitric oxide mediate the vasodilator activity of nitroglycerin? Circulation Research 2003 93 9 e104 e112
36. Palmer R. M. J., Ferrige A. G., Moncada S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature 1987 327 6122 524 526 (Pubitemid 17085822)
37. Mehta J. L., Endothelium, coronary vasodilation, and organic nitrates American Heart Journal 1995 129 2 382 391
38. Gerzer R., Karrenbrock B., Siess W., Heim J. M., Direct comparison of the effects of nitroprusside, SIN 1, and various nitrates on platelet aggregation and soluble guanylate cyclase activity Thrombosis Research 1988 52 1 11 21 (Pubitemid 18267483)
39. Bassenge E., Fink B., Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state Naunyn-Schmiedeberg's Archives of Pharmacology 1996 353 3 363 367 (Pubitemid 26090029)
40. Bassenge E., Fink N., Skatchkov M., Fink B., Dietary supplement with vitamin C prevents nitrate tolerance Journal of Clinical Investigation 1998 102 1 67 71 (Pubitemid 28323831)
41. Nez C., Vctor V. M., Tur R., Alvarez-Barrientos A., Moncada S., Esplugues J. V., D'Ocn P., Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO Circulation Research 2005 97 10 1063 1069 (Pubitemid 41668920)
42. Chen Z., Zhang J., Stamler J. S., Identification of the enzymatic mechanism of nitroglycerin bioactivation Proceedings of the National Academy of Sciences of the United States of America 2002 99 12 8306 8311 (Pubitemid 34651048)
43. Wenzel P., Hink U., Oelze M., Schuppan S., Schaeuble K., Schildknecht S., Ho K. K., Weiner H., Bachschmid M., Mnzel T., Daiber A., Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity: implications for mitochondrial oxidative stress and nitrate tolerance Journal of Biological Chemistry 2007 282 1 792 799 (Pubitemid 47076617)
44. Wenzel P., Hink U., Oelze M., Seeling A., Isse T., Bruns K., Steinhoff L., Brandt M., Kleschyov A. L., Schulz E., Lange K., Weiner H., Lehmann J., Lackner K. J., Kawamoto T., Mnzel T., Daiber A., Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2 mice British Journal of Pharmacology 2007 150 4 526 533 (Pubitemid 46280655)
45. Mnzel T., Bassenge E., Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo Circulation 1996 93 11 2052 2058 (Pubitemid 26165570)
46. Mnzel T., Mollnau H., Hartmann M., Geiger C., Oelze M., Warnholtz A., Yehia A. H., Frstermann U., Meinertz T., Effects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production Journal of the American College of Cardiology 2000 36 2 628 634 (Pubitemid 30624025)
47. Berkenboom G., Fontaine D., Unger P., Baldassarre S., Preumont N., Fontaine J., Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium-dependent mechanism Journal of Cardiovascular Pharmacology 1999 34 4 547 553 (Pubitemid 29446923)
48. Watanabe H., Kakihana M., Ohtsuka S., Sugishita Y., Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure Japanese Circulation Journal 1998 62 5 353 358
49. Cotter G., Metzkor-Cotter E., Kaluski E., Blatt A., Litinsky I., Baumohl Y., Moshkovitz Y., Vered Z., Zaidenstein R., Golik A., Usefulness of losartan, captopril, and furosemide in preventing nitrate tolerance and improving control of unstable angina pectoris American Journal of Cardiology 1998 82 9 1024 1029 (Pubitemid 28507081)
50. Pizzulli L., Hagendorff A., Zirbes M., Fehske W., Ewig S., Jung W., Lderitz B., Influence of captopril on nitroglycerin-mediated vasodilation and development of nitrate tolerance in arterial and venous circulation American Heart Journal 1996 131 2 342 349 (Pubitemid 26043396)
51. Katz R. J., Levy W. S., Buff L., Wasserman A. G., Prevention of nitrate tolerance with angiotensin converting enzyme inhibitors Circulation 1991 83 4 1271 1277
52. Otto A., Fontaine J., Berkenboom G., Ramipril treatment protects against nitrate-induced oxidative stress in eNOS mice: an implication of the NADPH oxidase pathway Journal of Cardiovascular Pharmacology 2006 48 1 842 849 (Pubitemid 44276462)
53. Hirai N., Kawano H., Yasue H., Shimomura H., Miyamoto S., Soejima H., Kajiwara I., Sakamoto T., Yoshimura M., Nakamura H., Yodoi J., Ogawa H., Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina Circulation 2003 108 12 1446 1450 (Pubitemid 37176449)
