Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats

European Journal of Pharmacology

Volumn 436, Issue 1-2, 2002, Pages 111-118

  Nassar, Taher ^a   Kadery, Bashir ^a   Lotan, Chaim ^b   Da'as, Nael ^c   Kleinman, Yosef ^c   Haj Yehia, Abdullah ^a,d  

^a David R Bloom Center for Pharmacy   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c BIKUR CHOLIM HOSPITAL   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Diabetes; Endothelial dysfunction; Nitric oxide (NO); Superoxide; Superoxide dismutase; Tempol

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ACETYLCHOLINE; CYCLIC GMP; GLYCERYL TRINITRATE; MALONALDEHYDE; NITROXIDE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG SCREENING; ENDOTHELIUM; HYPERGLYCEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VASCULAR DISEASE; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; AORTA; BLOOD GLUCOSE; BODY WEIGHT; CYCLIC GMP; CYCLIC N-OXIDES; DIABETES MELLITUS, EXPERIMENTAL; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; SPIN LABELS; SUPEROXIDES; VASODILATION; VASODILATOR AGENTS;

EID: 0036468992     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01566-7     Document Type: Article

References (47)

1. Nitric oxide; mediator, murderer, and medicine
2. Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide
3. Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes
4. Role of nitric oxide in cardiovascular disease: Focus on the endothelium
5. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration
6. Inhibition of hydroxyl radical production by lactobionate, adenine and tempol
7. Endothelial dysfunction in mesenteric resistance arteries of diabetic rat: Role of free radicals
8. Cardiac reperfusion damage prevented by a nitroxide free radical
9. Glycation of proteins as a source of superoxide
10. Diabetes mellitus, hypertension, and cardiovascular disease: Which role for oxidative stress?
11. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
12. In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: A thiol-nitrate interaction hypothesis as an explanation for nitroglycerin activity and tolerance
13. Effects of the superoxide dismutase-mimic compound tempol on oxidant stress-mediated endothelial dysfunction
14. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta
15. Superoxide production in the isolated rabbit aorta and the effect of alloxan, indomethacin and nitrovasodilators
16. Mechanisms underlying endothelial dysfunction in diabetes mellitus
17. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
18. Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus
19. Nitroxide as antioxidants
20. 2 - Or as SOD mimics?
21. Treatment with dimethylthiourea prevents impaired dilatation of the basilar artery during diabetes mellitus
22. Deficiency of ascorbic acid in experimental diabetes. Relationship with collagen and polyol pathway abnormalities
23. Impaired endothelium-dependent and independent vasodilation in patient with type 2 (non-insulin-dependent) diabetes mellitus
24. Biologically active metal-independent superoxide dismutase mimics
25. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators
26. Peroxynitrite: A biologically significant oxidant
27. Inhibition of lipid peroxidation by spin labels. Relationships between structure and function
28. Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat
29. Should we recommend the therapeutical use of vitamin E in diabetic patients?
30. Oxygen free radicals abolish endothelium-dependent relaxation in diabetic aorta
31. Diabetic-induced endothelial dysfunction in rat aorta: Role of hydroxyl radicals
32. Spin-trap protection from tumor necrosis factor cytotoxicity
33. Generation of superoxide by purified brain NO synthase
34. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
35. The generation and actions of isoprostanes
36. Superoxide production from non-enzymatically glycated proteins
37. Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage
38. The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes
39. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic. Role of nitric oxide
40. Alteration in human vascular endothelial cell function by oxygen free radical. Platelet adherence and prostacyclin release
41. Quantification of superoxide radical formation in intact vascular tissue using a Cypridina luciferin analog as an alternative to lucigenin
42. Free radicals mediate endothelial cell dysfunction caused by elevated glucose
43. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
44. Effects of vitamin E on the endothelium: Equivocal? α-tocopherol and endothelial dysfunction
45. Hyperglycemic pseudohypoxia and diabetic complications
46. Alteration in free radicals tissue-defense mechanisms in streptozotocin-induced diabetes
47. A simple fluorometric assay for lipoperoxide in blood plasma