Advancement in carbon nanotubes: Basics, biomedical applications and toxicity

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 2, 2011, Pages 141-163

  Beg, Sarwar ^a   Rizwan, Mohammad ^a   Sheikh, Asif M ^b   Hasnain, M Saquib ^a   Anwer, Khalid ^c   Kohli, Kanchan ^a  

^a HAMDARD UNIVERSITY   (India)

^b Wockhardt Research Center   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

biomedical application; carbon nanotubes; nanocarrier; nanomedicine; targeted drug delivery

Indexed keywords

AMPHOTERICIN B; CARBON NANOTUBE; CARBOPLATIN; CELLULOSE; CISPLATIN; COMBRETASTATIN; CURCUMIN; DEXAMETHASONE; DNA; DOXORUBICIN; FLUORESCEIN; IBUPROFEN; METAL DERIVATIVE; METHOTREXATE; MITOMYCIN C; NANOCARRIER; OXALIPLATIN; PACLITAXEL; PEPTIDE DERIVATIVE; POLYOXOMETALATE; RNA; SMALL INTERFERING RNA; THEOPHYLLINE; UNCLASSIFIED DRUG;

BIOCOMPATIBILITY; CARCINOGENICITY; COMPOSITE MATERIAL; DIAGNOSTIC VALUE; DRUG DELIVERY SYSTEM; DRUG SAFETY; DRUG TARGETING; GENOTOXICITY; HUMAN; MOLECULAR ELECTRONICS; MUTAGENICITY; NANOMEDICINE; NONHUMAN; REVIEW;

ANIMALS; BIOCOMPATIBLE MATERIALS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HUMANS; NANOMEDICINE; NANOTUBES, CARBON;

EID: 78751514108     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01167.x     Document Type: Review

References (227)

1. Sahoo SK, Labhasetwar V,. Nanotech approaches to drug delivery and imaging. Drug Discov Today 2003; 8: 1112-1120.
2. Iijima S,. Helical microtubules of graphitic carbon. Nature 1991; 354: 56-58.
3. Carbon nanotube science and technology: history. A Carbon Nanotube. [online] 2009; (accessed 13 January 2009).
4. Boczkowski J, Lanone S,. Potential uses of carbon nanotubes in the medical field: how worried should patients be? Nanomedicine 2007; 2: 407-410.
5. Kroto H, et al. C60: buckminsterfullerene. Nature 1985; 318: 162-163.
6. Zheng LX, et al. Ultralong single-wall carbon nanotubes. Nat Mater 2004; 3: 673-676.
7. Dresselhaus MS, et al. Electronic, thermal and mechanical properties of carbon nanotubes. Phil Trans A Math Phys Eng Sci 2004; 362: 2065-2098.
8. Awasthi K, et al. Synthesis of carbon nanotubes. J Nanosci Nanotechnol 2005; 5: 1616-1636.
9. Foldavari M, Bagonluri M,. Carbon nanotubes as functional excipients for nanomedicines: I. Pharmaceutical properties. Nanomed Nanotechnol Biol Med 2008; 4: 173-182.
10. Hilder TA, Hill JM,. Theoretical comparison of nanotube materials for drug delivery. Micro Nano Lett 2008; 3: 18-24.
11. Joselevich E,. Electronic structure and chemical reactivity of carbon nanotubes: a chemist's view. Chem Phys 2004; 5: 619-624.
12. Schonenberger C,. Multiwall carbon nanotubes. Physics world Article: [online] 2000; (accessed 2 June 2000).
13. Flahaut E, et al. Gram-Scale CCVD synthesis of double-walled carbon nanotubes. Chem Commun 2003; 12: 1442-1443. (Pubitemid 36734969)
14. Danailov D, et al. Bending properties of carbon nanotubes encapsulating solid nanowires. J Nanosci Nanotechnol 2002; 2: 503-507.
15. Iijima S, et al. Nano-aggregates of single-walled graphitic carbon nano-horns. Chem Phys Lett 1999; 309: 165-170.
16. Zhang Y, et al. Heterostructures of single-walled carbon nanotubes and carbide nanorods. Science 1999; 285: 1719-1722.