54. Dakak N., Makhoul N., Flugelman M. Y., Merdler A., Shehadeh H., Schneeweiss A., Halon D. A., Lewis B. S., Failure of captopril to prevent nitrate tolerance in congestive heart failure secondary to coronary artery disease American Journal of Cardiology 1990 66 5 608 613 (Pubitemid 20292519)
55. Longobardi G., Ferrara N., Leosco D., Abete P., Furgi G., Cacciatore F., Corbi G., Pescatore R., Rengo F., Angiotensin II-receptor antagonist Losartan does not prevent nitroglycerin tolerance in patients with coronary artery disease Cardiovascular Drugs and Therapy 2004 18 5 363 370 (Pubitemid 40558202)
56. Milone S. D., Azevedo E. R., Forster C., Parker J. D., The angiotensin II-receptor antagonist losartan does not prevent hemodynamic or vascular tolerance to nitroglycerin Journal of Cardiovascular Pharmacology 1999 34 5 645 650 (Pubitemid 29491725)
57. Milone S. D., Pace-Asciak C. R., Reynaud D., Azevedo E. R., Newton G. E., Parker J. D., Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance Journal of Cardiovascular Pharmacology 1999 33 5 685 690 (Pubitemid 29196704)
58. Mnzel T., Harrison D. G., Evidence for a role of oxygen derived free radicals and protein kinase C in nitrate tolerance Journal of Molecular Medicine 1997 75 11-12 891 900 (Pubitemid 27511566)
59. Kurz S., Hink U., Nickenig G., Borthayre A. B., Harrison D. G., Mnzel T., Evidence for a causal role of the renin-angiotensin system in nitrate tolerance Circulation 1999 99 24 3181 3187 (Pubitemid 29289085)
60. Abou-Mohamed G., Johnson J. A., Jin L., El-Remessy A. B., Do K., Kaesemeyer W. H., Caldwell R. B., Caldwell R. W., Roles of superoxide, peroxynitrite, and protein kinase C in the development of tolerance to nitroglycerin Journal of Pharmacology and Experimental Therapeutics 2004 308 1 289 299 (Pubitemid 38090730)
61. Banerjee S., Tang X. L., Qiu Y., Takano H., Manchikalapudi S., Dawn B., Shirk G., Bolli R., Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway American Journal of PhysiologyHeart and Circulatory Physiology 1999 277 6 H2488 H2494
62. Mnzel T., Kurz S., Rajagopalan S., Thoenes M., Berrington W. R., Thompson J. A., Freeman B. A., Harrison D. G., Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase: a new action for an old drug Journal of Clinical Investigation 1996 98 6 1465 1470 (Pubitemid 26322073)
63. Schwemmer M., Bassenge E., New approaches to overcome tolerance to nitrates Cardiovascular Drugs and Therapy 2003 17 2 159 173 (Pubitemid 37174690)
64. Fukatsu A., Hayashi T., Miyazaki-Akita A., Matsui-Hirai H., Furutate Y., Ishitsuka A., Hattori Y., Iguchi A., Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities American Journal of PhysiologyHeart and Circulatory Physiology 2007 293 1 H790 H797
65. Ratz J. D., McGuire J. J., Anderson D. J., Bennett B. M., Effects of the flavoprotein inhibitor, diphenyleneiodonium sulfate, on ex vivo organic nitrate tolerance in the rat Journal of Pharmacology and Experimental Therapeutics 2000 293 2 569 577 (Pubitemid 30244109)
66. Schulz E., Tsilimingas N., Rinze R., Reiter B., Wendt M., Oelze M., Woelken-Weckmller S., Walter U., Reichenspurner H., Meinertz T., Mnzel T., Functional and biochemical analysis of endothelial (Dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment Circulation 2002 105 10 1170 1175 (Pubitemid 34225816)
67. Gori T., Al-Hesayen A., Jolliffe C., Parker J. D., Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers American Journal of Cardiology 2003 91 11 1392 1394 (Pubitemid 36593497)
68. Thomas G. R., DiFabio J. M., Gori T., Parker J. D., Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans. Evidence of a free-radical-mediated mechanism Journal of the American College of Cardiology 2007 49 12 1289 1295 (Pubitemid 46476841)
69. Sekiya M., Sato M., Funada J., Ohtani T., Akutsu H., Watanabe K., Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis Journal of Cardiovascular Pharmacology 2005 46 1 63 67 (Pubitemid 40917780)
