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Volumn 76, Issue 1, 1998, Pages 21-31

Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

Author keywords

Diabetes mellitus; Diacylglycerol; Protein kinase C; Specific inhibitor for protein kinase C isoforms; Vascular complications; Vitamin E

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA TOCOPHEROL; CONTRACTILE PROTEIN; DIACYLGLYCEROL; PHOSPHOLIPASE A2; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

EID: 0031883161     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s109-1998-8101-y     Document Type: Review
Times cited : (268)

References (132)
  • 1
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 2
    • 0023116890 scopus 로고
    • Sorbitol, phosphoinositides and sodium-potassium-ATPase in the pathogenesis of diabetic complications
    • Greene D, Lattimer SA, Sima AAF (1987) Sorbitol, phosphoinositides and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N Engl J Med 316:599-606
    • (1987) N Engl J Med , vol.316 , pp. 599-606
    • Greene, D.1    Lattimer, S.A.2    Sima, A.A.F.3
  • 3
    • 0023950461 scopus 로고
    • Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
    • Brownlee M, Cerami A, Vlassara H (1988) Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 318:1315-1321
    • (1988) N Engl J Med , vol.318 , pp. 1315-1321
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 5
    • 0029975352 scopus 로고    scopus 로고
    • Biochemical and molecular mechanisms in the development of diabetic vascular complications
    • King GL, Kunisaki M, Nishi N, Inoguchi T, Shiba T, Xia P (1996) Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes 45 [Suppl 3]:S105-108
    • (1996) Diabetes , vol.45 , Issue.3 SUPPL.
    • King, G.L.1    Kunisaki, M.2    Nishi, N.3    Inoguchi, T.4    Shiba, T.5    Xia, P.6
  • 6
    • 0026451081 scopus 로고
    • Intracellular Signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y (1992) Intracellular Signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 7
    • 0027535742 scopus 로고
    • Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
    • Nakanishi H, Brewer KA, Exton JH (1993) Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 266:13-16
    • (1993) J Biol Chem , vol.266 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 10
    • 0023108159 scopus 로고
    • Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells
    • Kariya K, Kawahara Y, Tsuda T, FukuzakiH, Takai Y (1987) Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells. Atherosclerosis 63:251-255
    • (1987) Atherosclerosis , vol.63 , pp. 251-255
    • Kariya, K.1    Kawahara, Y.2    Tsuda, T.3    FukuzakiH4    Takai, Y.5
  • 11
    • 0025340185 scopus 로고
    • Structure of the human type IV collagen gene
    • Huhtala P, Chow LT, Tryggvason K (1990) Structure of the human type IV collagen gene. J Biol Chem 265: 11077-11082
    • (1990) J Biol Chem , vol.265 , pp. 11077-11082
    • Huhtala, P.1    Chow, L.T.2    Tryggvason, K.3
  • 12
    • 0023266203 scopus 로고
    • Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol esters
    • Hachiya HL, Takayama S, White MF, King GL (1987) Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol esters. J Biol Chem 262: 6417-6424
    • (1987) J Biol Chem , vol.262 , pp. 6417-6424
    • Hachiya, H.L.1    Takayama, S.2    White, M.F.3    King, G.L.4
  • 13
    • 0024444587 scopus 로고
    • The mitogenic signaling pathway but not plasminogen activator inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells
    • Presta M, Maier JAM, Ragnotti G (1989) The mitogenic signaling pathway but not plasminogen activator inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells. J Cell Biol 109:1877-1884
    • (1989) J Cell Biol , vol.109 , pp. 1877-1884
    • Presta, M.1    Maier, J.A.M.2    Ragnotti, G.3
  • 14
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform bII and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL (1992) Preferential elevation of protein kinase C isoform bII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89:11059-11063
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3    Sportsman, J.R.4    Heath, W.5    King, G.L.6
  • 15
    • 0027454103 scopus 로고
    • Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation
    • Shiba T, Inoguchi T, Sportsman JR, Heath W, Bursell S, King GL (1993) Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation. Am J Physiol 265: E783-E793
    • (1993) Am J Physiol , vol.265
    • Shiba, T.1    Inoguchi, T.2    Sportsman, J.R.3    Heath, W.4    Bursell, S.5    King, G.L.6
  • 16
    • 0024563795 scopus 로고
    • Protein kinase C is activated in glomeruli from streptozotocin diabetic rats
