Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor

Pharmaceutical Research

Volumn 19, Issue 9, 2002, Pages 1310-1316

  Quintana, A ^a,b   Raczka, E ^a,b   Piehler, L ^a   Lee, I ^a   Myc, A ^a   Majoros, I ^a   Patri, A K ^a   Thomas, T ^a   Mule J ^a   Baker Jr , J R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Department of Pharmacology   (Spain)

Author keywords

Chemotherapeutic molecular modeling; Dendrimer; Methotrexate; Nanotechnology

Indexed keywords

AMINE; DENDRIMER; ETHYLENEDIAMINE; FLUORESCEIN; FOLATE RECEPTOR; FOLIC ACID; FOLIC ACID DERIVATIVE; METHOTREXATE; POLYAMIDOAMINE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DEVICE; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; HUMAN; HUMAN CELL; NANOTECHNOLOGY; PRIORITY JOURNAL; RECEPTOR BINDING; TUMOR CELL;

CARRIER PROTEINS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; NANOTECHNOLOGY; RECEPTORS, CELL SURFACE; TUMOR CELLS, CULTURED;

EID: 0036744856     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020398624602     Document Type: Article

References (23)

1. A. C. Antony, M. A. Kane, R. M. Portillo, P. C. Elwood, and J. F. Kolhouse. Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells. J. Biol. Chem. 260:14911-14917 (1985).
2. C. P. Leamon and P. S. Low. Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc. Natl. Acad. Sci. USA 88:5572-5576 (1991).
3. J. J. Turek, C. P. Leamon, and P. S. Low. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J. Cell Sci. 106:423-430 (1993).
4. I. G. Campbell, T. A. Jones, W. D. Foulkes, and J. Trowsdale. Folate-binding protein is a marker for ovarian cancer. Cancer Res. 51:5329-5338 (1991).
5. S. D. Weitman, R. H. Lark, L. R. Coney, D. W. Fort, V. Frasca, V. R. Zurawski, Jr., and B.A Kamen. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res. 52:3396-3401 (1992).
6. J. F. Ross, P. K. Chaudhuri, and M. Ratnam. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Cancer 73:2432-2443 (1994).
7. R. J. Lee and P. S. Low. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim. Biophys. Acta 1233:134-144 (1995).
8. S. Wang, R. J. Lee, G. Cauchon, D. G. Gorenstein, and P. S. Low. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc. Natl. Acad. Sci. USA 92:3318-3322 (1995).
9. C. P. Leamon and P. S. Low. Selective targeting of malignant cells with cytotoxin-folate conjugates. J Drug Target. 2:101-112 (1994).
10. 67g ga-deferoxamine-folate, a potential radiopharmaceutical for tumor imaging. Bioconjug. Chem. 7:56-62 (1996).
11. D. A. Tomalia, A. M. Naylor, and W. A. Goddard. Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew. Chem. Int. Ed. 29:138-175 (1990).
12. A. Bielinska, J. F. Kukowska-Latallo, J. Johnson, D. A. Tomalia, and J. Baker, Jr. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acid Res. 24:2176-2182 (1996).
13. J. F. Kukowska-Latallo, A. Bielinska, J. Johnson, R. Spindler, D. A. Tomalia, and J. Baker, Jr. Efficient Transfer of genetic material into mammalian cells using starburst polyamidoamine dendrimers. Proc. Natl. Acad. Sci. USA 93:4897-4902 (1996).
14. N. Malik and E. G. Evagorou, and R. Duncan. Dendrimerplatinate: a novel approach to cancer chemotherapy. Anticancer Drugs 10:767-776 (1999).
15. E. C. Wiener, S. Konda, A. Shadron, M. Brechbiel, and O. Gansow. Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor. Invest. Radiol. 32:748-754 (1997).
16. 125I-labelled polyamidoamine dendrimers in vivo. J. Control. Release 65:133-148 (2000).
17. E. C. Wiener, S. Konda, A. Shadron, M. Brechbiel, and O. Gansow. Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor. Invest. Radiol. 32:748754 (1997).
18. D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder, and P. Smith. A new class of polymers - starburst-dendritic macromolecules. Polymer J. 17:117-132 (1985).
19. B. A. Kamen and J. D. Caston. Properties of a folate binding protein (FBP) isolated from porcine kidney. Biochem. Pharmacol. 14:2323-2329 (1986).
20. P. C. Elwood, M. A. Kane, R. M. Portillo, and J. F. Kolhouse. The isolation, characterization, and comparison of the membrane- associated and soluble folate-binding proteins from human KB cells. J. Biol. Chem. 261:15416-15423 (1986).
21. A. S. Bauchez, J. Lunardi, C. Pernin, D. Marti-Battle, and D. Fagret. Detection of chemoresistance profile of cell lines K562, KB, GLC4, and HL60 through characterisation of the hmdrl, mrp, and Irp transcripts. In Vivo 15:101-104 (2001).
22. G. Kong, R. D. Braun, and M. W. Dewhirst. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res. 60:4440-4445 (2001).
23. J. F. Ross, P. K. Chaudhuri, and M. Ratnam. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in Established cell lines. Cancer 73:2432-2443 (1994).