70. Ahlner J., Andersson R. G. G., Torfgard K., Axelsson K. L., Organic nitrate esters: clinical use and mechanisms of actions Pharmacological Reviews 1991 43 3 351 423
71. Jurt U., Gori T., Ravandi A., Babaei S., Zeman P., Parker J. D., Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study Journal of the American College of Cardiology 2001 38 3 854 859 (Pubitemid 32835764)
72. Mllenheim J., Mller S., Laber U., Thmer V., Meyer W., Bassenge E., Fink B., Kojda G., The effect of high-dose pentaerythritol tetranitrate on the development of nitrate tolerance in rabbits Naunyn-Schmiedeberg's Archives of Pharmacology 2001 364 3 269 275 (Pubitemid 32802156)
73. Koenig A., Lange K., Konter J., Daiber A., Stalleicken D., Glusa E., Lehmann J., Potency and in vitro tolerance of organic nitrates: partially denitrated metabolites contribute to the tolerance-devoid activity of pentaerythrityl tetranitrate Journal of Cardiovascular Pharmacology 2007 50 1 68 74 (Pubitemid 47220449)
74. Wenzel P., Schulz E., Gori T., Ostad M. A., Mthner F., Schildknecht S., Gbel S., Oelze M., Stalleicken D., Warnholtz A., Mnzel T., Daiber A., Monitoring white blood cell mitochondrial aldehyde dehydrogenase activity: implications for nitrate therapy in humans Journal of Pharmacology and Experimental Therapeutics 2009 330 1 63 71
75. Pautz A., Rauschkolb P., Schmidt N., Art J., Oelze M., Wenzel P., Frstermann U., Daiber A., Kleinert H., Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects Physiological Genomics 2009 38 2 176 185
76. Oberle S., Abate A., Grosser N., Hemmerle A., Vreman H. J., Dennery P. A., Schneider H. T., Stalleicken D., Schrder H., Endothelial protection by pentaerithrityl trinitrate: Bilirubin and carbon monoxide as possible mediators Experimental Biology and Medicine 2003 228 5 529 534 (Pubitemid 37203672)
77. Wenzel P., Oelze M., Coldewey M., Hortmann M., Seeling A., Hink U., Mollnau H., Stalleicken D., Weiner H., Lehmann J., Li H., Frstermann U., Mnzel T., Daiber A., Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 8 1729 1735 (Pubitemid 47207167)
78. Chen C. H., Budas G. R., Churchill E. N., Disatnik M. H., Hurley T. D., Mochly-Rosen D., Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart Science 2008 321 5895 1493 1495
79. Hink U., Daiber A., Kayhan N., Trischler J., Kraatz C., Oelze M., Mollnau H., Wenzel P., Vahl C. F., Ho K. K., Weiner H., Munzel T., Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels Journal of the American College of Cardiology 2007 50 23 2226 2232 (Pubitemid 350166814)
80. Gori T., Daiber A., Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate American Journal of Cardiovascular Drugs 2009 9 1 7 15
81. Gori T., Munzel T., Daiber A., Nicht-hmodynamische Wirkungen organischer Nitrate und unterschiedliche Charakteristika von Pentaerithrityltetranitrat Arzneimitteltherapie 2008 26 290 298
82. Munzel T., Sayegh H., Freeman B. A., Tarpey M. M., Harrison D. G., Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance Journal of Clinical Investigation 1995 95 1 187 194
83. Daiber A., Oelze M., Sulyok S., Coldewey M., Schulz E., Treiber N., Hink U., Mulsch A., Scharffetter-Kochanek K., Munzel T., Heterozygous deficiency of manganese superoxide dismutase in mice (Mn-SOD+/-): a novel approach to assess the role of oxidative stress for the development of nitrate tolerance Molecular Pharmacology 2005 68 3 579 588 (Pubitemid 41206011)
84. Hink U., Oelze M., Kolb P., Bachschmid M., Zou M. H., Daiber A., Mollnau H., August M., Baldus S., Tsilimingas N., Walter U., Ullrich V., Mnzel T., Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance Journal of the American College of Cardiology 2003 42 10 1826 1834 (Pubitemid 37433665)
85. Daiber A., Oelze M., Coldewey M., Bachschmid M., Wenzel P., Sydow K., Wendt M., Kleschyov A. L., Stalleicken D., Ullrich V., Mlsch A., Mnzel T., Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates Molecular Pharmacology 2004 66 6 1372 1382 (Pubitemid 39564764)