    • Craven PA, DeRubertis FR (1989) Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. J Clin Invest 83:1667-1675
    • (1989) J Clin Invest , vol.83 , pp. 1667-1675
    • Craven, P.A.1    DeRubertis, F.R.2
  • 19
    • 0027981889 scopus 로고
    • Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
    • Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL (1994) Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 43:1122-1129
    • (1994) Diabetes , vol.43 , pp. 1122-1129
    • Xia, P.1    Inoguchi, T.2    Kern, T.S.3    Engerman, R.L.4    Oates, P.J.5    King, G.L.6
  • 20
    • 0025990146 scopus 로고
    • High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures
    • Ayo SH, Radnik R, Garoni JA, Troyer DA, Kreisberg JI (1991) High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am J Physiol 261:F571-577
    • (1991) Am J Physiol , vol.261
    • Ayo, S.H.1    Radnik, R.2    Garoni, J.A.3    Troyer, D.A.4    Kreisberg, J.I.5
  • 21
    • 0027526916 scopus 로고
    • Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium
    • Studer RK, Craven PA, DeRubertis FR (1993) Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium. Diabetes 42:118-126
    • (1993) Diabetes , vol.42 , pp. 118-126
    • Studer, R.K.1    Craven, P.A.2    DeRubertis, F.R.3
  • 22
    • 0027977387 scopus 로고
    • Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues
    • Inoguchi T, Pu X, Kunisaki M, Higashi S, Feener EP, King GL (1994) Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol 267:E369-379
    • (1994) Am J Physiol , vol.267
    • Inoguchi, T.1    Pu, X.2    Kunisaki, M.3    Higashi, S.4    Feener, E.P.5    King, G.L.6
  • 23
    • 0018136359 scopus 로고
    • Metabolism of molecular species of diacylglycerol phospholipids
    • Holub BJ, Kuksis A (1986) Metabolism of molecular species of diacylglycerol phospholipids. Adv Lipid Res 16:1-125
    • (1986) Adv Lipid Res , vol.16 , pp. 1-125
    • Holub, B.J.1    Kuksis, A.2
  • 24
    • 0022371878 scopus 로고
    • Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate
    • Dunlop ME, Larkins RG (1985) Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate. Biochem Biophys Res Commun 132: 467-473
    • (1985) Biochem Biophys Res Commun , vol.132 , pp. 467-473
    • Dunlop, M.E.1    Larkins, R.G.2
  • 25
    • 70350271921 scopus 로고
    • Phosphatidate metabolism and its relation to triacylglycerol biosynthesis
    • Hawthorne JN, Ansel GB (eds) Elsevier, New York
    • Brindley DN, Sturton RG (1982) Phosphatidate metabolism and its relation to triacylglycerol biosynthesis. In: Hawthorne JN, Ansel GB (eds) Phospholipids. Elsevier, New York, pp 179-207
    • (1982) Phospholipids , pp. 179-207
    • Brindley, D.N.1    Sturton, R.G.2
  • 26
    • 0023261504 scopus 로고
    • Further studies on the specificity of diacylglycerol for protein kinase C activation
    • 26a. Go M, Sekiguchi K, Nomura H, Kikkawa N, Nishizuka Y (1987) Further studies on the specificity of diacylglycerol for protein kinase C activation. Biochem Biophys Res Commun 144:598-605
    • (1987) Biochem Biophys Res Commun , vol.144 , pp. 598-605
    • Go, M.1    Sekiguchi, K.2    Nomura, H.3    Kikkawa, N.4    Nishizuka, Y.5
  • 27
    • 0027231627 scopus 로고
    • Hydroperoxide-induced diacylglycerol formation and protein kinase C activation in vascular endothelial cells
    • 26b. Taher MM, Garcia JG, Natarajan V (1993) Hydroperoxide-induced diacylglycerol formation and protein kinase C activation in vascular endothelial cells. Arch. Biochem-Biophys 303:260-266
    • (1993) Arch. Biochem-Biophys , vol.303 , pp. 260-266
    • Taher, M.M.1    Garcia, J.G.2    Natarajan, V.3
  • 28
    • 0029784955 scopus 로고    scopus 로고
    • Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration
    • Yasunari K, Kohno M, Kano H, Yokokawa K, Horio T, Yoshikawa J (1996) Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Hypertension 28:159-68
    • (1996) Hypertension , vol.28 , pp. 159-168
    • Yasunari, K.1    Kohno, M.2    Kano, H.3    Yokokawa, K.4    Horio, T.5    Yoshikawa, J.6
  • 29
    • 0028564935 scopus 로고
    • Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels
    • Kunisaki M, Bursell S-E, Umeda F, Nawata H, King GL (1994) Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 43:1372-1377
    • (1994) Diabetes , vol.43 , pp. 1372-1377
    • Kunisaki, M.1    Bursell, S.-E.2    Umeda, F.3    Nawata, H.4    King, G.L.5
  • 30
    • 0028146675 scopus 로고
    • Translocation of protein kinase a and ζ in rat glomerular mesangial cells cultured under high glucose conditions
    • Kikkawa R, Haneda M, Uzu T, Koya D, Sugimoto T, Shigeta Y (1994) Translocation of protein kinase a and ζ in rat glomerular mesangial cells cultured under high glucose conditions. Diabetologia 37:838-841
