Small-molecule suppression of misfolding of mutated human carbonic anhydrase II linked to marble brain disease

Biochemistry

Volumn 48, Issue 23, 2009, Pages 5358-5364

  Almstedt, Karin ^a   Rafstedt, Therese ^a   Supuran, Claudiu T ^b   Carlsson, Uno ^a   Hammarström, Per ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DISEASE; CARBONIC ANHYDRASE II; FOLDING MODULATOR; HUMAN CARBONIC ANHYDRASE II; MISFOLDING; PROTEIN STABILITY; SMALL MOLECULES; THERMAL DENATURATIONS;

AMINES; AMINO ACIDS; DENATURATION; MARBLE; MOLECULES; ORGANIC ACIDS; PYROLYSIS; SULFUR COMPOUNDS;

STABILIZATION;

1,3,4 THIADIAZOLE DERIVATIVE; 1,3,4 THIADIAZOLYLSULFONAMIDE DERIVATIVE; 4 AMINOBENZOYLSULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; GUANIDINE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; DENATURATION; ENZYME INHIBITION; GENETIC ASSOCIATION; MARBLE BRAIN DISEASE; MOLECULAR INTERACTION; MOLECULAR SIZE; MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; RNA TRANSLATION; TEMPERATURE SENSITIVITY; THERMOSTABILITY;

BRAIN DISEASES, METABOLIC, INBORN; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; SULFONAMIDES; THERMODYNAMICS;

EID: 67049119436     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900128e     Document Type: Article

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