Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 3, 1996, Pages 363-367

  Bassenge, Eberhard ^a   Fink, Bruno ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Exogenous endogenous nitric oxide; Nitrovasodilators; O2 . radicals; Peroxynitrite; Vitamin C

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CALCIUM; CYCLIC GMP; GLYCERYL TRINITRATE; NITRATE; THROMBIN; THROMBIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CONTINUOUS INFUSION; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DOG; DRUG MECHANISM; DRUG TOLERANCE; FEMALE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RECEPTOR UPREGULATION; THROMBOCYTE FUNCTION; VEIN DILATATION; VISCOSITY;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD PLATELETS; BLOOD PRESSURE; CALCIUM; CYCLIC GMP; DOGS; DRUG INTERACTIONS; DRUG SYNERGISM; DRUG TOLERANCE; FEMALE; INFUSIONS, INTRAVENOUS; MALE; MUSCLE, SMOOTH, VASCULAR; NITROGLYCERIN; THROMBIN; UP-REGULATION; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 0029920495     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168641     Document Type: Article

References (30)

1. Ahlner J, Andersson RGG, Torfgard K, Axelsson KL (1991) Organic nitrate esters: clinical use and mechanisms of actions. Pharmacol Rev 43: 351-423
2. Bassenge E (1994) Coronary vasomotor responses: role of endothelium and nitrovasodilators. Cardiovasc Drugs Ther 8: 601-610
3. Bassenge E, Zanzinger J (1992) Nitrates in different vascular beds, nitrate tolerance, and interactions with endothelial function. Am J Cardiol 70: 23B-29B
4. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624
5. Boesgaard S, Poulsen HE, Aldershvile J, Loft S, Anderson ME, Meister A (1993) Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties. Circulation 87: 547-553
6. Cadenas E (1995) Thiyl radical formation during thiol oxidation by ferrylmyoglobin. Methods Enzymol 251: 107-116
7. De Caterina R, Giannessi D, Crea F, Chierchia S, Berini W, Gazzetti P, L'Abbate A (1984) Inhibition of platelet function by injectable isosorbide dinitrate. Am J Cardiol 53: 1683-1691
8. 2-radical formation resulting from impaired NO-scavenging (abstract). Pflügers Arch 429: R108
9. Fung HL (1993) Solving the mystery of nitrate tolerance. A new scent on the trail? Circulation 88: 322-324
10. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148
11. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450
12. 2 formation. Biochem J 292:545-550
13. Münzel T, Bassenge E (1993) Chronic angiotensin converting enzyme-inhibition retards nitrate tolerance and prevents coronary rebound constriction (abstract). Circulation 88: I-90
14. Münzel T, Bassenge E (1995) Chronic angiotensin converting enzyme inhibition with high dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo, Circulation (in press)
15. Münzel T, Holtz J, Mülsch A, Stewart DJ, Bassenge E (1989) Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist. Circulation 79: 188-197
16. Münzel T, Mülsch A, Holtz J, Just H, Harrison DG, Bassenge E (1992) Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate. Circulation 86: 995-1003
17. Münzel T, Giaid A, Kurz S, Stewart DJ, Harrison DG (1995a) Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc Natl Acad Sci USA 92: 5244-5248
18. Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG (1995b) Evidence for enhanced vascular superoxide anion production in nitrate tolerance. J Clin Invest 95: 187-194
19. Parker JD, Farrell B, Fenton T, Cohanim M, Parker JO (1991) Counter-regulatory responses to continuous and intermittent therapy with nitroglycerin. Circulation 84: 2336-2345
20. Pietraforte D, Minetti M (1995) Peroxynitrite-dependent oxidative modification of proteins in human plasma (abstract). Endothelium 3: S40
21. Rudolph W, Dirschinger J, Kraus F, Reiniger G, Hall D (1990) Nitrate therapy in patients with coronary artery disease, preparations and doses with and without development of tolerance. Z Kardiol 79 [Suppl]: III-57-III-65
22. Schmidt HHHW, Lohmann SM, Walter U (1993) The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim Biophys Acta 1178: 153-175
23. Schröder H, Schrör K (1988) Organische Nitrate und Thrombozytenfunktion. Hämostaseologie 8: 90-99
24. Skatchkov M, Fink B, Dikalov S, Sommer O, Bassenge E (1995) Antioxidant mediated prevention of nitrate tolerance is achieved through immediate inactivation of peroxynitrate (abstract). Endothelium 3 [Suppl]: 71
25. Stewart DJ, Elsner D, Sommer O, Holtz J, Bassenge E (1986) Altered spectrum of nitroglycerin action in longterm treatment: nitroglycerin-specific venous tolerance with maintenance of arterial vasodepressor potency. Circulation 74: 573-582
26. Stewart DJ, Holtz J, Bassenge E (1987) Long-term nitroglycerin treatment: effect on direct and endothelium-mediated large coronary artery dilation in conscious dogs. Circulation 75: 847-856
27. Vliet A van der, Smith D, O'Neill CA, Kaur H, Darley-Usmar V, Cross CE, Halliwell B (1994) Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. Biochem J 303: 295-301
28. Watanabe H, Kakihana M, Ohtsuka S, Enomoto T, Yasui K, Sugishita Y (1993) Platelet cyclic GMP: a potentially useful indicator to evaluate the effects of nitroglycerin and nitrate tolerance. Circulation 88: 29-36
29. Willigen G van, Akkerman JW (1991) Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Biochem J 273: 115-120
30. Winterbourn CC, Metodiewa D (1995) Reaction of superoxide with glutathione and other thiols. Methods Enzymol 251: 81-86