86. Sydow K., Daiber A., Oelze M., Chen Z., August M., Wendt M., Ullrich V., Mlsch A., Schulz E., Keaney J. F., Stamler J. S., Mnzel T., Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance Journal of Clinical Investigation 2004 113 3 482 489 (Pubitemid 38544192)
87. Wenzel P., Mollnau H., Oelze M., Schulz E., Wickramanayake J. M. D., Mller J., Schuhmacher S., Hortmann M., Baldus S., Gori T., Brandes R. P., Mnzel T., Daiber A., First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction Antioxidants and Redox Signaling 2008 10 8 1435 1447
88. Reis F., Rocha-Pereira P., Teixeira de Lemos E., Parada B., Baptista S., Figueiredo A., Santos-Silva A., Costa-Almeida C., Mota A., Teixeira F., Oxidative stress in cyclosporine-induced hypertension: evidence of beneficial effects or tolerance development with nitrate therapy Transplantation Proceedings 2007 39 8 2494 2500 (Pubitemid 47588361)
89. Tingberg E., hlin A. K., Gottster A., hlin H., Lipid peroxidation is not increased in heart failure patients on modern pharmacological therapy International Journal of Cardiology 2006 112 3 275 281 (Pubitemid 44415048)
90. Thum T., Fraccarollo D., Thum S., Schultheiss M., Daiber A., Wenzel P., Munzel T., Ertl G., Bauersachs J., Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 4 748 754 (Pubitemid 46606702)
91. Keimer R., Stutzer F. K., Tsikas D., Troost R., Gutzki F. M., Frlich J. C., Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study Journal of Cardiovascular Pharmacology 2003 41 2 284 292 (Pubitemid 36135254)
92. Taylor A. L., Ziesche S., Yancy C., Carson P., D'Agostino R., Ferdinand K., Taylor M., Adams K., Sabolinski M., Worcel M., Conn J. N., Combination of isosorbide dinitrate and hydralazine in blacks with heart failure New England Journal of Medicine 2004 351 20 2049 2141
93. Daiber A., Oelze M., Coldewey M., Kaiser K., Huth C., Schildknecht S., Bachschmid M., Nazirisadeh Y., Ullrich V., Mlsch A., Mnzel T., Tsilimingas N., Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure Biochemical and Biophysical Research Communications 2005 338 4 1865 1874 (Pubitemid 41643103)
94. Nakamura Y., Moss A. J., Brown M. W., Kinoshita M., Kawai C., Long-term nitrate use may be deleterious in ischemic heart disease: a study using the databases from two large-scale postinfarction studies American Heart Journal 1999 138 3, part 1 577 585 (Pubitemid 29428783)
95. Oppermann M., Balz V., Adams V., Thao-Vi Dao VU., Bas M., Suvorava T., Kojda G., Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo Journal of Cellular and Molecular Medicine 2009 13 7 1271 1278
96. Dovinov I., Caanyiov S., Fberov V., Kristek F., The effect of an NO donor, pentaerythrityl tetranitrate, on biochemical, functional, and morphological attributes of cardiovascular system of spontaneously hypertensive rats General Physiology and Biophysics 2009 28 1 86 93
97. Schnorbus B., Schiewe R., Ostad M. A., Medler C., Wachtlin D., Wenzel P., Daiber A., Mnzel T., Warnholtz A., Effects of pentaerythritol tetranitrate on endothelial function in coronary artery disease: results of the PENTA study Clinical Research in Cardiology 2010 99 2 115 124
98. Drexler H., Hornig B., Endothelial dysfunction in human disease Journal of Molecular and Cellular Cardiology 1999 31 1 51 60 (Pubitemid 29078218)
99. Maguire S. M., Nugent A. G., McGurk C., Johnston G. D., Nicholls D. P., Abnormal vascular responses in human chronic cardiac failure are both endothelium dependent and endothelium independent Heart 1998 80 2 141 145 (Pubitemid 28389474)
100. Fayers K. E., Cummings M. H., Shaw K. M., Laight D. W., Nitrate tolerance and the links with endothelial dysfunction and oxidative stress British Journal of Clinical Pharmacology 2003 56 6 620 628 (Pubitemid 37491713)
101. Laursen J. B., Boesgaard S., Poulsen H. E., Aldershvile J., Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo Cardiovascular Research 1996 31 5 814 819
102. McVeigh G., Brennan G., Hayes R., Johnston D., Primary nitrate tolerance in diabetes mellitus Diabetologia 1994 37 1 115 117 (Pubitemid 24044717)