17. Shiba K, et al. Carbon nanohorns as a novel drug carrier. Nippon Rinsho 2006; 64: 239-246.
18. Nasibulin AG, et al. A novel hybrid carbon material. Nat Nanotechnol 2007; 2: 156-161.
19. Murakami T, et al. Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy. Nanomedicine 2008; 3: 453-463.
20. Ajima K, et al. Carbon nanohorns as anticancer drug carriers. Mol Pharmacol 2005; 2: 475-480.
21. Liu L, et al. Colossal paramagnetic moments in metallic carbon nanotori. Phys Rev Lett 2002; 88: 217206.
22. Brian M,. Practical applications of carbon nanotubes in medicine. Basic Biotechnology ejournal. [online] 2009; MMG: 445. (accessed 13 January 2009).
23. Bronikowski MJ, et al. Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPCO process: a parametric study. J Vac Sci Technol A 2001; 19: 1800-1805.
24. Wang Y, et al. The effect of catalyst concentration on the synthesis of single walled carbon nanotubes. Spectrochim Acta A Mol Biomol Spectrosc 2002; 58: 2089-2095.
25. Ajayan PM, et al. Nanotubes in a flash-ignition and reconstruction. Science 2002; 296: 705.
26. Nagy B, et al. On the growth mechanism of single walled carbon nanotubes by catalytic carbon vapour deposition on supported metal catalysts. J Nanosci Nanotechnol 2004; 4: 326-345.
27. Thess A, et al. Crystalline ropes of metallic carbon nanotubes. Science 1996; 273: 483-487.
28. Conceicao J, et al. Photoelectron spectroscopy of transition-metal clusters: correlation of valence electronic structure to reactivity. Phys Rev B Condens Matter 1995; 51: 4668-4671.
29. Jose-Yacaman M,. Catalytic growth of carbon microtubules with fullerene structure. Appl Phys Lett 1993; 273: 483-487.
30. Abdulkareem AS, et al. Synthesis of carbon nanotubes by swirled floating catalyst chemical vapour deposition method. J Nanosci Nanotechnol 2007; 7: 3233-3238.
31. Inami N, et al. Synthesis-condition dependence of carbon nanotube growth by alcohol catalytic chemical vapor deposition method. Sci Technol Adv Mater 2007; 8: 292-295.
32. Choi EC, et al. Synthesis of carbon nanotubes on diamond-like carbon by the hot filament plasma-enhanced chemical vapor deposition method. Micron 2009; 40: 612-616.
33. Kleinsorge B, et al. Growth of aligned carbon nanofibres over large areas using colloidal catalysts at low temperatures. Chem Commun 2004; 10: 1416-1417.
34. Vajtai R, et al. Controlled growth of carbon nanotubes. Phil Trans A Math Phys Eng Sci 2004; 362: 2143-2160.
35. Baddour C, Briens C,. Carbon nanotube synthesis: a review. Int J Chem Reactor Eng 2005; 3: R3-R9.
36. Ose-Yacaman M,. Catalytic growth of carbon microtubules with fullerene structure. Appl Phys Lett 1993; 62: 657-659.
37. Dresselhaus MS, et al. Carbon nanotubes. Physicsworld.com. [online] 2009; 1761. (accessed 13 January 2009).
38. Dresselhaus MS, Dresselhaus G,. Single walled nanotubes raman spectroscopy. Acc Chem Res 2002; 35: 1070-1078.
39. Couvreur P, Vauthier C,. Nanotechnology: intelligent design to treat complex disease. Pharm Res 2006; 23: 1417-1450.
40. Park K,. Controlled Drug Delivery: Challenges and Strategies. Washington, DC: American Chemical Society, 1997.
41. Hui HW, et al. Design and fabrication of oral controlled release drug delivery systems. In:, Robinson JR, Lee VHL, eds. Controlled Drug Delivery: Fundamentals and Applications. New York: Marcel Dekker, 1987: 373-432.
42. Riggio C,. Combination of polymer technology and carbon nanotube array for the development of an effective drug delivery system at cellular level. Nanoscale Res Lett 2009; 4: 668-673.