    • (1994) Diabetologia , vol.37 , pp. 838-841
    • Kikkawa, R.1    Haneda, M.2    Uzu, T.3    Koya, D.4    Sugimoto, T.5    Shigeta, Y.6
  • 31
    • 0023764824 scopus 로고
    • The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    • Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334:661-665
    • (1988) Nature , vol.334 , pp. 661-665
    • Nishizuka, Y.1
  • 32
    • 0024416291 scopus 로고
    • The family of protein kinase C for signal transduction
    • Nishizuka Y (1989) The family of protein kinase C for signal transduction. JAMA 262:1826-1833
    • (1989) JAMA , vol.262 , pp. 1826-1833
    • Nishizuka, Y.1
  • 39
    • 0014075574 scopus 로고
    • Abnormally increased glomerular filtration rates in short-term insulin treated diabetic subjects
    • Ditzel J, Schwartz M (1967) Abnormally increased glomerular filtration rates in short-term insulin treated diabetic subjects. Diabetes 16:264-267
    • (1967) Diabetes , vol.16 , pp. 264-267
    • Ditzel, J.1    Schwartz, M.2
  • 40
    • 0019424778 scopus 로고
    • Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin-dependent diabetes
    • Chiristiansen JS, Gammelgaard J, Frandsen M, Parving HH (1981) Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin-dependent diabetes. Diabetologia 20:451-456
    • (1981) Diabetologia , vol.20 , pp. 451-456
    • Chiristiansen, J.S.1    Gammelgaard, J.2    Frandsen, M.3    Parving, H.H.4
  • 41
    • 0019460233 scopus 로고
    • Glomerular hemodynamics in experimental diabetes mellitus
    • Hostetter TH, Troy JL, Brenner BM (1981) Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19: 410-415
    • (1981) Kidney Int , vol.19 , pp. 410-415
    • Hostetter, T.H.1    Troy, J.L.2    Brenner, B.M.3
  • 42
    • 0018733826 scopus 로고
    • Early functional and morphological changes in diabetic nephropathy
    • Viberti GC (1979) Early functional and morphological changes in diabetic nephropathy. Clin Nephrol 12:47-53
    • (1979) Clin Nephrol , vol.12 , pp. 47-53
    • Viberti, G.C.1
  • 43
    • 0021960218 scopus 로고
    • Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus
    • Schambelan M, Blake S (1985) Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. J Clin Invest 75:404-412
    • (1985) J Clin Invest , vol.75 , pp. 404-412
    • Schambelan, M.1    Blake, S.2
  • 44
    • 0023099831 scopus 로고
    • Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats: Relationship to the hyperfiltration of early diabetes
    • Craven PA, Caines MA, DeRubertis FR (1987) Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats: relationship to the hyperfiltration of early diabetes. Metabolism 36:95-103
    • (1987) Metabolism , vol.36 , pp. 95-103
    • Craven, P.A.1    Caines, M.A.2    DeRubertis, F.R.3
  • 45
    • 0027143190 scopus 로고
    • Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells
    • Williams B, Schrier RW (1993) Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells. J Clin Invest 92:2889-2896
    • (1993) J Clin Invest , vol.92 , pp. 2889-2896
    • Williams, B.1    Schrier, R.W.2
  • 46
    • 0023948928 scopus 로고
    • 2 pathway in mediation of increased prostaglandin synthesis by glomeruli from diabetic rats
    • 2 pathway in mediation of increased prostaglandin synthesis by glomeruli from diabetic rats. Diabetes 37:429-435
    • (1988) Diabetes , vol.37 , pp. 429-435
    • Craven, P.A.1    Patterson, M.C.2    DeRubertis, F.R.3
  • 47
    • 0026696584 scopus 로고
    • Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperperfusion of diabetic rats
    • Perico N, Benigni A, Gabanelli M, Piccinelli A, Ròg M, Riva CD, Remuzzi G (1992) Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperperfusion of diabetic rats. Diabetes 41:533-538
    • (1992) Diabetes , vol.41 , pp. 533-538
    • Perico, N.1    Benigni, A.2    Gabanelli, M.3    Piccinelli, A.4    Ròg, M.5    Riva, C.D.6    Remuzzi, G.7
  • 50
    • 0027311108 scopus 로고
    • Role of EDRF (nitric oxide) in diabetic renal hyperfiltration
    • Bank N, Aynedjian HS (1993) Role of EDRF (nitric oxide) in diabetic renal hyperfiltration. Kidney Int 43:1306-1312
    • (1993) Kidney Int , vol.43 , pp. 1306-1312
    • Bank, N.1    Aynedjian, H.S.2
  • 51
    • 0027750804 scopus 로고
    • Abnormal renal hemodynamic response to reduced renal perfusion pressure in diabetic rats: Role of NO
    • Tolins JP, Shultz PJ, Raij L, Brown DM, Mauer SM (1993) Abnormal renal hemodynamic response to reduced renal perfusion pressure in diabetic rats: role of NO. Am J Physiol 265:F886-F895
    • (1993) Am J Physiol , vol.265
    • Tolins, J.P.1    Shultz, P.J.2    Raij, L.3    Brown, D.M.4    Mauer, S.M.5
  • 52
    • 0028117041 scopus 로고
    • Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes
    • Komers R, AllenTJ, Cooper ME (1994) Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes. Diabetes 43:1190-1197
    • (1994) Diabetes , vol.43 , pp. 1190-1197
    • Komers, R.1    Allen, T.J.2    Cooper, M.E.3
  • 53
    • 0028899528 scopus 로고
    • Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: Possible mediation via protein kinase C
    • Sharma K, Danoff TM, DePiero A, Ziyadeh FN (1995) Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: possible mediation via protein kinase C. Biochem Biophys Res Commun 207:80-88
    • (1995) Biochem Biophys Res Commun , vol.207 , pp. 80-88
    • Sharma, K.1    Danoff, T.M.2    DePiero, A.3    Ziyadeh, F.N.4
  • 54
    • 0027233703 scopus 로고
    • Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats
    • Wang Y-X, Brooks DP, Edwards RM (1993) Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats. Am J Physiol 264:R952-R956
    • (1993) Am J Physiol , vol.264
    • Wang, Y.-X.1    Brooks, D.P.2    Edwards, R.M.3
  • 55
    • 0028039015 scopus 로고
    • Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats
    • Craven PA, Studer RK, DeRubertis FR (1994) Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. J Clin Invest 93:311-320
    • (1994) J Clin Invest , vol.93 , pp. 311-320
    • Craven, P.A.1    Studer, R.K.2    DeRubertis, F.R.3
  • 56
    • 0029075671 scopus 로고
    • Impaired nitric oxide release by glomeruli from diabetic rats
    • Craven PA, Studer RK, DeRubertis FR (1995) Impaired nitric oxide release by glomeruli from diabetic rats. Metabolism 44:695-698
    • (1995) Metabolism , vol.44 , pp. 695-698
    • Craven, P.A.1    Studer, R.K.2    DeRubertis, F.R.3
  • 57
    • 0029945324 scopus 로고    scopus 로고
    • Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats
    • Yagihashi N, Nishida N, Seo HG, Taniguchi N, Yagihashi S (1996) Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats. Diabetologia 39:793-799
    • (1996) Diabetologia , vol.39 , pp. 793-799
    • Yagihashi, N.1    Nishida, N.2    Seo, H.G.3    Taniguchi, N.4    Yagihashi, S.5
  • 59
    • 0027222109 scopus 로고
    • Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics
    • Ito S, Ren YL (1993) Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics. J Clin Invest 92:1093-1098
    • (1993) J Clin Invest , vol.92 , pp. 1093-1098
    • Ito, S.1    Ren, Y.L.2
  • 60
    • 0024344494 scopus 로고
    • Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in native and streptozotocin-induced diabetic rats
    • Kamata K, Miyata N, Kasuya Y (1989) Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in native and streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 249:890-894
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 890-894
    • Kamata, K.1    Miyata, N.2    Kasuya, Y.3
  • 61
    • 0004427864 scopus 로고
    • Impairment of endothelium-dependent dilatation cerebral arterioles during diabetes mellitus
    • Mayhan WG (1989) Impairment of endothelium-dependent dilatation cerebral arterioles during diabetes mellitus. Am J Physiol 256:H621-H625
    • (1989) Am J Physiol , vol.256
    • Mayhan, W.G.1
  • 63
  • 64
    • 0025832494 scopus 로고
    • Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C
    • Tesfamariam B, Brown ML, Cohen RA (1991) Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 87:1643-1648
    • (1991) J Clin Invest , vol.87 , pp. 1643-1648
    • Tesfamariam, B.1    Brown, M.L.2    Cohen, R.A.3
  • 65
    • 0028955927 scopus 로고
    • Regulation of endothelial constitutive nitric oxide synthase by protein kinase C
    • Ohara Y, Sayegh HS, Yamin JJ, Harrison DG (1995) Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension 25:415-420
    • (1995) Hypertension , vol.25 , pp. 415-420
    • Ohara, Y.1    Sayegh, H.S.2    Yamin, J.J.3    Harrison, D.G.4
  • 67
    • 0028239247 scopus 로고
    • Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display
    • Aiello LP, Robinson GS, Lin Y-W, Nishio Y, King GL (1994) Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display. Proc Natl Acad Sci USA 91: 6231-6235
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6231-6235
    • Aiello, L.P.1    Robinson, G.S.2    Lin, Y.-W.3    Nishio, Y.4    King, G.L.5
  • 68
    • 7144245147 scopus 로고
    • Normalization of glucose-induced gene expression, caldesmon. both in vitro and in vivo by an isoform-selective protein kinase C (PKC) inhibitor
    • Kunisaki M, Jirousek MR, Feener EP, King GL (1995) Normalization of glucose-induced gene expression, caldesmon. both in vitro and in vivo by an isoform-selective protein kinase C (PKC) inhibitor. Diabetes 44 |Suppl 1|:59A
    • (1995) Diabetes , vol.44 , Issue.1 SUPPL.
