Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2043-2048

  Briganti, Fabrizio ^a   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE ACTIVATOR; ENZYME ACTIVATOR; HISTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE;

BINDING SITES; CARBONIC ANHYDRASES; DRUG DESIGN; ENZYME ACTIVATION; HISTAMINE; IMIDAZOLES; ISOENZYMES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 0033584160     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00310-8     Document Type: Article

References (22)

1. Maren, T.H. J. Glaucoma 1995, 4, 49-62.
2. a) Supuran, CT.; Scozzafava, A.; Ilies, M.A.; Iorga, B.; Cristea, T.; Briganti, F.; Chiraleu, F.; Banciu, M.D. Eur. J. Med Chem., 1998, 33, 577-595;
3. b) Supuran, C.T.; Scozzafava, A. J. Enzyme Inhib., 1997, 12, 37-51.
4. Reiss, W.G.; Oles, K.S. Ann. Pharmacother. 1996, 30, 514-519.
5. Supuran C.T. In Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism, Puscas I., Ed.; Helicon, Timisoara, 1994, pp. 29-112.
6. Supuran, C.T.; Conroy, C.W.; Maren T.H. Eur.J.Med.Chem., 1996, 31, 843-846.
7. Hewett-Emmett D.; Tashian R.E. Mol. Phylogenet. Evol. 1996, 5, 50-77.
8. Briganti, F.; Mangani, S.; Orioli, P.; Scozzafava, A.; Vernaglione, G.; Supuran, C.T. Biochemistry 1997, 36, 10384-10392.
9. Briganti, F.; Iaconi, V.; Mangani, S.; Orioli, P.; Scozzafava, A.; Vernaglione, G.; Supuran, C.T. Inorg. Chim. Acta 1998, 275-276, 295-300.
10. a) Clare, B.W.; Supuran, C.T. J. Pharm. Sci. 1994, 83, 768-779;
11. b) Supuran, C.T.; Balaban, A.T.; Cabildo, P.; Claramunt, R.M.; Lavandera, J.L.; Elguero, J. Biol. Pharm. Bull. 1993, 16, 1236-1239;
12. c) Supuran, C.T.; Claramunt, R.M.; Lavandera, J.L.; Elguero, J. Biol. Pharm. Bull. 1996, 19, 1417-1422.
13. a) Supuran, C.T.; Barboiu, M.; Luca, C.; Pop, E.; Brewster, M.E.; Dinculescu, A. Eur. J. Med. Chem. 1996, 31, 597-606;
14. b) Ilies, M.A.; Banciu, M.D.; Ilies, M.; Chiraleu, F.; Briganti, F.; Scozzafava, A.; Supuran, C.T Eur. J. Med Chem. 1997, 32, 911-918.
15. Sly, W.S. In The Carbonic Anhydrases, Dodgson, S.J.; Tashian, R.E.; Gros, G.; Carter, N.D. Eds., Plenum Press, New York and London, 1991, pp. 183-196.
16. a) Jain, A.; Whitesides, G.M.; Alexander, R.S.; Christianson, D.W. J. Med. Chem., 1994, 37, 2100-2105;
17. b) Boriack, P.A., Christianson, D.W., Kingery-Wood, J., and Whitesides, G.M., J. Med. Chem., 1995, 38, 2286-2291.
18. a) Supuran, CT.; Ilies, M.A.; Scozzafava, A. Eur. J. Med Chem., 1998, 33, 739-751;
19. b) Scozzafava, A; Menabuoni, L.; Mincione, F.; Briganti, F.; Mincione, G.; Supuran, CT., J. Med. Chem., 1999, in press.
20. Wolin, R.; Connolly, M., Afonso, A.; Hey, J.A.; She, H.; Rivelli, M.A.; Williams, S.M.; West, R.E. Bioorg. Med. Chem. Lett., 1998, 8, 2157-2162
21. 7 Enzyme concentrations were 3.5 nM for hCA II, 12 nM for hCA I and 31 nM for bCA IV.
22. Maren, T.H.; Wynns, G.C.; Wistrand, P.J. Mol. Pharmacol. 1993, 44, 901-906.