43. Liu Z, et al. Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano 2007; 1: 50-56.
44. Sinha N, Yeow JTW,. Carbon nanotubes for biomedical applications. IEEE Trans Nanobioscience 2005; 4: 180-195.
45. Gao H, et al. Spontaneous insertion of DNA oilgonucleotide into carbon nanotubes. Nano Lett 2003; 3: 471-473.
46. Mitchell DT, et al. Smart nanotubes for bioseparation and biocatalysis. J Am Chem Soc 2001; 124: 11864-11865.
47. Pastorin G, et al. Double functionalization of carbon nanotubes for multi modal drug delivery. Chem Commun 2006; 1182-1184.
48. Kam NW, Dai H,. Carbon nanotubes as intracellular protein transporters: generality and biological functionality. J Am Chem Soc 2005; 127: 6021-6026.
49. Singh R, et al. Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J Am Chem Soc 2005; 127: 4388-4396.
50. Pantarotto D, et al. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed Engl 2004; 43: 5242-5246.
51. Martin CR, Kohli P,. The emerging field of nanotube biotechnology. Nat Rev Drug Discov 2003; 2: 29-37.
52. Pantoratto D, et al. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed Engl 2004; 43: 5242-5246.
53. Pantarotto D, et al. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun 2004; 1: 16-17.
54. Penman D,. Carbon nanotubes show drug delivery promise. New scientist.com [online] 2003; (accessed 6 August 2009).
55. Yang YJ, et al. Fluorescent mesoporous silica nanotubes incorporating CdS quantum dots for controlled release of ibuprofen. Acta Biomater 2009; 5: 3488-3496.
56. Zhang CH, et al. Preparation and theophylline delivery applications of novel PMAA/MWNT-COOH nanohybrid hydrogels. J Biomater Sci Polym Ed 2009; 20: 1119-1135.
57. 'Smart' bio-nanotubes developed; may help in drug delivery. Science Daily [online] 3 August 2005; (accessed 11 August 2009).
58. Leonard S,. Titanium nanotubes offer implant integration, drug delivery. Qmed Beta. [online] 17 May 2009; (accessed 11 June 2010).
59. Mohapatra SS, Kumar A,. Method of drug delivery by carbon nanotube-chitosan nanocomplexes. US20080214494.
60. Kam NW, et al. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci USA 2005; 102: 11600-11605.
61. Ferrari M,. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 2005; 5: 161-171.
62. Prakash S, Kulamarva AG,. Recent advances in drug delivery: potential and limitations of carbon nanotubes. Recent Pat Drug Deliv Formul 2007; 1: 214-221.
63. Quintana A, et al. Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm Res 2002; 19: 1310-1316.
64. Pantarotto D, et al. Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides. J Am Chem Soc 2003; 125: 6160-6164.
65. Wu W, et al. Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes. Angew Chem Int Ed Engl 2005; 44: 6358-6362.
66. Special nanotubes may be used as a vehicle for treating neurodegenerative disorders. Science daily: Science news [online] 2009; (accessed 28 July 2009).
67. Kulamarva A, et al. Microcapsule carbon nanotube devices for therapeutic applications. Nanotechnology 2009; 20: 025612.
68. Singh R, Lillard JW Jr,. Nanoparticles based targeted delivery. Exp Mol Pathol 2009; 86: 215-223.
69. McDevit MR, et al. Tumor targeting with antibody-functionalized radiolabelled carbon nanotubes. J Nucl Med 2007; 48: 1180-1189.
70. Ashcroft JM, et al. Fullerene (C60) immunoconjugates: interaction of water-soluble C60 derivatives with the murine anti-gp240 melanoma antibody. Chem Commun 2006; 3004-3006.
71. Welsher K, et al. Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. Nano Lett 2008; 8: 586-590.
72. Kasab AC, et al. Rifampicin carrying polyhydroxybutyrate microspheres as a potential chemoembolization agent. J Biomater Sci Polym Ed 1997; 8: 947-961.
73. Yang F, et al. Pilot study of targeting magnetic carbon nanotubes to lymph nodes. Nanomedicine 2009; 4: 317-330.
74. Bystrzejewski M, et al. Carbon encapsulated magnetic nanoparticles for biomedical applications: thermal stability studies. Biomol Eng 2007; 24: 555-558.
