Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease

Journal of Molecular Medicine

Volumn 83, Issue 4, 2005, Pages 279-286

  Andreassi, Maria Grazia ^a,b   Botto, Nicoletta ^a   Simi, Silvana ^a   Casella, Marta ^a   Manfredi, Samantha ^a   Lucarelli, Marilena ^a   Venneri, Lucia ^a   Biagini, Andrea ^a   Picano, Eugenio ^a,c,d  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b G PASQUINUCCI HOSPITAL   (Italy)

^c CNR   (Italy)

^d Clinica Cardiologica 'Montevergine'   (Italy)

Author keywords

Coronary artery disease; Diabetes; DNA damage; Nitrate therapy

Indexed keywords

ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; NITRATE;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DNA DAMAGE; DYSLIPIDEMIA; FEMALE; HOSPITAL PATIENT; HUMAN; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS TEST; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK;

CORONARY ANGIOGRAPHY; CORONARY ARTERIOSCLEROSIS; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; FEMALE; HUMANS; HYPERLIPIDEMIAS; MALE; MICRONUCLEUS TESTS; MIDDLE AGED; NITRATES; REGRESSION ANALYSIS;

EID: 18744391953     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-005-0634-8     Document Type: Article

References (38)

1. Adams J, Apple F (2004) Cardiology patient page. New blood tests for detecting heart disease. Circulation 109:E12-E14
2. De Flora S, Izzotti A, Randerath K, et al (1996) DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine. Mutat Res 366:197-238
3. Migliore L, Coppede F (2002) Genetic and environmental factors in cancer and neurodegenerative diseases. Mutat Res 512:135-153
4. Izzotti (2003) DNA damage and alterations of gene expression in chronic-degenerative diseases. Acta Biochim Pol 50:145-154
5. Andreassi MG (2003) Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage. Mutat Res 543:67-86
6. Cooke MS, Evans MD, Dizdaroglu M, et al (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17:1195-1214
7. Casella M, Lucarelli M, Simili M, et al (2003) Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1. Cytogenet Genome Res 100:224-229
8. Botto N, Masetti S, Petrozzi L, et al (2002) Elevated levels of oxidative DNA damage in patients with coronary artery disease. Coron Artery Dis 13:269-274
9. Andreassi MG, Botto N, Rizza A, et al (2001) Chronic long-term nitrate therapy: possible cytogenetic effect in humans? Mutagenesis 16:517-521
10. Andreassi MG, Botto N, Rizza A, et al (2002) Deoxyribonucleic acid damage in human lymphocytes after percutaneous transluminal coronary angioplasty. J Am Coll Cardiol 40:862-868
11. Fenech M (1993) The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ Health Perspect 101:101-107
12. Fenech M (2002) Biomarkers of genetic damage for cancer epidemiology. Toxicology 181-182:411-416
13. Barale R, Chelotti L, Davini T, et al (1998) Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian population: II. Contribution of sex, age, and lifestyle. Environ Mol Mutagen 31:228-242
14. Bonassi S, Fenech M, Lando C, et al (2001) Human MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen 37:31-45
15. Olinski R, Gackowski D, Foksinski M, et al (2002) Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome. Free Radic Biol Med 33:192-200
16. Baynes JW, Thorpe SR (1999) Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48:1-9
17. Jialal I, Devaraj S, Venugopal SK (2002) Oxidative stress, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy. Free Radic Res 36:1331-1336
18. Dandona P, Thusu K, Cook S, et al (1996) Oxidative damage to DNA in diabetes mellitus. Lancet 347444-347445
19. Collins AR, Raslova K, Somorovska M, et al (1998) DNA damage in diabetes: correlation with a clinical marker. Free Radic Biol Med 25:373-377
20. Hinokio Y, Suzuki S, Hirai M, et al (1999) Oxidative DNA damage in diabetes mellitus: its association with diabetic complications. Diabetologia 42:995-998
21. Hannon-Fletcher MP, O'Kane MJ, Moles KW, et al (2000) Levels of peripheral blood cell DNA damage in insulin dependent diabetes mellitus human subjects. Mutat Res 460:53-60
22. Sardas S, Yilmaz M, Oztok U, et al (2001) Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementation. Mutat Res 490:123-129
23. Shin CS, Moon BS, Park KS, et al (2001) Serum 8-hydroxyguanine levels are increased in diabetic patients. Diabetes Care 24:733-737
24. Dincer Y, Akcay T, Ilkova H, et al (2003) DNA damage and antioxidant defense in peripheral leukocytes of patients with type I diabetes mellitus. Mutat Res 527:49-55
25. Moochhala S, Rajnakova A (1999) Role of nitric oxide in cancer biology. Free Radic Res 31:671-679
26. Felley-Bosco E (1998) Role of nitric oxide in genotoxicity: implication for carcinogenesis. Cancer Metastasis Rev 17:25-37
27. Burney S, Caulfield J, Niles J, et al (1999) The chemistry of DNA damage from nitric oxide and peroxynitrite. Mutat Res 424:37-49
28. Nakamura Y, Moss AJ, Brown MW, et al (1999) Long-term nitrate use may be deleterious in ischemic heart disease: a study using the databases from two large-scale postinfarction studies. Am Heart J 138:577-585
29. Kanamasa K, Hayashi T, Kimura A, et al (2002) Long-term, continuous treatment with both oral and transdermal nitrates increases cardiac events in healed myocardial infarction patients. Angiology 53:399-340
30. Nesto RW, Libby P (2001) Diabetes mellitus abd the cardiovascular system. In: Braunwald E, Zipes DP, Libby P (eds). Heart disease. A textbook of cardiovascular medicine, 6th edn. WB Saunders, Philadelphia, pp 2133-2150
31. Garcia Soriano F, Virag L, Jagtap P, et al (2001) Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med 7:108-113
32. Garcia Soriano F, Pacher P, Mabley J, Liaudet L, Szabo C (2001) Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 89:684-691
33. Pacher P, Liaudet L, Soriano FG, Mabley JG, Szabo E, Szabo C (2002) The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes. Diabetes 51:514-521
34. Garcia Soriano F, Virag L, Szabo C (2001) Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly (ADP-ribose) polymerase activation. J Mol Med 79:437-448
35. Virag L, Szabo E, Gergely P, Szabo C (2003) Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett 140-141:113-124
36. Szabo C (2002) PARP as a drug target for the therapy of diabetic cardiovascular dysfunction. Drug News Perspect 15:197-205
37. Miller MC III, Mohrenweiser HW, Bell DA (2001) Genetic variability in susceptibility and response to toxicants. Toxicol Lett 120:269-280
38. Picano E (2003) Stress echocardiography: a historical perspective. Am J Med 114:126-130