    • Kunisaki, M.1    Jirousek, M.R.2    Feener, E.P.3    King, G.L.4
  • 71
    • 0025200974 scopus 로고
    • Characterization of caldesmon binding to myosin
    • Hemric ME, Chalovich JM (1990) Characterization of caldesmon binding to myosin. J Biol Chem 265:19672-19678
    • (1990) J Biol Chem , vol.265 , pp. 19672-19678
    • Hemric, M.E.1    Chalovich, J.M.2
  • 72
    • 0002223544 scopus 로고
    • Extracellular matrix changes in diabetes mellitus
    • Scarpelli DG, Migahi G (eds) Liss, New York
    • Williamson JR, Kilo C (1984) Extracellular matrix changes in diabetes mellitus. In: Scarpelli DG, Migahi G (eds) Comparative pathobiology of major age-related diseases. Liss, New York, pp 269-288
    • (1984) Comparative Pathobiology of Major Age-related Diseases , pp. 269-288
    • Williamson, J.R.1    Kilo, C.2
  • 73
    • 0017838921 scopus 로고
    • The immunohistopathology of glomerular antigens. II. The glomerular basement membrane, actomyosin, and fibroblast surface antigens in normal, diseased and transplanted human kidneys
    • Scheinman JL, Fish AJ, Matas AJ, Michael AF (1978) The immunohistopathology of glomerular antigens. II. The glomerular basement membrane, actomyosin, and fibroblast surface antigens in normal, diseased and transplanted human kidneys. Am J Pathol 90:71-88
    • (1978) Am J Pathol , vol.90 , pp. 71-88
    • Scheinman, J.L.1    Fish, A.J.2    Matas, A.J.3    Michael, A.F.4
  • 74
    • 0021825268 scopus 로고
    • Glomerular matrix proteins in nodular glomerulosclerosis in association with light chain deposition disease and diabetes mellitus
    • Bruneval P, Foidart JM, Nochy D, Camilleri JP, Bariety J (1985) Glomerular matrix proteins in nodular glomerulosclerosis in association with light chain deposition disease and diabetes mellitus. Hum Pathol 16:477-484
    • (1985) Hum Pathol , vol.16 , pp. 477-484
    • Bruneval, P.1    Foidart, J.M.2    Nochy, D.3    Camilleri, J.P.4    Bariety, J.5
  • 76
    • 0025369136 scopus 로고
    • High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells
    • Ayo SH, Radnik RA, Garoni J, Glass II WF, Kreisberg JI (1990) High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells. Am J Pathol 136: 1339-1348
    • (1990) Am J Pathol , vol.136 , pp. 1339-1348
    • Ayo, S.H.1    Radnik, R.A.2    Garoni, J.3    Glass II, W.F.4    Kreisberg, J.I.5
  • 80
    • 0027942025 scopus 로고
    • 1 (IV) transcriptional activity in a reporter mesangial cell line
    • 1 (IV) transcriptional activity in a reporter mesangial cell line. Am J Physiol 267:F632-F638
    • (1994) Am J Physiol , vol.267
    • Fumo, P.1    Kuncio, G.S.2    Ziyadeh, F.N.3
  • 81
    • 0025966026 scopus 로고
    • Characteristics and mechanisms of high-glucose-induced overexpression of basement membrane components in cultured endothelial cells
    • Cagliero E, Roth T, Roy S, Lorenzi M (1991) Characteristics and mechanisms of high-glucose-induced overexpression of basement membrane components in cultured endothelial cells. Diabetes 40:102-110
    • (1991) Diabetes , vol.40 , pp. 102-110
    • Cagliero, E.1    Roth, T.2    Roy, S.3    Lorenzi, M.4
  • 82
    • 0026317124 scopus 로고
    • Expression of genes related the extracellular matrix in human endothelial cells
    • Cagliero E, Roth T, Roy S, Maiello M, Lorenzi M (1991) Expression of genes related the extracellular matrix in human endothelial cells. J Biol Chem 266:14244-14250
    • (1991) J Biol Chem , vol.266 , pp. 14244-14250
    • Cagliero, E.1    Roth, T.2    Roy, S.3    Maiello, M.4    Lorenzi, M.5
  • 83
    • 0027391242 scopus 로고
    • Increased rat myocardial type VI collagen in diabetes mellitus and hypertension
    • Spiro MJ, Crowley TJ (1993) Increased rat myocardial type VI collagen in diabetes mellitus and hypertension. Diabetologia 36:93-98
    • (1993) Diabetologia , vol.36 , pp. 93-98
    • Spiro, M.J.1    Crowley, T.J.2
  • 84
    • 0024595171 scopus 로고
    • Transforming growth factor β. Murine glomerular receptors and responses of isolated glomerular cells
    • MacKay K, Striker LJ, Stauffer JW, Doi T, Agodoa LY, Striker GE (1989) Transforming growth factor β. Murine glomerular receptors and responses of isolated glomerular cells. J Clin Invest 83:1160-1167
    • (1989) J Clin Invest , vol.83 , pp. 1160-1167
    • MacKay, K.1    Striker, L.J.2    Stauffer, J.W.3    Doi, T.4    Agodoa, L.Y.5    Striker, G.E.6
  • 85
    • 0027631720 scopus 로고
    • Transcriptional activation of matrix genes by transforming growth factor beta 1 in mesangial cells
    • Suzuki S, Ebihara I, Tomino Y, Koide H (1993) Transcriptional activation of matrix genes by transforming growth factor beta 1 in mesangial cells. Exp Nephrol 1:229-237
    • (1993) Exp Nephrol , vol.1 , pp. 229-237
    • Suzuki, S.1    Ebihara, I.2    Tomino, Y.3    Koide, H.4
  • 86
    • 0026557672 scopus 로고
    • Production of extracellular matrix by glomerular epithelial cells in regulated by transforming growth factor-β1