75. Yang F, et al. Magnetic lymphatic targeting drug delivery system using carbon nanotubes. Med Hypotheses 2008; 70: 765-767.
76. Pardridge WM,. The blood-brain barrier: bottleneck in brain drug development. NeuroRxR 2005; 2: 3-14.
77. Pardridge WM,. Blood-brain barrier delivery. Drug Discov Today 2007; 12: 54-61.
78. Hunyh GH, et al. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release 2006; 110: 236-259.
79. Rautioa J, Chikhale PJ,. Drug delivery systems for brain tumor therapy. Curr Pharm Des 2004; 10: 1341-1353.
80. Kateb B, et al. Internalization of MWNTs by microglia: possible application in immunotherapy of brain tumors. Neuroimage 2007; 37 (Suppl. 1): S9-S17.
81. VanHandel M, et al. Selective uptake of multi-walled carbon nanotubes by tumor macrophages in a murine glioma model. J Neuroimmunol 2009; 208: 3-9.
82. Rosen Y, Elman NM,. Carbon nanotubes in drug delivery: focus on infectious diseases. Expert Opin Drug Deliv 2009; 6: 517-530.
83. Jingyi C, et al. Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J Am Chem Soc 2008; 130: 16778-16785.
84. Sharon G,. MIT uses nanotubes to help fight cancer. Computerworld IDG. [online] 2009; 15idg. (accessed 13 July 2009).
85. Nanotubes the 'bomb diggity' for cancer treatment? Inpharma Weekly. [online] 2009; (accessed 27 October 2009).
86. Liz K,. Carbon nanotubes pass through body fast. Nanotechweb org. [online] 2009; 24233. (accessed 12 January 2009).
87. Gannon CJ, et al. Carbon nanotube-enhanced thermal destruction of cancer cells in a non-invasive radiofrequency field. Cancer 2007; 2654.
88. Zhou F, et al. Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes. J Biomed Opt 2009; 14: 021009.
89. Levi-Polyachenko NH, et al. Rapid photo thermal intracellular drug delivery using multiwalled carbon nanotubes. Mol Pharm 2009; 6: 1092-1099.
90. Torti SV, et al. Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. Int J Nanomedicine 2007; 2: 707-714.
91. Burke A, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci USA 2009; 106: 12897-12902.
92. Zach Z,. Killing cancer with red-hot nanotubes. Discover Magazine. [online] 2005; (accessed 27 June 2009).
93. Guenzel JDN,. A-coated nanotubes help kill tumors without harm to surrounding tissue. Eureka alert. [online] 2009; (accessed 19 August 2009).
94. Podesta JE, et al. Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model. Small 2009; 5: 1176-1185.
95. Liu Z, et al. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 2008; 68: 6652-6660.
96. Zhang X, et al. Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 2009; 30: 6041-6047.
97. Zhao Q, et al. Carbon-nanotube-assisted high loading and controlled release of polyoxometalates in biodegradable multilayer thin films. Nanotechnology 2009; 20: 105101.
98. Hampel S, et al. Carbon nanotubes filled with a chemotherapeutic agent: a nanocarrier mediates inhibition of tumor cell growth. Nanomedicine 2008; 3: 175-182.
99. Dhar S, et al. Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J Am Chem Soc 2008; 130: 11467-11476.
100. Chen J, et al. Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J Am Chem Soc 2008; 130: 16778-16785.
101. Zhang Z, et al. Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth. Clin Cancer Res 2006; 12: 4933-4939.
102. Wang X, et al. Targeted RNA interference of cyclin A2 mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells. Chem Med Chem 2008; 3: 940-945.
103. Yang J, et al. Oxygen adsorption by carbon nanotubes and its application in radiotherapy. IET Nanobiotechnol 2007; 1: 10-14.
104. Ou Z, et al. Functional single-walled carbon nanotubes based on an integrin alpha v beta 3 monoclonal antibody for highly efficient cancer cell targeting. Nanotechnology 2009; 20: 105102.
105. Murakami T, et al. Solubilization of single-wall carbon nanohorns using a PEG-doxorubicin conjugate. Mol Pharm 2006; 3: 407-414.
