Carbonic anhydrase activators: Activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2440-2443

  Abdo, Marie Rose ^a   Vullo, Daniela ^b   Saada, Mohamed Chiheb ^a   Montero, Jean Louis ^a   Scozzafava, Andrea ^b   Winum, Jean Yves ^a   Supuran, Claudiu T ^b  

^a INSTITUT CHARLES GERHARDT   (France)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Activator; Arylsulfonylhydrazido l histidine; Carbonic anhydrase; Isoform selective activator; Isozyme I, II, IX; l Histidine

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; ENZYME ACTIVATOR; HISTIDINE DERIVATIVE; HYDRAZINE DERIVATIVE; SULFONE DERIVATIVE;

ARTICLE; DRUG BINDING; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME ACTIVATION; STRUCTURE ACTIVITY RELATION;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME ACTIVATION; HISTIDINE; HUMANS; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN ISOFORMS; RECOMBINANT PROTEINS;

EID: 64249168342     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.050     Document Type: Article

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