103. Caramori P. R. A., Adelman A. G., Azevedo E. R., Newton G. E., Parker A. B., Parker J. D., Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine Journal of the American College of Cardiology 1998 32 7 1969 1974 (Pubitemid 29010463)
104. Gori T., Mak S. S., Kelly S., Parker J. D., Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans Journal of the American College of Cardiology 2001 38 4 1096 1101 (Pubitemid 32912717)
105. McVeigh G. E., Brennan G. M., Johnston G. D., McDermott B. J., McGrath L. T., Henry W. R., Andrews J. W., Hayes J. R., Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus Diabetologia 1992 35 8 771 776
106. McVeigh G. E., Morgan D. R., Allen P., Trimble M., Hamilton P., Dixon L. J., Silke B., Hayes J. R., Early vascular abnormalities and de novo nitrate tolerance in diabetes mellitus Diabetes, Obesity and Metabolism 2002 4 5 336 341 (Pubitemid 34947096)
107. Needleman P., Jakschik B., Johnson E. M. Jr., Sulfhydryl requirement for relaxation of vascular smooth muscle Journal of Pharmacology and Experimental Therapeutics 1973 187 2 324 331
108. Collier A., Wilson R., Bradley H., Thomson J. A., Small M., Free radical activity in Type 2 diabetes Diabetic Medicine 1990 7 1 27 30 (Pubitemid 20015084)
109. Frizzell N., Rajesh M., Jepson M. J., Nagai R., Carson J. A., Thorpe S. R., Baynes J. W., Succination of thiol groups in adipose tissue proteins in diabetes. Succination inhibits polymerization and secretion of adiponectin Journal of Biological Chemistry 2009 284 38 25772 25781
110. Seeling A., Lehmann J., NO-donors, part X[1]: investigations on the stability of pentaerythrityl tetranitrate (PETN) by HPLC-chemoluminescence-N- detection (CLND) versus UV-detection in HPLC Journal of Pharmaceutical and Biomedical Analysis 2006 40 5 1131 1136 (Pubitemid 43247450)
111. Chandrashekar K. N., Muralidhara, Evidence of oxidative stress and mitochondrial dysfunctions in the testis of prepubertal diabetic rats International Journal of Impotence Research 2009 21 3 198 206
112. Churchill E. N., Disatnik M. H., Mochly-Rosen D., Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of e{open}PKC and activation of aldehyde dehydrogenase 2 Journal of Molecular and Cellular Cardiology 2009 46 2 278 284
113. Ma H., Guo R., Yu L., Zhang Y., Ren J., Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. European Heart Journal. In press
114. Musi N., Fujii N., Hirshman M. F., Ekberg I., Frberg S., Ljungqvist O., Thorell A., Goodyear L. J., AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise Diabetes 2001 50 5 921 927 (Pubitemid 32374520)
115. Wang S., Xu J., Song P., Viollet B., Zou M. H., In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I Diabetes 2009 58 8 1893 1901
116. Taylor E. B., Goodyear L. J., Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes Current Diabetes Reports 2007 7 6 399 401 (Pubitemid 350284968)
117. Nugent A. G., Mcgurk C., Hayes J. R., Johnston G. D., Vascular responses to glyceryl trinitrate and sodium nitroprusside in type 2 diabetes mellitus British Journal of Clinical Pharmacology 1996 41 5 443 444
118. Ghio S., de Servi S., Perotti R., Eleuteri E., Montemartini C., Specchia G., Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans: effects of N-acetylcysteine administration Circulation 1992 86 3 798 802
119. Fontaine D., Otto A., Fontaine J., Berkenboom G., Prevention of nitrate tolerance by long-term treatment with statins Cardiovascular Drugs and Therapy 2003 17 2 123 128 (Pubitemid 37174685)
120. Watanabe H., Kakihana M., Ohtsuka S., Sugishita Y., Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure Journal of the American College of Cardiology 1998 32 5 1194 1200 (Pubitemid 28522373)
121. Daiber A., Wenzel P., Oelze M., Schuhmacher S., Jansen T., Mnzel T., Mitochondrial aldehyde dehydrogenase (ALDH-2)-Maker of and marker for nitrate tolerance in response to nitroglycerin treatment Chemico-Biological Interactions 2009 178 13 40 47
122. Timimi F. K., Ting H. H., Haley E. A., Roddy M. A., Ganz P., Creager M. A., Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus Journal of the American College of Cardiology 1998 31 3 552 557 (Pubitemid 28144120)