106. Ajima K, et al. Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns. ACS Nano 2008; 2: 2057-2064.
107. Pramanik M, et al. Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent. J Biomed Opt 2009; 14: 034018.
108. Schulz MJ, et al. On beating cancer (with nanotechnology). Nano werk spotlight [online] 2007; (accessed 31 October 2007).
109. Prato M, et al. Functionalized carbon nanotubes in drug design and discovery. Acc Chem Res 2008; 41: 60-68.
110. Dyke CA, Tour JM,. Overcoming the insolubility of carbon nanotubes through high degrees of sidewall functionalization. Chem Eur J 2004; 10: 812.
111. Tasis D, et al. Soluble carbon nanotubes. Chem Eur J 2003; 9: 4000-4008.
112. Bianco A, et al. Biomedical applications of functionalized carbon nanotubes. Chem Commun 2005; 5: 571-577. (Pubitemid 40299037)
113. Gao Y, et al. Temperature-sensitive and highly water-soluble titanate nanotubes. Polymer 2009; 50: 2572-2577.
114. Klumpp C, et al. Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics. Biochim Biophys Acta 2006; 1758: 404-412.
115. LaVan DA, et al. Small-scale systems for in vivo drug delivery. Nat Biotechnol 2003; 21: 1184-1191.
116. Gasparc R, et al. Template synthesis of nano test tubes. Nano Lett 2004; 4: 513.
117. Kim BM, et al. Filling nanotubes with particles. Nano Lett 2005; 5: 873-878.
118. Jorgensen WL,. The many roles of computation in drug discovery. Science 2004; 303: 1813-1818.
119. Briefing paper: Inst. Neurosci. Mental health and addiction. CIHR. [online] 2003; (accessed 15 September 2009).
120. Guo X, Xu H,. Research and development of biomedical application of carbon nanotubes and related composites. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2006; 23: 438-441.
121. Kramer K, et al. Multifunctional carbon nano-tubes for biomedical applications (CARBIO). A project of the European Marie Curie Network. Urologe A 2007; 46: 1248.
122. Mehra NK, et al. Challenges in the use of carbon nanotubes for biomedical applications. Crit Rev Ther Drug Carrier Syst 2008; 25: 169-206.
123. Bhargava A,. Nanorobots: medicine of the future. IEEE [online] July 1999; (accessed 6 July 2009).
124. Polizu S, et al. Applications of carbon nanotubes-based biomaterials in biomedical nanotechnology. J Nanosci Nanotechnol 2006; 6: 1883-1904.
125. Liu J, Dai H,. Design, fabrication, and testing of piezoresistive pressure sensors using carbon nanotubes. [online] 2002; (accessed 11 June 2010).
126. Romero M, et al. Pressure sensing systems for medical devices. Med Dev Diag Ind Mag [online] 2000; (accessed 12 October 2009).
127. Joseph H, et al. MEMS in the medical world. Sens Mag 1997; 14: 47-51.
128. Sakai K,. Artificial kidney engineering-dialysis membrane and dialyzer for blood purification. J Chem Eng Jpn 1997; 30: 587-599.
129. Sotiropoulou S, Chaniotakis NA,. Carbon nanotube array-based biosensor. Anal Bioanal Chem 2003; 375: 103-105.
130. Wang J, et al. Ultrasensitive electrical biosensing of proteins and DNA: carbon-nanotube derived amplification of the recognition and transduction events. J Am Chem Soc 2004; 126: 3010-3011.
131. Xu Y, et al. Electrochemical impedance detection of DNA hybridization based on the formation of M-DNA on ploypyrrole/carbon nanotube modified electrode. Anal Chim Acta 2004; 516: 19-27.
132. He P, Dai L,. Aligned carbon nanotube-DNA electrochemical sensors. Chem Commun 2004; 3: 348-349.
133. Galaasen OP,. Nanomedicine and the future of healthcare. Med Technol [online] 2002; (accessed 3 August 2009).
134. Adrian P,. Nanosensors targeted at the right markets could generate big business opportunities. Sens Bus Dig [online] 2003; (accessed 19 October 2009).
135. Shandas R, Lanning C,. Development and evaluation of implantable sensors for monitoring function of prosthetic heart valves: in vitro studies. Med Biol Eng Comput 2003; 41: 416-424.
