Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?

American Journal of Clinical Nutrition

Volumn 80, Issue 5, 2004, Pages 1194-1200

  Lee, Duk Hee ^a,b   Folsom, Aaron R ^a   Harnack, Lisa ^a   Halliwell, Barry ^c   Jacobs Jr , David R ^a,d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Kyungpook National University School of Medicine   (South Korea)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Cardiovascular diseases; Diabetes mellitus; Iron; Vitamin C

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; FOLIC ACID; ANTIOXIDANT;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; DIET; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; POSTMENOPAUSE; QUESTIONNAIRE; VITAMIN SUPPLEMENTATION; AGED; CARDIOVASCULAR DISEASE; CHEMICALLY INDUCED DISORDER; MIDDLE AGED; PROSPECTIVE STUDY; REGISTER; UNITED STATES;

AGED; ANTIOXIDANTS; ASCORBIC ACID; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; DIET SURVEYS; FEMALE; HUMANS; IOWA; MIDDLE AGED; POSTMENOPAUSE; PROSPECTIVE STUDIES; QUESTIONNAIRES; REGISTRIES;

EID: 14544300684     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/80.5.1194     Document Type: Article

References (37)

1. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 1989;86:6377-81.
2. Halliwell B. Vitamin C: antioxidant or pro-oxidant in vivo? Free Radic Res 1996;25:439-54.
3. Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J. Vitamin C exhibits pro-oxidant properties. Nature 1998;392:559.
4. Lee SH, Oe T, Blair IA. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 2001;292:2083-6.
5. Lee KW, Mossine V, Ortwerth BJ. The relative ability of glucose and ascorbate to glycate and crosslink lens proteins in vitro. Exp Eye Res 1998;67:95-104.
6. Will JC, Byers T. Does diabetes mellitus increase the requirement for vitamin C? Nutr Rev 1996;54:193-202.
7. Will JC, Ford ES, Bowman BA. Serum vitamin C concentrations and diabetes: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 1999;70:49-52.
8. Gapstur SM, Potter JD, Folsom AR. Increased risk of breast cancer with alcohol consumption in postmenopausal women. Am J Epidemiol 1993;136:1221-31.
9. Willett WC, Sampson L, Browne ML, et al. The use of self-administered questionnaire to assess diet four years in the past. Am J Epidemiol 1988;127:188-99.
10. US Department of Agriculture. Composition of foods, 1976 to 1992. Agricultural handbook no. 8. Washington, DC; US Government Printing Office, 1989.
11. Munger RG, Folsom AR, Kushi LH, Kaye SA, Sellers TA. Dietary assessment of older Iowa women with a food frequency questionnaire: nutrient intake, reproducibility, and comparison with 24-hour dietary recall interviews. Am J Epidemiol 1992;136:192-200.
12. Willet WC, Sampson L, Stampfer MJ, ET AL. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985;122:51-65.
13. Fuller JH, Stevens LK, Wang SL. Risk factors for cardiovascular mortality and morbidity: the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 2001;44:S54-64.
14. Beitz R, Mensink GB, Fischer B. Blood pressure and vitamin C and fruit and vegetable intake. Ann Nutr Metab 2003;47:214-20.
15. Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects. Br J Nutr 2004;91:81-90.
16. Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 2002;51:2348-54.
17. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003;52:581-7.
18. Van Campenhout A, Van Campenhout C, Lagrou AR, Manuel-Y-Keenoy B. Transferrin modifications and lipid peroxidation: implications in diabetes mellitus. Free Radic Res 2003;37:1069-77.
19. Joshipura KJ, Hu FB, Manson JE, et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 2001;134:1106-14.
20. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA 2002;288:2569-78.
21. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-6.
22. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328:1444-9.
23. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr 1996;64:190-6.
24. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3:194-202.
25. Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996;334:1156-62.
26. Yochum LA, Folsom AR, Kushi LH. Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women. Am J Clin Nutr 2000;72:476-83.
27. Osganian SK, Stampfer MJ, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol 2003;42:246-52.
28. Waters DD, Alderman EL, Hsia J, et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. JAMA 2002;288:2432-40.
29. Timimi FK, Ting HH, Haley EA, Roddy MA, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. J Am Coll Cardiol 1998;31:552-7.
30. Upritchard JE, Sutherland WH, Mann JI. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000;23:733-8.
31. Omaye ST, Krinsky NI, Kagan VE, Mayne ST, Liebler DC, Bidlack WR. Beta-carotene: friend or foe? Fundam Appl Toxicol 1997;40:163-74.
32. Herbert V. The antioxidant supplement myth. Am J Clin Nutr 1994;60:157-8.
33. Eastwood MA. Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease? QJM 1999;92:527-30.
34. Kaye SA, Folsom AR, Sprafka JM, Prineas RJ, Wallace RB. Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women. J Clin Epidemiol 1991;44:329-34.
35. Midthjell K, Holmen J, Bjorndal A, Lund-Larsen G. Is questionnaire information valid in the study of a chronic disease such as diabetes?. The Nord-Trondelag Diabetes Study. J Epidemiol Community Health 1992;46:537-42.
36. Kannel WB, Neaton JD, Wentworth D, et al. Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT. Multiple Risk Factor Intervention Trial. Am Heart J 1986;112:825-36.
37. Halliwell B, Gutteridge JM. The antioxidants of human extracellular fluids. Arch Biochem Biophys 1990;280:1-8.