    • Nakamura T, Miller D, Ruoslahti E, Border WA (1992) Production of extracellular matrix by glomerular epithelial cells in regulated by transforming growth factor-β1. Kidney Int 41: 1213-1221
    • (1992) Kidney Int , vol.41 , pp. 1213-1221
    • Nakamura, T.1    Miller, D.2    Ruoslahti, E.3    Border, W.A.4
  • 87
    • 0027479442 scopus 로고
    • Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy
    • Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA (1993) Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90:1814-1818
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1814-1818
    • Yamamoto, T.1    Nakamura, T.2    Noble, N.A.3    Ruoslahti, E.4    Border, W.A.5
  • 89
    • 0028556383 scopus 로고
    • Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse
    • Sharma K, Ziyadeh FN (1994) Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse. Am J Physiol 267:F1094-F1101
    • (1994) Am J Physiol , vol.267
    • Sharma, K.1    Ziyadeh, F.N.2
  • 90
    • 0028100437 scopus 로고
    • Renal TGF-β regulation in spontaneously diabetic NOD mice with correlations in mesangial cells
    • Pankewycz OG, Guan J-X, Bolton WK, Gomez A, Benedict JF (1994) Renal TGF-β regulation in spontaneously diabetic NOD mice with correlations in mesangial cells. Kidney Int 46:748-758
    • (1994) Kidney Int , vol.46 , pp. 748-758
    • Pankewycz, O.G.1    Guan, J.-X.2    Bolton, W.K.3    Gomez, A.4    Benedict, J.F.5
  • 91
    • 0027930856 scopus 로고
    • Expression of transforming growth factor-β1 during diabetic hypertrophy
    • Shankland SJ, Scholey JW (1994) Expression of transforming growth factor-β1 during diabetic hypertrophy. Kidney Int 46:430-442
    • (1994) Kidney Int , vol.46 , pp. 430-442
    • Shankland, S.J.1    Scholey, J.W.2
  • 92
    • 0026787630 scopus 로고
    • High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β
    • Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh FN (1992) High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β. Kidney Int 42:647-656
    • (1992) Kidney Int , vol.42 , pp. 647-656
    • Wolf, G.1    Sharma, K.2    Chen, Y.3    Ericksen, M.4    Ziyadeh, F.N.5
  • 93
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN (1996) Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45:522-530
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 94
    • 0027375770 scopus 로고
    • 1 enhances glomerular collagen synthesis in diabetic-rats
    • 1 enhances glomerular collagen synthesis in diabetic-rats. Diabetes 42:1673-1677
    • (1993) Diabetes , vol.42 , pp. 1673-1677
    • Bollineni, J.S.1    Reddi, A.S.2
  • 95
    • 0028218461 scopus 로고
    • Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β
    • Ziyadeh FN, Sharma K, Ericksen M, Wolf G (1994) Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β. J Clin Invest 93:536-542
    • (1994) J Clin Invest , vol.93 , pp. 536-542
    • Ziyadeh, F.N.1    Sharma, K.2    Ericksen, M.3    Wolf, G.4
  • 96
    • 0028180793 scopus 로고
    • High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures
    • Kreisberg JI, Radnik RA, Ayo SH, Garoni J, Saikumar P (1994) High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures. Kidney Int 46:105-112
    • (1994) Kidney Int , vol.46 , pp. 105-112
    • Kreisberg, J.I.1    Radnik, R.A.2    Ayo, S.H.3    Garoni, J.4    Saikumar, P.5
  • 97
    • 0028913179 scopus 로고
    • Expression of growth-related protooncogenes during diabetic renal hypertrophy
    • Shankland SJ, Scholey JW (1995) Expression of growth-related protooncogenes during diabetic renal hypertrophy. Kidney Int 47:782-788
    • (1995) Kidney Int , vol.47 , pp. 782-788
    • Shankland, S.J.1    Scholey, J.W.2
  • 100
    • 0023832053 scopus 로고
    • The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites
    • Franza BR Jr, Rauscher III FJ, Josephs SF, Curran T (1988) The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239:1150-1153
    • (1988) Science , vol.239 , pp. 1150-1153
    • Franza Jr., B.R.1    Rauscher III, F.J.2    Josephs, S.F.3    Curran, T.4
  • 101
    • 0023782359 scopus 로고
    • The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes
    • Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M (1988) The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54:541-552
    • (1988) Cell , vol.54 , pp. 541-552
    • Chiu, R.1    Boyle, W.J.2    Meek, J.3    Smeal, T.4    Hunter, T.5    Karin, M.6
  • 103
    • 0025259688 scopus 로고
    • Serum stimulation of fibronectin gene expression appears to result from rapid serum-induced binding of nuclear proteins to a cAMP response element
    • Dean DC, McQuillian JJ, Weintraub S (1990) Serum stimulation of fibronectin gene expression appears to result from rapid serum-induced binding of nuclear proteins to a cAMP response element. J Biol Chem 265:3522-3527
    • (1990) J Biol Chem , vol.265 , pp. 3522-3527