136. Shultts MC, et al. A telemetry instrumentation system for monitoring multiple subcutaneously implanted glucose sensors. MEEE Trans Biomed Eng 1994; 41: 937-972.
137. Liao KJ, et al. Experimental studies on flow velocity sensors based on multiwalled carbon nanotubes. Microfab Technol 2003; 4: 57.
138. Ghosh S, et al. Carbon nanotube flow sensors. Science 2003; 299: 1042-1044.
139. Schulz MJ, et al. Electrochemical impedance measurement of prostate cancer cells using carbon nanotube array electrodes in a microfluidic channel. Nanotechnology 2007; 18: 465505.
140. Popov AM, et al. Biocompatibility and applications of carbon nanotubes in medical nanorobots. Int J Nanomedicine 2007; 2: 361-372.
141. Cavalcanti A, et al. Nanorobots for laparoscopic cancer surgery. 6th IEEE/ACIS 2007 International Conference on Computer and Information Science (ICIS 2007). IEEE Computer Society, 2007: 738-743.
142. Mamalis AG,. Recent advances in nanotechnology. J Mat Process Technol 2007; 181: 52-58.
143. Harutyunyan AR, et al. Carbon nanotubes for medical applications. Eur Cell Mater 2002; 3 (Suppl. 2): 84-87.
144. Stevens RMD, et al. Carbon nanotube scanning probe for imaging in aqueous environment. IEEE Trans Nanobioscience 2004; 3: 56-60.
145. Nguyen CV, et al. High lateral resolution imaging with sharpened tip of multi walled carbon nanotube probe. J Phys Chem B 2004; 108: 2816-2821.
146. Emirov YN, et al. Making carbon nanotube probes for high aspect ratio scanning probe metrology. Proc SPIE 2003; 5038: 493-495.
147. Stevens RMD, et al. Carbon nanotubes as probes for atomic force microscopy. Nanotechnology 2000; 11: 1-5.
148. Baughman RH, et al. Carbon nanotubes: the route toward applications. Science 2002; 297: 787-792.
149. Akita S, et al. Nanotweezers consisting of carbon nanotubes operating in an atomic force microscope. Appl Phys Lett 2001; 79: 1691-1693. (Pubitemid 33598506)
150. Kim P, Lieber CM,. Nanotube nanotweezers. Science 1999; 286: 2148-2150.
151. Vohrer U, et al. Carbon nanotube sheets for use as artificial muscles. Carbon 2000; 42: 316-319.
152. Baughman RH, et al. Carbon nanotube actuators. Science 1999; 284: 408-410.
153. Kiernan G, et al. Characterization of nanotube based artificial muscles materials. Proc SPIE 2002; 4876: 775-782.
154. Gao M, et al. Electrochemical properties of aligned nanotube arrays: Basis of new electrochemical actuators. Proc SPIE 2000; 3987: 18-24.
155. Megaridis CM, et al. Attoliter fluid experiment in individual closed-end carbon nanotubes: liquid film and fluid interface dynamics. Phys Fluids 2002; 14: L5-L8.
156. Gogotsi Y, et al. In situ multiphase fluid experiments in hydrothermal carbon nanotubes. Appl Phys Lett 2001; 79: 1021-1023. (Pubitemid 33600602)
157. Lim YT, et al. Selection of quantum dot wavelengths for biomedical assays and imaging. Mol Imaging 2003; 2: 50-64.
158. Tans SJ, et al. Individual single-wall carbon nanotubes as quantum wires. Nature 1997; 386: 474-477.
159. Jia N, et al. Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes. Nano Lett 2007; 7: 2976-2980.
160. Bhirde AA, et al. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 2009; 3: 307-316.
161. Czaja WK, et al. The future prospects of microbial cellulose in biomedical applications. Biomacromolecules 2007; 8: 1-12.
162. Park W-II, et al. Synthesis of bacterial celluloses in multiwalled carbon nanotube dispersed medium. Carbohydr Polym 2009; 77: 457-463.
163. Harrison BS, Atala A,. Carbon nanotube applications for tissue engineering. Biomaterials 2007; 28: 344-353.
164. Ada GL,. The traditional vaccines: an overview. In:, Levine MM, et al., ed. New Generation Vaccines. New York: Marcel Dekker, 1997: 13-23.
