Clinically based evidence of drugherb interactions: A systematic review

Expert Opinion on Drug Safety

Volumn 9, Issue 1, 2010, Pages 79-124

  Kennedy, Deborah A ^a   Seely, Dugald ^a  

^a CANADIAN COLLEGE OF NATUROPATHIC MEDICINE   (Canada)

Author keywords

Alternative medicine; Botanical medicine; Complementary and alternative medicine; Complementary medicine; Drug herb interaction; Herbal medicine

Indexed keywords

ADALA; CILOSTAZOL; CIMICIFUGA RACEMOSA EXTRACT; CRANBERRY EXTRACT; CRATAEGUS EXTRACT; CURCUMA LONGA EXTRACT; DIGOXIN; ECHINACEA PURPUREA EXTRACT; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; FELODIPINE; FEXOFENADINE; GARLIC EXTRACT; GARLIPURE; GINGER EXTRACT; GINKGO BILOBA EXTRACT; GINKGOLON; GINSENG EXTRACT; GREEN TEA EXTRACT; KAVA EXTRACT; METRONIDAZOLE; MIDAZOLAM; MIDAZOLAM MALEATE; NIFEDIPINE; OMEPRAZOLE; PEPPERMINT; PLACEBO; SABAL EXTRACT; SAQUINAVIR; SILYBON; SILYBUM MARIANUM EXTRACT; SIVYLAR; TALINOLOL; TAVONIN; TOLBUTAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALERIAN; WARFARIN;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ABSENCE OF SIDE EFFECTS; ANOREXIA; AREA UNDER THE CURVE; CLINICAL TRIAL; CONSTIPATION; DIARRHEA; DIZZINESS; DROWSINESS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ERUPTION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG WITHDRAWAL; DRY LIP; DYSPEPSIA; EPISTAXIS; EVIDENCE BASED MEDICINE; FLATULENCE; GASTROINTESTINAL SYMPTOM; HEART PALPITATION; HERB DRUG INTERACTION; HOT FLUSH; HUMAN; INCREASED APPETITE; INDIGESTION; INSOMNIA; IRRITABLE COLON; LOW BACK PAIN; MAXIMUM PLASMA CONCENTRATION; MENSTRUATION; NAUSEA; NIGHTMARE; PARESTHESIA; PROSTATE HYPERTROPHY; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; TIME TO MAXIMUM PLASMA CONCENTRATION; UNSPECIFIED SIDE EFFECT; URINARY TRACT INFECTION; VERTIGO; VIVID DREAM; VOMITING; XEROSIS;

CLINICAL TRIALS AS TOPIC; CYTOCHROME P-450 ENZYME SYSTEM; EVIDENCE-BASED MEDICINE; HERB-DRUG INTERACTIONS; HUMANS; PHYTOTHERAPY;

EID: 74349130588     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740330903405593     Document Type: Review

References (92)

