Combination of polymer technology and carbon nanotube array for the development of an effective drug delivery system at cellular level

Nanoscale Research Letters

Volumn 4, Issue 7, 2009, Pages 668-673

  Riggio, Cristina ^b   Ciofani, Gianni ^a   Raffa, Vittoria ^a   Cuschieri, Alfred ^a   Micera, Silvestro ^a,c  

^a SCUOLA SUPERIORE SANT ANNA   (Italy)

^b CRIM and ARTS Lab Scuola Superiore sant'Anna   (Italy)

^c ETH ZURICH   (Switzerland)

Author keywords

Alginate; Drug delivery; NGF; PC12 cells; Vertically aligned carbon nanotubes

Indexed keywords

A-CARBON; CARBON NANOTUBE ARRAY; CELLULAR LEVELS; DRUG DELIVERY SYSTEM; DRUG RELEASE; IN-VITRO ASSAYS; NEURAL GROWTH; NGF; PC12 CELLS; POLYMER TECHNOLOGY; POLYMER THIN FILMS; POLYMERIC FILMS; RELEASE KINETICS; SINGLE PLATFORM; VERTICALLY ALIGNED CARBON NANOTUBES;

ALGINATE; CELL CULTURE; DRUG DELIVERY; FILM GROWTH; FUNCTIONAL POLYMERS; GROWTH KINETICS; PLASTIC FILMS; POLYMERS;

CARBON NANOTUBES;

EID: 67349097848     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1007/s11671-009-9291-0     Document Type: Article

References (27)

1. D Maysinger A Morinville 1997 Drug delivery to the nervous system Trend. Biotechnol. 15 410 418 10.1016/S0167-7799(97)01095-0
2. M Danckwerts A Fassihi 1991 Implantable controlled release drug delivery systems: a review Drug Dev. Ind. Pharm. 17 1465 1502 10.3109/03639049109026629
3. M Ferrari 2005 Nanovector therapeutics Curr. Opin. Chem. Biol. 9 343 346 10.1016/j.cbpa.2005.06.001
4. D Tasis N Tagmatarchis A Bianco M Prato 2006 Chemistry of carbon nanotubes Chem. Rev. 106 1105 1136 10.1021/cr050569o
5. TD Nguyen-Vu H Chen AM Cassell RJ Andrews M Meyyappan J Li 2007 Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface IEEE Trans. Biomed. Eng. 54 1121 1128 10.1109/TBME.2007. 891169
6. TD Nguyen-Vu H Chen AM Cassell R Andrews M Meyyappan J Li 2006 Vertically aligned carbon nanofiber arrays: an advance toward electrical-neural interfaces Small 2 89 94 10.1002/smll.200500175
7. T Gabay M Ben-David I Kalifa R Sorkin ZR Abrams E Ben-Jacob Y Hanein 2007 Electro-chemical and biological properties of carbon nanotube-based multi-electrode arrays Nanotechnology 18 1 6 10.1088/0957-4484/18/3/035201
8. C Chretien JC Chaumeil 2005 Release of a macromolecular drug from alginate-impregnated particles Int. J. Pharm. 304 18 28 10.1016/j.ijpharm.2005. 06.030
9. A Mikkelsen A Eigsaeter 1995 Density distribution of calcium induces alginate gels: a numerical study Biopolymers 36 17 114 10.1002/bip.360360104
10. WR Gombotz SF Wee 1998 Protein release from alginate matrices Adv. Drug Deliv. Rev. 31 267 285 10.1016/S0169-409X(97)00124-5
11. G Ciofani MG Cascone LP Serino L Lazzeri 2008 Urease loaded alginate microspheres for blood purification J. Microencapsul. 25 569 576 10.1080/02652040802081227
12. G Murtas M Capuani Dentini C Manetti G Masci M Massimi A Miccheli V Crescenzi 2005 Alginate beads as immobilization matrix for hepatocytes perfused in a bioreactor J. Biomater. Sci. Polym. Ed. 16 829 846 10.1163/1568562054255718
13. Kimberly L Douglas CA Piccirillo M Tabrizian 2006 Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles J. Control Release 115 354 361 10.1016/j.jconrel.2006.08.021
14. JO Winter SF Cogan JF Rizzo III 2007 Neurotrophin-eluting hydrogel coatings for neural stimulating electrodes J Biomed. Mater. Res. B Appl. Biomater. 81B 551 563 10.1002/jbm.b.30696
15. 2-guluronic acid interaction on alginate encapsulated betaTC3 cells Biomaterials 25 2603 2610 (Pubitemid 38147451)
16. CM Stoscheck 1990 Quantitation of protein Methods Enzymol. 182 50 69 10.1016/0076-6879(90)82008-P
17. L.A. Greene, S.E. Farinelli, M.E. Cunningham, D.S. Park, in Culture and experimental use of the PC12 rat pheochromocytoma cell line, ed. by F. Banker, K. Gosling. Culturing Nerve Cells (1998), p. 2
18. G Ciofani V Raffa T Pizzorusso A Dario P Dario 2008 Characterization of an alginate based drug delivery system for neurological applications Med. Eng. Phys. 30 848 855 10.1016/j.medengphy.2007.10.003
19. G Ciofani V Raffa Y Obata A Menciassi P Dario S Takeoka 2008 Magnetic driven alginate nanoparticles for targeted drug delivery Curr. Nanosci. 4 212 218 10.2174/157341308784340886
20. A Laca LA Garcia F Argueso M Diaz 1999 Protein diffusion in alginate beads monitored by confocal microscopy, The application of wavelets for data reconstruction and analysis J. Ind. Microbiol. Biotechnol. 23 155 165 10.1038/sj.jim.2900703
21. BJ Hinds N Chopra T Rantell R Andrews V Gavalas LG Bachas 2004 Aligned multiwalled carbon nanotube membranes Science 303 62 65 10.1126/science.1092048
22. X Navarro S Calvet CA Rodriguez C Blau M Buti E Valderrama JU Meyer T Stieglitz 1998 Stimulation and recording from regenerated peripheral nerves through polyimide sieve electrodes J. Peripher. Nerv. Syst. 3 91 101 (Pubitemid 28185681)
23. X Navarro T Lago S Micera T Stieglitz P Dario 2005 A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems J. Peripher. Nerv. Syst. 10 229 258 10.1111/j.1085-9489.2005.10303.x
24. GA Silva 2009 Nanomedicine: shorting neurons with nanotubes Nat. Nanotechnol. 4 82 83 10.1038/nnano.2008.424
25. G Cellot E Cilia S Cipollone V Rancic A Sucapane S Giordani L Gambazzi H Markram M Grandolfo D Scaini F Gelain L Casalis M Prato M Giugliano L Ballerini 2009 Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts Nat. Nanotechnol. 4 126 133 10.1038/nnano.2008.374
26. G Terenghi 1999 Peripheral nerve regeneration and neurotrophic factors J. Anat. 194 1 14 10.1046/j.1469-7580.1999.19410001.x (Pubitemid 29126690)
27. JJ Pancrazio 2008 Neural interfaces at the nano scale Nanomedicine 3 823 830 10.2217/17435889.3.6.823