165. Bianco A, et al. Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 2005; 9: 674-679. (Pubitemid 41612196)
166. Carbon nanotubes offer a new approach to gene therapy. The Medical News: from News-Medical.net [online] 2004; (accessed 11 October 2004).
167. Pan B, et al. Synthesis and characterization of polyamidoamine dendrimer-coated multi-walled carbon nanotubes and their application in gene delivery systems. Nanotechnology 2009; 20: 125101.
168. Zhang M, Gorski W,. Electrochemical sensing platform based on the carbon nanotubes/redox mediators-biopolymer system. J Am Chem Soc 2005; 127: 2058-2059.
169. Zhang M, Gorski W,. Electrochemical sensing based on redox mediation at carbon nanotubes. Anal Chem 2005; 77: 3960-3965.
170. Svistunenko DA,. Reaction of haem containing proteins and enzymes with hydroperoxides: the radical view. Biochim Biophys Acta 2005; 1707: 127-155.
171. Bi-feng P, et al. Design of dendrimer modified carbon nanotubes for gene delivery. Chin J Cancer Res 2007; 19: 1-6.
172. Yang R, et al. Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells. Gene Ther 2006; 13: 1714-1723.
173. Wu Y, et al. Carbon nanotubes protect DNA strands during cellular delivery. ACS Nano 2008; 2: 2023-2028.
174. Wang H, et al. Unique aggregation of anthrax (Bacillus anthracis) spores by sugar coated single-walled carbon nanotubes. J Am Chem Soc 2006; 128: 13364-13365.
175. Hilder TA, Hill JM,. Modeling the loading and unloading of drugs into nanotubes. Small 2009; 5: 300-308.
176. Lanone S, Boczkowski J,. Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Curr Mol Med 2006; 6: 651-666.
177. Soto K, et al. Cytotoxic effects of aggregated nanomaterials. Acta Biomater 2007; 3: 351-358.
178. Wick P, et al. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 2007; 168: 121-131.
179. Fraczek A, et al. Comparative in vivo biocompatibility study of single- and multi-wall carbon nanotubes. Acta Biomater 2008; 4: 1593-1602.
180. Qu G, et al. The effect of multiwalled carbon nanotube agglomeration on their accumulation in and damage to organs in mice. Carbon 2009; 47: 2060-2069.
181. Belyanskaya L, et al. Effects of carbon nanotubes on primary neurons and glial cells. Neurotoxicol 2009; 30: 702-711.
182. Bottini M, et al. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett 2006; 160: 121-126.
183. Davoren E, et al. In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells. Toxicol In Vitro 2007; 21: 438-448.
184. Chiaretti M, et al. Carbon nanotubes toxicology and effects on metabolism and immunological modification in vitro and in vivo. J Phys Condens Matter 2008; 20: 10.
185. Rotoli BM, et al. Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of human airway epithelial cells. Toxicol Lett 2008; 178: 95-102.
186. Poland CA, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008; 3: 423-428.
187. Shvedova AA, et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 2003; 66: 1909-1926.
188. Pulskamp K, et al. Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 2007; 168: 58-74.
189. Szendi K, Varga C,. Lack of genotoxicity of carbon nanotubes in a pilot study. Anticancer Res 2008; 28: 349-352.
190. Zhu L, et al. DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Lett 2007; 7: 3592-3597.
191. Muller J, et al. Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 2008; 29: 427-433.
192. Kisin ER, et al. Single-walled carbon nanotubes: geno and cytotoxic effects in lung fibroblast V79 cells. J Toxicol Environ Health A 2007; 70: 2071-2079.
193. Takagi A, et al. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008; 33: 105-116.
194. Sakamoto Y, et al. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 2009; 34: 65-76.
195. Muller J, et al. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol Sci 2009; 110: 442-448.
196. Tong H, et al. Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice. Toxicol Appl Pharmacol 2009; 239: 224-232.
197. Yang S, et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol Lett 2008; 181: 182-189.
198. Zeni O, et al. Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes. Sensor 2008; 8: 488-499.
199. Yacobi NR, et al. Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol In Vitro 2007; 21: 1373-1381.
200. Huczko A, Lange H,. Carbon nanotubes: experimental evidence for a null risk of skin irritation and allergy. Fuller Sci Technol 2001; 9: 247-250.
