Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor

Journal of Agricultural and Food Chemistry

Volumn 51, Issue 19, 2003, Pages 5661-5670

  Burdette, Joanna E ^a   Liu, Jianghua ^a   Chen, Shao Nong ^a   Fabricant, Daniel S ^a   Piersen, Colleen E ^a   Barker, Eric L ^b   Pezzuto, John M ^b   Mesecar, Andrew ^a   Van Breemen, Richard B ^a   Farnsworth, Norman R ^a   Bolton, Judy L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Actaea racemosa L.; Black cohosh; Cimicifuga racemosa (L.) Nutt.; Estrogen receptor; Hot flashes; Serotonin receptor

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 PROPANOL; ACETAEA RACEMOSA EXTRACT; ANTIESTROGEN; CYCLIC AMP; ESTRADIOL; ESTROGEN; LIGAND; LYSERGIDE; METHANOL; METITEPINE; RADIOLIGAND; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ACETAEA RACEMOSA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL MEMBRANE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; ESTROGEN ACTIVITY; FEEDING; FEMALE; HOT FLUSH; HYPOTHALAMUS; IC 50; LIGAND BINDING; MENOPAUSE; NONHUMAN; OVARIECTOMY; RAT; RECEPTOR BINDING; RHIZOME;

ANIMALS; BINDING, COMPETITIVE; CELL DIFFERENTIATION; CIMICIFUGA; CYCLIC AMP; FEMALE; HOT FLASHES; HUMANS; MENOPAUSE; OVARIECTOMY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; RHIZOME; VAGINA;

ANIMALIA; CAULOPHYLLUM; CIMICIFUGA; CIMICIFUGA DAHURICA; CIMICIFUGA RACEMOSA;

EID: 0042835793     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf034264r     Document Type: Article

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