Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1144-1152

  Kruger, Adam L ^a   Peterson, Stephen J ^a   Schwartzman, Michal L ^a   Fusco, Heidi ^a   McClung, John A ^a   Weiss, Melvin ^a   Shenouda, Sylvia ^a   Goodman, Alvin I ^a   Goligorsky, Michael S ^a   Kappas, Attallah ^b   Abraham, Nader G ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; EBSELEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXYNITRITE; PORPHYRIN COBALT; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; STANNOUS CHLORIDE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-X PROTEIN; BLOOD PRESSURE; BLOTTING, WESTERN; DIABETIC ANGIOPATHIES; ENDOTHELIAL CELLS; HEME OXYGENASE (DECYCLIZING); HYPERTENSION; MALE; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN; OXYGEN CONSUMPTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXYNITROUS ACID; PHOSPHORYLATION; RATS; RATS, ZUCKER; SIGNAL TRANSDUCTION; TYROSINE; UP-REGULATION;

EID: 33751194898     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107482     Document Type: Article

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