1. Boon HS, Olatunde F, Zick SM. Trends in complementary/alternative medicine use by breast cancer survivors: comparing survey data from 1998 and 2005. BMC women's health 2007;7:4
2. Reid I. Baseline Natural Health Products Survey among Consumers. Final Report: Health Canada; 2005 March 2005
3. Barnes P, Bloom B. Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007: Centre for Disease Control and Prevention December 10, 2008
4. Xin HW, Wu XC, Li Q, et al. Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. Br J Clin Pharmacol 2007;64(4):469-475
5. Tanaka E, Hisawa S. Clinically significant pharmacokinetic drug interactions with psychoactive drugs: antidepressants and antipsychotics and the cytochrome P450 system. J Clin Pharmacy ther 1999;24(1):7-16
6. Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998;46(2):101-110
7. Zhou SF, Lai X. An update on clinical drug interactions with the herbal antidepressant St. John's wort. Current drug metabolism 2008;9(5):394-409
8. Mills S, Bone K. Principles and practice of phytotherapy: modern herbal medicine. Edinburgh; New York: Churchill Livingstone; 2000
9. Boon H, Smith M. 55 Most Common Medicinal Herbs. Toronto: Robert Rose; 2009
10. Cavaliere C, Rea P, Blumenthal M. Herbal Supplement Sales in United States Show Growth in All Channels. HerbalGram; May-Jul 2008;(78): 60-3, 4p, 5 charts 2008 May-Jul 2008(78):60-63
11. Gurley B, Hubbard MA, Williams DK, et al. Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol 2006;46(2):201-213
12. Gurley BJ, Barone GW, Williams DK, et al. Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos 2006;34(1):69-74
13. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77(5):415-426
14. Gurley BJ, Swain A, Hubbard MA, et al. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. Molecular nutrition & food research 2008;52(7):755-763
15. Piscitelli SC, Burstein AH, Welden N. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 2002;34(2):234-238
16. Gwilt PR, Lear CL, Tempero MA, et al. The effect of garlic extract on human metabolism of acetaminophen. Cancer Epidemiol Biomarkers Prev 1994;3(2):155-160
17. Gallicano K, Foster B, Choudhri S. Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2003;55(2):199-202
18. Abdul M, Jiang X, Williams K, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-1700
19. Markowitz JS, Devane CL, Chavin KD. Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clin Pharmacol Ther 2003;74(2):170-177
20. Gurley BJ, Gardner SF, Hubbard MA, et al. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging 2005;22(6):525-539
21. Donovan JL, Chavin KD, Devane CL, et al. Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32(9):906-908
22. Chow HH, Hakim IA, Vining DR, et al. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev 2006;15(12):2473-2476
23. Engels FK, de Jong FA, Sparreboom A, et al. Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel. Oncologist 2007;12(3):291-300
24. Citrus aurantium, Professional monograph. Available from: www. naturalstandards.com [cited 11 February 2009]
25. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004;76(5):428-440
26. Tankanow R, Tamer HR, Streetman DS, et al. Interaction study between digoxin and a preparation of hawthorn (Crataegus oxyacantha). J Clin Pharmacol 2003;43(6):637-642
27. Curcuma longa, Professional monograph. Available from: www.naturalstandards. com [cited 2 April 2009]
28. Juan H, Terhaag B, Cong Z, et al. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers. Eur J Clin Pharmacol 2007;63(7):663-668
29. Gorski JC, Huang SM, Pinto A, et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther 2004;75(1):89-100
30. Gurley BJ, Swain A, Williams DK, et al. Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics. Molecular nutrition & food research 2008;52(7):772-779
31. Donovan JL, DeVane CL, Chavin KD, et al. Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug Metab Dispos 2003;31(5):519-522
32. Smith M, Lin KM, Zheng YP. An open trial of nifedipine-herb interactions: nifedipine with St. John's wort, ginseng, or Gingko biloba. Clin Pharmacol Ther 2001;69:86
33. Aruna D, Naidu MU. Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects. Br J Clin Pharmacol 2007;63(3):333-338
34. Fan L, Mao XQ, Tao GY, et al. Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. Xenobiotica; the fate of foreign compounds in biological systems 2009;39(3):249-254
35. Gardner CD, Zehnder JL, Rigby AJ, et al. Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial. Blood Coagul Fibrinolysis 2007;18(8):787-793
36. Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005;59(4):425-432
37. Kudolo GB, Wang W, Javors M, Blodgett J. The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects-a double blind placebo-controlled, crossover study. Clinical nutrition (Edinburgh, Scotland) 2006;25(4):606-616
38. Markowitz JS, Donovan JL, Lindsay DeVane C, et al. Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. J Clin Psychopharmacol 2003;23(6):576-581
39. Mauro VF, Mauro LS, Kleshinski JF, et al. Impact of ginkgo biloba on the pharmacokinetics of digoxin. Am J Ther 2003;10(4):247-251
40. Robertson SM, Davey RT, Voell J, et al. Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. Curr med Res Opin 2008;24(2):591-599
41. Uchida S, Yamada H, Li XD, et al. Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. J Clin Pharmacol 2006;46(11):1290-1298
42. Wolf HR. Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily? Drugs R D 2006;7(3):163-172
43. Yin OQ, Tomlinson B, Waye MM, et al. Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics 2004;14(12):841-850
44. Yoshioka M, Ohnishi N, Koishi T, et al. Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers. Biol Pharm Bull 2004;27(12):2006-2009 (Pubitemid 41701579)
45. Chatterjee SS, Doelman CJ, Noldner M, et al. Influence of the Ginkgo extract EGb 761 on rat liver cytochrome P450 and steroid metabolism and excretion in rats and man. J Pharm Pharmacol 2005;57(5):641-650
46. Markowitz J, DeVane C, Donovan J, Resch S. An Assessment of CYP2D6 inhibitory effects of Ginkgo biloba in normal volunteers. Int J Neuropsychopharmacol 2002;5:s192