    • Dean, D.C.1    McQuillian, J.J.2    Weintraub, S.3
  • 104
    • 0026808488 scopus 로고
    • Characterization of a novel promoter structure and its transcriptional regulation of the murine laminin B1 gene
    • Okano R, Mita T, Matsui T (1992) Characterization of a novel promoter structure and its transcriptional regulation of the murine laminin B1 gene. Biochim Biophys Acta 1132:49-57
    • (1992) Biochim Biophys Acta , vol.1132 , pp. 49-57
    • Okano, R.1    Mita, T.2    Matsui, T.3
  • 105
    • 0023253280 scopus 로고
    • Increased Vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes
    • Williamson JR, Chang K, Tilton RG, Prater C, Jeffrey JR, Weigel C, Sherman WR, Eades DM, Kilo C (1987) Increased Vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes. Diabetes 36:813-821
    • (1987) Diabetes , vol.36 , pp. 813-821
    • Williamson, J.R.1    Chang, K.2    Tilton, R.G.3    Prater, C.4    Jeffrey, J.R.5    Weigel, C.6    Sherman, W.R.7    Eades, D.M.8    Kilo, C.9
  • 106
    • 0025610836 scopus 로고
    • Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions
    • Oliver JA (1990) Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions. J Cell Physiol 145:536-542
    • (1990) J Cell Physiol , vol.145 , pp. 536-542
    • Oliver, J.A.1
  • 107
    • 0026035977 scopus 로고
    • Diacylglycerol accumulation and micro-vascular abnormalities induced by elevated glucose levels
    • Wolf BA, Williamson JR, Easom RA, Chang K, Sherman WR, Turk J (1991) Diacylglycerol accumulation and micro-vascular abnormalities induced by elevated glucose levels. J Clin Invest 87:31-38
    • (1991) J Clin Invest , vol.87 , pp. 31-38
    • Wolf, B.A.1    Williamson, J.R.2    Easom, R.A.3    Chang, K.4    Sherman, W.R.5    Turk, J.6
  • 108
    • 0021100170 scopus 로고
    • Vinculin, a cytoskeletal substrate of protein kinase C
    • Werth DK, Niedel JE, Pastan I (1983) Vinculin, a cytoskeletal substrate of protein kinase C. J Biol Chem 258: 11423-11426
    • (1983) J Biol Chem , vol.258 , pp. 11423-11426
    • Werth, D.K.1    Niedel, J.E.2    Pastan, I.3
  • 109
    • 0026781107 scopus 로고
    • 77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers
    • 77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers. J Cell Physiol 153:62-75)
    • (1992) J Cell Physiol , vol.153 , pp. 62-75
    • Stasek, J.E.1    Patterson, C.E.2    Garcia, J.G.N.3
  • 110
    • 0021210339 scopus 로고
    • A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells
    • Schliwa M, Nakamura T, Porter KR, Euteneuer U (1984) A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells. J Cell Biol 99: 1054-1059
    • (1984) J Cell Biol , vol.99 , pp. 1054-1059
    • Schliwa, M.1    Nakamura, T.2    Porter, K.R.3    Euteneuer, U.4
  • 111
    • 0022446980 scopus 로고
    • Tumor promoter-induced disruption of junctional complexes in cultured epithelial cells is followed by the inhibition of cytokeratin and desmoplakin synthesis
    • Ben-Ze'ev A (1986) Tumor promoter-induced disruption of junctional complexes in cultured epithelial cells is followed by the inhibition of cytokeratin and desmoplakin synthesis. Exp Cell Res 164:335-352
    • (1986) Exp Cell Res , vol.164 , pp. 335-352
    • Ben-Ze'ev, A.1
  • 112
    • 0024379267 scopus 로고
    • The role of phosphorylation and limited proteolytic cleavage of talin and vi-nculin in the disruption of focal adhesion integrity
    • Turner CE, Pavalko FM, Burridge K (1989) The role of phosphorylation and limited proteolytic cleavage of talin and vi-nculin in the disruption of focal adhesion integrity. J Biol Chem 264:11938-11944
    • (1989) J Biol Chem , vol.264 , pp. 11938-11944
    • Turner, C.E.1    Pavalko, F.M.2    Burridge, K.3
  • 113
    • 0030053505 scopus 로고    scopus 로고
    • 1 overexpression augments phorbol ester-induced increase in endothelial permeability
    • 1 overexpression augments phorbol ester-induced increase in endothelial permeability. J Cell Physiol 166: 249-255
    • (1996) J Cell Physiol , vol.166 , pp. 249-255
    • Nagpala, P.G.1    Malik, A.B.2    Vuong, P.T.3    Lum, H.4
  • 114
    • 0028158817 scopus 로고
    • Calphostin-C stimulates epidermal growth factor receptor phosphorylation and internalization via light-dependent mechanism
    • Gamou S, Shimizu N (1994) Calphostin-C stimulates epidermal growth factor receptor phosphorylation and internalization via light-dependent mechanism. J Cell Physiol 158: 151-159
    • (1994) J Cell Physiol , vol.158 , pp. 151-159
    • Gamou, S.1    Shimizu, N.2
  • 115
    • 0000324360 scopus 로고
    • Elevated glucose level regulates epidermal growth factor receptor (EGF-R) in aortic smooth muscle cells overexpressing protein kinase C
    • Xia P, Feener EP, King GL (1994) Elevated glucose level regulates epidermal growth factor receptor (EGF-R) in aortic smooth muscle cells overexpressing protein kinase C. Diabetes 43 [Suppl 1]:101A
    • (1994) Diabetes , vol.43 , Issue.1 SUPPL.
