Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 8, 2010, Pages 2822-2828

  Innocenti, Alessio ^a   Durdagi, Serdar ^b   Doostdar, Nadjmeh ^c   Amanda Strom, T ^c   Barron, Andrew R ^c,d   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CALGARY   (Canada)

^c RICE UNIVERSITY   (United States)

^d SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Amino acid; Carbonic anhydrase; Docking; Enzyme inhibition; Fullerene

Indexed keywords

ALCOHOL; AMINE; AMINO ACID; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE 5B; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE V; CARBONATE DEHYDRATASE VI; CARBONATE DEHYDRATASE VII; CARBONATE DEHYDRATASE XIII; CARBONATE DEHYDRATASE XIV; CARBONATE DEHYDRATASE XV; CARBONIC ANHYDRATASE 5A; COUMARIN DERIVATIVE; FULLERENE DERIVATIVE; HISTIDINE; SULFONAMIDE; THREONINE; UNCLASSIFIED DRUG; VALINE; ZINC;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; MOLECULAR DOCKING; NONHUMAN;

BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; COMPUTER SIMULATION; FULLERENES; HUMANS; NANOPARTICLES; PROTEIN ISOFORMS;

MAMMALIA;

EID: 77950516142     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.026     Document Type: Article

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