123. Ting H. H., Timimi F. K., Boles K. S., Creager S. J., Ganz P., Creager M. A., Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus Journal of Clinical Investigation 1996 97 1 22 28 (Pubitemid 26021690)
124. Bitar M. S., Wahid S., Pilcher C. W. T., Al-Saleh E., Al-Mulla F., -lipoic acid mitigates insulin resistance in Goto-Kakizaki rats Hormone and Metabolic Research 2004 36 8 542 549 (Pubitemid 39233526)
125. Zhang L., Zalewski A., Liu Y., Mazurek T., Cowan S., Martin J. L., Hofmann S. M., Vlassara H., Shi YI., Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries Circulation 2003 108 4 472 478 (Pubitemid 36935542)
126. Giugliano D., Marfella R., Verrazzo G., Acampora R., Donzella C., Quatraro A., Coppola L., D'Onofrio F., Abnormal rheologic effects of glyceryl trinitrate in patients with non- insulin-dependent diabetes mellitus and reversal by antioxidants Annals of Internal Medicine 1995 123 5 338 343
127. Wenzel P., Daiber A., Oelze M., Brandt M., Closs E., Xu J., Thum T., Bauersachs J., Ertl G., Zou M.-H., Frstermann U., Mnzel T., Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus Atherosclerosis 2008 198 1 65 76
128. Yusuf S., Teo K. K., Pogue J., Dyal L., Copland I., Schumacher H., Dagenais G., Sleight P., Anderson C., Telmisartan, ramipril, or both in patients at high risk for vascular events New England Journal of Medicine 2008 358 15 1547 1559 (Pubitemid 351522739)
129. Chen H., Karne R. J., Hall G., Campia U., Panza J. A., Cannon III R. O., Wang Y., Katz A., Levine M., Quon M. J., High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance American Journal of PhysiologyHeart and Circulatory Physiology 2006 290 1 H137 H145
130. Lee D. H., Folsom A. R., Harnack L., Halliwell B., Jacobs D. R. Jr., Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? American Journal of Clinical Nutrition 2004 80 5 1194 1200 (Pubitemid 41350678)
131. Kowluru R. A., Kowluru V., Xiong Y., Ho Y. S., Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress Free Radical Biology and Medicine 2006 41 8 1191 1196 (Pubitemid 44466317)
132. Andreassi M. G., Botto N., Simi S., Casella M., Manfredi S., Lucarelli M., Venneri L., Biagini A., Picano E., Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease Journal of Molecular Medicine 2005 83 4 279 286 (Pubitemid 40674954)
133. Warnholtz A., Mollnau H., Heitzer T., Kontush A., Mller-Bertram T., Lavall D., Giaid A., Beisiegel U., Marklund S. L., Walter U., Meinertz T., Munzel T., Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits Journal of the American College of Cardiology 2002 40 7 1356 1363
134. Hacker A., Mller S., Meyer W., Kojda G., The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis British Journal of Pharmacology 2001 132 8 1707 1714 (Pubitemid 32397962)
135. Oberle S., Schwartz P., Abate A., Schrder H., The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells Biochemical and Biophysical Research Communications 1999 261 1 28 34 (Pubitemid 29371613)
136. Kruger A. L., Peterson S. J., Schwartzman M. L., Fusco H., McClung J. A., Weiss M., Shenouda S., Goodman A. I., Goligorsky M. S., Kappas A., Abraham N. G., Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects Journal of Pharmacology and Experimental Therapeutics 2006 319 3 1144 1152
137. Liu X., Wei J., Peng D. H., Layne M. D., Yet S. F., Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice Diabetes 2005 54 3 778 784 (Pubitemid 40322082)
138. Schuhmacher S., Wenzel P., Schulz E., Oelze M., Mang C., Kamuf J., Gori T., Jansen T., Knorr M., Karbach S., Hortmann M., Mthner F., Bhatnagar A., Frstermann U., Li H., Mnzel T., Daiber A., Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1 Hypertension 2010 55 4 897 904
139. Icks A., Haastert B., Rathmann W., Schrder-Bemhardi D., Giani G., Cost comparison analysis: pentaerythrithyl tetranitrate (PETN) and isosorbide dinitrate (ISDN) prescribed to diabetic patients in primary care practices in Germany International Journal of Clinical Pharmacology and Therapeutics 2007 45 9 516 523 (Pubitemid 47408261)