201. Bardi G, et al. Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomedicine 2009; 5: 96-104.
202. Sotto AD, et al. Multi-walled carbon nanotubes: lack of mutagenic activity in the bacterial reverse mutation assay. Toxicol Lett 2009; 184: 192-197.
203. Vittorio O, et al. Influence of purity and surface oxidation on cytotoxicity of multiwalled carbon nanotubes with human neuroblastoma cells. Nanomed Nanotechnol Biol Med 2009; 5: 524-531.
204. Smart SK, et al. The biocompatibility of carbon nanotubes. Carbon 2006; 44: 1034-1047.
205. Pelley J, Saner M,. International approaches to the regulatory governance of nanotechnology. RegulatoryGovernance Initiatives. [online] April 2009; (accessed 13 June 2010).
206. Lewinski N,. Nanotechnology policy and environmental regulatory issues. J Eng Public Pol 2005; 9: 1-37.
207. Ensysce receives funding for carbon nanotube therapeutics for siRNA delivery. Nano werk [online] June 11 2010; (accessed 13 June 2010).
208. Arrowhead Research Corporation (ARWR.O). [online] 11 June 2010; (accessed 13 June 2010).
209. Nanotechnology in clinical trials. NCI Alliance for nanotechnology in cancer. National Cancer Research Institute. [online] 2010; (accessed 14 June 2010).
210. Arkema receives EPA approval to market its carbon nanotubes in the United States. Nano werk [online] June 2 2010; (accessed 13 June 2010).
211. Multi wall carbon nanotubes modified to resolve dispersion problems. Plastermart.com [online] 2010; (accessed 13 June 2010)
212. Itkis ME, et al. Comparison of analytical techniques for evaluation of single-walled carbon nanotubes. J Am Chem Soc 2005; 127: 3439-3448.
213. McKee GS, Vecciho KS,. Thermogravimetric analysis synthesis variation effects on CVD generated multiwalled carbon nanotubes. J Phys Chem B 2006; 110: 1179-1186.
214. Georgakilas V, et al. Purification of HiPCO carbon nanotubes via organic functionalization. J Am Chem Soc 2002; 124: 14318-14319. (Pubitemid 35403749)
215. Pantoratto D, et al. Synthesis, structural characterization and immunological properties of carbon nanotubes functionalized with peptides. J Am Chem Soc 2003; 125: 6160-6164.
216. Li PH, et al. Synthesis of cactus top decorated aligned carbon nanotubes and their third order nonlinear optical properties. J Nanosci Nanotechnol 2006; 6: 990-995.
217. Odom TW, et al. Single-walled nanotubes from fundamental studies to new device concepts. Ann N Y Acad Sci 2002; 960: 203-215.
218. Sanchez S, et al. Carbon nanotubes/polysulfone screen printed electrochemical immunosensor. Biosens Bioelectron 2007; 23: 332-340.
219. Heller D, et al. Using Raman spectroscopy to elucidate the aggregation state of single-walled carbon nanotubes. J Phys Chem B 2004; 108: 6905-6909.
220. Eklund P, et al. Vibrational modes of carbon nanotubes; spectroscopy & theory. Carbon 2004; 33: 6905-6909.
221. Rao AM, et al. Diameter-selective Raman scattering from vibrational modes in carbon nanotubes. Science 1997; 275: 187-191.
222. Georgakilas V, et al. Organic functionalization of carbon nanotubes. J Am Chem Soc 2002; 124: 760-761.
223. Karajanagi SS, et al. Structure and function of enzyme adsorbed onto single-walled carbon nanotubes. Langmuir 2004; 20: 11594-11599.
224. Vinogradov SV, et al. Curcumin-Combretastatin nanocells as breast cancer cytotoxic and antiangiogenic agent. [online] 2008; (accessed 24 September 2008).
225. Murakami T, et al. Drug-loaded carbon nanohorns: adsorption and release of dexamethasone in vitro. Mol Pharm 2004; 1: 399-405.
226. Inoue K, et al. Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol 2009; 237: 306-316.
227. Kishore AS, et al. Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods. Toxicol Lett 2009; 191: 268-274.