    • Xia, P.1    Feener, E.P.2    King, G.L.3
  • 119
    • 0028321899 scopus 로고
    • Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus
    • King GL, Shiba T, Oliver J, Inoguchi T, Bursell S-E (1994) Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annu Rev Med 45:179-188
    • (1994) Annu Rev Med , vol.45 , pp. 179-188
    • King, G.L.1    Shiba, T.2    Oliver, J.3    Inoguchi, T.4    Bursell, S.-E.5
  • 120
    • 0023575388 scopus 로고
    • Does a common mechanism induce the diverse complications of diabetes?
    • Winegrad AI (1987) Does a common mechanism induce the diverse complications of diabetes? Diabetes. 36:396-406
    • (1987) Diabetes , vol.36 , pp. 396-406
    • Winegrad, A.I.1
  • 121
    • 0022982072 scopus 로고
    • Altered retinal metabolism in diabetes. II. Measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers
    • MacGregor LC, Matschinsky FM (1986) Altered retinal metabolism in diabetes. II. measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers. J Biol Chem 261:4052-4058
    • (1986) J Biol Chem , vol.261 , pp. 4052-4058
    • MacGregor, L.C.1    Matschinsky, F.M.2
  • 122
    • 0022580561 scopus 로고
    • Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve: Implications for (Na.K)-ATPase regulation and diabetic complications
    • Greene DA, Lattimer SA (1986) Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve: implications for (Na.K)-ATPase regulation and diabetic complications. Diabetes 35:242-245
    • (1986) Diabetes , vol.35 , pp. 242-245
    • Greene, D.A.1    Lattimer, S.A.2
  • 124
    • 0025924051 scopus 로고
    • 2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium
    • 2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium. J Clin Invest 87: 1992-1998
    • (1991) J Clin Invest , vol.87 , pp. 1992-1998
    • Hebert, R.L.1    Jacobson, H.R.2    Breyer, M.D.3
  • 128
  • 130
    • 0003372194 scopus 로고    scopus 로고
    • Vitamin E (vit E) prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity
    • Lee I-K, Koya D, Ishii H, King GL (1996) Vitamin E (vit E) prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes 45 [Suppl 2]:64A
    • (1996) Diabetes , vol.45 , Issue.2 SUPPL.
    • Lee, I.-K.1    Koya, D.2    Ishii, H.3    King, G.L.4
  • 131
    • 0031093983 scopus 로고    scopus 로고
    • Prevention of glomerular dysfunctions in diabetic rats by treatment of d-α-tocopherol
    • in press
    • Koya D, Lee I-K, Ishii H, Kanoh H, King GL (1997) Prevention of glomerular dysfunctions in diabetic rats by treatment of d-α-tocopherol. J Am Soc Nephrol (in press)
    • (1997) J Am Soc Nephrol
    • Koya, D.1    Lee, I.-K.2    Ishii, H.3    Kanoh, H.4    King, G.L.5
  • 132
    • 57249093617 scopus 로고    scopus 로고
    • Characterization of the role of PKC β in the regulation of extracellular matrix abnormalities in diabetic rats
    • Koya D, Jirousek MR, Ishii H, King GL (1996) Characterization of the role of PKC β in the regulation of extracellular matrix abnormalities in diabetic rats. J Am Soc Nephrol 7:1874
    • (1996) J Am Soc Nephrol , vol.7 , pp. 1874
    • Koya, D.1    Jirousek, M.R.2    Ishii, H.3    King, G.L.4


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