Carbonic anhydrase activators: Gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1170-1177

  Saada, Mohamed Chiheb ^a   Montero, Jean Louis ^a   Vullo, Daniela ^b   Scozzafava, Andrea ^b   Winum, Jean Yves ^a   Supuran, Claudiu T ^b  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE ACTIVATOR; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE VA; CARBONATE DEHYDRATASE VII; CARBONATE DEHYDRATASE XIV; CARNOSINE; ENZYME ACTIVATOR; GOLD NANOPARTICLE; HISTAMINE; HISTIDINE; METHYL 2 [3 [5 (1,2 DITHIOLAN 3 YL)PENTANAMIDO]PROPANAMIDO] 3 (4H IMIDAZOL 5 YL)PROPANOATE; METHYL 2 [5 (1,2 DITHIOLAN 3 YL)PENTANAMIDO] 3 (1H IMIDAZOL 4 YL)PROPANOATE; N [2 (1H IMIDAZOL 4 YL)ETHYL] 5 (1,2 DITHIOLAN 3 YL)PENTANAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CYTOSOL; DERIVATIZATION; DRUG EFFECT; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; MAMMAL; MEMBRANE BINDING; MITOCHONDRIAL MEMBRANE;

CARBONIC ANHYDRASES; CARNOSINE; CELL MEMBRANE; CYTOSOL; ENZYME ACTIVATORS; ERYTHROCYTES; GOLD; HISTAMINE; HISTIDINE; HUMANS; ISOENZYMES; METAL NANOPARTICLES; MITOCHONDRIA; MODELS, MOLECULAR; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCTIC ACID;

EID: 79952261049     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101284a     Document Type: Article

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