Pregnane X receptor-mediated induction of Cyp3a by black cohosh

Xenobiotica

Volumn 41, Issue 2, 2011, Pages 112-123

  Pang, Xiaoyan ^a,b   Cheng, Jie ^b   Krausz, Kristopher W ^b   Guo, De An ^a,c   Gonzalez, Frank J ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Black cohosh; CYP3A; Midazolam; Pregnane X receptor; Pregnenolone 16 carbonitrile

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CIMICIFUGA RACEMOSA EXTRACT; CYTOCHROME P450 3A11; LUCIFERASE; MIDAZOLAM; PREGNANE X RECEPTOR; RIFAMPICIN;

ARTICLE; CIMICIFUGA RACEMOSA; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER FUNCTION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CIMICIFUGA; CYTOCHROME P-450 CYP3A; ENZYME ASSAYS; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HEP G2 CELLS; HUMANS; INTESTINE, SMALL; KIDNEY; LIVER; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MIDAZOLAM; PLANT EXTRACTS; RECEPTORS, STEROID; RNA, MESSENGER; SAPONINS; TRITERPENES;

CIMICIFUGA DAHURICA; MUS;

EID: 78651366483     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.527021     Document Type: Article

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