Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes

Current Diabetes Reports

Volumn 7, Issue 6, 2007, Pages 399-401

  Taylor, Eric B ^b   Goodyear, Laurie J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ADIPONECTIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LEPTIN; METFORMIN; PIOGLITAZONE; RIBONUCLEOSIDE; ROSIGLITAZONE;

CLINICAL FEATURE; CLINICAL PROTOCOL; DISEASE MODEL; DRUG ACTIVITY; DRUG EFFICACY; DRUG TARGETING; DYSLIPIDEMIA; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; EXERCISE; HUMAN; INCIDENCE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; HYPOGLYCEMIC AGENTS; MICE; MULTIENZYME COMPLEXES; MUSCLE, SKELETAL; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOTIDES;

EID: 37349029044     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-007-0065-8     Document Type: Note

References (5)

1. Fujii N, Jessen N, Goodyear LJ: AMP-activated protein kinase and the regulation of glucose transport. Am J Physiol Endocrinol Metab 2006, 291:E867-E877.
2. Dolinsky VW, Dyck JR: Role of AMP-activated protein kinase in healthy and diseased hearts. Am J Physiol Heart Circ Physiol 2006, 291:H2557-H2569.
3. Xue B, Kahn BB: AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 2006, 574(Pt 1):73-83.
4. Birk JB, Wojtaszewski JF: Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol 2006, 577(Pt 3):1021-1032.
5. Winder WW, Holmes BF, Rubink DS, et al.: Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol 2000, 88:2219-2226.