New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance

Clinical Research in Cardiology

Volumn 97, Issue 1, 2008, Pages 12-20

  Daiber, Andreas ^a   Wenzel, Philip ^a   Oelze, Matthias ^a   Münzel, Thomas ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Endothelial dysfunction; Heme oxygenase 1; Nitrate tolerance; Nitroglycerin; Organic nitrate; Oxidative stress; Pentaerithrityl tetranitrate

Indexed keywords

ALDEHYDE DEHYDROGENASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCERYL TRINITRATE; ISOSORBIDE 5 NITRATE; ISOSORBIDE DINITRATE; NITRATE; ORGANIC NITRATE; PENTAERYTHRITYL TETRANITRATE; REACTIVE OXYGEN METABOLITE;

ANGINA PECTORIS; BINDING AFFINITY; CROSS TOLERANCE; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; HEART FAILURE; HEART HEMODYNAMICS; HISTORY OF MEDICINE; HUMAN; LONG TERM CARE; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; REVIEW; SIGNAL TRANSDUCTION; TACHYPHYLAXIS;

ALDEHYDE DEHYDROGENASE; DRUG TOLERANCE; HEART DISEASES; HUMANS; MITOCHONDRIA; NITRATES; OXIDATIVE STRESS; PENTAERYTHRITOL TETRANITRATE; REACTIVE OXYGEN SPECIES; UP-REGULATION; VASODILATOR AGENTS;

EID: 38149029311     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-007-0588-7     Document Type: Review

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