47. Mohutsky MA, Anderson GD, Miller JW, Elmer GW. Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivo. Am J Ther 2006;13(1):24-31
48. Gurley BJ, Swain A, Barone GW, et al. Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos 2007;35(2):240-245
49. Gurley BJ, Swain A, Hubbard MA, et al. Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clin Pharmacol Ther 2008;83(1):61-69
50. Sandhu RS, Prescilla RP, Simonelli TM, Edwards DJ. Influence of goldenseal root on the pharmacokinetics of indinavir. J Clin Pharmacol 2003;43(11):1283-1288
51. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72(3):247-255
52. Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2004;57(5):592-599
53. Andrade AS, Hendrix C, Parsons TL, et al. Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir. BMC Complement Altern Med 2008;8:50
54. Lee LS, Wise SD, Chan C, et al. Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius. J Clin Pharmacol 2008;48(5):599-609
55. Yuan CS, Wei G, Dey L, et al. Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial. Ann Intern Med 2004;141(1):23-27
56. Piper methysticum, Professional monograph. Available from: www. naturalstandards.com [cited 11 February 2009]
57. Schisandra sphenanthera, Professional Mongraph. Available from: www. naturalstandards.com [cited 11 February 2009]
58. Gerber GS. Saw palmetto for the treatment of men with lower urinary tract symptoms. J urol 2000;163(5):1408-1412
59. Markowitz JS, Donovan JL, Devane CL, et al. Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers. Clin Pharmacol Ther 2003;74(6):536-542
60. DiCenzo R, Shelton M, Jordan K, et al. Coadministration of milk thistle and indinavir in healthy subjects. Pharmacotherapy 2003;23(7):866-870
61. Fuhr U, Beckmann-Knopp S, Jetter A, et al. The effect of silymarin on oral nifedipine pharmacokinetics. Planta medica 2007;73(14):1429-1435
62. Mills E, Wilson K, Clarke M, et al. Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis. Eur J Clin Pharmacol 2005;61(1):1-7
63. Piscitelli SC, Formentini E, Burstein AH, et al. Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers. Pharmacotherapy 2002;22(5):551-556
64. van Erp NP, Baker SD, Zhao M, et al. Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan. Clin Cancer Res. 2005 11(21):7800-7806
65. Deng JW, Shon JH, Shin HJ, et al. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Pharm Res 2008 25(8):1807-1814
66. Leber HW, Knauff S. Influence of silymarin on drug metabolizing enzymes in rat and man. Arzneimittel-Forschung 1976;26(8):1603-1605
67. Rajnarayana K, Reddy MS, Vidyasagar J, Krishna DR. Study on the influence of silymarin pretreatment on metabolism and disposition of metronidazole. Arzneimittel-Forschung 2004;54(2):109-113
68. Rao BN, Srinivas M, Kumar YS, Rao YM. Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers. Drug Metabol Drug Interact 2007;22(2-3):175-185
69. Ansell J, McDonough M, Harmatz J, Greenblatt DJ. A randomized double-blind trial of the interaction between cranberry juice and warfarin. J Thromb Thrombolysis 2007;25:112
70. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79(1):125-133
71. Grenier J, Fradette C, Morelli G, et al. Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clin Pharmacol Ther 2006;79(3):255-262
72. Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. Journal of the American Dietetic Association 2006;106(12):2057-2061
73. Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam-probes of CYP2C9, CYP1A2, and CYP3A4. Clin Pharmacol Ther 2007;81(6):833-839
74. Donovan JL, DeVane CL, Chavin KD, et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32(12):1333-1336
75. Zingiber officinale, Professional monograph. Available from: www. naturalstandards.com [cited 11 February 2009]
76. Chang GW, Kam PC. The physiological and pharmacological roles of cytochrome P450 isoenzymes. Anaesthesia 1999;54(1):42-50
77. Gonzalez FJ, Gelboin HV. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab Rev 1994;26(1-2):165-183
78. Shapiro LE, Shear NH. Drug interactions: Proteins, pumps, and P-450s. Journal of the American Academy of Dermatology 2002;47(4):467-84; quiz 85-88
79. Kalra BS. Cytochrome P450 enzyme isoforms and their therapeutic implications: an update. Indian journal of medical sciences 2007;61(2):102-116
80. Omari AA, Murry DJ. Pharmacogenetics of the Cytochrome P450 Enzyme System: Review of Current Knowledge. J Pharm Pract 2007;20:206-208
81. Pirmohamed M, Park BK. Cytochrome P450 enzyme polymorphisms and adverse drug reactions. Toxicology 2003;192(1):23-32
82. Peng WX, Li HD, Zhou HH. Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers. Eur J Clin Pharmacol 2003;59(3):237-241
83. Chen MF, Shimada F, Kato H, et al. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinologia japonica 1990;37(3):331-341
84. Chen MF, Shimada F, Kato H, et al. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Endocrinologia japonica 1991;38(2):167-174
85. Izzo AA. Herb-drug interactions: an overview of the clinical evidence. Fundam Clin Pharm 2005;19(1):1-16
86. Ginkgo biloba, Professional monograph. Available from: www.naturalstandards. com [cited 11 February 2009]
87. Silybum maranium, Professional monograph. Available from: www. naturalstandards.com [cited 11 February 2009]
88. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, et al. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. Journal of toxicology and environmental health 2008;71(21):1415-1429
89. Pattanaik S, Hota D, Prabhakar S, et al. Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. Phytother Res 2006;20(8):683-686
90. Mei Y, Qian F, Wei D, Liu J. Reversal of cancer multidrug resistance by green tea polyphenols. J Pharm. Pharmacol 2004;56(10):1307-1314
91. Zhang Q, Wei D, Liu J. In vivo reversal of doxorubicin resistance by (-)-epigallocatechin gallate in a solid human carcinoma xenograft. Cancer letters 2004;208(2):179-186
92. Hydrastis canadensis, Professional monograph. Available from: www. naturalstandards.com [cited 11 February 2009]